Web Desc
G Protein-Coupled Receptors: New Insights in Functional Regulation and Clinical Application
Organizer(s): Heidi E. Hamm, P. Jeffrey Conn, Jean-Philippe Pin and Olivier Civelli
Date: May 18 - 23, 2008
Location: INEC Killarney Convention Centre, Killarney, Co. Kerry, Ireland
In collaboration with Science Foundation Ireland; Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development
Summary of Meeting:
The G-protein-coupled-receptor (GPCR) family accounts for almost 3% of the human genome and encompasses the largest number of receptors identified to date. Further, GPCRs have proven to be one of the primary targets for therapeutic drug intervention. Work in the field is rapidly progressing through the identification of structural aspects of activation, dimerization and its functional significance, ligand-directed signaling, de-orphanization of GPCRs and their signaling pathways, allosteric modulators of GPCR activation, as well as novel interacting protein complexes and their correlate signaling cascades. This Keystone Symposia meeting will focus on these important aspects of GPCRs as well as how they regulate functional systems such as sleep, stress and feeding. Finally, the effect of genetic disease on GPCR activation and signaling will be discussed.
Scholarship Deadline: January 18 2008
Discounted Abstract Deadline: January 18 2008
Abstract Deadline: February 19 2008
Discounted Registration Deadline: March 31 2008
We gratefully acknowledge additional support for this conference from:
Fáilte IrelandMerck & Co., Inc.Pfizer Global Research & DevelopmentScience Foundation Ireland
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Addex Pharmaceuticals SA

Merck & Co., Inc.

Senomyx, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH083445-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 18 | 3:00PM - 7:30PM
Registration
Room: INEC Conference Centre Foyer


Sunday, May 18 | 6:30PM - 7:30PM
Refreshments
Room: INEC Conference Centre Foyer


Sunday, May 18 | 7:30PM - 8:30PM
Keynote Address
Room: INEC Main Auditorium

Speaker 1 of 1
Brian K. Kobilka, Stanford University School of Medicine, USA
Structure and Dynamics of the Human beta 2 Adrenergic Receptor

Monday, May 19 | 7:00AM - 8:00AM
Breakfast
Room: INEC Conference Centre Foyer


Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 6 of 6
Jean-Louis Banères, CNRS - UMR5247 IBMM, France
Heterodimer Regulation of GPCR Activation

Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 5 of 6
Jonathan A. Javitch, Columbia University, USA
Dopamine D2 Receptors Form Higher Order Oligomers at Physiological Expression Levels


Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 4 of 6
Martin Caffrey, University of Limerick, Ireland
Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases

Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 3 of 6
Gebhard F. X. Schertler, Paul Scherrer Institut, Switzerland
Structure of the Beta 1 Adrenergic Receptor: Progress in Obtaining Recombinant G Protein Coupled Receptor Structures

Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 2 of 6
Krzysztof Palczewski, Case Western Reserve University, USA
Structure of Rhodopsin

Monday, May 19 | 8:00AM - 11:15AM
GPCR Conformation
Room: INEC Main Auditorium

Speaker 1 of 6
* Jean-Philippe Pin, Montpellier University, France

Monday, May 19 | 9:20AM - 9:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Monday, May 19 | 11:15AM - 11:15AM
On Own for Lunch


Monday, May 19 | 11:15AM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Monday, May 19 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Monday, May 19 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Monday, May 19 | 5:00PM - 7:15PM
Intracellular Signaling
Room: INEC Main Auditorium

Speaker 5 of 5
Brigitte L. Kieffer, Douglas Institute, Canada
A New Approach to Study GPCR Trafficking in vivo

Monday, May 19 | 5:00PM - 7:15PM
Intracellular Signaling
Room: INEC Main Auditorium

Speaker 4 of 5
Joan Heller Heller Brown, University of California, San Diego, USA
GPCR Regulation of Cell Proliferation

Monday, May 19 | 5:00PM - 7:15PM
Intracellular Signaling
Room: INEC Main Auditorium

Speaker 3 of 5
Lan Ma, Fudan University, China
Beta-Arrestin and Synaptic Plasticity

Monday, May 19 | 5:00PM - 7:15PM
Intracellular Signaling
Room: INEC Main Auditorium

Speaker 2 of 5
Xia Zhang, University of Ottawa, Canada
Role of PTEN and 5-HT2c Receptor Coupling in Drug Abuse

Monday, May 19 | 5:00PM - 7:15PM
Intracellular Signaling
Room: INEC Main Auditorium

Speaker 1 of 5
* Jonathan A. Javitch, Columbia University, USA

Monday, May 19 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Monday, May 19 | 7:30PM - 10:00PM
Poster Session 1
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 7:00AM - 8:00AM
Breakfast
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 1 of 6
* Joan Heller Heller Brown, University of California, San Diego, USA

Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 2 of 6
John J.G. Tesmer, University of Michigan, USA
Structural Analysis of an Ancient Pathway Linking Gq-Coupled Receptors to RhoA

Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 3 of 6
Emiliana Borrelli, University of California, Irvine, USA
Specificity of Dopamine Mediated Signaling Differentially Directed by the Two D2 Receptor Isoforms

Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 4 of 6
Taroh Iiri, University of Tokyo, Japan
Talk Title to be Determined

Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 5 of 6
Zoe Jade Barclay, University of Edinburgh, UK
Short Talk: Evidence for the Formation of a Functional Signaling Complex of the 5-HT2A Receptor with ARF1 and PLD1 and its Disruption in an H452Y Polymorphic Variant of the Receptor

Tuesday, May 20 | 8:00AM - 11:00AM
Interacting Proteins
Room: INEC Main Auditorium

Speaker 6 of 6
Dominique Massotte, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France

Tuesday, May 20 | 9:20AM - 9:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, May 20 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 1 of 6
* Olivier Civelli, University of California, Irvine, USA

Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 2 of 6
Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Welcome Remarks

Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 3 of 6
Stefan Offermanns, Universität Heidelberg, Germany
Nicotinic Acid Receptor - Pharmacological and Physiological Functions

Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 4 of 6
Rainer K. Reinscheid, University of California, Irvine, USA
Neuropeptide S Modulates Arousal and Stress Responses

Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 5 of 6
Hans Bräuner-Osborne, University of Copenhagen, Denmark
Basic Amino Acid Receptor GPRC6A Uncovered

Tuesday, May 20 | 5:00PM - 7:00PM
Deorphanized GPCRs
Room: INEC Main Auditorium

Speaker 6 of 6
Deborah Greene Nguyen, Organovo, USA
Short Talk: Utilizing High-Throughput Profiling to Identify Modulators of Novel GPCRs

Tuesday, May 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Tuesday, May 20 | 7:30PM - 10:00PM
Poster Session 2
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 7:00AM - 8:00AM
Breakfast
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 7:00AM - 8:00AM
Poster Setup
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 1 of 6
* Stefan Offermanns, Universität Heidelberg, Germany

Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 2 of 6
Kenji Kangawa, National Cardiovascular Center Research Institute, Japan
Ghrelin: Physiological Significance and Therapeutic Potential for Cardiovascular Diseases

Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 3 of 6
Mark J. Zoller, Senomyx, Inc., USA
Using Sweet and Umami Taste Receptors to Discover Taste Enhancers

Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 4 of 6
William Henry Colledge, University of Cambridge, UK
GPR54 and Kisspeptins

Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 5 of 6
Shuh Narumiya, Kyoto University, Japan
Physiology and Clinical Application of the Prostanoid Receptors

Wednesday, May 21 | 8:00AM - 11:15AM
GPCRs in Physiology 1
Room: INEC Main Auditorium

Speaker 6 of 6
Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandin Receptors in Cardiovascular Disease

Wednesday, May 21 | 9:20AM - 9:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 11:15AM - 12:00PM
Lunch
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 12:00PM - 2:30PM
Poster Session 3
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 2:30PM - 4:30PM
Workshop: Can Industry and Academic Scientists Cooperate to
Facilitate Drug Discovery?
Room: INEC Main Auditorium

Speaker 1 of 5
* Jeffrey Jeffrey Conn, Vanderbilt University, USA
A Model for Early Stage Drug Discovery in an Academic Setting

Wednesday, May 21 | 2:30PM - 4:30PM
Workshop: Can Industry and Academic Scientists Cooperate to
Facilitate Drug Discovery?
Room: INEC Main Auditorium

Speaker 2 of 5
Roy G. Smith, The Scripps Research Institute, USA
Growth Hormone Secretagogue Receptor

Wednesday, May 21 | 2:30PM - 4:30PM
Workshop: Can Industry and Academic Scientists Cooperate to
Facilitate Drug Discovery?
Room: INEC Main Auditorium

Speaker 3 of 5
Gerard J. Marek, Abbott Laboratories, USA
Academic-Industry Collaborations: An Industry Perspective

Wednesday, May 21 | 2:30PM - 4:30PM
Workshop: Can Industry and Academic Scientists Cooperate to
Facilitate Drug Discovery?
Room: INEC Main Auditorium

Speaker 4 of 5
Hugh Rosen, ActivX Biosciences, USA
Chemical Probes not Drugs from Academia

Wednesday, May 21 | 2:30PM - 4:30PM
Workshop: Can Industry and Academic Scientists Cooperate to
Facilitate Drug Discovery?
Room: INEC Main Auditorium

Speaker 5 of 5
Bruce Posner, University of Texas Southwestern Medical Center, USA
The Pfizer-TSRI Collaboration: Partnering for Success in Early Lead Discovery

Wednesday, May 21 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Wednesday, May 21 | 5:00PM - 7:00PM
GPCRs in Physiology 2
Room: INEC Main Auditorium

Speaker 1 of 5
* Brigitte L. Kieffer, Douglas Institute, Canada

Wednesday, May 21 | 5:00PM - 7:00PM
GPCRs in Physiology 2
Room: INEC Main Auditorium

Speaker 2 of 5
Wylie W. Vale, The Salk Institute, USA
Corticotropin Releasing Factor Family of Ligands and their Receptors and Binding Protein

Wednesday, May 21 | 5:00PM - 7:00PM
GPCRs in Physiology 2
Room: INEC Main Auditorium

Speaker 3 of 5
Gilbert Vassart, Université Libre de Bruxelles, Belgium
Constitutive Activity of Wild Type GPCRs: Physiological and Evolutionary Significance

Wednesday, May 21 | 5:00PM - 7:00PM
GPCRs in Physiology 2
Room: INEC Main Auditorium

Speaker 4 of 5
Masayasu Kojima, Kurume University, Japan
Phenotypic Analysis of Ghrelin Knockout Mouse

Wednesday, May 21 | 5:00PM - 7:00PM
GPCRs in Physiology 2
Room: INEC Main Auditorium

Speaker 5 of 5
Jean-Pierre Vilardaga, University of Pittsburgh, USA
Short Talk: Conformational Cross-Talk between GPCR Heterodimers Controls Cell Signaling

Wednesday, May 21 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, May 22 | 7:00AM - 8:00AM
Breakfast
Room: INEC Conference Centre Foyer


Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 1 of 6
* Heidi E. Hamm, USA

Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 2 of 6
Hugh Rosen, ActivX Biosciences, USA
Under the Influence: S1P Receptor Therapeutics

Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 3 of 6
Timothy W. Lovenberg, Johnson & Johnson Pharmaceutical Research and Development LLC, USA
Relaxin 3 and Insulin 5 as Unique GPCR Agonists: Pharmacology and Preclinical Challenges

Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 4 of 6
Andrew D. Howard, Merck Research Laboratories, USA
GPCRs in Metabolism

Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 5 of 6
Colleen Marie Niswender, Vanderbilt University, USA
Allosteric Modulation of mGluR4 as a Novel Therapeutic Direction for the Treatment of Parkinson's Disease

Thursday, May 22 | 8:00AM - 11:00AM
GPCRs in Preclinical Drug Programs
Room: INEC Main Auditorium

Speaker 6 of 6
Katsutoshi Sasaki, Kyowa Hakko Kirin Co., Ltd., Japan
Short Talk: Reverse Chemical Genetics Approach Using a GPR4 Antagonist to Find a Novel Drug Candidate for Respiratory Diseases

Thursday, May 22 | 9:20AM - 9:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Thursday, May 22 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, May 22 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Thursday, May 22 | 5:00PM - 7:00PM
Novel GPCR Drugs in the Clinic
Room: INEC Main Auditorium

Speaker 1 of 4
Vincent Mutel, INFLAM ALPS, Switzerland
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Clinical Efficacy in Gastroesophageal Reflux Disease, Migraine and Acute Anticipatory Anxiety

Thursday, May 22 | 5:00PM - 7:00PM
Novel GPCR Drugs in the Clinic
Room: INEC Main Auditorium

Speaker 2 of 4
* Gerard J. Marek, Abbott Laboratories, USA
Use of mGluR Allosteric Modulators in Schizophrenia

Thursday, May 22 | 5:00PM - 7:00PM
Novel GPCR Drugs in the Clinic
Room: INEC Main Auditorium

Speaker 3 of 4
Madhu Chintala, Schering Plough Research Institute, USA
PAR1 Antagonist

Thursday, May 22 | 5:00PM - 7:00PM
Novel GPCR Drugs in the Clinic
Room: INEC Main Auditorium

Speaker 4 of 4
Javier González-Maeso, Mount Sinai School of Medicine, USA
Short Talk: Identification of a Serotonin/Glutamate Receptor Complex Implicated in Psychosis

Thursday, May 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Thursday, May 22 | 8:00PM - 11:00PM
Entertainment
Room: INEC Conference Centre Foyer


Thursday, May 22 | 8:00PM - 11:00PM
Cash Bar
Room: INEC Conference Centre Foyer


Friday, May 23 | 10:25AM - 10:25AM
Departure


*Session Chair.