Web Desc
Malaria: Immunology, Pathogenesis and Vaccine Perspectives
Organizer(s): Michael F. Good and Nick M. Anstey
Date: June 08 - 13, 2008
Location: Alpbach Congress Centrum, Alpbach, Austria
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Our increased knowledge in basic immunology is having dramatic repercussions on our understanding of the immune responses to the malaria parasite and how these contribute to parasite resistance and to immunopathogenesis. Consequently, we are refining our classical approach to malaria vaccine development which has been based centrally on production of recombinant proteins of the merozoite or sporozoite surface. While these still represent the major pathway, we can now evaluate our approaches in terms of adjuvants, vectors and prime boost approaches to optimize immune responses and chances of success. Simultaneously, we are re-evaluating approaches based on whole parasites (sporozoites, red cell stages) using attenuated and inactivated organisms. The meeting will bring together world leaders in the three inter-related sub themes and update all attendees on the complex interactions between induction of immune responses and the consequences, both positive (i.e. immunity) and negative (immune dysregulation and disease). We will hear the latest reports on clinical trials for both the leading subunit and whole organismal vaccines in a venue which will see scientists from both developed countries and malaria-endemic countries sharing ideas and planning strategic research collaborations.
Global Health Travel Award Deadline: January 7 2008
Scholarship Deadline: February 8 2008
Discounted Abstract Deadline: February 8 2008
Abstract Deadline: March 11 2008
Discounted Registration Deadline: April 8 2008
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Sanaria Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI078721-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 08 | 3:00PM - 7:30PM
Registration
Room: Otto Molden Foyer


Sunday, June 08 | 6:30PM - 7:30PM
Welcome
Room: Otto Molden Foyer


Sunday, June 08 | 7:30PM - 8:30PM
Keynote Address
Room: Erwin Schrödinger Hall

Speaker 1 of 2
* Michael F. Good, Griffith University, Australia

Sunday, June 08 | 7:30PM - 8:30PM
Keynote Address
Room: Erwin Schrödinger Hall

Speaker 2 of 2
Stephen L. Hoffman, Sanaria, USA
The Role of an Attenuated Sporozoite Vaccine in a Changing Malaria World

Monday, June 09 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 1 of 8
* Mary M. Stevenson, McGill University, Canada
Dissecting the Innate Immune Response to Malaria in a Mouse Model

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 2 of 8
Jean Langhorne, Francis Crick Institute, UK
Antigen Presentation, Inflammatory Monocytes and CD4 T Cell Responses in a Blood-Stage Malaria Infection

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 3 of 8
* Eleanor M. Riley, Roslin Institute, UK
Innate Immunity to Malaria

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 4 of 8
Isabella A. Quakyi, University of Ghana, Ghana
Acquired Immunity and Biomarkers of Functional Relevance in Plasmodium falciparum Malaria

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 5 of 8
Greta Weiss, NIAID, National Institutes of Health, USA
Short Talk: The Impact of P. falciparum Infection on the Development and Maintenance of Memory B Cells

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 6 of 8
Tonia Woodberry, Menzies School of Health Research, Australia
Short Talk: Human T Cell Recognition of the Novel Vaccine Target Plasmodium HGXPRT following Natural Parasite Exposure

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 7 of 8
Diane Wallace Taylor, University of Hawaii, USA
Short Talk: Are Antimalarial Immune Responses Altered in Pregnant Women?

Monday, June 09 | 8:00AM - 11:45AM
Immunology I
Room: Erwin Schrödinger Hall

Speaker 8 of 8
Shazia Khanam, Tata Institute of Fundamental Research, India
Short Talk: Murine Malarial Infections Affect Thymic T Cell Development

Monday, June 09 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Monday, June 09 | 11:45AM - 1:00PM
Poster Setup
Room: Otto Molden Foyer


Monday, June 09 | 11:45AM - 11:45AM
On Own for Lunch


Monday, June 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Otto Molden Foyer


Monday, June 09 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Monday, June 09 | 5:00PM - 7:00PM
Worms and Malaria
Room: Erwin Schrödinger Hall

Speaker 1 of 3
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunological Consequences of Malaria and Helminth Coinfection

Monday, June 09 | 5:00PM - 7:00PM
Worms and Malaria
Room: Erwin Schrödinger Hall

Speaker 2 of 3
Christian R. Engwerda, Queensland Institute of Medical Research, Australia
The Pathogenesis of Experimental Cerebral Malaria during Schistosoma mansoni Infection

Monday, June 09 | 5:00PM - 7:00PM
Worms and Malaria
Room: Erwin Schrödinger Hall

Speaker 3 of 3
Pierre Druilhe, Institut Pasteur, France
Worms Worsen Malaria: Understanding Human-P. falciparum Immune Interactions Uncovers the Immunological Role of Worms

Monday, June 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Monday, June 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Otto Molden Foyer


Tuesday, June 10 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Tuesday, June 10 | 7:00AM - 8:00AM
Poster Setup
Room: Otto Molden Foyer


Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 1 of 8
* James W. Kazura, Case Western Reserve University, USA
Natural Evolution of Adaptive Immunity to MSP1 during Childhood in Holoendemic Malaria: Relation to Resistance to Blood Stage Plasmodium falciparum in vivo

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 2 of 8
* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Generation and Maintenance of B Cell Immunological Memory in Response to Plasmodium falciparum

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 3 of 8
William R. Heath, University of Melbourne, Australia
Murine Blood-Stage Plasmodium berghei Infection Induces Pathogen-Specific CD8+ Cytotoxic T cell Immunity

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 4 of 8
Hajime Hisaeda, Kyushu University, Japan
Short Talk: Malaria Parasites Require Toll-Like Receptor 9 Signaling for Immune Evasion by Activating Regulatory T Cells

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 5 of 8
Maria Sophia Mackroth, Case Western Reserve University, USA
Short Talk: Human Cord Blood CD4+CD25hi Regulatory T Cells Suppress Prenatally Acquired T Cell Response to Plasmodium falciparum Antigens

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 6 of 8
Gabriela Minigo, Menzies School of Health Research, Australia
Short Talk: Mechanisms of Induction of Unconventional CD25- Regulatory T Cells and Conventional Treg and Association with Parasitemia in Malaria Infection

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 7 of 8
Michael Walther, Medical Research Council Laboratories, Fajara, Gambia
Short Talk: Immunoregulation in Uncomplicated and Severe P. falciparum Malaria

Tuesday, June 10 | 8:00AM - 11:30AM
Immunology II
Room: Erwin Schrödinger Hall

Speaker 8 of 8
John T. Harty, University of Iowa, USA
Short Talk: Numerical Requirements for Long-Term CD8+ T Cell Immunity to P. berghei Sporozoite Challenge

Tuesday, June 10 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Tuesday, June 10 | 11:30AM - 12:30PM
Lunch
Room: Otto Molden Foyer


Tuesday, June 10 | 12:30PM - 2:30PM
Poster Session 2
Room: Otto Molden Foyer


Tuesday, June 10 | 2:30PM - 4:30PM
Pathogenesis I
Room: Erwin Schrödinger Hall

Speaker 1 of 4
Kamija Samuel Phiri, College of Medicine, University of Malawi, Malawi
Pathogenesis of Severe Anaemia in Malawian Children Living in a Malaria Endemic Area

Tuesday, June 10 | 2:30PM - 4:30PM
Pathogenesis I
Room: Erwin Schrödinger Hall

Speaker 2 of 4
* Louis Schofield, James Cook University, Australia
Immunological Mechanisms Controlling Erythropoietic Suppression and Severe Anaemia in Experimental Malaria Infections

Tuesday, June 10 | 2:30PM - 4:30PM
Pathogenesis I
Room: Erwin Schrödinger Hall

Speaker 3 of 4
Douglas Golenbock, University of Massachusetts Medical School, USA
The Basis of Fever and Proinflammatory Cytokinemia in Acute Malaria


Tuesday, June 10 | 2:30PM - 4:30PM
Pathogenesis I
Room: Erwin Schrödinger Hall

Speaker 4 of 4
Constance A. Finney, University of Toronto, Canada
Short Talk: TLR Involvement during Experimental Malaria: Implications at both Ends of the Clinical Spectrum of Human Disease

Tuesday, June 10 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Tuesday, June 10 | 5:00PM - 7:00PM
Pathogenesis II - Cerebral Malaria
Room: Erwin Schrödinger Hall

Speaker 1 of 4
Dan Milner, Harvard School of Public Health, USA
Pediatric Cerebral Malaria: Insights from the Ongoing Autopsy Study in Blantyre, Malawi

Tuesday, June 10 | 5:00PM - 7:00PM
Pathogenesis II - Cerebral Malaria
Room: Erwin Schrödinger Hall

Speaker 2 of 4
Isabelle Medana, Oxford University, UK
The Pathology and Pathophysiology of Cerebral Malaria in Adults

Tuesday, June 10 | 5:00PM - 7:00PM
Pathogenesis II - Cerebral Malaria
Room: Erwin Schrödinger Hall

Speaker 3 of 4
* Georges E. R. Grau, University of Sydney, Australia
Cerebral Malaria: Malarial Antigen Transfer by Microparticles or Trogocytosis as Effectors of Microvascular Endothelial Lesions

Tuesday, June 10 | 5:00PM - 7:00PM
Pathogenesis II - Cerebral Malaria
Room: Erwin Schrödinger Hall

Speaker 4 of 4
Gregory S. Park, University of Minnesota, USA
Short Talk: von Willebrand Factor, but not sVCAM-1 or sICAM-1, Effectively Discriminates between Cerebral and Uncomplicated Malaria in Ugandan Children

Tuesday, June 10 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, June 11 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 1 of 7
Nicholas Beare, Royal Liverpool University Hospital, UK
Retinal Microvasculature and the Pathophysiology of Cerebral Malaria

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 2 of 7
* Nick M. Anstey, Menzies School of Health Research, Australia
Impaired Nitric Oxide Bioavailability and Endothelial Dysfunction in Severe Malaria: A Target for Adjunctive Therapy?

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 3 of 7
* Patrick E. Duffy, NIAID, National Institutes for Health, USA
Maternal and Fetal Factors Predict Malaria Outcomes during Infancy

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 4 of 7
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Immunogenetics of Disease Susceptibility

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 5 of 7
Gabriele S.V. Campanella, Massachusetts General Hospital, USA
Short Talk: Chemokine Receptor CXCR3 and its Ligands CXCL9 and CXCL10 are Required for the Development of Murine Cerebral Malaria

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 6 of 7
Brendan J. McMorran, University of Tasmania, Australia
Short Talk: Platelets have a Protective Role in Erythrocytic Stage Malaria Infection

Wednesday, June 11 | 8:00AM - 11:30AM
Pathogenesis III
Room: Erwin Schrödinger Hall

Speaker 7 of 7
Katsuyuki Yui, Nagasaki University, Japan
Short Talk: Malaria-Specific and Non-Specific Activation of CD8+ T-Cells during Blood Stage of Plasmodium berghei Infection

Wednesday, June 11 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Wednesday, June 11 | 11:30AM - 1:00PM
Poster Setup
Room: Otto Molden Foyer


Wednesday, June 11 | 11:30AM - 11:30AM
On Own for Lunch


Wednesday, June 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Otto Molden Foyer


Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 1 of 6
Ana Pamplona Pamplona, University of Lisbon, Portugal
Heme Oxygenase-1 and Carbon Monoxide Suppress the Pathogenesis of Experimental Cerebral Malaria

Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 2 of 6
Patti Kiser, Colorado State University, USA
IL-10-Producing CD4+T-Cells Mitigate Malaria-Associated Anemia

Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 3 of 6
Bernd Lepenies, Max Planck Institute of Colloids and Interfaces, Germany
Ligation of B and T Lymphocyte Attenuator (BTLA) Protects Mice from Cerebral Malaria during P. berghei ANKA Infection

Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 4 of 6
* Ian A. Cockburn, Australian National University, Australia
Long-Term Antigen Presentation Following Exposure to Plasmodium Sporozoites may Induce T Cell Dysfunction

Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 5 of 6
Olivia C. Finney, Seattle Childrens Research Institute, USA
Regulatory T Cells are Upregulated after Natural Exposure to Plasmodium falciparum

Wednesday, June 11 | 2:30PM - 4:30PM
Workshop: Presentations by Travel Scholarship Awardees
Room: Erwin Schrödinger Hall

Speaker 6 of 6
Indu Malhotra, Case Western Reserve University, USA
Effect of Prenatal Exposure to Malaria on the Susceptibility to Infection during Childhood

Wednesday, June 11 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Wednesday, June 11 | 5:00PM - 7:15PM
Vaccines I
Room: Erwin Schrödinger Hall

Speaker 1 of 5
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Vectored Malaria Vaccines

Wednesday, June 11 | 5:00PM - 7:15PM
Vaccines I
Room: Erwin Schrödinger Hall

Speaker 2 of 5
* Thomas L. Richie, Sanaria Inc., USA
Developing a Multi-Stage, Multi-Antigen Adenovirus-Vectored Vaccine against P. falciparum Malaria

Wednesday, June 11 | 5:00PM - 7:15PM
Vaccines I
Room: Erwin Schrödinger Hall

Speaker 3 of 5
Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium
The RTS,S. Malaria Vaccine Candidate: From Phase II to Phase III

Wednesday, June 11 | 5:00PM - 7:15PM
Vaccines I
Room: Erwin Schrödinger Hall

Speaker 4 of 5
Alessandro Sette, La Jolla Institute for Immunology, USA
Short Talk: Meta-Analysis of Immune Epitope Data for Plasmodium Species: Overview and Applications for Malarial Immunobiology and Vaccine-Related Issues

Wednesday, June 11 | 5:00PM - 7:15PM
Vaccines I
Room: Erwin Schrödinger Hall

Speaker 5 of 5
Sope Omowale Olugbile, Institut de Biochimie, Switzerland
Short Talk: Novel Polyepitope Malaria Vaccine Candidate

Wednesday, June 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Wednesday, June 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Otto Molden Foyer


Thursday, June 12 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 1 of 7
* Louis H. Miller, National Institutes of Health, USA
Why a Malaria Vaccine is Possible

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 2 of 7
Brendan S. Crabb, Burnet Institute, Australia
New Insights into Merozoite Invasion and Post-Invasion Events

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 3 of 7
Denise L. Doolan, James Cook University, Australia
Plasmodium falciparum Immunomics and Vaccine Development

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 4 of 7
* Sanjai Kumar, Food And Drug Administration, USA
Considerations for Whole Parasite Based Malaria Vaccines

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 5 of 7
Arturo Reyes-Sandoval, University of Oxford, UK
Short Talk: A Phase I Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidate AdCh63 ME-TRAP, Alone and with MVA ME-TRAP, using a Prime-Boost Delivery Schedule

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 6 of 7
Edmond Joseph Remarque, Biomedical Primate Research Centre, Netherlands
Short Talk: Diversity-Covering Immunization with Plasmodium falciparum AMA1 (PfAMA1) Induces Broader Allelic Recognition and Growth Inhibition Responses in Rabbits and Rhesus

Thursday, June 12 | 8:00AM - 11:30AM
Vaccines II
Room: Erwin Schrödinger Hall

Speaker 7 of 7
Toshihiro Horii, Research Institute for Microbial Diseases, Japan
Short Talk: Learning from Interfacing Studies on SE36: A Candidate Malaria Vaccine that Targets the Achilles’ Heel Antigen of Plasmodium falciparum

Thursday, June 12 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Thursday, June 12 | 11:30AM - 11:30AM
On Own for Lunch


Thursday, June 12 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Thursday, June 12 | 5:00PM - 7:15PM
Whole Parasite Vaccines
Room: Erwin Schrödinger Hall

Speaker 1 of 5
* Stephen L. Hoffman, Sanaria, USA
Progress Toward Development of a Metabolically Active, Non Replicating Plasmodium falciparum Sporozoite Vaccine

Thursday, June 12 | 5:00PM - 7:15PM
Whole Parasite Vaccines
Room: Erwin Schrödinger Hall

Speaker 2 of 5
Stefan Kappe, Seattle BioMed, USA
Genetically Engineered Malaria Parasite Vaccines

Thursday, June 12 | 5:00PM - 7:15PM
Whole Parasite Vaccines
Room: Erwin Schrödinger Hall

Speaker 3 of 5
Michael F. Good, Griffith University, Australia
Could a Whole Parasite Vaccine be Effective Against the Blood Stages?

Thursday, June 12 | 5:00PM - 7:15PM
Whole Parasite Vaccines
Room: Erwin Schrödinger Hall

Speaker 4 of 5
Meta Roestenberg, Radboud University Medical Center Nijmegen, Netherlands
Short Talk: Sterile Protection against P. falciparum Challenge in Human Volunteers after Repeated Exposure to Sporozoites under Chloroquine Prophylaxis

Thursday, June 12 | 5:00PM - 7:15PM
Whole Parasite Vaccines
Room: Erwin Schrödinger Hall

Speaker 5 of 5
Kavita Singh, National Institutes of Health, USA
Short Talk: Structures of the Plasmodium falciparum VAR2CSA DBL3x Domain and its Complex with Chondroitin Sulfate A that is Implicated in Pregnancy-Associated Malaria

Thursday, June 12 | 7:15PM - 7:30PM
Closing Remarks
Room: Erwin Schrödinger Hall

Speaker 1 of 1
Nick M. Anstey, Menzies School of Health Research, Australia

Thursday, June 12 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Thursday, June 12 | 8:00PM - 11:00PM
Entertainment
Room: Otto Molden Foyer


Friday, June 13 | 10:25AM - 10:25AM
Departure


*Session Chair.