Web Desc
Metabolic Pathways of Longevity
Organizer(s): Arlan G. Richardson, Eva L. Feldman and Nir Barzilai
Date: March 30 - April 04, 2008
Location: Copper Mountain Resort, Copper Mountain, Colorado, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
This meeting brings together leading investigators in aging and diabetes to discuss how alterations in insulin/IGF-I signaling affect longevity, and the similarities between insulin resistance and aging. Data emerging from several areas suggest that insulin and insulin-like growth factor (IGF-I) could be key players in the regulation of longevity in organisms as diverse as invertebrates and humans. Caloric restriction, which retards aging, is shown to reduce plasma levels of insulin and IGF-I, and the disruption of the insulin/IGF-I receptor in nematodes and flies is shown to increase lifespan. However, mammals with genetic or acquired defects in the insulin signaling pathway are at risk for age-related diseases and increased mortality, e.g., insulin resistance and diabetes.
Scholarship Deadline: November 30 2007
Discounted Abstract Deadline: November 30 2007
Abstract Deadline: December 31 2007
Discounted Registration Deadline: January 29 2008
We gratefully acknowledge additional support for this conference from:
Glenn Foundation for Medical ResearchSeahorse Bioscience, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG032146-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 30 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Sunday, March 30 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn B

Speaker 1 of 2
* Arlan G. Richardson, University of Texas Health Science Center, USA

Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn B

Speaker 2 of 2
Nir Barzilai, Albert Einstein College of Medicine, USA
The Paradigm of Longevity across Models and its Paradoxes

Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 1 of 7
* Brian K. Kennedy, National University of Singapore, Singapore

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 2 of 7
Radhika Muzumdar, Yeshiva University, USA
Talk Title to be Determined

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 3 of 7
Dominic J. Withers, Imperial College London, UK
The Role of Insulin Receptor Substrate (IRS) Adaptor Proteins in the Regulation of Longevity in Mice and Drosophila

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 4 of 7
Marc Tatar, Brown University, USA
Role of Insulin Signaling in Drosophila

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 5 of 7
Andrew G. Dillin, University of California, Berkeley, USA
PHA-4/Foxa is Essential and Specific for DR-mediated Longevity

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 6 of 7
Michael A. Riehle, University of Arizona, USA
Short Talk: Shutting Down Insulin Signaling: PTEN in the Mosquito Aedes Aegypti and its Effect on Reproduction and Lifespan

Monday, March 31 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Invertebrates
Room: Bighorn B

Speaker 7 of 7
Mirela Matecic, University of Virginia, USA
Short Talk: Identification of Genetic and Metabolic Pathways that Regulate Yeast Chronological Lifespan

Monday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, March 31 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn C


Monday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Monday, March 31 | 5:00PM - 7:00PM
Longevity and Insulin/IGF-I Signaling in Humans
Room: Bighorn B

Speaker 1 of 5
* Nir Barzilai, Albert Einstein College of Medicine, USA

Monday, March 31 | 5:00PM - 7:00PM
Longevity and Insulin/IGF-I Signaling in Humans
Room: Bighorn B

Speaker 2 of 5
Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Genome Wide Association Study of Glucose Homeostasis and Cardiovascular Aging

Monday, March 31 | 5:00PM - 7:00PM
Longevity and Insulin/IGF-I Signaling in Humans
Room: Bighorn B

Speaker 3 of 5
Yousin Suh, Albert Einstein College of Medicine, USA
Functional Insulin-like Growth Factor-I Receptor Mutations in Centenarians

Monday, March 31 | 5:00PM - 7:00PM
Longevity and Insulin/IGF-I Signaling in Humans
Room: Bighorn B

Speaker 4 of 5
David R. Clemmons, University of North Carolina at Chapel Hill, USA
Modulation of Tissue Responsiveness to IGF-I by Hyperglycemic Stress

Monday, March 31 | 5:00PM - 7:00PM
Longevity and Insulin/IGF-I Signaling in Humans
Room: Bighorn B

Speaker 5 of 5
Gil Atzmon, Albert Einstein College Of Medicine, USA
Short Talk: The Growth Hormone Receptor exon-3 Deletion is a Marker for Exceptional Longevity

Monday, March 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Monday, March 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Bighorn C


Tuesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 1 of 7
* Marc Tatar, Brown University, USA

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 2 of 7
Makoto Kuro-O, UT Southwestern Medical Center at Dallas, USA
The Anti-Aging Mechanism Mediated by Klotho Gene Family

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 3 of 7
Anne Brunet, Stanford University, USA
FOXO Transcription Factors: Central Sensors of Environmental Stimuli that Regulate Longevity

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 4 of 7
Feng Liu, University of Texas Health Science Center, USA
Neuronal Insulin/IGF-I Signaling and the Regulation of Mammalian Lifespan

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 5 of 7
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Signaling, Adipose Tissue and Mechanisms of Increased Lifespan

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 6 of 7
Johan Svensson, Sahlgrenska University Hospital, Sweden
Short Talk: Liver-Derived IGF-I Regulates Life Span in Mice

Tuesday, April 01 | 8:00AM - 11:15AM
Longevity and Insulin/IGF-I Signaling in Rodents
Room: Bighorn B

Speaker 7 of 7
Joseph A. Baur, University of Pennsylvania, USA
Short Talk: Resveratrol in Health and Longevity

Tuesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, April 01 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn C


Tuesday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Therapeutic Intervention
Room: Bighorn B

Speaker 1 of 4
* Nancy L. Nadon, National Institute on Aging, USA

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Therapeutic Intervention
Room: Bighorn B

Speaker 2 of 4
Richard A. Miller, University of Michigan, USA
NIA Interventions Testing Program: Current Status and Future Plans

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Therapeutic Intervention
Room: Bighorn B

Speaker 3 of 4
David E. Harrison, The Jackson Laboratory, USA
The Checkered History of Anti-Aging Interventions

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 1: Drug Discovery/Therapeutic Intervention
Room: Bighorn B

Speaker 4 of 4
Randy Strong, South Texas Veterans Health Care System, USA
Pharmacological Intervention in the mTOR Signaling Pathway during Aging: Technical Challenges and Solutions

Tuesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Tuesday, April 01 | 5:00PM - 7:00PM
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Room: Bighorn B

Speaker 1 of 5
* Richard A. Miller, University of Michigan, USA

Tuesday, April 01 | 5:00PM - 7:00PM
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Room: Bighorn B

Speaker 2 of 5
Brian K. Kennedy, National University of Singapore, Singapore
Conserved Longevity Pathways and Dietary Restriction

Tuesday, April 01 | 5:00PM - 7:00PM
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Room: Bighorn B

Speaker 3 of 5
Pankaj Kapahi, Buck Institute for Research on Aging, USA
Regulation of Nutrient Modulated Lifespan by TOR Pathway in Drosophila

Tuesday, April 01 | 5:00PM - 7:00PM
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Room: Bighorn B

Speaker 4 of 5
Christopher J. Lynch, Pennsylvania State University, USA
Rodent Models of Altered mTOR and Plasma Leucine



Tuesday, April 01 | 5:00PM - 7:00PM
The Role of Nutrient Sensing in Aging I: The mTOR Pathway
Room: Bighorn B

Speaker 5 of 5
Navdeep S. Mutti, DuPont-Pioneer, USA
Short Talk: Deciphering the Role of Insulin / Insulin-like (IIS) and TOR Signaling Cascade in Diphenic Caste Development in the Honey Bees, Apis Mellifera

Tuesday, April 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Tuesday, April 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Bighorn C


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 1 of 7
* Arlan G. Richardson, University of Texas Health Science Center, USA

Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 2 of 7
David A. Sinclair, Harvard Medical School, USA
Evidence that Chromatin Reorganization is a Driver of Genomic Instability and Aging in Mammals


Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 3 of 7
Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Control of Metabolism through the PGC-1 Pathways

Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 4 of 7
Cheryl A. Conover, Mayo Clinic College of Medicine, USA
Role of Reduced IGF Binding Protein Protease on Local IGF-I and Lifespan

Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 5 of 7
Leanne M. Redman, Pennington Biomedical Research Center, USA
Calorie Restriction (CR) in Humans and the Phenotype of Aging

Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 6 of 7
Michael Ristow, Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Short Talk: Extending Life Span by Increasing Oxidative Stress: The Concept of Mitohormesis

Wednesday, April 02 | 8:00AM - 11:15AM
The Role of Nutrient Sensing in Aging II: Caloric Restrictio
n

Room: Bighorn B

Speaker 7 of 7
Johannes Bauer, Southern Methodist University, USA
Short Talk: dSir2 and Dmp53 Interact to Mediate Aspects of CR-Dependent Life Span Extension in D. melanogaster

Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 1 of 8
* James F. Nelson, University of Texas Health Science Center, USA

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 2 of 8
Fernanda Menezes Cerqueira, Universidade de São Paulo, Brazil
Mild Mitochondrial Uncoupling Increases Life Span and Improves Redox State in Mice: A New Caloric Restriction Mimetic

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 3 of 8
Shailender Singh Chauhan, Panjab University, India
Beneficial Effects of Dietary Restriction (DR) in Retarding Age Related Biochemical Complications - A Possible Remedy for Aging

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 4 of 8
Chen-Yu Liao, Barshop Institute for Longevity and Aging Studies, USA
Does Fat Mass Play a Role in Life Extension by Caloric Restriction?
--- Verification by QTL Mapping


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 5 of 8
Tadasuke Komori, Wakayama Medical University, Japan
Fasting-Induced Expression of Klotho in the Mouse Hypothalamus

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 6 of 8
Meng C. Wang, Baylor College of Medicine/HHMI, USA
Regulation of Longevity by the Coordination of Fat Metabolism and Reproduction

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 7 of 8
Philip Turnbull, Receptos, USA
The Hunt for Small Molecule Direct Activators of SIRT-1

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2 : Modulation of Longevity by Nutritional Manipula
tions
Room: Bighorn B

Speaker 8 of 8
Vladimir I. Titorenko, Concordia University, Canada
A Modular Network Regulates Longevity in Yeast

Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Wednesday, April 02 | 5:00PM - 7:00PM
Metabolic Signaling and Aging
Room: Bighorn B

Speaker 1 of 5
* Randy Strong, South Texas Veterans Health Care System, USA

Wednesday, April 02 | 5:00PM - 7:00PM
Metabolic Signaling and Aging
Room: Bighorn B

Speaker 2 of 5
Dean Jones, Emory University, USA
Redox Compartmentation and Signaling in Aging: Is there a Redox Code?

Wednesday, April 02 | 5:00PM - 7:00PM
Metabolic Signaling and Aging
Room: Bighorn B

Speaker 3 of 5
Martin G. Myers, Jr., University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action

Wednesday, April 02 | 5:00PM - 7:00PM
Metabolic Signaling and Aging
Room: Bighorn B

Speaker 4 of 5
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Regulation of Metabolism and Life Span by Neuronal Insulin Signaling Cascades

Wednesday, April 02 | 5:00PM - 7:00PM
Metabolic Signaling and Aging
Room: Bighorn B

Speaker 5 of 5
Shin-ichi Oka, University of Medicine and Dentistry of New Jersey, USA
Short Talk: Cardiac Sirt1 Negatively Regulates PPARalpha and PGC-1alpha: Implication of Energy Metabolism and Heart Failure

Wednesday, April 02 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 1 of 6
* Eva L. Feldman, University of Michigan, USA

Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 2 of 6
Arlan G. Richardson, University of Texas Health Science Center, USA
Does Altered Insulin/IGF-1 Signaling Increase Life Span and Reduce Oxidative Stress?

Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 3 of 6
Evan D. Rosen, Harvard University, USA
Genomic Analysis of Insulin Resistance

Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 4 of 6
K. Sreekumaran Nair, Mayo Clinic, USA
Insulin Resistance, Mitochondrial Function and Aging

Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 5 of 6
Gaelle Laurent, Curie Institute, France
Short Talk: Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin-Signaling

Thursday, April 03 | 8:00AM - 11:00AM
Oxidative Stress, Aging, & Insulin/IGF1 Signaling
Room: Bighorn B

Speaker 6 of 6
Mette Soerensen, University of Southern Denmark, Denmark
Short Talk: Genetic Determinants of Extreme Survival - Genetic Variation in Mn-Superoxide Dismutase and Glutathione Peroxidase 1 Genes

Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Thursday, April 03 | 5:00PM - 7:00PM
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Room: Bighorn B

Speaker 1 of 5
* Yousin Suh, Albert Einstein College of Medicine, USA

Thursday, April 03 | 5:00PM - 7:00PM
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Room: Bighorn B

Speaker 2 of 5
Holly Van Remmen, Oklahoma Medical Research Foundation, USA
Potential Role of Mitochondria and Oxidative Stress in Muscle Loss

Thursday, April 03 | 5:00PM - 7:00PM
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Room: Bighorn B

Speaker 3 of 5
Eva L. Feldman, University of Michigan, USA
Mitochondrial Fusion and Fission Mediate Senescence

Thursday, April 03 | 5:00PM - 7:00PM
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Room: Bighorn B

Speaker 4 of 5
Enrique Cadenas, University of Southern California, USA
Energy Metabolism and Mitochondrial Function in Aging: Role of Protein Post-Translational Modifications

Thursday, April 03 | 5:00PM - 7:00PM
Mitochondria Dysfunction, Aging, & Insulin/IGF1
Room: Bighorn B

Speaker 5 of 5
Natascia Ventura, University of Rome, Italy
Short Talk: p53 Rheostatically Modulates C. elegans Longevity Depending on the Level of Mitochondrial Stress

Thursday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Thursday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Kokopelli's


Thursday, April 03 | 8:00PM - 11:00PM
Cash Bar
Room: Kokopelli's


Friday, April 04 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.