Web Desc
Chemokines and Chemokine Receptors
joint with Leukocyte Trafficking
Organizer(s): Alberto Mantovani, Andrew D. Luster and Philip M. Murphy
Date: January 13 - 18, 2008
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Cell migration is a key element for the ontogenesis of lymphoid tissues under homeostatic and pathological conditions, for the patrolling of body compartments by leukocytes, and for the activation and orientation of innate and adaptive immunity. Chemokines are a major component of the trafficking, positioning and functional regulation of leukocytes and nonhematopoietic cells in normal conditions and in diverse pathologies. Structural analysis and imaging approaches have resulted in a better understanding of the action of this complex family of mediators. Chemokines are a prime target for the development of innovative therapeutic strategies, some of which are beginning to undergo clinical assessment. This meeting will bring together scientists and clinicians with different expertise to summarize the current understanding of the chemokine system and its involvement in human pathology, focusing on prospects and challenges for translation into new diagnostic and therapeutic tools.
Scholarship Deadline: September 13 2007
Discounted Abstract Deadline: September 13 2007
Abstract Deadline: October 16 2007
Discounted Registration Deadline: November 13 2007
We gratefully acknowledge additional support for this conference from:
ChemoCentryx, Inc.
GlaxoSmithKline Research & Development, Ltd.
Merck & Co., Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

ChemoCentryx, Inc.

Pfizer Global Research & Development
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI075642-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Sunday, January 13 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Sunday, January 13 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 1 of 2
Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Transendothelial Migration and Bidirectional Signal Transmission in Integrins

Sunday, January 13 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 2 of 2
Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland
Targeting the Chemokine System: From Technology to Evolution

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 1 of 6
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
PI3K gamma in Lymphocyte Trafficking

Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 2 of 6
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Cell Migration through Extracellular Matrix

Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 3 of 6
Stephen J. Weiss, University of Michigan, USA
MMPs and Cell Migration: Just How Similar are Tumor Cells and Leukocytes?

Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 4 of 6
Dimitris Kioussis, National Institute for Medical Research, UK
Imaging of the Lymphoid System and Associated Organs

Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 5 of 6
Ashok Kumar, Mayo Clinic College of Medicine, USA
Short Talk: CXCR4 Signals in T lymphocytes by Trafficking into MTOC-Associated Signaling Endosome Complex (MSEC)

Monday, January 14 | 8:00AM - 11:15AM
Cell Biology of Migration (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 6 of 6
Lawrence R. Shiow, University of California, San Francisco, USA
Short Talk: Characterization of ptcd – a Spontaneous Thymic Egress Mutant

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Trafficking of Innate Immune Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 1 of 5
* Charles R. Mackay, Monash University, Australia
Innate Receptors for Inflammatory Responses: The Role of C5aR, C5L2, GPR43 and the Angiogenic Receptors CXCR2 and CXCR7


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Trafficking of Innate Immune Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 2 of 5
Eun Young Choi, National Cancer Institute, National Institutes of Health, USA
Del-1 (Developmentally regulated Endothelial Locus-1): a novel endogenous anti-adhesive protein that blocks inflammatory cell recruitment.


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Trafficking of Innate Immune Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 3 of 5
Jonathan S. Bromberg, University of Maryland School of Medicine, USA
S1P1 Stimulation Inhibits Afferent Lymphatic Migration


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Trafficking of Innate Immune Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 4 of 5
Elina Kivi, University of Turku, Finland
Identification of a counter-receptor for Vascular Adhesion Protein-1


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Trafficking of Innate Immune Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 5 of 5
Alexander Zarbock, University of Muenster, Germany
Gái2 is required for chemokine-induced neutrophil arrest.


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, January 14 | 5:00PM - 7:00PM
Chemokines in Lymphoid Tissue Homeostasis
Room: Shavano/Torreys

Speaker 1 of 5
* Reinhold Förster, Hannover Medical School, Germany

Monday, January 14 | 5:00PM - 7:00PM
Chemokines in Lymphoid Tissue Homeostasis
Room: Shavano/Torreys

Speaker 2 of 5
Tsvee Lapidot, Weizmann Institute of Science, Israel
Regulation of Stem Cell Trafficking, Retention and Development

Monday, January 14 | 5:00PM - 7:00PM
Chemokines in Lymphoid Tissue Homeostasis
Room: Shavano/Torreys

Speaker 3 of 5
Sergio A. Lira, Mount Sinai School of Medicine, USA
Construction of Extranodal Lymphoid Tissue in Pathology

Monday, January 14 | 5:00PM - 7:00PM
Chemokines in Lymphoid Tissue Homeostasis
Room: Shavano/Torreys

Speaker 4 of 5
Yousuke Takahama, University of Tokushima, Japan
The Chemokine System in the Construction and Function of the Thymus

Monday, January 14 | 5:00PM - 7:00PM
Chemokines in Lymphoid Tissue Homeostasis
Room: Shavano/Torreys

Speaker 5 of 5
Scott N. Mueller, University of Melbourne, Australia
Short Talk: Regulation of Homeostatic Chemokine Expression and Cell Trafficking during Immune Responses

Monday, January 14 | 5:00PM - 7:15PM
In Vivo Insights into Effector and Memory Lymphocyte Traffic
king
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 1 of 5
* Alf Hamann, Charité University Medicine Berlin, Germany
Imprinting of Homing Behavior in Regulatory and Conventional T Cells


Monday, January 14 | 5:00PM - 7:15PM
In Vivo Insights into Effector and Memory Lymphocyte Traffic
king
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 2 of 5
Jorge Rodrigo Mora, Takeda Pharmaceuticals, USA
Conditioning Dendritic Cells to Imprint Gut-Homing Lymphocytes


Monday, January 14 | 5:00PM - 7:15PM
In Vivo Insights into Effector and Memory Lymphocyte Traffic
king
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 3 of 5
Leo Lefrançois, University of Connecticut Health Center, USA
Imaging the Endogenous CD8 T Cell Response to Infection in situ


Monday, January 14 | 5:00PM - 7:15PM
In Vivo Insights into Effector and Memory Lymphocyte Traffic
king
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 4 of 5
Linda F. Thompson, Oklahoma Medical Research Foundation, USA
Short Talk: CD73-generated Adenosine Regulates Lymphocyte Migration into Draining Lymph Nodes


Monday, January 14 | 5:00PM - 7:15PM
In Vivo Insights into Effector and Memory Lymphocyte Traffic
king
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 5 of 5
Irina Mazo, Harvard Medical School, USA
Short Talk: Kinetics of primary and secondary CD8 T cell-mediated immune response in bone marrow


Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays Peak 1-3


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 1 of 6
Michael Sixt, Institute of Science and Technology Austria, Austria
The Role of Integrins in Leukocyte Migration and Motility

Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 2 of 6
Michael L. Dustin, University of Oxford, UK
Natural Killer Patrolling of Liver Sinusoids

Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 3 of 6
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic Intravital Visualization of Immune Cell Activity Using 2-Photon Microscopy

Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 4 of 6
Charles P. Lin, Harvard Medical School, Massachusetts General Hospital, USA
In vivo Flow Cytometry

Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 5 of 6
Steffen Jung, Weizmann Institute of Science, Israel
Short Talk: Perivascular Bone Marrow Dendritic cell clusters provide critical B cell survival signals

Tuesday, January 15 | 8:00AM - 11:15AM
In Situ Visualization of Lymphocyte Migration and Activation
(Joint)

Room: Crestone/Red Cloud/Shavano

Speaker 6 of 6
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Short Talk: In vivo imaging of natalizumab reduced T cell interaction with the blood-brain barrier

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 1 of 10
* Ann Richmond, Vanderbilt University School of Medicine, USA

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 2 of 10
* Jo Van Damme, University of Leuven, Belgium

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 3 of 10
Konstanitina Alexandropoulos, Immunology Institute, Mt. Sinai School of Medicine, USA
A Signaling Complex Comprised of the Adapter Proteins Chat-H and CasL Regulates Activated but not Homeostatic T Cell Migration

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 4 of 10
Songhai Chen, University of Iowa, USA
RACK1 Regulates Directional Cell Migration by Acting on G Protein beta gamma Subunits at the Interface with its Effectors PLCbeta and PI3Kgamma

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 5 of 10
Richard A. Colvin, Massachusetts General Hospital, USA
CXCR3 Requires a Terminal PDZ-Binding Domain and Functionally Interacts with a PDZ-Domain containing Protein

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 6 of 10
Giljun Park, University of Tennessee at Knoxville, USA
An N-terminal Single Point Mutation in CXCR2 Induces Constitutive Activity and Results in Cellular Transformation of NIH 3T3 Cells

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 7 of 10
Daniel Campbell, Benaroya Research Institute, USA
Transcriptional Control of Regulatory T Cell Migration in vivo

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 8 of 10
Ji-Liang Gao, National Institutes of Health, USA
Defective Cognitive Function In Mice Lacking of CX3CR1

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 9 of 10
Aiko Shirakawa, Kinki University School of Medicine, Japan
Induction of CCR10 by 1,25-Dihydroxyvitamin D3 in Terminally Differentiating Human B Cells

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop 1: Chemokine Immunobiology and Signaling
Room: Shavano/Torreys

Speaker 10 of 10
Antje Margret Wengner, Imperial College London, UK
The Co-Ordinated Action of G-CSF and ELR+CXC Chemokines in Neutrophil Mobilisation during Acute Inflammation

Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, January 15 | 5:00PM - 7:00PM
The Chemokine System in Adaptive Immunity
Room: Shavano/Torreys

Speaker 1 of 5
* Bernhard Moser, Cardiff University School of Medicine, UK

Tuesday, January 15 | 5:00PM - 7:00PM
The Chemokine System in Adaptive Immunity
Room: Shavano/Torreys

Speaker 2 of 5
Joshua M. Farber, NIAID, National Institutes of Health, USA
Chemokine Receptors on Th17 Cells and Other CD4+ Effector/Memory T Cell Subsets in Humans

Tuesday, January 15 | 5:00PM - 7:00PM
The Chemokine System in Adaptive Immunity
Room: Shavano/Torreys

Speaker 3 of 5
Gwendalyn J. Randolph, Washington University, USA
The Unexpected Passage Of DC To Lymph Node Through Perinodal Adipose Tissue

Tuesday, January 15 | 5:00PM - 7:00PM
The Chemokine System in Adaptive Immunity
Room: Shavano/Torreys

Speaker 4 of 5
Karen E. Hedin, Mayo Clinic, USA
New Paradigms for Understanding How Chemokines Regulate Immunity: CXCR4 Signaling via the TCR

Tuesday, January 15 | 5:00PM - 7:00PM
The Chemokine System in Adaptive Immunity
Room: Shavano/Torreys

Speaker 5 of 5
James J. Campbell, Brigham and Women's Hospital, USA
Short Talk: Specificity And Dissemination Of Thropic Memory T Cells

Tuesday, January 15 | 5:00PM - 7:15PM
Regulation of Leukocyte Traffic by Endothelial Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 1 of 5
Steffen Massberg, Ludwig-Maximilians-Universität München, Germany
Trafficking Routes of Hematopoietic Stem and Progenitor Cells


Tuesday, January 15 | 5:00PM - 7:15PM
Regulation of Leukocyte Traffic by Endothelial Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 2 of 5
* Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Germany
Control of Leukocyte Diapedesis by Endothelial Cell Contact Proteins


Tuesday, January 15 | 5:00PM - 7:15PM
Regulation of Leukocyte Traffic by Endothelial Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 3 of 5
Sussan Nourshargh, Barts and The London Medical School, UK
Leukocyte Transmigration in Vivo: Role of Endothelial Cell Junctional Molecules and Basement Membrane Remodelling


Tuesday, January 15 | 5:00PM - 7:15PM
Regulation of Leukocyte Traffic by Endothelial Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 4 of 5
Gabriele Bixel, Max Planck Institute of Molecular Biomedicine, Germany
Short Talk: CD99 and CD99L2 Mediate Neutrophil Extravasation to Inflamed Sites


Tuesday, January 15 | 5:00PM - 7:15PM
Regulation of Leukocyte Traffic by Endothelial Cells
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 5 of 5
Lynn M. Schnapp, University of Wisconsin-Madison, USA
Short Talk: Ligand-Induced Adhesion Depends on Cdk4 and Mediates Lymphocyte Binding


Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays Peak 1-3


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 1 of 7
* Robert J. Nibbs, University of Glasgow, UK

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 2 of 7
Massimo Locatti, Istituto Clinico Humanitas IRCCS, Italy
Role of the Chemokine Decoy Receptor D6 in Balancing Inflammation, Immune Activation and Antimicrobial Resistance

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 3 of 7
Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain
Immune Modulation by Chemokine Binding Proteins from Herpesviruses

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 4 of 7
John H. Kehrl, NIAID, National Institutes of Health, USA
Heterodimeric G Proteins In Chemokine Receptor Signalling and Lymphocyte Trafficking

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 5 of 7
Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA
Chemokines in Eosinophils and Type II Inflammation

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 6 of 7
Paul Proost, Rega Institute, K.U.Leuven, Belgium
Short Talk: CD13/Aminopeptidase N-Processed I-TAC/CXCL11 has Reduced CXCR3 and CXCR7 Binding and Signaling Properties that Result in Impaired Lymphocyte Chemotaxis and Reduced Inhibition of Endothelial Cell Migration

Wednesday, January 16 | 8:00AM - 11:15AM
Tuning Chemokines in Inflammation
Room: Shavano/Torreys

Speaker 7 of 7
Yi Le, Naval Medical Research Center, USA
Short Talk: Developmental Regulation of CXCR4-FAK Signaling by SOCS3 during B Lymphopoiesis

Wednesday, January 16 | 8:00AM - 11:00AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 1 of 5
Ronen Alon, Weizmann Institute of Science, Israel
Force Regulated Chemokine Cues for Lymphocyte Adhesion and Motility on Vascular Endothelium and in Interstitial Spaces


Wednesday, January 16 | 8:00AM - 11:00AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 2 of 5
Carlo Laudanna, Italy
Modularity of Signaling Networks Controlling Integrin Activation: The Rho-Module of LFA-1 Affinity Triggering


Wednesday, January 16 | 8:00AM - 11:00AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 3 of 5
Sirpa T. Jalkanen, University of Turku, Finland
Ectoenzyme-Mediated Leukocyte Recruitment


Wednesday, January 16 | 8:00AM - 11:00AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 4 of 5
* Denisa D. Wagner, Harvard Medical School, USA
CalDAG-GEFI and von Willebrand Factor in Leukocyte Adhesion


Wednesday, January 16 | 8:00AM - 11:00AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 5 of 5
Jens V. Stein, University of Bern, Switzerland
Short Talk: In vivo imaging of the roles of endothelial ICAM-1 and ICAM-2 during lymphocyte adhesion in lymph node venules


Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, January 16 | 11:15AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 1 of 6
* Craig Gerard, Children's Hospital Harvard University, USA
C5L2 Does Not Signal through ERK Kinase Pathways


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 2 of 6
Norbert Wagner, RWTH Aachen University Hospital, Germany
Generation and analysis of a mouse mutant deficient for the adhesion molecule MAdCAM-1


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 3 of 6
João Pereira, Yale University School of Medicine, USA
Transient alpha4beta1 integrin-mediated retention of immature B cells in bone marrow sinusoids during egress


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 4 of 6
Stefano Angiari, Trinity College Dublin, Ireland
Role of Fucosyltransferase-VII and P-selectin glycoprotein ligand-1 in the migration of CD4+CD25+ regulatory T cells in inflamed brain


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 5 of 6
Charles Colin Brinkman, University of Virginia, USA
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory cell characteristics


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: Lymphocyte Migration in Inflammation and Infecti
on
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 6 of 6
Linda S. Cauley, University of Connecticut Health Center, USA
Naïve and memory influenza-specific CD8 T cells respond to different APCs in reactive lymph nodes during late antigen presentation


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 1 of 6
* Joost J. Oppenheim, National Institutes of Health, USA

Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 2 of 6
Christian Weber, RWTH Aachen University Hospital, Germany
Chemokine-Like Functions of MIF in Leukocyte Recruitment

Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 3 of 6
Annalisa Del Prete, University of Bari, Italy
The Role of Chemerin in the Recruitment of Plasmacytoid Dendritic Cells in Normal and Pathological Conditions

Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 4 of 6
Andrew M. Tager, Massachusetts General Hospital, USA
Grease On Fire: Lipid-Chemokine Cooperation On Leukocyte Trafficking

Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 5 of 6
Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Short Talk: CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues

Wednesday, January 16 | 5:00PM - 7:15PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)
Room: Crestone/Red Cloud/Shavano

Speaker 6 of 6
Masayuki Miyasaka, Osaka University, Japan
Short Talk: The role of a cell-motility inducing protein, autotaxin, in high endothelial venules of lymph nodes and Peyer’s patches

Wednesday, January 16 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Wednesday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays Peak 1-3


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 1 of 7
* Robert M. Strieter, University of Virginia School of Medicine, USA

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 2 of 7
Richard M. Ransohoff, Third Rock Ventures, USA
CXCR2 Deficiency Promotes CNS Myelin Repair: Anti-Inflammatory Neurobiological Effects

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 3 of 7
Nicholas W. Lukacs, University of Michigan, USA
Chemokine Receptors and Leukocyte Accumulation Influence Pulmonary Disease Pathology

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 4 of 7
Luigi D. Notarangelo, Children's Hospital, Boston, USA
Chemokine-Guided Leukocyte Traffic: Lessons from Human Congenital Immunodeficiencies

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 5 of 7
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Chemokines and their Receptors in Gynaecological Malignancies

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 6 of 7
† Martine J. Smit, VU University Amsterdam, Netherlands
Short Talk: Viral Chemokine Receptor US28 Acts as Potential Oncogene: A Key Role for COX-2 in US28-Induced Tumorigenesis

Thursday, January 17 | 8:00AM - 11:15AM
The Chemokine System in Pathology and Clinics
Room: Shavano/Torreys

Speaker 7 of 7
Nikolaos G. Frangogiannis, Baylor College of Medicine, USA
Short Talk: CXCL10/IP-10 Induction Orchestrates Infarct Healing

Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 1 of 6
Tanya N. Mayadas, Brigham and Women's Hospital, USA
Immune Complex-Mediated Leukocyte Trafficking and Injury In vivo


Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 2 of 6
Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis


Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 3 of 6
* Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Migratory and Functional Properties of Monocyte Subsets


Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 4 of 6
Francois Mach, University Hospital, Geneva Foundation for Medical Research, Switzerland
Cannabinoid Receptors in Atherosclerosis


Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 5 of 6
Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: CXCR6 promotes atherosclerosis by supporting T cell homing, interferon gamma production and macrophage accumulation in the aortic wall


Thursday, January 17 | 8:00AM - 11:15AM
Immune Cell Trafficking in Inflammation and Atherosclerosis
This session is from Leukocyte Trafficking
Room: Crestone/Red Cloud

Speaker 6 of 6
Scott I. Simon, University of California, Davis, USA
Short Talk: Triglyceride-Rich Lipoproteins Prime Aortic Endothelium
For Enhanced Inflammation


Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 1 of 9
* Nicholas W. Lukacs, University of Michigan, USA

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 2 of 9
Ting Jia, Memorial Sloan Kettering Cancer Center, USA
Role of MCP-3 in Monocyte Recruitment and Innate Immune Defense during Intracellular Bacterial Infection

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 3 of 9
Shiro Kanegasaki, Effector Cell Institute, Inc., Japan
ECI301, an Active Variant of MIP-1alpha, Consistently Induced the Abscopal Effect of Radiation

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 4 of 9
Pawel Kalinski, University of Pittsburgh, USA
Dendritic Cells Regulate the Lymphoid/Memory versus Peripheral/ Effector Pathway of Differentiation of CD8+ T Cells

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 5 of 9
Marion Leick, University Hospital Freiburg, Germany
The Orphan Chemokine Receptor CRAM-A/B is an Atypical Receptor Expressed on B Cells in a Maturation Stage Dependent and CCL5 Modulated Manner

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 6 of 9
Jean K. Lim, Icahn School of Medicine at Mount Sinai, USA
Chemokine Receptor CCR2 Directs Macrophage Recruitment to the CNS and Promotes Survival from West Nile Virus Infection in Mice

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 7 of 9
Federica Marchesi, IRCCS Istituto Clinico Humanitas, Italy
The Neurotactin/Fractalkine Chemokine Receptor CX3CR1 Mediates Perineural Invasion and Malignant Behavior of Human Ductal Pancreatic Adenocarcinoma

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 8 of 9
Benjamin D. Medoff, Massachusetts General Hospital, USA
CD11b+ Dendritic Cells are the Critical Cellular Mediator of Th2 Cell Homing into the Lung in Allergic Airway Inflammation

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Chemokines in Pathology and Therapy
Room: Shavano/Torreys

Speaker 9 of 9
Marco Prinz, University of Freiburg, Germany
Spatial and Temporal Expression of CCR2 Determines the Outcome of Autoimmunity in the Central Nervous System

Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Thursday, January 17 | 5:00PM - 7:15PM
Chemokines as Targets for Pharmacological Intervention
Room: Shavano/Torreys

Speaker 1 of 5
* Kouji Matsushima, University of Tokyo School of Medicine, Japan

Thursday, January 17 | 5:00PM - 7:15PM
Chemokines as Targets for Pharmacological Intervention
Room: Shavano/Torreys

Speaker 2 of 5
Thomas J. Schall, ChemoCentryx, Inc., USA
Targeting CCR9: Rationale and Clinical Development

Thursday, January 17 | 5:00PM - 7:15PM
Chemokines as Targets for Pharmacological Intervention
Room: Shavano/Torreys

Speaker 3 of 5
Elna Van Der Ryst, Pfizer Global Research and Development, UK
Challenges in the Design and Development of Maraviroc, a Novel CCR5 Antagonist for the Treatment of CCR5-Tropic HIV-1 Infection

Thursday, January 17 | 5:00PM - 7:15PM
Chemokines as Targets for Pharmacological Intervention
Room: Shavano/Torreys

Speaker 4 of 5
John F. Dipersio, Washington University, USA
CXCR4 and Hemopoietic Precursor Mobilization in the Clinic

Thursday, January 17 | 5:00PM - 7:15PM
Chemokines as Targets for Pharmacological Intervention
Room: Shavano/Torreys

Speaker 5 of 5
R. William Hipkin, Schering-Plough Research Institute, USA
Short Talk: SCH 527123: a Potent, Orally-Active CXCR2 Antagonist

Thursday, January 17 | 5:00PM - 7:00PM
Preclinical and Clinical Anti-Adhesion and Anti-Chemokine Th
erapy
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 1 of 4
* Gabriela Constantin, University of Verona, INSTITUTI BIOLOGICI, Italy
Anti-Leukocyte Recruitment Treatment for the Prevention and Therapy of Epilepsy


Thursday, January 17 | 5:00PM - 7:00PM
Preclinical and Clinical Anti-Adhesion and Anti-Chemokine Th
erapy
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 2 of 4
Stefan Hemmerich, Y's Therapeutics Inc., USA
Clinical Development of a Recombinant Selectin Antagonist for Prevention of Ischemia Repurfusion Injury in Solid Organ Transplantation


Thursday, January 17 | 5:00PM - 7:00PM
Preclinical and Clinical Anti-Adhesion and Anti-Chemokine Th
erapy
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 3 of 4
Daniel Bock, Revotar Biopharmaceuticals, Germany
Short Talk: Targeting Selectins: Thinking Outside the Paradigm


Thursday, January 17 | 5:00PM - 7:00PM
Preclinical and Clinical Anti-Adhesion and Anti-Chemokine Th
erapy
This session is from Leukocyte Trafficking

Room: Crestone/Red Cloud

Speaker 4 of 4
Martin K. Wild, Max Planck Institute of Molecular Biomedicine, Germany
Leukocyte Adhesion Deficiency II: In vivo leukocyte migration and therapy


Thursday, January 17 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Grays Peak 1-3


Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Grays Peak 1-3


Friday, January 18 | 10:25AM - 10:25AM
Departure


*Session Chair.