Molecular Mechanisms of Angiogenesis in Development and Disease

joint with Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia

Organizer(s): Mark W. Majesky, Peter M. Carmeliet and Luisa Iruela-Arispe

Sponsored by Abbott Laboratories and Genentech, Inc.

For important information on the coronavirus, please click here

Summary of Meeting:

This conference will discuss advances in vascular biology and angiogenesis research, with an emphasis on the role of developmental pathways in vascular disease. Substantial progress has been made in our understanding of molecular mechanisms that direct early steps in vascular development. Yet many important questions remain in the areas of angioblast formation, establishment of arterial, venous and lymphatic identity, lumen formation and stabilization of nascent vessels by mural cell recruitment. Moreover, lineage-mapping studies show that blood vessels are highly mosaic in their origins, raising new questions about the role of lineage diversity in patterns of vascular disease seen in adult vessels. Intrinsic pathways for planar cell polarity in endothelial cells will be discussed in terms of vascular growth, responses to blood flow, repair of endothelial injury, and tube formation. Lessons learned from genetic studies in model organisms will be applied to questions concerning how angiogenesis is controlled by soluble growth factors, cell-matrix interactions, proteases, hypoxia and heterotypic cell-cell interactions in higher vertebrates. An important and highly-debated topic in the field involves the multiple types of endothelial progenitor cells that have been identified, and what promise they may hold for vascular therapeutic applications. An update on these questions will be included, along with discussions of advances in vascular imaging, and emerging novel angiogenesis and anti-angiogenesis strategies. Thus, an integrated view of angiogenesis linking developmental pathways and disease pathogenesis will be presented so as to highlight basic mechanisms and identify new opportunities for control of blood vessel formation in tissue ischemia, wound repair, diabetes and cancer.

Scholarship Deadline: September 17 2007

Discounted Abstract Deadline: September 17 2007

Abstract Deadline: October 22 2007

Discounted Registration Deadline: November 19 2007

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations