Web Desc
Molecular Mechanisms of Angiogenesis in Development and Disease
joint with Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia
Organizer(s): Mark W. Majesky, Peter M. Carmeliet and Luisa Iruela-Arispe
Date: January 15 - 20, 2008
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Abbott Laboratories and Genentech, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
This conference will discuss advances in vascular biology and angiogenesis research, with an emphasis on the role of developmental pathways in vascular disease. Substantial progress has been made in our understanding of molecular mechanisms that direct early steps in vascular development. Yet many important questions remain in the areas of angioblast formation, establishment of arterial, venous and lymphatic identity, lumen formation and stabilization of nascent vessels by mural cell recruitment. Moreover, lineage-mapping studies show that blood vessels are highly mosaic in their origins, raising new questions about the role of lineage diversity in patterns of vascular disease seen in adult vessels. Intrinsic pathways for planar cell polarity in endothelial cells will be discussed in terms of vascular growth, responses to blood flow, repair of endothelial injury, and tube formation. Lessons learned from genetic studies in model organisms will be applied to questions concerning how angiogenesis is controlled by soluble growth factors, cell-matrix interactions, proteases, hypoxia and heterotypic cell-cell interactions in higher vertebrates. An important and highly-debated topic in the field involves the multiple types of endothelial progenitor cells that have been identified, and what promise they may hold for vascular therapeutic applications. An update on these questions will be included, along with discussions of advances in vascular imaging, and emerging novel angiogenesis and anti-angiogenesis strategies. Thus, an integrated view of angiogenesis linking developmental pathways and disease pathogenesis will be presented so as to highlight basic mechanisms and identify new opportunities for control of blood vessel formation in tissue ischemia, wound repair, diabetes and cancer.
Scholarship Deadline: September 17 2007
Discounted Abstract Deadline: September 17 2007
Abstract Deadline: October 22 2007
Discounted Registration Deadline: November 19 2007
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesGenentech, Inc.March of Dimes Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 15 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Tuesday, January 15 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Tuesday, January 15 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: British Columbia Ballroom

Speaker 1 of 1
Salvador Moncada, University of Manchester, UK
Nitric Oxide and Oxygen Homeostasis

Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 1 of 6
* Peter F. Carmeliet, University of Leuven, VIB, Belgium

Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 2 of 6
Brant M. Weinstein, NICHD, National Institutes of Health, USA
Pathways for Arterial Specification in Zebrafish

Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 3 of 6
Takashi Mikawa, Cardiovascular Research Institute, University of California, San Francisco, USA
Control of Vessel Patterning by BMP Signaling

Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 4 of 6
Sophia Y. Tsai, Baylor College of Medicine, USA
Role of COUP-TFII in Venous Specification

Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 5 of 6
Michael Simons, Yale University, USA
Regulation of Arterial Branching Morphogenesis

Wednesday, January 16 | 8:00AM - 11:00AM
Vascular Development
Room: British Ballroom

Speaker 6 of 6
Robert Herpers, Hubrecht Institute, Netherlands
Short Talk: Redundant Roles for sox7 and sox18 in Arteriovenous Specification in Zebrafish

Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 8
* Lorenz Poellinger, Karolinska Institutet, Sweden


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 8
Sten Lindahl, Karolinska Institutet, Sweden
Short Talk: Oxygen Biology: An Historical Perspective


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 8
Peter J. Ratcliffe, University of Oxford, UK
Protein Hydroxylation and the Cellular Response to Hypoxia


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 8
Paul T. Schumacker, Northwestern University, USA
Signaling by Mitochondrial Reactive Oxygen Species during Hypoxia


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 8
Edward T.H. Yeh, University of Texas MD Anderson Cancer Center, USA
Short Talk: SUMO-specific Protease 1 is Essential for Stabilization of HIF-1alpha during Hypoxia


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 8
Bradly G. Wouters, University Health Network, Canada
Short Talk: Hypoxia Inhibits Disulfide Bond Formation and Protein Folding in the Endoplasmic Reticulum


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 8
Walter F. Boron, Case Western Reserve University, USA
Gas Channels


Wednesday, January 16 | 8:00AM - 11:00AM
Oxygen and Cells
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 8 of 8
José López-Barneó, University of Seville, Spain
Facilitated O2 Diffusion and O2 Regulated Ion Channels


Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 1 of 7
* George E. Davis, University of Missouri School of Medicine, USA

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 2 of 7
Jeffrey J. Essner, Iowa State University, USA
Moesin is Required For VEGF-dependent Endothelial Tube Formation In Vivo

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 3 of 7
Maria J. Machado, INSERM U833, France
Longitudinal Analyses of Blind-Ended Vessel Permeability During Angiogenesis in vivo

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 4 of 7
Jing Chen, Boston Children's Hospital / Harvard Medical School, USA
Erythropoietin Prevents Pathologic Vessel Loss and Subsequent Proliferation in a Mouse Model of Oxygen-Induced Retinopathy

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 5 of 7
Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA
Dendritic Cells Regulate Lymph Node Vascular Growth

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 6 of 7
Bruno Larrivée, College de France, France
Activation of the UNC5B Receptor by Netrin-1 Inhibits Sprouting Angiogenesis


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Experimental Models of Angiogenesis
Room: British Ballroom

Speaker 7 of 7
Ping Ao, University of Washington, USA
Cancer Genesis and Progression as Dynamics in Functional Landscape of Endogenous Molecular-Cellular Network

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 7
* Jan-Marino Ramirez, University of Chicago, USA


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 7
Ganesh K. Kumar, University Of Chicago, USA
ROS Signaling Mediates Intermittent Hypoxia-Induced Neurotransmitter Synthesis Via Post-translational Modifications of Synthesizing Enzymes


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 7
Stephen T. Brown, McMaster University, Canada
Chronic Hypoxia Regulates Genes Important for Metabolism, Packaging, and Secretion of Catecholamines in an Immortalized Adrenomedullary Chromaffin Cell Line


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 7
Alfredo J. Garcia, University of Chicago, USA
Redox State Modulates the Respiratory Rhythmogenesis in the Pre-Botzinger Complex


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 7
Jay B. Dean, University of South Florida, USA
Hyperoxia Induces CA1 Hippocampal Redox Stress, Neural Plasticity, and Hyperexcitability in Rat Brain Slices


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 7
Thomas F. Floyd, Stony Brook University, USA
Impact of Aging Upon Cerebral Hypoxia Sensing of Anemia


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 1: Neurophysiological Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 7
† Fei Meng, Birmingham University, UK
Hypoxia-induced Calcium Elevation in Human Embryonic Kidney Cells


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Wednesday, January 16 | 5:00PM - 7:00PM
Endothelial Guidance and Signaling
Room: British Ballroom

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Wednesday, January 16 | 5:00PM - 7:00PM
Endothelial Guidance and Signaling
Room: British Ballroom

Speaker 2 of 5
Tuomas Tammela, Koch Institute for Integrative Cancer Research at MIT, USA
Featured Speaker: 'Next Generation of Vascular Biologists': VEGF-C/VEGFR-3 in Angiogenic Sprouting and Lymphatic Vessel Maturation

Wednesday, January 16 | 5:00PM - 7:00PM
Endothelial Guidance and Signaling
Room: British Ballroom

Speaker 3 of 5
Holger Gerhardt, Max Delbrück Center for Molecular Medicine, Germany
Molecular Regulation of Endothelial Tip and Stalk Cells in Sprouting Angiogenesis

Wednesday, January 16 | 5:00PM - 7:00PM
Endothelial Guidance and Signaling
Room: British Ballroom

Speaker 4 of 5
Christiana Ruhrberg, University College London, UK
Neuropilin Signalling in Neuronal and Vascular Development

Wednesday, January 16 | 5:00PM - 7:00PM
Endothelial Guidance and Signaling
Room: British Ballroom

Speaker 5 of 5
Michael Potente, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: SIRT1 Regulates Endothelial Tip Cell Formation during Sprouting Angiogenesis

Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 6
* Randall S. Johnson, University of Cambridge, UK


Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 6
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Role of Hypoxia-Inducible Factor 1 in Oxygen Homeostasis


Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 6
Joseph A. Garcia, Columbia University Medical Center, USA
Molecular Mechanisms Underlying HIF-2 Selective Signal Transduction


Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 6
John G. Wood, University of Kansas Medical Center, USA
Short Talk: Microvascular Acclimatization to Hypoxia


Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 6
Mircea Ivan, Tufts-New England Medical Center, USA
Short Talk: A microRNA Component of the Hypoxia Response


Wednesday, January 16 | 5:00PM - 7:00PM
Adaptive Responses to Hypoxia
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 6
Cynthia M. Beall, Case Western Reserve University, USA
Contrasting Adaptations to Hypoxia by Andean, Tibetan and East African Populations


Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, January 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, January 17 | 7:00AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 1 of 7
* Michael Simons, Yale University, USA

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 2 of 7
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Hypoxia, Angiogenesis, Metabolism

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 3 of 7
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Dll4-Notch Signaling in Angiogenesis

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 4 of 7
Florian P. Limbourg, Medizinische Hochschule Hannover, Germany
Short Talk: Notch Signaling in the Arterial Endothelium Determines Postnatal Arteriogenesis

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 5 of 7
Donald M. McDonald, University of California, San Francisco, USA
Endothelial-Pericyte Interactions in Angiogenic Blood Vessels

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 6 of 7
Charles A. Lambert, Tour de Pathologie B23/3, Belgium
Short Talk: VEGF111, a New VEGF-A Isoform Induced by Genotoxic Agents: Resistance to Proteolytic Degradation and Effect on Heart Ischemia after Infarction in Mice

Thursday, January 17 | 8:00AM - 11:00AM
Angiogenesis in Disease & Tissue Maintenance
Room: British Ballroom

Speaker 7 of 7
Jason U. Tilan, Georgetown University, USA
Short Talk: The NPY-Y2 Receptor (R) System and Platelets are Important for Ischemic Angiogenesis.

Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 8
* Peter J. Ratcliffe, University of Oxford, UK


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 8
Randall S. Johnson, University of Cambridge, UK
Tissue-Specific Effects of HIF-1 Loss of Function


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 8
Guo-Hua Fong, University of Connecticut Health Center, USA
Short Talk: The HIF-Specific Prolyl Hydroxylase PHD2 Protein may be Directly Required in the Vascular Endothelium to Prevent Excessive Angiogenesis in Mice


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 8
Erinn B. Rankin, Stanford University, USA
Short Talk: Hypoxia-Inducible Factor 2 Regulates VHL Associated Vascular Tumorigenesis and Hepatic Lipid Metabolism In Vivo


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 8
Susan Quaggin, Northwestern University, USA
Podocyte-Endothelial Interactions and Angiogenic Factors in the Kidney


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 8
Ellen van Rooijen, Hubrecht Institute, Developmental Biology and Stem Cell Research, Netherlands
Short Talk: The von Hippel-Lindau Tumor Suppressor Gene Ortholog vhl1 Regulates Zebrafish Hematopoiesis


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 8
Lorenz Poellinger, Karolinska Institutet, Sweden
Oxygen-Dependent Regulation of Cellular Differentiation


Thursday, January 17 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 8 of 8
M. Celeste Simon, University of Pennsylvania, USA
Hypoxia and Stem Cells


Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Thursday, January 17 | 11:30AM - 12:30PM
Lunch
Room: Pacific Ballroom


Thursday, January 17 | 12:00PM - 2:30PM
Poster Session 2
Room: Pacific Ballroom


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 1 of 6
* Karen K. Hirschi, Yale University, USA

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 2 of 6
Jessica L. Dries, East Carolina University, USA
Enhanced Post-MI Angiogenesis Protects Hearts of Mice Null for the Circadian Clock Gene mPer2


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 3 of 6
Tatiana V. Byzova, Cleveland Clinic Foundation, USA
Beta 3 Integrin Function on Bone Marrow-Derived Cells Determines the Course of Adaptive and Pathological Angiogenesis

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 4 of 6
Masamichi Eguchi, Tukai University School of Medicine, Japan
Thrombopoietin (TPO) Contributes to Therapeutic Vasculogenesis through Promoting Mobilization and Survival of Endothelial Progenitor Cells (EPCs) via akt/mTOR/p70S6K Pathway

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 5 of 6
Elazar Zelzer, Weizmann Institute of Science, Israel
SOX9 Regulation of Vegf in the Developing Skeleton Regulates Early Limb Vasculature Patterning

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Stem Cells and Endothelial Progenitors
Room: British Ballroom

Speaker 6 of 6
Priya Prahalad, Georgetown University, USA
9-cis-Retinoic Acid Mediated Regulation of Vasculogenic Mimicry in Breast Cancer

Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 8
* M. Celeste Simon, University of Pennsylvania, USA


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 8
Xin Qi, Stanford University School of Medicine, USA
The Complex of Protein Kinase C delta and c-Abl Communicates Endoplasmic Reticulum Stress to the Mitochondria; an Essential Step in the Subsequent Apoptosis


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 8
Reiko Inagi, University of Tokyo School of Medicine, Japan
Glyoxalase I Overexpression Lowers Oxidative Stress and Ameliorates Renal Ischemia-Reperfusion Injury in the Rat


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 8
Sunghee Cho, Burke Medical Research Institute, USA
Hyperlipidemia Exacerbates Ischemic Brain Injury Via CD36-mediated Foam Cell Formation


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 8
Gail Walkinshaw, FibroGen, USA
Novel HIF Prolyl Hydroxylase Inhibitors are Neuroprotective in Both Permanent and Transient Rodent Models of Middle Cerebral Artery Occlusion


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 8
Holger K. Eltzschig, University of Texas Health Science Center at Houston, USA
Role of HIF-1alpha in A2B Adenosine Receptor-dependent Cardioprotection During Ischemic Preconditioning


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 8
Mikko A. I. Keränen, University of Helsinki,, Finland
Constitutively Expressed Hypoxia-Inducible Factor-1Ą Prevents the Development of Cardiac Allograft Vasculopathy in the Rat


Thursday, January 17 | 2:30PM - 4:30PM
Workshop 2: Animal Models
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 8 of 8
Cormac Taylor, University College Dublin, Ireland
The Hydroxylase Inhibitor DMOG is Protective in a Murine Model of Colitis


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Thursday, January 17 | 5:00PM - 7:00PM
Extracellular Matrix and Angiogenesis
Room: British Ballroom

Speaker 1 of 4
* Victoria L. Bautch, University of North Carolina at Chapel Hill, USA

Thursday, January 17 | 5:00PM - 7:00PM
Extracellular Matrix and Angiogenesis
Room: British Ballroom

Speaker 2 of 4
Weilan Ye, Genentech, Inc., USA
The Roles of EGFL7 and EGFL8 in Vascular Morphogenesis

Thursday, January 17 | 5:00PM - 7:00PM
Extracellular Matrix and Angiogenesis
Room: British Ballroom

Speaker 3 of 4
David A. Cheresh, University of California, San Diego, USA
Chemical Disruption of B-RAF/C-RAF Dimerization Blocks Angiogenesis and Tumor Growth

Thursday, January 17 | 5:00PM - 7:00PM
Extracellular Matrix and Angiogenesis
Room: British Ballroom

Speaker 4 of 4
R. Andrea DeYoung, University of California, Los Angeles, USA
Short Talk: An Essential Role for CCN2 in Skin Angiogenesis

Thursday, January 17 | 5:00PM - 7:00PM
Metabolism
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 5
* Chi Van Dang, University of Pennsylvania, USA
Oxygen-Dependent Regulation of Glucose Metabolism and Oncogenesis: Interplay between MYC and HIF


Thursday, January 17 | 5:00PM - 7:00PM
Metabolism
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 5
Kathleen A. O'Hagan, University College Dublin, Ireland
Short Talk: PGC-1alpha Induced Increase in Oxygen Consumption Leads to Activity of HIF Target Genes


Thursday, January 17 | 5:00PM - 7:00PM
Metabolism
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 5
Julián Aragonés Lopez, Research Institute Princesa, Spain
Short Talk: PHD1 Deficient Mice Lower Oxygen Consumption by Reprogramming Skeletal Muscle Glucose Metabolism via PPARA Transcription Factor


Thursday, January 17 | 5:00PM - 7:00PM
Metabolism
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 5
Robert T. Abraham, Pfizer Worldwide Research and Development, USA
Interplay between mTOR Signaling and Autophagy during Metabolic Stress in Human Cancer Cells


Thursday, January 17 | 5:00PM - 7:00PM
Metabolism
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 5
Keith Laderoute, SRI International, USA
5'-AMP-Activated Protein Kinase (AMPK): Overview and Relevance for Tumor Biology


Thursday, January 17 | 7:00PM - 7:00PM
On Own for Dinner


Friday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 1 of 6
* Mark W. Majesky, University of North Carolina at Chapel Hill, USA

Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 2 of 6
* Gregg L. Semenza, Johns Hopkins University School of Medicine, USA

Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 3 of 6
Eli Keshet, Hebrew University, Israel
Angiogenic- and non-Angiogenic Roles of VEGF in Adult Organs

Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 4 of 6
Maria B. Grant, University of Florida, USA
IGF Binding Protein-3 Regulates Hematopoietic Stem Cell and Endothelial Precursor Cell Function During Vascular Development

Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 5 of 6
Vivek Mittal, Weill Cornell Medical College, USA
Bone Marrow-Derived Endothelial Progenitor Cells Regulate the Angiogenic Switch in Tumor Growth and Metastasis

Friday, January 18 | 8:00AM - 11:00AM
Endothelial Progenitors, Ischemia and Cardiovascular Disease
(Joint)

Room: British Columbia Ballroom

Speaker 6 of 6
Stefanie Dimmeler, University of Frankfurt, Germany
Bone Marrow Progenitor Cell Therapy for Myocardial Infarction

Friday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, January 18 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Friday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, January 18 | 5:00PM - 7:00PM
Vascular Growth, Assembly, and Polarity
Room: British Ballroom

Speaker 1 of 5
* Eli Keshet, Hebrew University, Israel

Friday, January 18 | 5:00PM - 7:00PM
Vascular Growth, Assembly, and Polarity
Room: British Ballroom

Speaker 2 of 5
Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Tube Formation and Branching

Friday, January 18 | 5:00PM - 7:00PM
Vascular Growth, Assembly, and Polarity
Room: British Ballroom

Speaker 3 of 5
George E. Davis, University of Missouri School of Medicine, USA
Molecular Control of Endothelial Lumen Formation

Friday, January 18 | 5:00PM - 7:00PM
Vascular Growth, Assembly, and Polarity
Room: British Ballroom

Speaker 4 of 5
Victoria L. Bautch, University of North Carolina at Chapel Hill, USA
Integrating Cell Division and Vascular Morphogenesis

Friday, January 18 | 5:00PM - 7:00PM
Vascular Growth, Assembly, and Polarity
Room: British Ballroom

Speaker 5 of 5
Hiroyasu Kidoya, Research Institute for Microbial Diseases, Osaka University, Japan
Short Talk: Apelin, as an Induction Factor for Neovascular Maturation

Friday, January 18 | 5:00PM - 7:00PM
ROS and Redox
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 5
* Nanduri R. Prabhakar, University of Chicago, USA
Responses to Intermittent Hypoxia: Consequences of Altered Red-Ox Homeostasis?


Friday, January 18 | 5:00PM - 7:00PM
ROS and Redox
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 5
Stephen L. Archer, Queen's University, Canada
Metabolic-Electric Signaling in the Pulmonary Circulation - The Interface Between Oxygen Sensing, Pulmonary Hypertension and Cancer


Friday, January 18 | 5:00PM - 7:00PM
ROS and Redox
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 5
Kay F. Macleod, University of Chicago, USA
Short Talk: Regulation of Mitochondrial Integrity, Autophagy, and Cell Survival by BNIP3


Friday, January 18 | 5:00PM - 7:00PM
ROS and Redox
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 5
Patrick van Uden, Dundee University, Scotland
Short Talk: NF-kappaB modulates the HIF pathway


Friday, January 18 | 5:00PM - 7:00PM
ROS and Redox
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 5
Masayuki Yamamoto, Tohoku University Graduate School of Medicine, Japan
Protective Responses to Oxidant Stress


Friday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, January 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Saturday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, January 19 | 7:00AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 1 of 8
* Arie Horowitz, USA

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 2 of 8
Michael J. Detmar, ETH - Zürich, Switzerland
Tumor Lymphangiogenesis

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 3 of 8
Christiana DelloRusso, Children's Hospital Boston, USA
Short Talk: Loss of p53 Tumor Suppressor Function may be Rescued by Re-Expression of the Endogenous Angiogenesis Inhibitors TSP-1 and Endostatin

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 4 of 8
Shira Landskroner, Alexion Pharmaceuticals, USA
Short Talk: The Adipocyte-Derived Factor Adiponectin Contributes to Mammary Tumor Growth through Enhanced Angiogenesis

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 5 of 8
Gabriele A.I. Bergers, University of Leuven, Belgium
Regulation and Function of Bone Marrow-Derived Cells in Tumors

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 6 of 8
Daniela C. Tirziu, Yale University School of Medicine, USA
Short Talk: Angiogenesis-Driven Myocardial Hypertrophy

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 7 of 8
Yoshihide Asano, Medical University of South Carolina, USA
Short Talk: Fli1 Impairs the Interaction of Endothelial Cells with Pericytes - a Possible Mechanism for Scleroderma Vasculopathy

Saturday, January 19 | 8:00AM - 11:00AM
Pathological Angiogenesis
Room: British Ballroom

Speaker 8 of 8
Christopher G. Kevil, Louisiana State University Health Sciences Center, USA
Short Talk: Endothelial Cav-1 Mediates Pathological Angiogenesis in the 3% DSS Model of Experimental Colitis

Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 7
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The VHL Gene: Oxygen Sensing and Cancer


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 7
Poul H. B. Sorensen, University of British Columbia, Canada
Short Talk: A Novel E3 Ubiquitin Ligase HACE1 Represses HIF-1alpha Accumulation Under Hypoxic Conditions


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 7
Jacques Pouysségur, University of Nice, France
Targeting Hypoxia-Induced Tumor Metabolism


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 7
Amato J. Giaccia, Stanford University, USA
Hypoxia Induced Gene Expression in Cancer Cells


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 7
Erwin G. Van Meir, Emory University School of Medicine, USA
Short Talk: KCN1, a Novel HIF Inhibitor Blocks Tumor Growth Through Binding of Plectin-1 and Inhibition of the HSP90 Pathway


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 7
* Mark W. Dewhirst, Duke University Medical Center, USA
Exploring Oxidative Stress and HIF-1 in Early Angiogenesis and Response to Radiotherapy and Chemotherapy


Saturday, January 19 | 8:00AM - 11:00AM
Cancer
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 7
Annamaria Rapisarda, SAIC-Frederick, Inc., USA
Short Talk: Antitumor Activity of Antiangiogenic Agents Combined with HIF-1 Inhibitors:
Blocking Hypoxic Dependent Survival Pathways Improves Therapeutic Efficacy


Saturday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, January 19 | 11:30AM - 12:30PM
Lunch
Room: Pacific Ballroom


Saturday, January 19 | 12:00PM - 2:30PM
Poster Session 4
Room: Pacific Ballroom


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 8
* Amato J. Giaccia, Stanford University, USA


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 8
Joseph R. Marszalek, Merck Research Laboratories, USA
Using RNAi to Identify Modulators of the HIF Pathway/Hypoxia for Cancer


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 8
Navdeep S. Chandel, Northwestern University, USA
A Chemical Genomics Screen Highlights the Essential Role of Mitochondria in HIF Regulation


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 8
Natalya A. Smirnova, Burke Research Medical Institute, USA
High-throughput Screening for HIF Prolyl Hydroxylase Inhibitors


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 8
Stephen John Klaus, Fibrogen, USA
Induction of Erythropoiesis in Rodents by Novel and Distinct Families of Orally Active HIF Prolyl Hydroxylase Inhibitors


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 6 of 8
Sean P. Colgan, University of Colorado Denver, USA
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 7 of 8
Shan Ping Yu, Emory University School of Medicine, USA
In Vitro Hypoxic Preconditioning of Stem Cells as a Strategy of Promoting Cell Survival and Functional Benefits After Transplantation into the Ischemic Rat Brain


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Therapeutics
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 8 of 8
† Periannan Kuppusamy, Ohio State University, USA
Oxygen Sensing in Myocardial Stem Cell Therapy


Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 1 of 7
* Donald M. McDonald, University of California, San Francisco, USA

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 2 of 7
Suphansa Sawamiphak, Max Planck Institute of Neurobiology, Germany
Eph/Ephrin-Mediated Endothelial Cell Interactions

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 3 of 7
Masahiro Murakami, Yale University School of Medicine, USA
Mechanism of FGF-Mediated Maintenance of Vascular Integrity

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 4 of 7
Tetsuya Saito, University of Tokyo, Japan
Molecular Mechanism of Alternative VEGFR-1 Gene Expression in Human Endothelial Cell

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 5 of 7
Richard J. Bodnar, University of Pittsburgh, USA
Vessel Dissociation: The Role of CXC Receptor 3

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 6 of 7
Arie Horowitz, USA
VEGF and Semaphorin Induce Neuropilin-1 Endocytosis via Separate Pathways

Saturday, January 19 | 2:30PM - 4:30PM
Workshop 3: Vascular Cell Signaling
Room: British Ballroom

Speaker 7 of 7
Robert C. Doebele, University of Colorado, USA
Epac/Rap1 Inhibit Endothelial Cell Chemotaxis and Angiogenesis via Induction of Thrombospondin-1

Saturday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 1 of 7
* Gabriele A.I. Bergers, University of Leuven, Belgium

Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 2 of 7
Paul R. Riley, University of Oxford, UK
Thymosin beta4 and Coronary Angiogenesis

Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 3 of 7
Zoltan P. Arany, University of Pennsylvania, USA
Short Talk: HIF-Independent Regulation of VEGF and Angiogenesis by the Metabolic Sensor and Transcriptional Coactivator PGC-1á

Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 4 of 7
Sara Weis, University of California, San Diego, USA
Short Talk: Compensatory Role for Pyk2 during Angiogenesis
in Adult Mice Lacking Endothelial Cell FAK


Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 5 of 7
Angela K. Nevins, Indiana University School of Medicine, USA
Short Talk: The Role of VEGF-Induced Surface Expression of Nucleolin in Tumor Angiogenesis

Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 6 of 7
Melanie A. Simpson, University of Nebraska, USA
Short Talk: Prostate Tumor Growth, Vascularization, and Metastasis are Modulated by Differential Turnover of Hyaluronan

Saturday, January 19 | 5:00PM - 7:00PM
Novel Therapeutic Targets in Angiogenesis
Room: British Ballroom

Speaker 7 of 7
Kristin E. Hubert, Oregon Health & Sciences University, USA
Short Talk: Trail Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization

Saturday, January 19 | 5:00PM - 7:00PM
Respiratory Disease
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 1 of 5
* Peter A. Robbins, University of Oxford, UK
Hypoxia and Mechanisms of Cardio-Respiratory Control in Humans


Saturday, January 19 | 5:00PM - 7:00PM
Respiratory Disease
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 2 of 5
Larrisa A. Shimoda, Johns Hopkins School of Medicine, USA
Hypoxic Pulmonary Hypertension


Saturday, January 19 | 5:00PM - 7:00PM
Respiratory Disease
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 3 of 5
Michael L. Maitland, University of Chicago, USA
Short Talk: Developing the Anti-cancer VEGFR2/Multikinase Inhibitor Sorafenib for Treatment of Human Pulmonary Arterial Hypertension


Saturday, January 19 | 5:00PM - 7:00PM
Respiratory Disease
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 4 of 5
Agnes Görlach, German Heart Center Munich, TU Munich, Germany
Short Talk: The Serum- and Glucocorticoid Regulated Kinase-1 is a Novel Regulator of Hypoxia-Inducible Factor 1


Saturday, January 19 | 5:00PM - 7:00PM
Respiratory Disease
This session is from Hypoxia
Room: Columbia Ballroom

Speaker 5 of 5
Michail Sitkovsky, Northeastern University, USA
Iatrogenic Complication Due to Elimination of Hypoxia-driven, Immunosuppressive and Tissue Protecting Adenosinergic Pathway


Saturday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Saturday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Sunday, January 20 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.