Web Desc
Cell Death in the Immune System
joint with Cell Death and Cellular Senescence
Organizer(s): Douglas R. Green, Michael J. Lenardo and Pam S. Ohashi
Date: February 07 - 12, 2008
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Director's Fund
Summary of Meeting:
There are two processes in the body in which the life or death of a single cell can profoundly impact on the health of the individual. One is, of course, cancer. The other is the immune response which can be mediated by the progeny of one specific lymphocyte. This meeting will focus on the molecular mechanisms controlling cell death and survival during immune responses, and how these processes affect immune outcome. Topics at the forefront of this field include the regulation of caspases and their control of inflammatory events, the clearance and impact of apoptotic cells and their associated antigens on immune responses, cytotoxic mechanisms including novel granzymes and death receptors, and the role of autophagy in host defense, all to be addressed in this meeting. Joint sessions, with the Keystone Symposium entitled “Cell Death and Cellular Senescence”, will focus on general mechanisms of apoptosis, including the Bcl-2 family, cellular homeostasis, and signaling events in cell survival.
Scholarship Deadline: October 8 2007
Discounted Abstract Deadline: October 8 2007
Abstract Deadline: November 7 2007
Discounted Registration Deadline: December 10 2007
We gratefully acknowledge additional support for this conference from:
Merck & Co., Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI075718-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 07 | 3:00PM - 7:30PM
Registration
Room: Foyer


Thursday, February 07 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 4 of 4
Jürg Tschopp, University of Lausanne, Switzerland
Inflammatory Caspases

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 3 of 4
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Anergy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 2 of 4
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 1 of 4
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Friday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 5 of 5
Vishva M. Dixit, Genentech, Inc., USA
Role of cIAP1/2 in the Non-Canonical NF-kappaB Survival Pathway

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 4 of 5
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Mechanism of Immunopathology Induced by TNFalpha or Fas Ligand

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 3 of 5
Gerard I. Evan, University of Cambridge, UK
Intrinsic Tumor Suppression

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 2 of 5
Jacqueline A. Lees, Massachusetts Institute of Technology, USA
The Role of Bmi1 in Tumorigenesis

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 1 of 5
* Sally A. Kornbluth, Duke University Medical Center, USA

Friday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Friday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Friday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 4
Nika N. Danial, Dana-Farber Cancer Institute, USA
A Phospho-BAD BH3 Helix Selectively Activates Glucose Metabolism

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 4
Michael Karin, University of California, San Diego, USA
IKK-NF-kappaB Signaling and the Control of Caspase Activation and Cell Survival

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 4
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 4
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA

Friday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Friday, February 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Saturday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 1 of 6
* Thomas A. Ferguson, Washington University School of Medicine, USA

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 2 of 6
David Hildeman, Cincinnati Children's Hospital, USA
Roles of Bim and Bcl-2 in Control of T Cell Homeostasis

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 3 of 6
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of Caspase 3 in T Lymphocyte Death, Anergy and Cross Presentation

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 4 of 6
Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
CTL Memory and T Cell Survival

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 5 of 6
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Life and Death in the Thymus

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
Room: Peak 5

Speaker 6 of 6
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: TCR and Subset-Specific Regulation of Fas-Induced Cell Death

Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 1 of 5
* Joan S. Brugge, Harvard Medical School, USA


Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 2 of 5
Kristin White, Harvard Medical School, USA
Regulation of Neural Stem Cell Apoptosis in Drosophila


Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 3 of 5
John M. Abrams, University of Texas Southwestern Medical Center, USA
The Drosophila p53 regulatory network


Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 4 of 5
David W. Andrews, Sunnybrook Research Institute, Canada
Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax


Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 5 of 5
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Conserved Mitochondrial Regulators of Cell Death


Saturday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Saturday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Saturday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
Room: Peak 5

Speaker 1 of 5
* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA

Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
Room: Peak 5

Speaker 2 of 5
Shigekazu Nagata, IFReC, Osaka University, Japan
Phosphatidylserine Receptor for Engulfment of Apoptotic Cells

Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
Room: Peak 5

Speaker 3 of 5
Thomas A. Ferguson, Washington University School of Medicine, USA
Immune Tolerance by Apoptotic Cells: The Role of Caspase-Induced Mitochondrial Disruption

Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
Room: Peak 5

Speaker 4 of 5
Matthew L. Albert, Genentech, Inc., USA
Autophagic Death Facilitates Efficient Antigen Cross-Priming

Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
Room: Peak 5

Speaker 5 of 5
Colin S. Duckett, University of Michigan, USA
Short Talk

Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 1 of 5
* Laura D. Attardi, Stanford University School of Medicine, USA


Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 2 of 5
Joan S. Brugge, Harvard Medical School, USA
Entosis: Suicide/Murder of Homeless Cells


Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 3 of 5
Kay F. Macleod, University of Chicago, USA
Short Talk: Regulation of Mitochondrial Integrity and Non-Apoptotic Cell Death by BNIP3 and Tumor Progression


Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 4 of 5
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Cul7 a Novel Antiapoptotic Oncogene


Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 5 of 5
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
The Mdm2/Mdm4 Complex: A Rheostat for p53 Activity


Saturday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Saturday, February 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Sunday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 1 of 6
* Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 2 of 6
David Wallach, Weizmann Institute of Science, Israel
What is the REAL Functional Significance of Death Signaling by Receptors of the TNF/NGF Family?

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 3 of 6
Joseph A. Trapani, Peter MacCallum Cancer Centre, Australia
Structure/Function Analysis of the Lymphocyte Toxins Perforin and Granzyme B

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 4 of 6
Marcus E. Peter, University of Chicago, USA
The Role of microRNAs in Tumor Progression

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 5 of 6
Judy Lieberman, Harvard University, USA
New Features of Granzyme A-Mediated Caspase-Independent Programmed Cell Death

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
Room: Peak 5

Speaker 6 of 6
† Henning Walczak, University College London, Cancer Institute, UK
Short Talk: Identification of the Apoptosis-Inducing Murine TRAIL-R as a Specific Suppressor of Metastasis Derived from Autochthonous Epithelial Tumors

Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 1 of 4
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks In Vivo


Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 2 of 4
Jeffrey C. Rathmell, Vanderbilt University, USA
Metabolism and Cell Death


Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 3 of 4
Aimee L. Edinger, University of California, Irvine, USA
Short Talk: Nutrient Transporter Down-Regulation Contributes to the Induction of Cell Death by Ceramide


Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 4 of 4
Laura D. Attardi, Stanford University School of Medicine, USA
Dissecting P53 Function using Knock-in Mice


Sunday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Sunday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Sunday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
Room: Peak 5

Speaker 1 of 5
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
Room: Peak 5

Speaker 2 of 5
Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy, Innate Immunity, and Microbial Countermeasures

Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
Room: Peak 5

Speaker 3 of 5
Savithramma P. Dinesh-Kumar, Yale University, USA
Life After Death: Role for Autophagy during Plant Innate Immunity

Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
Room: Peak 5

Speaker 4 of 5
Christian Münz, University of Zurich, Switzerland
Viral Regulation of Autophagy for Antigen Presentation on MHC Class II Molecules

Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
Room: Peak 5

Speaker 5 of 5
David J. Granville, University of British Columbia, Canada
Short Talk: To be Determined

Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 1 of 4
* Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA


Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 2 of 4
Steven E. Artandi, Stanford University, USA
Telomerase in Stem Cells and Cancer


Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 3 of 4
Chunying Du, Stowers Institute for Medical Research, USA
Short Talk: Bruce, an Inhibitor of Spoptosis and Role in DNA Damage Resistance to Suppress Tumor Development


Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
This session is from Cell Death & Cell Senescence
Room: Peaks 1-4

Speaker 4 of 4
Murray O. Robinson, Molquant, Inc., USA
Human in Mouse Tissue Transgenic Breast Tomors: Dissecting Genetic Requirements for Tumorigenesis


Sunday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Sunday, February 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom


Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 6
* Gerard I. Evan, University of Cambridge, UK

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
Matters of Life and Death; Mitochondria, ER and the Greasy Road to Apoptosis

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 6
Sally A. Kornbluth, Duke University Medical Center, USA
Apoptosome Regulation in Cancer a Point of Resistance to Chemotherapy

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 6
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspase Pathways

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 5 of 6
Huseyin Mehmet, Atlas Venture, USA
Cell Death Modulation

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 6 of 6
Xiaodong Wang, BeiGene, China
Short Talk: CAS/PHAP/Hsp70 Promote Nucleotide Exchange on Apaf-1 and Block Cytochrome C Induced Apaf-1 Aggregation

Monday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 5
* Christian Münz, University of Zurich, Switzerland

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 5
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Role of Autophagy Genes ATG5 and ATG16L1 in Immunity and Inflammation

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Role of Autophagy in Cancer and Therapy

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 5
Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Organ-Specific Regulation of Cancer Development

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 5 of 5
You-Wen He, Duke University Medical Center, USA
Short Talk: Autophagy in T Lymphocytes

Monday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Monday, February 11 | 8:00PM - 11:00PM
End of Meeting Reception and Entertainment Supported in part
by Merck & Co., Inc.
Room: Breckenridge Ballroom


Monday, February 11 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Tuesday, February 12 | 10:25AM - 10:25AM
Departure


*Session Chair.