Web Desc
Cell Death and Cellular Senescence
joint with Cell Death in the Immune System
Organizer(s): Jacqueline A. Lees, Sally A. Kornbluth and Gerard I. Evan
Date: February 07 - 12, 2008
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Cell death is known to play a critical role in both normal development and human disease. We have a good understanding of the proteins that constitute the apoptotic machinery as well as the signaling pathways that regulate this process. Many of these regulatory proteins can also induce cellular senescence, a state of irreversible cell arrest. After some initial speculation that cellular senescence might be primarily a phenomenon of cultured cells, there is now unequivocal evidence that cellular senescence occurs in vivo in response to both telomere erosion and oncogenic activation and, furthermore, that this plays a key role in tissue maintenance and tumor suppression. This meeting will explore the fundamental mechanisms that control cell death and cellular senescence and discuss how each of these processes impact both normal development and tumor suppression. To achieve this goal, the meeting assembles a broad spectrum of speakers whose interests span a variety of model organisms. The Keynote Speaker, Craig Thompson, will discuss the relationship between metabolic status and cell survival. This meeting will be held in conjunction with “Cell Death in the Immune System”. Joint sessions will include the core apoptotic machinery, cell death and cellular homeostasis, signaling and apoptosis, and autophagy, inflammation and apoptosis.
Scholarship Deadline: October 8 2007
Discounted Abstract Deadline: October 8 2007
Abstract Deadline: November 7 2007
Discounted Registration Deadline: December 10 2007
We gratefully acknowledge additional support for this conference from:
Merck & Co., Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA130252-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 07 | 3:00PM - 7:30PM
Registration
Room: Foyer


Thursday, February 07 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 1 of 4
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 2 of 4
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 3 of 4
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Anergy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress

Thursday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Colorado Ballroom

Speaker 4 of 4
Jürg Tschopp, University of Lausanne, Switzerland
Inflammatory Caspases

Friday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 1 of 5
* Sally A. Kornbluth, Duke University Medical Center, USA

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 2 of 5
Jacqueline A. Lees, Massachusetts Institute of Technology, USA
The Role of Bmi1 in Tumorigenesis

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 3 of 5
Gerard I. Evan, University of Cambridge, UK
Intrinsic Tumor Suppression

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 4 of 5
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Mechanism of Immunopathology Induced by TNFalpha or Fas Ligand

Friday, February 08 | 8:00AM - 11:00AM
Cell Death and Cellular Homeostasis (Joint)
Room: Colorado Ballroom

Speaker 5 of 5
Vishva M. Dixit, Genentech, Inc., USA
Targeting the IAPs

Friday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Friday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Friday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 4
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 4
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 4
Michael Karin, University of California, San Diego, USA
NF-kB has Important Antiapoptotic Functions, a Negative Regulator of Caspase 1

Friday, February 08 | 5:00PM - 7:00PM
Regulation of Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 4
Nika N. Danial, Dana-Farber Cancer Institute, USA
A Phospho-BAD BH3 Helix Selectively Activates Glucose Metabolism

Friday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Friday, February 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Saturday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Ballroom


Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
Room: Peaks 1-4

Speaker 1 of 5
* Joan S. Brugge, Harvard Medical School, USA

Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
Room: Peaks 1-4

Speaker 2 of 5
Kristin White, Harvard Medical School, USA
Regulation of Neural Stem Cell Apoptosis in Drosophila

Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
Room: Peaks 1-4

Speaker 3 of 5
John M. Abrams, University of Texas Southwestern Medical Center, USA
The Drosophila p53 regulatory network

Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
Room: Peaks 1-4

Speaker 4 of 5
David W. Andrews, Sunnybrook Research Institute, Canada
Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

Saturday, February 09 | 8:00AM - 11:00AM
Apoptosis Pathways in Model Organisms
Room: Peaks 1-4

Speaker 5 of 5
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Conserved Mitochondrial Regulators of Cell Death

Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 1 of 6
* Thomas A. Ferguson, Washington University School of Medicine, USA


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 2 of 6
David Hildeman, Cincinnati Children's Hospital, USA
Roles of Bim and Bcl-2 in Control of T Cell Homeostasis


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 3 of 6
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of Caspase 3 in T Lymphocyte Death, Anergy and Cross Presentation


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 4 of 6
Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
CTL Memory and T Cell Survival


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 5 of 6
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Life and Death in the Thymus


Saturday, February 09 | 8:00AM - 11:00AM
Lymphocyte Activation, Tolerance, and Survival
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 6 of 6
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: TCR and Subset-Specific Regulation of Fas-Induced Cell Death


Saturday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Saturday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Saturday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
Room: Peaks 1-4

Speaker 1 of 5
* Laura D. Attardi, Stanford University School of Medicine, USA

Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
Room: Peaks 1-4

Speaker 2 of 5
Joan S. Brugge, Harvard Medical School, USA
Entosis: Suicide/Murder of Homeless Cells

Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
Room: Peaks 1-4

Speaker 3 of 5
Kay F. Macleod, University of Chicago, USA
Short Talk: Regulation of Mitochondrial Integrity and Non-Apoptotic Cell Death by BNIP3 and Tumor Progression

Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
Room: Peaks 1-4

Speaker 4 of 5
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Cul7 a Novel Antiapoptotic Oncogene

Saturday, February 09 | 5:00PM - 7:00PM
Apoptosis Pathways in Vertebrates
Room: Peaks 1-4

Speaker 5 of 5
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
The Mdm2/Mdm4 Complex: A Rheostat for p53 Activity

Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 1 of 5
* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA


Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 2 of 5
Shigekazu Nagata, IFReC, Osaka University, Japan
Phosphatidylserine Receptor for Engulfment of Apoptotic Cells


Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 3 of 5
Thomas A. Ferguson, Washington University School of Medicine, USA
Immune Tolerance by Apoptotic Cells: The Role of Caspase-Induced Mitochondrial Disruption


Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 4 of 5
Matthew L. Albert, Genentech, Inc., USA
Autophagic Death Facilitates Efficient Antigen Cross-Priming


Saturday, February 09 | 5:00PM - 7:00PM
Impact of Apoptotic Cells on the Immune System
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 5 of 5
Colin S. Duckett, University of Michigan, USA
Short Talk


Saturday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Saturday, February 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Sunday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Ballroom


Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
Room: Peaks 1-4

Speaker 1 of 4
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks In Vivo

Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
Room: Peaks 1-4

Speaker 2 of 4
Jeffrey C. Rathmell, Vanderbilt University, USA
Metabolism and Cell Death

Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
Room: Peaks 1-4

Speaker 3 of 4
Aimee L. Edinger, University of California, Irvine, USA
Short Talk: Nutrient Transporter Down-Regulation Contributes to the Induction of Cell Death by Ceramide

Sunday, February 10 | 8:00AM - 11:00AM
Signaling Pathways, Cell Death and Senescence
Room: Peaks 1-4

Speaker 4 of 4
Laura D. Attardi, Stanford University School of Medicine, USA
Dissecting P53 Function using Knock-in Mice

Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 1 of 6
* Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 2 of 6
David Wallach, Weizmann Institute of Science, Israel
What is the REAL Functional Significance of Death Signaling by Receptors of the TNF/NGF Family?


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 3 of 6
Joseph A. Trapani, Peter MacCallum Cancer Centre, Australia
Structure/Function Analysis of the Lymphocyte Toxins Perforin and Granzyme B


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 4 of 6
Marcus E. Peter, University of Chicago, USA
The Role of microRNAs in Tumor Progression


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 5 of 6
Judy Lieberman, Harvard University, USA
New Features of Granzyme A-Mediated Caspase-Independent Programmed Cell Death


Sunday, February 10 | 8:00AM - 11:00AM
Cytotoxic Mechanisms, Granzymes, and Death Receptors
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 6 of 6
† Henning Walczak, University College London, Cancer Institute, UK
Short Talk: Identification of the Apoptosis-Inducing Murine TRAIL-R as a Specific Suppressor of Metastasis Derived from Autochthonous Epithelial Tumors


Sunday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Sunday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Sunday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
Room: Peaks 1-4

Speaker 1 of 4
* Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA

Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
Room: Peaks 1-4

Speaker 2 of 4
Steven E. Artandi, Stanford University, USA
Telomerase in Stem Cells and Cancer

Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
Room: Peaks 1-4

Speaker 3 of 4
Chunying Du, Stowers Institute for Medical Research, USA
Short Talk: Bruce, an Inhibitor of Spoptosis and Role in DNA Damage Resistance to Suppress Tumor Development

Sunday, February 10 | 5:00PM - 7:00PM
Telomeres and Senescence
Room: Peaks 1-4

Speaker 4 of 4
Murray O. Robinson, Molquant, Inc., USA
Human in Mouse Tissue Transgenic Breast Tomors: Dissecting Genetic Requirements for Tumorigenesis

Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 1 of 5
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia


Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 2 of 5
Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy, Innate Immunity, and Microbial Countermeasures


Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 3 of 5
Savithramma P. Dinesh-Kumar, Yale University, USA
Life After Death: Role for Autophagy during Plant Innate Immunity


Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 4 of 5
Christian Münz, University of Zurich, Switzerland
Viral Regulation of Autophagy for Antigen Presentation on MHC Class II Molecules


Sunday, February 10 | 5:00PM - 7:00PM
Autophagy and Host Defense
This session is from Cell Death in the Immune Syste
Room: Peak 5

Speaker 5 of 5
David J. Granville, University of British Columbia, Canada
Short Talk: To be Determined


Sunday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Sunday, February 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom


Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Ballroom


Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 6
* Gerard I. Evan, University of Cambridge, UK

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
Matters of Life and Death; Mitochondria, ER and the Greasy Road to Apoptosis

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 6
Sally A. Kornbluth, Duke University Medical Center, USA
Apoptosome Regulation in Cancer a Point of Resistance to Chemotherapy

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 6
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspase Pathways

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 5 of 6
Huseyin Mehmet, Atlas Venture, USA
Caspase-12 in Inflammation, Association with Sepsis and Neonatal Brain Injury

Monday, February 11 | 8:00AM - 11:00AM
Signaling and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 6 of 6
Xiaodong Wang, BeiGene, China
Short Talk: CAS/PHAP/Hsp70 Promote Nucleotide Exchange on Apaf-1 and Block Cytochrome C Induced Apaf-1 Aggregation

Monday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 1 of 5
* Christian Münz, University of Zurich, Switzerland

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 2 of 5
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Role of Autophagy Genes ATG5 and ATG16L1 in Immunity and Inflammation

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 3 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Role of Autophagy in Cancer and Therapy

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 4 of 5
Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Organ-Specific Regulation of Cancer Development

Monday, February 11 | 5:00PM - 7:00PM
Autophagy, Inflammation and Apoptosis (Joint)
Room: Colorado Ballroom

Speaker 5 of 5
You-Wen He, Duke University Medical Center, USA
Short Talk: Autophagy in T Lymphocytes

Monday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Monday, February 11 | 8:00PM - 11:00PM
End of Meeting Reception and Entertainment Supported in part
by Merck & Co., Inc.
Room: Breckenridge Ballroom


Monday, February 11 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Tuesday, February 12 | 10:25AM - 10:25AM
Departure


*Session Chair.