Web Desc
The Transient Receptor Potential Ion Channel Superfamily
Organizer(s): James W. Putney, Bernd Nilius and Craig Montell
Date: September 18 - 23, 2007
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Director's Fund
Summary of Meeting:
In recent years, knowledge of TRP channel biology has increased at a tremendous pace. These channels are now known to be regulated in two general ways: by physical perturbations (i.e., temperature, mechanical) or by classical signal transduction cascades (most commonly phospholipases). In addition, mutations in TRP channels are known to be the basis for a number of inherited diseases, including mucolipidosis and polycystic kidney disease. However, there is a great deal of controversy regarding the mechanisms of activation and regulation of many TRPs, especially those thought to be involved in the long elusive mechanism of store-operated channels. This symposium will highlight current knowledge of structure, function, regulation and pharmacology of the TRPs, especially with regard to current controversies. Additionally, the roles of TRPs in diseases will be addressed, including the potential for treating diseases through knowledge of their regulation, and through design of therapeutic agents to modify their behavior.
Scholarship Deadline: May 18 2007
Discounted Abstract Deadline: May 18 2007
Abstract Deadline: June 19 2007
Discounted Registration Deadline: July 18 2007
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS059298-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, September 18 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, September 18 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, September 18 | 7:30PM - 8:30PM
Keynote Session
Room: Peaks 4 - 5

Speaker 1 of 1
Craig Montell, Johns Hopkins University, USA
TRP Channels: Mediators of Sensory Signaling

Wednesday, September 19 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 6 of 6
Vera Y. Moiseenkova-Bell, Baylor College of Medicine, USA
Short Talk: Cryo-Electron Microscopy of TRP Family Channels

Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 5 of 6
Paul Garrity, Brandeis University, USA
Feeling the Heat: Thermosensory Behavior in Drosophila

Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 4 of 6
Michael J. Caterina, Johns Hopkins School of Medicine, USA
A Novel Mechanism of Use - Dependent Changes in TRPV Channel Signaling

Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 3 of 6
Ardem Patapoutian, The Scripps Research Institute, USA
Molecular Mechanisms of Temperature Sensation

Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 2 of 6
Makoto Tominaga, National Institutes of Natural Sciences, Japan
Physiological Significance of the Thermosensitive TRP Channels

Wednesday, September 19 | 8:00AM - 11:00AM
TRPs: Temperature and Pain
Room: Peaks 4 - 5

Speaker 1 of 6
* Owen P. Hamill, University of Texas Medical Branch, USA

Wednesday, September 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, September 19 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Wednesday, September 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Wednesday, September 19 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Wednesday, September 19 | 4:30PM - 6:30PM
TRPs: Taste and Mechanosensation
Room: Peaks 4 - 5

Speaker 5 of 5
Julia F. Doerner, Ruhr University, Germany
Short Talk: Direct Activation of TRPA1 by Ca2+

Wednesday, September 19 | 4:30PM - 6:30PM
TRPs: Taste and Mechanosensation
Room: Peaks 4 - 5

Speaker 4 of 5
Owen P. Hamill, University of Texas Medical Branch, USA
The Role of the Mechanosensitive Ca2+ Permeant Channel in Prostate Tumor Cell Migration

Wednesday, September 19 | 4:30PM - 6:30PM
TRPs: Taste and Mechanosensation
Room: Peaks 4 - 5

Speaker 3 of 5
Diana Bautista, University of California, Berkeley, USA
Mammalian Mechanotransduction

Wednesday, September 19 | 4:30PM - 6:30PM
TRPs: Taste and Mechanosensation
Room: Peaks 4 - 5

Speaker 2 of 5
Emily Liman, University of Southern California, USA
TRPM5 and Taste Transduction

Wednesday, September 19 | 4:30PM - 6:30PM
TRPs: Taste and Mechanosensation
Room: Peaks 4 - 5

Speaker 1 of 5
* Bernd Nilius, Katholieke Universiteit Leuven, Belgium

Wednesday, September 19 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 1 - 3


Wednesday, September 19 | 7:00PM - 9:30PM
Poster Session 1
Room: Peaks 1 - 3


Thursday, September 20 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 2 of 6
Johannes Oberwinkler, Universitaet des Saarlandes, Germany
TRPM3, A Novel Ionotropic Steroid Receptor in the Endocrine System

Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 1 of 6
* Shmuel Muallem, University of Texas Southwestern Medical Center, USA

Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 3 of 6
Andrea Fleig, Queen's Medical Center, USA
Gating Mechanisms of TRPM2

Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 4 of 6
Donald L. Gill, Temple University School of Medicine, USA
TRPC Channels – Transducers of Multiple Signals

Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 5 of 6
Lutz Birnbaumer, NIEHS, National Institutes of Health, USA
Molecular Basis of Capacitative Calcium Entry (CCE): TRPCs, 1P3rs, STIMs, and Orai

Thursday, September 20 | 8:00AM - 11:00AM
Activation Mechanisms
Room: Peaks 4 - 5

Speaker 6 of 6
Moshe Parnas, Hebrew University, Israel
Short Talk: Membrane Lipids Remove Divalent Open Channel Block in TRP and NMDA Channels

Thursday, September 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, September 20 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Thursday, September 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Thursday, September 20 | 2:30PM - 4:00PM
Workshop 1: Controversies Concerning Activation Mechanisms I
: Direct Activation by Thermal and Mechanical Stimuli
Room: Peaks 4 - 5

Speaker 1 of 5
* Andrea Fleig, Queen's Medical Center, USA

Thursday, September 20 | 2:30PM - 4:00PM
Workshop 1: Controversies Concerning Activation Mechanisms I
: Direct Activation by Thermal and Mechanical Stimuli
Room: Peaks 4 - 5

Speaker 2 of 5
Adriana Sumoza-Toledo, Columbus Children's Hospital, USA
Reactive Oxygen Species Induce Calcium Influx and Phagocyte Cell Death by a Mechanism Dependent on ADPR and PARP-1; Possible Functional Role for TRPM2 Cation Channel

Thursday, September 20 | 2:30PM - 4:00PM
Workshop 1: Controversies Concerning Activation Mechanisms I
: Direct Activation by Thermal and Mechanical Stimuli
Room: Peaks 4 - 5

Speaker 3 of 5
Frank John Patrick Kühn, Institute of Physiology, Germany
Activation of TRPM8 Channel by Icilin and Menthol is Mediated on Different Sides of the Cell Membrane

Thursday, September 20 | 2:30PM - 4:00PM
Workshop 1: Controversies Concerning Activation Mechanisms I
: Direct Activation by Thermal and Mechanical Stimuli
Room: Peaks 4 - 5

Speaker 4 of 5
Gerard Ahern, Georgetown University, USA
Voltage is a Partial Activator of Thermo-Sensitive TRP Channels

Thursday, September 20 | 2:30PM - 4:00PM
Workshop 1: Controversies Concerning Activation Mechanisms I
: Direct Activation by Thermal and Mechanical Stimuli
Room: Peaks 4 - 5

Speaker 5 of 5
Celine E. Riera, Cedars-Sinai Medical Center, USA
Artificial Sweeteners and Metallic Tasting Salts Activate TRPV1 Receptors

Thursday, September 20 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Thursday, September 20 | 4:30PM - 6:30PM
TRPs and Protein-Protein Interaction
Room: Peaks 4 - 5

Speaker 1 of 5
* Emily Liman, University of Southern California, USA

Thursday, September 20 | 4:30PM - 6:30PM
TRPs and Protein-Protein Interaction
Room: Peaks 4 - 5

Speaker 2 of 5
René J.M. Bindels, Radboud University Nijmegen Medical Centre, Netherlands
Regulation of Epithelial TRP Channels

Thursday, September 20 | 4:30PM - 6:30PM
TRPs and Protein-Protein Interaction
Room: Peaks 4 - 5

Speaker 3 of 5
Shmuel Muallem, University of Texas Southwestern Medical Center, USA
The TRPML Channels: Properties and Function

Thursday, September 20 | 4:30PM - 6:30PM
TRPs and Protein-Protein Interaction
Room: Peaks 4 - 5

Speaker 4 of 5
Rachelle Gaudet, Harvard University, USA
Unexpected Journey from Crystal Structure to New Model of TRPV1 Activity

Thursday, September 20 | 4:30PM - 6:30PM
TRPs and Protein-Protein Interaction
Room: Peaks 4 - 5

Speaker 5 of 5
Rui Xiao, Baylor College of Medicine, USA
Short Talk: Synergistic Activation of TRPC4 and TRPC5 by Receptor Signaling through Gq/11 and Gi/o Proteins

Thursday, September 20 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 1 - 3


Thursday, September 20 | 7:00PM - 9:30PM
Poster Session 2
Room: Peaks 1 - 3


Friday, September 21 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 1 of 6
* Craig Montell, Johns Hopkins University, USA

Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 2 of 6
Bernd Nilius, Katholieke Universiteit Leuven, Belgium
Functional Roles of TRP Channels: Unexpected Views

Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 3 of 6
Yasuo Mori, Kyoto University, Japan
Oxidative Stress-Activated Ca2+ Channel TRPM2 Mediates Inflammation via Chemokine Production

Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 4 of 6
X.Z. Shawn Xu, University of Michigan, USA
TRP Channel Regulation of Proprioception and Drug Dependence in C. elegans

Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 5 of 6
Thomas Gudermann, Ludwig-Maximilians-Universitaet, Germany
TRPC Channel Function in the Cardiopulmonary System

Friday, September 21 | 8:00AM - 11:00AM
Reverse Genetic Approaches
Room: Peaks 4 - 5

Speaker 6 of 6
Melissa A. Fowler, University of Texas Southwestern Medical Center, USA
Short Talk: Corticolimbic Expression of TRPC1, TRPC4, and TRPC5 Channels in the Rodent Brain

Friday, September 21 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, September 21 | 11:00AM - 11:30AM
Poster Setup
Room: Peaks 1-3


Friday, September 21 | 11:30AM - 12:30PM
Lunch
Room: Foyer / Peaks 1 - 3


Friday, September 21 | 12:00PM - 9:00PM
Poster Viewing
Room: Peaks 1-3


Friday, September 21 | 12:00PM - 2:30PM
Poster Session 3
Room: Peaks 1 - 3


Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 1 of 6
* Donald L. Gill, Temple University School of Medicine, USA

Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 2 of 6
Tibor Rohacs, Rutgers University, New Jersey Medical School, USA
Dual Regulation of TRPV1 by Phosphoinositides

Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 3 of 6
Leonidas Tsiokas, Oklahoma University Health Science Center, USA
Assembly of TRPP2 and TRPC1 Forms a Novel G Protein Coupled Receptor-Activated Ion Channel

Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 4 of 6
Sandeep C. Pingle, Georgetown University Medical Center, USA
TRP and Store-Operated Calcium Channels in Dendritic Cells

Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 5 of 6
Sohag Saleh, St. George's University, London, UK
Diverse TRPC Heteromultimers Form Store- Operated Channels in Native Vascular Smooth Muscle Preparations

Friday, September 21 | 2:30PM - 4:00PM
Workshop 2: Controversies Concerning Activation Mechanisms I
I: Activation by Signal Transduction Cascades
Room: Peaks 4 - 5

Speaker 6 of 6
Nathaniel A. Jeske, University of Texas Health Science Center, USA
PKA Sensitization of TRPV1 is Dependent on A-Kinase Anchoring Protein

Friday, September 21 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Friday, September 21 | 4:30PM - 6:30PM
TRPs in the Nervous System
Room: Peaks 4 - 5

Speaker 1 of 5
* Indu S. Ambudkar, NIDCR, National Institutes of Health, USA

Friday, September 21 | 4:30PM - 6:30PM
TRPs in the Nervous System
Room: Peaks 4 - 5

Speaker 2 of 5
Martha C. Nowycky, UMDNJ-New Jersey Medical School, USA
TRPC5 Channels: Function and Properties

Friday, September 21 | 4:30PM - 6:30PM
TRPs in the Nervous System
Room: Peaks 4 - 5

Speaker 3 of 5
Michael Tymianski, Toronto Western Research Institute (TWRI), Canada
Role of TRP Channels in Ischemic Brain Damage

Friday, September 21 | 4:30PM - 6:30PM
TRPs in the Nervous System
Room: Peaks 4 - 5

Speaker 4 of 5
Guo-li Ming, University of Pennsylvania, USA
TRPC in Neuronal Navigation: Development and Guidance

Friday, September 21 | 4:30PM - 6:30PM
TRPs in the Nervous System
Room: Peaks 4 - 5

Speaker 5 of 5
Seog Bae Oh, Seoul National University, South Korea
Short Talk: Membrane-Delimited Activation of Transient Receptor Potential Vanilloid 1 by mGluR5 in Nociceptors

Saturday, September 22 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 1 of 6
* Thomas Gudermann, Ludwig-Maximilians-Universitaet, Germany

Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 2 of 6
James W. Putney, Jr., NIEHS, National Institutes of Health, USA
Store-Activation of CRAC and TRPC Channels

Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 3 of 6
Indu S. Ambudkar, NIDCR, National Institutes of Health, USA
Function and Regulation of TRPC1 in Salivary Gland

Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 4 of 6
Victoria M. Bolotina, Boston Medical Center, USA
Calcium Influx Factor

Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 5 of 6
Patrick G. Hogan, La Jolla Institute of Allergy and Immunology, USA
Stim-Orai Signalling in T-Lymphocytes

Saturday, September 22 | 8:00AM - 11:00AM
Store-Operated Channels
Room: Peaks 4 - 5

Speaker 6 of 6
Paul Rosenberg, Duke University, USA
Short Talk: STIM1/Orai1 Signaling Controls Store Operated Calcium Entry in Skeletal Muscle

Saturday, September 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, September 22 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Saturday, September 22 | 4:30PM - 6:30PM
TRPs and Disease
Room: Peaks 4 - 5

Speaker 1 of 5
* Michael Tymianski, Toronto Western Research Institute (TWRI), Canada

Saturday, September 22 | 4:30PM - 6:30PM
TRPs and Disease
Room: Peaks 4 - 5

Speaker 2 of 5
Michael Köttgen, Johns Hopkins University, USA
Calcium Signaling through TRPP2: from Polycystic Kidney Disease to Fly Sperm

Saturday, September 22 | 4:30PM - 6:30PM
TRPs and Disease
Room: Peaks 4 - 5

Speaker 3 of 5
Chris Benham, University of Hertfordshire, UK
TRPM2 Channels and Neurodegeneration: TRPV1 and Inflammatory Pain

Saturday, September 22 | 4:30PM - 6:30PM
TRPs and Disease
Room: Peaks 4 - 5

Speaker 4 of 5
Thierry Capiod, Inserm U800, France
Short Talk: Capacitative Calcium Entry and TRPC6 Expression Control Human Hepatoma Cells Proliferation

Saturday, September 22 | 4:30PM - 6:30PM
TRPs and Disease
Room: Peaks 4 - 5

Speaker 5 of 5
James W. Putney, Jr., NIEHS, National Institutes of Health, USA
Meeting Highlights

Saturday, September 22 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 1 - 3


Saturday, September 22 | 7:30PM - 10:30PM
Entertainment
Room: Peaks 1 - 3


Saturday, September 22 | 7:30PM - 10:30PM
Cash Bar
Room: Peaks 1 - 3


Sunday, September 23 | 10:25AM - 10:25AM
Departure


*Session Chair.