Web Desc
Challenges of Global Vaccine Development
Organizer(s): Margaret Liu, Paul-Henri Lambert and Sir Gustav Nossal
Date: October 08 - 13, 2007
Location: Cape Town Conference Centre, Cape Town, South Africa
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation and the Wellcome Trust
Summary of Meeting:
Despite the tremendous impact of vaccines to save countless lives, significant scientific and technical barriers exist that limit both their effectiveness against many diseases and their utilization, resulting in millions of needless deaths and substantial morbidity particularly in the developing world. Even with the large increase of our understanding of host immune responses, the sequencing of pathogen genomes, and other technological advances, important hurdles remain for developing and deploying vaccines for a variety of diseases. The goals of this meeting will be to bring together scientists, physicians and students from the developed and developing world to discuss the advances in (1) understanding the generation of effective systemic and mucosal immunity at a cellular and organ system level, (2) new technologies for prophylactic and therapeutic immunization, including those useful for resource-poor settings, (3) understanding the unique requirements to stimulate immunity in early childhood, (4) pre-clinical models, and (5) correlates of protection.
Global Health Travel Award Deadline: May 7 2007
Scholarship Deadline: June 6 2007
Discounted Abstract Deadline: June 6 2007
Abstract Deadline: July 11 2007
Discounted Registration Deadline: August 8 2007
We gratefully acknowledge additional support for this conference from:
Becton DickinsonBill & Melinda Gates FoundationWellcome Trust
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

BD Medical Pharmaceutical Systems

Genentech, Inc.

GlaxoSmithKline Biologicals

IOMAI Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI076090-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, October 08 | 3:00PM - 7:30PM
Registration
Room: Strelitzia


Monday, October 08 | 6:30PM - 7:30PM
Welcome Reception
Room: Day Restaurant


Monday, October 08 | 7:30PM - 7:50PM
Welcome and Orientation
Room: Auditorium 2

Speaker 1 of 1
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA
The Unique Scientific and Real-World Challenges of Global Vaccine Development

Monday, October 08 | 7:50PM - 8:30PM
Keynote Address

Speaker 1 of 1
Regina N. Rabinovich, ISGlobal, Spain / Harvard T.H. Chan School of Public Health, USA, Spain
The Challenges of Translation of Vaccine Research into Impact

Tuesday, October 09 | 7:00AM - 8:00AM
Breakfast
Room: Day Restaurant


Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 1 of 7
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 2 of 7
* Gustav Nossal, University of Melbourne, Australia

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 3 of 7
* Paul-Henri Lambert, University of Geneva, Switzerland

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 4 of 7
Myron M. Levine, University of Maryland School of Medicine, USA
Differences in Immune Responses in Different Populations

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 5 of 7
Hazel M. Dockrell, London School Hygiene & Tropical Medicine, UK
BCG Vaccination Induces Different Immune Responses in Malawian and UK Vaccinees

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 6 of 7
Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
BCG-Induced Immune Correlates of Protection Against Tuberculosis

Tuesday, October 09 | 8:00AM - 11:30AM
Population Differences in Immune Responses to Vaccines and I
mplications for Childhood and Pandemic Diseases

Room: Auditorium 2

Speaker 7 of 7
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
HIV/TB Host-Pathogen Interactions

Tuesday, October 09 | 9:20AM - 9:40AM
Coffee Break
Room: Day Restaurant


Tuesday, October 09 | 11:30AM - 12:00PM
Poster Setup
Room: Day Restaurant


Tuesday, October 09 | 12:00PM - 2:00PM
Luncheon with Grand Challenges in Global Health Meeting
Room: Ballroom

Speaker 1 of 4
Harold E. Varmus, Weill Cornell Medical College, USA

Tuesday, October 09 | 12:00PM - 2:00PM
Luncheon with Grand Challenges in Global Health Meeting
Room: Ballroom

Speaker 2 of 4
Bishop Desmond Tutu, Former Archbishop of Cape Town, South Africa

Tuesday, October 09 | 12:00PM - 2:00PM
Luncheon with Grand Challenges in Global Health Meeting
Room: Ballroom

Speaker 3 of 4
Graça Machel, South Africa

Tuesday, October 09 | 12:00PM - 2:00PM
Luncheon with Grand Challenges in Global Health Meeting
Room: Ballroom

Speaker 4 of 4
Tadataka Yamada, Mountain Field LLC, USA

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 1 of 6
* Michal Fried, Seattle Biomedical Research Institute, USA

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 2 of 6
* Stefan Kappe, Seattle BioMed, USA

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 3 of 6
Dominic Kwiatkowski, Wellcome Trust Centre for Human Genetics, UK
Learning from the Human Genome How Protective Immunity Against Malaria Works

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 4 of 6
Patrick E. Duffy, NIAID, National Institutes for Health, USA
Protective Immunity Against Severe Malaria in Young Children

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 5 of 6
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Vectored Vaccines for Malaria

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 1A Devoted to Specific Diseases that Overwhelm the
Developing World: Malaria
Room: Auditorium 2

Speaker 6 of 6
Salim Abdulla, Ifakara Health Institute, Tanzania
Malaria Vaccine Clinical Trials in Africa

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 2A on Vaccine Technologies: Stability of Vaccines
Room: Roof Terrace Room

Speaker 1 of 4
* Marie-Paule Kieny, World Health Organization, Switzerland

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 2A on Vaccine Technologies: Stability of Vaccines
Room: Roof Terrace Room

Speaker 2 of 4
Colin R. Gardner, TransForm Pharmaceuticals, Inc., USA
Increasing Vaccine Stability through Novel Technology

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 2A on Vaccine Technologies: Stability of Vaccines
Room: Roof Terrace Room

Speaker 3 of 4
Claire M. Coeshott, GlobeImmune, Inc., USA
Thermostable Vaccines with Improved Stability at Non-Refrigerated Temperatures

Tuesday, October 09 | 2:30PM - 4:30PM
Workshop 2A on Vaccine Technologies: Stability of Vaccines
Room: Roof Terrace Room

Speaker 4 of 4
Yoshikazu Yuki, Institute of Medical Science, Japan
Development of Needle- and Cold-Chain-Free Vaccine: Rice-Based Oral Vaccine

Tuesday, October 09 | 4:30PM - 5:00PM
Coffee Available
Room: Day Restaurant


Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 1 of 6
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 2 of 6
* Carolyn Williamson, University of Cape Town, South Africa

Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 3 of 6
Rafi Ahmed, Emory University School of Medicine, USA
Manipulating Regulatory T Cell in the Development of Vaccines or Translating Innate Immunity into Immunologic Memory: Implications for Vaccine Development

Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 4 of 6
Rudolf A. Manz, Deutsches Rheuma-Forschungszentrum, Germany
Plasma Cell Niches: Molecular Determinants of Long-Lived Plasma Cells

Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 5 of 6
Kenneth Smith, University of Cambridge, UK
The Inhibitory Fc Receptor FcgammaRIIb, Immune Responses, Autoimmunity and Malaria

Tuesday, October 09 | 5:00PM - 7:30PM
Effector vs. Memory Responses
Room: Auditorium 2

Speaker 6 of 6
George M. Shaw, University of Pennsylvania, USA
Identification of the Transmitted HIV-1 Envelope and Its Evolution in Acute and Early Human Infection

Tuesday, October 09 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Day Restaurant


Tuesday, October 09 | 8:00PM - 10:00PM
Poster Session 1
Room: Day Restaurant


Wednesday, October 10 | 7:00AM - 8:00AM
Breakfast
Room: Day Restaurant


Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 1 of 7
* Marie-Paule Kieny, World Health Organization, Switzerland

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 2 of 7
* Souleymane Mboup, Universite Cheikh Anta DIOP, Senegal

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 3 of 7
Paul-Henri Lambert, University of Geneva, Switzerland
Towards Effective and Safe Vaccines: Assessing the Risk-Benefit Ratio of Activating Innate Immunity

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 4 of 7
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Vaccine Development

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 5 of 7
Eyal Raz, University of California, San Diego, USA
Irradiated Pathogens to Activate Dendritic Cells via TLRs for the Induction of T Cell Responses

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 6 of 7
David C. Jackson, University of Melbourne, Australia
The Use of Simple Synthetic Lipid Structures for Targeting Different Vaccine Cargos to Dendritic Cells

Wednesday, October 10 | 8:00AM - 11:30AM
Innate and Adaptive Immune Responses/Adjuvants
Room: Auditorium 2

Speaker 7 of 7
Peter L. Andersen, Statens Serum Institut, Denmark
TB Vaccine - Pre/Post Exposure

Wednesday, October 10 | 9:20AM - 9:40AM
Coffee Break
Room: Day Restaurant


Wednesday, October 10 | 11:00AM - 12:00PM
Poster Setup
Room: Day Restaurant


Wednesday, October 10 | 11:30AM - 12:30PM
Lunch
Room: Day Restaurant


Wednesday, October 10 | 12:30PM - 2:30PM
Poster Session 2
Room: Day Restaurant


Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 1 of 8
* Martin Ota, Medical Research Council, Gambia

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 2 of 8
* Jerald C. Sadoff, Crucell Vaccine Institute, Janssen Pharmaceutical Companies of Johnson & Johnson, Netherlands

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 3 of 8
Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Results from a Safety and Immunogenicity Clinical Trial with an Adjuvanted Ag85/ESAT6 Subunit Vaccine against Tuberculosis

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 4 of 8
Helen McShane, Jenner Institute, UK
MVA85A - An Update on Clinical Trials

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 5 of 8
Greg D. Hussey, University of Cape Town, South Africa
BCG and Clinical Trails

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 6 of 8
Leander Grode, Vakzine Projekt Management, Germany
Developing a TB Vaccine for Human Use

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 7 of 8
Francois Spertini, Centre Hospitalier Universitaire Vaudois, Switzerland
Safety and Immunogenicity of the Mtb72F/AS02A Tuberculosis Vaccine

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 1B Devoted to Specific Diseases that Overwhelm the
Developing World: Tuberculosis Vaccines
Room: Auditorium 2

Speaker 8 of 8
Megan Murray, Harvard Medical School, USA
Modeling of Clinical TB

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 1 of 6
* Sujit Kuman Bhattacharya, National Institute of Cholera and Enteric Diseases, India

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 2 of 6
Ana Maria Henao-Restrepo, World Health Organization, Switzerland
Development of a Measles Aerosol Vaccine

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 3 of 6
David A. Edwards, Harvard University, USA
Dry Powder Nanoparticle Inhaled Aerosols for Needle-Free Vaccination

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 4 of 6
Robert E. Sievers, University of Colorado, USA
Needle-Free Delivery of Stable, Respirable Dry Powder Measles Vaccine Formulations

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 5 of 6
James R. Baker Jr., University of Michigan, USA
Naoemulsions as Adjuvants for Nasal-Spray Vaccines

Wednesday, October 10 | 2:30PM - 4:30PM
Workshop 2B on Vaccine Technologies: Needle Free Delivery, A
erosol Delivery and Nanoparticles
Room: Roof Terrace Room

Speaker 6 of 6
David D. Lo, University of California, Riverside, USA
Development of a Targeted Mucosal Vaccine Delivery Technology

Wednesday, October 10 | 4:30PM - 5:00PM
Coffee Available
Room: Day Restaurant


Wednesday, October 10 | 5:00PM - 7:30PM
Neonatal and Infant Immunity
Room: Auditorium 2

Speaker 1 of 5
* Claire-Anne Siegrist, University of Geneva, Switzerland
Challenges and Perspectives for Optimal Early Life Vaccine Responses

Wednesday, October 10 | 5:00PM - 7:30PM
Neonatal and Infant Immunity
Room: Auditorium 2

Speaker 2 of 5
Lorne A. Babiuk, University of Alberta, Canada
Linking Innate and Specific Immunity to Develop Single-Dose Vaccines for Neonates

Wednesday, October 10 | 5:00PM - 7:30PM
Neonatal and Infant Immunity
Room: Auditorium 2

Speaker 3 of 5
Victoria J. Philbin, USA
Distinct Function of Toll-Like Receptors (TLRs) in Human Neonatal Antigen-Presenting Cells: Unique Potential of TLR8 Agonists as Neonatal Vaccine Adjuvents

Wednesday, October 10 | 5:00PM - 7:30PM
Neonatal and Infant Immunity
Room: Auditorium 2

Speaker 4 of 5
Martha Sedegah, Naval Medical Research Center, USA
Immunological Responses of Neonates and Infants to DNA-Based Vaccines

Wednesday, October 10 | 5:00PM - 7:30PM
Neonatal and Infant Immunity
Room: Auditorium 2

Speaker 5 of 5
Mustafa Akkoyunlu, US Food and Drug Administration, USA
Differences in Adult and Neonatal BAFF/APRIL System: Implications for Polysaccharide Vaccines

Thursday, October 11 | 7:00AM - 8:00AM
Breakfast
Room: Day Restaurant


Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 1 of 7
* Luis Jodar, International Vaccine Institute, South Korea

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 2 of 7
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 3 of 7
Richard Adegbola, Bill & Melinda Gates Foundation, USA
Haemophilus influnzae type b (Hib) Conjugate Vaccine: Clinical Trials and Implementation of an Effective Routine Hib Immunization Programme in The Gambia

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 4 of 7
Helena Käyhty, National Public Health Institute, Finland
The Use of Nasopharyngeal Carriage as an End Point for Efficacy Trials and Registration and Use of New Pneumococcal Vaccine Formulations

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 5 of 7
Shabir Madhi, National Institute for Communicable Diseases, South Africa
Pneumococcal Conjugate Vaccine in Developing Countries: Potential for Addressing the Ignored Epidemic

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 6 of 7
Jonathan Carapetis, Telethon Institute for Child Health Research, Australia
Global Burden of Group A Streptococcal Disease, and Progress in Vaccine Development

Thursday, October 11 | 8:00AM - 11:15AM
Vaccines Impacting on Microbial Ecology
Room: Auditorium 2

Speaker 7 of 7
John D. Clemens, International Vaccine Institute, South Korea
New Approaches to the Assessment of Vaccine Herd Immunity and Herd Protection

Thursday, October 11 | 9:20AM - 9:40AM
Coffee Break
Room: Day Restaurant


Thursday, October 11 | 11:15AM - 11:30AM
Special Announcement
Dr. Jose Esparza, Senior Advisor on HIV Vaccines for the Bill & Melinda Gates Foundation, will announce an important new development in the growth of the Global HIV Vaccine Enterprise, an alliance of independent organizations around the world dedicated to accelerating the development of a preventive HIV vaccine. Originally proposed in 2003, the purpose of the Enterprise is to build consensus in the HIV vaccine field on scientific priorities, mobilize new resources to implement these priorities, and facilitate the rapid sharing of information that can advance the field as a whole. To date, the Enterprise has mobilized more than $750 million in support of its scientific plan.

Thursday, October 11 | 11:30AM - 12:00PM
Poster Setup
Room: Day Restaurant


Thursday, October 11 | 11:30AM - 12:30PM
Lunch
Room: Day Restaurant


Thursday, October 11 | 12:30PM - 2:30PM
Poster Session 3
Room: Day Restaurant


Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 1 of 6
* Glenda E. Gray, South African Medical Research Council, South Africa

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 2 of 6
Blake Ball, University of Manitoba, Canada
Comprehensive Studies of Mechanisms of HIV Resistance in Highly Exposed Uninfected Women

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 3 of 6
George K. Lewis, University of Maryland, USA
Targeting Co-receptor Steps for Protective Immunity Against HIV-1

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 4 of 6
Hongkui Deng, Peking University, China
Development of Novel Mouse Models for HIV and HCV Infection

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 5 of 6
Michael Ott, Hannover Medical School, Germany
Novel Mouse Models for Testing HIV and HCV Vaccines

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1C Devoted to Specific Diseases that Overwhelm the
Developing World: HIV Vaccines
Room: Auditorium 2

Speaker 6 of 6
Rudi Balling, Centre for Systems Biology Luxembourg, University of Luxembourg, Luxembourg
Novel Mouse Models for Testing HIV and HCV Vaccines

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1D: Enteric Pathogens
Room: Roof Terrace Room

Speaker 1 of 4
* John D. Clemens, International Vaccine Institute, South Korea

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1D: Enteric Pathogens
Room: Roof Terrace Room

Speaker 2 of 4
Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh
Mucosal Immunity to Common Enteric Pathogens and Relevance to Vaccine Development

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1D: Enteric Pathogens
Room: Roof Terrace Room

Speaker 3 of 4
Sujit Kuman Bhattacharya, National Institute of Cholera and Enteric Diseases, India
Field Trial of Enteric Vaccines in Kolkata

Thursday, October 11 | 2:30PM - 4:30PM
Workshop 1D: Enteric Pathogens
Room: Roof Terrace Room

Speaker 4 of 4
Gregory M. Glenn, Novavax, USA
Transcutaneous Immunization with LT: Development of a Needle-Free Vaccine Patch

Thursday, October 11 | 4:30PM - 5:00PM
Coffee Available
Room: Day Restaurant


Thursday, October 11 | 5:00PM - 7:30PM
Mucosal and Dermal Vaccines and Immunity
Room: Auditorium 2

Speaker 1 of 5
* Gustav Nossal, University of Melbourne, Australia

Thursday, October 11 | 5:00PM - 7:30PM
Mucosal and Dermal Vaccines and Immunity
Room: Auditorium 2

Speaker 2 of 5
Charles J. Arntzen, Biodesign Institute, Arizona State University, USA
Progress in Plant-Made Vaccines

Thursday, October 11 | 5:00PM - 7:30PM
Mucosal and Dermal Vaccines and Immunity
Room: Auditorium 2

Speaker 3 of 5
Robin Shattock, Imperial College London, UK
Novel Antigen Design and Delivery for Mucosal Protection Against HIV-1 Infection

Thursday, October 11 | 5:00PM - 7:30PM
Mucosal and Dermal Vaccines and Immunity
Room: Auditorium 2

Speaker 4 of 5
Roy Curtiss III, Arizona State University, USA
A Live Recombinant Attenuated Salmonella Anti-Pneumococcal Vaccine for Newborns

Thursday, October 11 | 5:00PM - 7:30PM
Mucosal and Dermal Vaccines and Immunity
Room: Auditorium 2

Speaker 5 of 5
Béhazine Combadiere, Centre d'Immunologie et des Maladies Infectieuses, France
Short Talk: Follicular Targeting: From Skin Explant to Transcutaneous Vaccination in Humans

Friday, October 12 | 7:00AM - 8:00AM
Breakfast
Room: Day Restaurant


Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 1 of 7
* Glenda E. Gray, South African Medical Research Council, South Africa

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 2 of 7
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Towards Characterization of Protective Immunity against TB

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 3 of 7
Markus G. Manz, University Hospital Zürich, Switzerland
A Mouse Model to Evaluate Live Attenuated Vaccine Candidates

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 4 of 7
Britta E. Wahren, Karolinska Institute, Sweden
Progress of the HIV Vaccine Phase I/II Immunogenicity Study (HIVIS Project) in Dar es Salaam, Tanzania: HIV-1 DNA Plasmid Prime and MVA Boost

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 5 of 7
Sarah L. Rowland-Jones, Oxford University, UK
Long-Term Non-Progression with HIV Infection: Lessons from HIV-2

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 6 of 7
Carolyn Williamson, University of Cape Town, South Africa
Multigene Human Immunodeficiency Virus Type 1 Subtype C DNA and Modified Vaccinia Ankara (MVA) Vaccine

Friday, October 12 | 8:00AM - 11:45AM
Correlates of Immunity in Pre-Clinical Models and Clinical S
tudies

Room: Auditorium 2

Speaker 7 of 7
* Gary J. Nabel, Sanofi, USA
Development and Evaluation of a T-Cell Based Multi-Clade AIDS Vaccine

Friday, October 12 | 9:20AM - 9:40AM
Coffee Break
Room: Day Restaurant


Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 1 of 6
* José G. Esparza, Bill & Melinda Gates Foundation, USA

Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 2 of 6
Bernard Fourie, Medicine in Need, South Africa
Challenges to Vaccine Access in High-Burden Settings

Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 3 of 6
Duncan Steele, PATH, USA
Delivering Rotavirus Vaccines to Impact the Millennium Development Goals

Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 4 of 6
Jean Stephenne, GlaxoSmithKline Biologicals, Belgium
GSK Issues for Global Vaccine Manufacturers

Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 5 of 6
Luis Jodar, International Vaccine Institute, South Korea
Translational Research to Assist Policy Decisions about Introducing New Vaccines into Developing Countries

Friday, October 12 | 2:30PM - 4:30PM
Workshop 3: Issues for Introducing Vaccines to Developing Co
untries: Coordination of Clinical Trials in Different Populations and Markets, Access, Vaccine Cost, Affordability, and Financing
Room: Auditorium 2

Speaker 6 of 6
Carl E. Frasch, Frasch Biologics Consulting, USA
Strategies for Production of Pneumococcal Conjugate Vaccines in and for Developing Countries

Friday, October 12 | 2:30PM - 4:30PM
Workshop 2C on Vaccine Technologies and Other Novel Technolo
gies: Mucosal and Dermal Vaccines
Room: Roof Terrace Room

Speaker 1 of 4
* Britta E. Wahren, Karolinska Institute, Sweden
Novel Delivery Devices and Approaches for Immunization

Friday, October 12 | 2:30PM - 4:30PM
Workshop 2C on Vaccine Technologies and Other Novel Technolo
gies: Mucosal and Dermal Vaccines
Room: Roof Terrace Room

Speaker 2 of 4
* Rachel Chikwamba, Council for Scientific and Industrial Research (CSIR), South Africa
Plant Derived Vaccines for Mucosal Delivery

Friday, October 12 | 2:30PM - 4:30PM
Workshop 2C on Vaccine Technologies and Other Novel Technolo
gies: Mucosal and Dermal Vaccines
Room: Roof Terrace Room

Speaker 3 of 4
Edward P. Rybicki, University of Cape Town, South Africa
Plant-Produced Vaccines: Promise and Reality

Friday, October 12 | 2:30PM - 4:30PM
Workshop 2C on Vaccine Technologies and Other Novel Technolo
gies: Mucosal and Dermal Vaccines
Room: Roof Terrace Room

Speaker 4 of 4
Philippe E. Laurent, Becton Dickinson, France
Evaluation of the Clinical Performance of BD™ Microinjection System for Intradermal Vaccine Delivery

Friday, October 12 | 4:30PM - 5:00PM
Coffee Available
Room: Day Restaurant


Friday, October 12 | 5:00PM - 6:30PM
Novel Approaches to Immunity
Room: Auditorium 2

Speaker 1 of 5
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Friday, October 12 | 5:00PM - 6:30PM
Novel Approaches to Immunity
Room: Auditorium 2

Speaker 2 of 5
* Gustav Nossal, University of Melbourne, Australia

Friday, October 12 | 5:00PM - 6:30PM
Novel Approaches to Immunity
Room: Auditorium 2

Speaker 3 of 5
Reinhard Kurth, Ernst Schering Foundation, Germany
Novel Approaches to Flu Vaccine Development

Friday, October 12 | 5:00PM - 6:30PM
Novel Approaches to Immunity
Room: Auditorium 2

Speaker 4 of 5
Abraham L. Sonenshein, Tufts University, School of Medicine, USA
Bacterial Spores as Heat-Stable Vaccine Delivery Systems

Friday, October 12 | 5:00PM - 6:30PM
Novel Approaches to Immunity
Room: Auditorium 2

Speaker 5 of 5
Lennart Hammarström, Karolinska Institute, Sweden
Passive Immunity via Orally-Administered lactobacilli

Friday, October 12 | 6:30PM - 7:30PM
Concluding Keynote Address
Room: Auditorium 2

Speaker 1 of 1
Anna-Lise Williamson, University of Cape Town, South Africa
Vaccine Development: An Essential Part of Health Security in Africa

Friday, October 12 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Day Restaurant


Friday, October 12 | 8:00PM - 11:00PM
Entertainment
Room: Day Restaurant


Friday, October 12 | 8:00PM - 11:00PM
Cash Bar
Room: Day Restaurant


Saturday, October 13 | 10:25AM - 10:25AM
Departure


*Session Chair.