Web Desc
Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy
Organizer(s): Qimin Zhan, Yang Ke, Xin Wei Wang, Raymond DuBois and Zongtang Sun
Date: October 14 - 19, 2007
Location: Capital Hotel, Beijing, China
In Collaboration with and Cosponsored by Chinese Academy of Medical Sciences and Peking University Health Science Center
Summary of Meeting:
Gastrointestinal (GI) malignancies account for a large fraction of human cancers. They are almost without exception incurable when gross metastases exist. Three of the 20 top leading causes of worldwide mortality are related to GI malignancies. For example, liver cancer is the third leading cause of worldwide cancer deaths and most of them (>79%) are in Asia. Liver and gastric cancers are the leading cause of cancer deaths in China. There is a strong need to discuss and develop a coherent strategy by joining efforts from both east and west to study GI malignancies. The Keystone Symposia is an excellent platform for a conference on GI malignancies because of its high scientific standard and impact. An in depth discussion of the interest in molecular epidemiology, GI cancer models, molecular diagnostic/prognostic, therapeutic strategies and cancer stem cells in the context of rapid development of these areas is therefore timely. The goals of this symposium are to bring together Academia, Government and Industry laboratories from Asia, North America and Europe working on gastroenterological malignancies, to exchange state-of-the-art and late-breaking discoveries, and to update consensus strategies in a fight against these malignancies.
We gratefully acknowledge additional support for this conference from:
AstraZeneca
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, October 14 | 3:00PM - 7:00PM
Registration
Room: Jinyun Foyer


Sunday, October 14 | 6:00PM - 7:00PM
Refreshments
Room: Jinyun Foyer


Sunday, October 14 | 7:00PM - 7:15PM
Opening Remarks
Room: Jinyun Ballroom


Sunday, October 14 | 7:15PM - 8:15PM
Keynote Session
Room: Jinyun Ballroom

Speaker 1 of 1
Carlo M. Croce, Ohio State University, USA

Monday, October 15 | 7:30AM - 8:30AM
Breakfast
Room: Coffee House


Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 1 of 8
* Michael Karin, University of California, San Diego, USA

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 2 of 8
* Xiaodong Wang, BeiGene, China

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 3 of 8
Joanna L. Groden, Ohio State University, USA
DNA Repair and Colon Cancer

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 4 of 8
Benjamin C.Y. Wong, University of Hong Kong, China
Stomach Cancer: Molecular Targets for Prevention and Treatment

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 5 of 8
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Probing the genetics and biology of liver carcinoma using mouse models and RNA interference

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 6 of 8
Vincent W. Yang, Emory University, USA
Krüppel-Like Factors (KLFs) and Intestinal Tumorigenesis

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 7 of 8
Ursula Barbara Kurzik-Dumke, Institute of Medical Microbiology and Hygiene, Comparative Tumor Biology, Germany
Short Talk: Htid-1, the Human Homolog of the Drosophila Melanogaster l(2)tid Tumor Suppressor, is a Novel Physiological Ligand of APC Associated with Progression of Colorectal Cancer

Monday, October 15 | 8:30AM - 11:45AM
Biology and Genetics of GI Malignancies I
Room: Jinyun Ballroom

Speaker 8 of 8
Lin Yang, University of Texas, MD Anderson Cancer Center, USA
ZNF306, a Novel “Master Regulator” of Gene Expression, Drives Progression of Colorectal Cancers Unaltered for Commonly-mutated Genes

Monday, October 15 | 9:45AM - 10:15AM
Coffee Break
Room: Jinyun Foyer


Monday, October 15 | 12:00PM - 1:00PM
Poster Setup
Room: Jinyun Foyer


Monday, October 15 | 3:30PM - 5:30PM
Poster Session 1
Room: Jinyun Foyer


Monday, October 15 | 4:30PM - 5:30PM
Coffee & Snacks Available
Room: Jinyun Foyer


Monday, October 15 | 5:30PM - 6:30PM
Evening Keynote Address
Room: Jinyun Ballroom

Speaker 1 of 2
* Qimin Zhan, Chinese Academy of Medical Sciences, China

Monday, October 15 | 5:30PM - 6:30PM
Evening Keynote Address
Room: Jinyun Ballroom

Speaker 2 of 2
Xiaodong Wang, BeiGene, China
Apoptosis and Cancer

Monday, October 15 | 6:30PM - 7:45PM
Cancer Biology and Genetics of GI Malignancies II
Room: Jinyun Ballroom

Speaker 1 of 3
* Xin Wei Wang, NCI, National Institutes of Health, USA

Monday, October 15 | 6:30PM - 7:45PM
Cancer Biology and Genetics of GI Malignancies II
Room: Jinyun Ballroom

Speaker 2 of 3
Qimin Zhan, Chinese Academy of Medical Sciences, China
The Cell Cycle Regulator in Malignant Development of Human Esophageal Cancer

Monday, October 15 | 6:30PM - 7:45PM
Cancer Biology and Genetics of GI Malignancies II
Room: Jinyun Ballroom

Speaker 3 of 3
Hong-Yang Wang, International Cooperation Laboratory on Signal Transduction, SMMU, China
Cell Signaling and Human Hepatocellular Carcinoma

Tuesday, October 16 | 7:30AM - 8:30AM
Breakfast
Room: Coffee House


Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 1 of 7
* Raymond N. DuBois, Arizona State University, USA

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 2 of 7
Curtis C. Harris, NCI, National Institutes of Health, USA
Inflammation and Cancer: Interactions of the MicroRNA, p53 and Cytokine Pathways

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 3 of 7
Martin J. Blaser, New York University School of Medicine, USA
Oncogenic Pathways Related to Helicobacter pylori

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 4 of 7
Michael Karin, University of California, San Diego, USA
How Inflammation Affects Cancer Development and Progression: The IKK Complex and Beyond

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 5 of 7
Timothy C. Wang, Columbia University, USA
The Role of Inflammation and Bone Marrow Progenitor Cells in the Pathogenesis of Gastric Cancer

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 6 of 7
Anna Bigas, IDIBELL-Institut de Recerca Oncologica, Spain
Short Talk: Notch Cooperates with Beta-catenin to Activate a Specific Gene Program

Tuesday, October 16 | 8:30AM - 11:45AM
Role of Microenvironment and Inflammation in GI Cancers I
Room: Jinyun Ballroom

Speaker 7 of 7
Hiroyuki Marusawa, Kyoto University, Japan
Short Talk: Activation-induced Cytidine Deaminase Links Liver Inflammation to Human Hepatocarcinogenesis

Tuesday, October 16 | 9:45AM - 10:15AM
Coffee Break
Room: Jinyun Foyer


Tuesday, October 16 | 11:30AM - 1:30PM
Lunch
Room: Coffee House


Tuesday, October 16 | 12:00PM - 1:00PM
Poster Setup
Room: Jinyun Foyer


Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 1 of 9
* Zongtang Sun, Chinese Academy of Medical Sciences, China

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 2 of 9
* Xiaodong Wang, BeiGene, China

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 3 of 9
François Boudreau, University of Sherbrooke, Canada
Loss of Cathepsin L Activity Promotes Claudin-1 over Expression and Intestinal Neoplasia

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 4 of 9
Rachid A. Karam, MD Anderson Cancer Center, USA
The NMD RNA Surveillance Pathway Degrades Aberrant E-Cadherin Transcripts in Hereditary Diffuse Gastric Cancer

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 5 of 9
Giang Huong Nguyen, National Institutes of Health, USA
A Unique Inflammatory Gene Signature Associated with Reduced Survival in Esophageal Cancer


Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 6 of 9
Hui Xiao, Institut Pasteur of Shanghai, China
The Regulatory Role of SIGIRR in Colonic Epithelial Homeostasis, Inflammation and Tumorigenesis

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 7 of 9
Ying Yang, Institute of Molecular Medicine, Peking University, China
Shp2 Suppresses the mT-induced Transformation by Inhibiting Stat3 and mTOR/S6K1 Signaling Pathways

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 8 of 9
Mi-Ock Lee, Seoul National University, South Korea
Hepatitis B Virus X Protein Induces the Expression of MTA1 and HDAC1, which Enhances Hypoxia Signaling in Hepatocellular Carcinoma Cells

Tuesday, October 16 | 1:30PM - 3:30PM
Workshop
Room: Jinyun Ballroom

Speaker 9 of 9
Siina Junnila, University of Helsinki, Finland
Different Gastric Cancer Subtypes Exhibit Distinct Molecular Profiles by Gene Copy Number, Expression and Tissue Microarrays

Tuesday, October 16 | 3:30PM - 5:30PM
Poster Session 2
Room: Jinyun Foyer


Tuesday, October 16 | 4:30PM - 5:30PM
Coffee & Snacks Available
Room: Jinyun Foyer


Tuesday, October 16 | 5:30PM - 7:30PM
Role of Microenvironment and Inflammation in GI Cancers II
Room: Jinyun Ballroom

Speaker 1 of 3
* Snorri S. Thorgeirsson, National Institutes of Health, USA

Tuesday, October 16 | 5:30PM - 7:30PM
Role of Microenvironment and Inflammation in GI Cancers II
Room: Jinyun Ballroom

Speaker 2 of 3
Varda Rotter, Weizmann Institute of Science, Israel
Identification and Characterization “Gene Signatures” Involved in Cells Transformed in vitro

Tuesday, October 16 | 5:30PM - 7:30PM
Role of Microenvironment and Inflammation in GI Cancers II
Room: Jinyun Ballroom

Speaker 3 of 3
Hiroshi Ohshima, University of Shizuoka, Japan
Helicobacter pylori Infection, Oxidative and Nitrative Stress and Stomach Cancer

Wednesday, October 17 | 7:30AM - 8:30AM
Breakfast
Room: Coffee House


Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 1 of 7
* Curtis C. Harris, NCI, National Institutes of Health, USA

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 2 of 7
Yu-Tang Gao, Shanghai Cancer Institute, China
Gastrointestinal Cancer Incidence and Trends in China

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 3 of 7
Dongxin Lin, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Genetic Polymorphisms and Risk of Gastroesophageal Cancer

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 4 of 7
Raymond N. DuBois, Arizona State University, USA
Colorectal Cancer Prevention: Molecular Targets

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 5 of 7
Yang Ke, Peking University, China
HPV and Esophageal Cancer

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 6 of 7
† Wei-guo Zhu, Peking University Health Sciences Center, China
Short Talk: A Correlation Exists between Numb and Notch1 Expression in Colorectal Cancer with Clinicopathological Parameters

Wednesday, October 17 | 8:30AM - 11:45AM
GI Cancer Epidemiology and Prevention I
Room: Jinyun Ballroom

Speaker 7 of 7
Donghui Li, University of Texas, MD Anderson Cancer Center, Health Science Center, USA
Short Talk: Genetic Variations in Drug Metabolism and DNA Repair as Predictors for Clinical Outcomes of Pancreatic Adenocarcinoma

Wednesday, October 17 | 9:45AM - 10:15AM
Coffee Break
Room: Jinyun Foyer


Wednesday, October 17 | 12:00PM - 1:00PM
Poster Setup
Room: Jinyun Foyer


Wednesday, October 17 | 12:00PM - 5:00PM
Optional Tour with Lunch


Wednesday, October 17 | 5:00PM - 5:30PM
Coffee Available
Room: Jinyun Foyer


Wednesday, October 17 | 5:30PM - 7:30PM
GI Cancer Epidemiology and Prevention II
Room: Jinyun Ballroom

Speaker 1 of 4
* Edison T. Liu, The Jackson Laboratory, USA

Wednesday, October 17 | 5:30PM - 7:30PM
GI Cancer Epidemiology and Prevention II
Room: Jinyun Ballroom

Speaker 2 of 4
Thomas Ried, National Cancer Institute, National Institutes of Health, USA
Causes and Consequences of Chromosomal Aneuploidy in Colon Cancer

Wednesday, October 17 | 5:30PM - 7:30PM
GI Cancer Epidemiology and Prevention II
Room: Jinyun Ballroom

Speaker 3 of 4
Gangqiao Zhou, Beijing Proteom Research Center, China
Genetic Susceptibility to Common Cancers of Chinese

Wednesday, October 17 | 5:30PM - 7:30PM
GI Cancer Epidemiology and Prevention II
Room: Jinyun Ballroom

Speaker 4 of 4
Suet Yi Leung, University of Hong Kong, La Ka Shing Faculty of Medicine, Hong Kong
Microsatellite Instability in Hereditary and Sporadic Colorectal Cancer – Genetic and Epigenetic Mechanisms

Wednesday, October 17 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Jinyun Foyer


Wednesday, October 17 | 7:30PM - 10:00PM
Poster Session 3
Room: Jinyun Foyer


Thursday, October 18 | 7:30AM - 8:30AM
Breakfast
Room: Coffee House


Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 1 of 7
* Peter R. Galle, University of Mainz, Germany

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 2 of 7
Edison T. Liu, The Jackson Laboratory, USA
Systems Pharmacology: Cancer Therapeutics

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 3 of 7
Xin Wei Wang, NCI, National Institutes of Health, USA
Diagnostic and Prognostic Signatures of Liver Cancer

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 4 of 7
Zhao-You Tang, Fudan University, China
Liver Cancer Therapy at Liver Cancer Institute of Fudan University

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 5 of 7
Frédéric Hollande, University of Melbourne, Australia
Short Talk: Inhibition of Beta-catenin/Tcf-4 and Notch After Progastrin-Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 6 of 7
Guihua Wang, Tongji Hospital, China
Short Talk: A Peptide Inhibitor Targeting p55PIK PI 3-Kinase Regulatory Subunit is Effective in Cancer Therapy

Thursday, October 18 | 8:30AM - 11:30AM
New Horizon in Early Detection and Therapies I
Room: Jinyun Ballroom

Speaker 7 of 7
XiangMei Chen, Peking University, China
Short Talk: Aberrant Hypermethylation of Retinoic Acid Signaling Related Genes RARâ1/CRBP1/TIG1 in Gastric Carcinoma

Thursday, October 18 | 9:45AM - 10:15AM
Coffee Break
Room: Jinyun Foyer


Thursday, October 18 | 5:00PM - 5:30PM
Coffee Available
Room: Jinyun Foyer


Thursday, October 18 | 5:30PM - 7:30PM
New Horizon in Early Detection and Therapies II
Room: Jinyun Ballroom

Speaker 1 of 3
* Yang Ke, Peking University, China

Thursday, October 18 | 5:30PM - 7:30PM
New Horizon in Early Detection and Therapies II
Room: Jinyun Ballroom

Speaker 2 of 3
Snorri S. Thorgeirsson, National Institutes of Health, USA
Genomic Decoding of Human Liver Cancer

Thursday, October 18 | 5:30PM - 7:30PM
New Horizon in Early Detection and Therapies II
Room: Jinyun Ballroom

Speaker 3 of 3
Peter R. Galle, University of Mainz, Germany
Signal Transduction Pathways and Targeted Therapies in HCC

Thursday, October 18 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Jinyun Foyer


Friday, October 19 | 10:25AM - 10:25AM
Departure


*Session Chair.