Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Innate and Non-Classical Immune Cells in Cancer Immunotherapy (2019C5)
NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses (2011A4)
Pattern Recognition Molecules and Immune Sensors of Pathogens (2009Z1)

Web Desc
NK and NKT Cell Biology joint with Innate Immunity: Signaling Mechanisms Organizer(s): Michael B. Brenner and Lewis L. Lanier Date: February 24 - 29, 2008 Location: Keystone Resort, Keystone, CO, USA Sponsored by Novo Nordisk A/S Summary of Meeting: Innate immunity is immediate and involves invariant receptors that recognize conserved structures in microbes or host-encoded ligands induced by stress, inflammation or transformation. Although myeloid cells comprise the majority of leukocytes mediating innate immunity, two specialized lymphocyte populations, NK cells and NKT cells, play a central role in orchestrating and amplifying the innate response – and in shaping the nature of the adaptive response of T cells and B cells. The “NK and NKT Cell Biology” meeting will bring together, for the first time, researchers focusing on NK cells and NKT cells. This should initiate discussions, foster collaborations and lead to a better understanding how these cells use independent recognition mechanisms to achieve common effector functions and work coordinately to mediate immune responses against tumors and pathogens, as well as influence autoimmunity. Scholarship Deadline: October 29 2007 Discounted Abstract Deadline: October 29 2007 Abstract Deadline: November 27 2007 Discounted Registration Deadline: December 27 2007 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI077250-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

NK and NKT Cell Biology

joint with Innate Immunity: Signaling Mechanisms

Organizer(s): Michael B. Brenner and Lewis L. Lanier

Date: February 24 - 29, 2008
Location: Keystone Resort, Keystone, CO, USA

Program


Sunday, February 24 \| 3:00PM - 7:30PM Registration Room: Shavano Peak Foyer
Sunday, February 24 \| 6:30PM - 7:30PM Refreshments Room: Shavano Peak Foyer
Sunday, February 24 \| 7:30PM - 8:30PM Keynote Address Room: Grays 2-3 Speaker 1 of 1 Irving L. Weissman, Stanford University, USA Self and Non-Self Recognition by the Innate Immune System
Monday, February 25 \| 7:00AM - 8:00AM Breakfast Room: Grays 1/Torreys
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 1 of 7 Lewis L. Lanier, University of California, San Francisco, USA Introduction & Welcome
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 2 of 7 Michael B. Brenner, Harvard Medical School, USA and
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 3 of 7 Peter D. Sun, NIAID, National Institutes of Health, USA Ligand Recognition by NK Receptors
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 4 of 7 Ian A. Wilson, The Scripps Research Institute, USA Structural Analysis of Potent NKT Cell Agonists
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 5 of 7 * Yvonne Yvonne Jones, University of Oxford, UK Structure of CD1 Molecules and the TCRs that Recognize them
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 6 of 7 Roland Strong, Fred Hutchinson Cancer Research Center, USA The NKG2A/CD94/HLA-E Complex
Monday, February 25 \| 8:00AM - 11:00AM Structure of NK and NKT Cell Recognition Molecules Room: Grays 2-3 Speaker 7 of 7 Natalie A. Borg, Monash University, Australia Short Talk: Glycolipid Recognition by an NKT Cell
Monday, February 25 \| 8:00AM - 11:45AM TLR Signaling: Role of Adapters This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 5 Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA Cell Biology of TLR Signal Transduction
Monday, February 25 \| 8:00AM - 11:45AM TLR Signaling: Role of Adapters This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 5 * Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland Novel Regulators of Toll-like Receptor Signaling
Monday, February 25 \| 8:00AM - 11:45AM TLR Signaling: Role of Adapters This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 5 Kate A. Fitzgerald, University of Massachusetts Medical School, USA Negative Regulation of Innate Immunity
Monday, February 25 \| 8:00AM - 11:45AM TLR Signaling: Role of Adapters This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 5 Alan Aderem, Center for Infectious Disease Research, USA A Systems Approach to Dissecting Immunity
Monday, February 25 \| 8:00AM - 11:45AM TLR Signaling: Role of Adapters This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 5 Abigail M. Spear, Defence Science and Technology Laboratory, UK Short Talk: Identification and Characterization of Toll/Interleukin-1 Receptor Family Proteins in a Range of Pathogenic Bacteria
Monday, February 25 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Monday, February 25 \| 11:00AM - 1:00PM Poster Setup Room: Grays 1/Torreys
Monday, February 25 \| 1:00PM - 10:00PM Poster Viewing Room: Grays 1/Torreys
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 1 of 10 * Moriya Tsuji, Aaron Diamond AIDS Research Center (ADARC), USA
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 2 of 10 * Marcus Altfeld, Heinrich-Pette-Institute, Germany
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 3 of 10 Laurent Brossay, Brown University, USA Valpha14i NK T Cells Participate to the Early Response to MCMV Infection
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 4 of 10 * Eric Vivier, Aix Marseille University, France Natural Killer Cell Trafficking and Function
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 5 of 10 Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA iNK T Cells Provide Cognate Help for Lipid Antigen Specific B Cells
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 6 of 10 Vasileios Bekiaris, USA Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection: Cues for Reciprocal NK-Stroma interactions
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 7 of 10 Galit Alter, MIT and Harvard University, USA Ligand Dependent Expansion of Clonal NK Cell Populations in Acute HIV-1 Infection
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 8 of 10 Agnès C. Lehuen, Institut Cochin, France iNKT Cells Prevent Virus-Induced Diabetes by Promoting Plasmacytoid Dendritic Cell Function in the Pancreas
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 9 of 10 Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA Tolerance of NK Cells Encountering their Viral Ligand during Development
Monday, February 25 \| 2:30PM - 4:30PM Workshop 1 : Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 10 of 10 Sandeep K. Tripathy, Washington University School of Medicine, USA Self-MHC-Specific Inhibitory Receptor effects on Natural Killer Cell Tolerance Induced by Self-Specific Activation Receptor Engagement
Monday, February 25 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Monday, February 25 \| 5:00PM - 7:00PM Pathways of Ligand Presentation and Immune Evasion Room: Grays 2-3 Speaker 1 of 4 * Michael B. Brenner, Harvard Medical School, USA Antigen Presentation by CD1 Results in both Innate and Adaptive Immunity
Monday, February 25 \| 5:00PM - 7:00PM Pathways of Ligand Presentation and Immune Evasion Room: Grays 2-3 Speaker 2 of 4 Randy R. Brutkiewicz, Indiana University School of Medicine, USA Viral Immune Evasion of NKT Cells
Monday, February 25 \| 5:00PM - 7:00PM Pathways of Ligand Presentation and Immune Evasion Room: Grays 2-3 Speaker 3 of 4 Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia NK Cell Immune Evasion by Murine Cytomegalovirus
Monday, February 25 \| 5:00PM - 7:00PM Pathways of Ligand Presentation and Immune Evasion Room: Grays 2-3 Speaker 4 of 4 Seung-Hwan Lee, University of Ottawa, Canada Short Talk: A Role for Ly49H Receptor in Controlling NK Cell Proliferation during MCMV Infection
Monday, February 25 \| 5:00PM - 7:15PM TLR Signaling: Role of Protein Kinases This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 4 Alexander Tarakhovsky, Rockefeller University, USA Essential Role of Histone Lysine Methyltransferase G9a in Innate Antiviral Response
Monday, February 25 \| 5:00PM - 7:15PM TLR Signaling: Role of Protein Kinases This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 4 * Sankar Ghosh, Columbia University, USA TLR-Mediated Signaling to NF-kappaB
Monday, February 25 \| 5:00PM - 7:15PM TLR Signaling: Role of Protein Kinases This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 4 Carla V. Rothlin, Yale University, USA Short Talk: TAM Receptors are Pleiotropic Inhibitors of the Innate Immune Response
Monday, February 25 \| 5:00PM - 7:15PM TLR Signaling: Role of Protein Kinases This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 4 Sinead Keating, Trinity College Dublin, Ireland Short Talk: IRAK-2 Participates in Multiple Toll-Like Receptor Signalling Pathways to NF-kappaB via Activation of TRAF6 Ubiquitination
Monday, February 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Grays 1/Torreys
Monday, February 25 \| 7:30PM - 10:00PM Poster Session 1 Room: Grays 1/Torreys
Tuesday, February 26 \| 7:00AM - 8:00AM Breakfast Room: Grays 1/Torreys
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 1 of 6 * James P. Di Santo, Institut Pasteur, France NK Cell Developmental Pathways
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 2 of 6 Markus Boos, University of Chicago, USA Short Talk: Differential Requirements for Id2 in Natural Killer Cell Development in Distinct Microenvironments
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 3 of 6 Michael Caligiuri, Ohio State University, USA Development of NK Cells in Humans
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 4 of 6 Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA Analysis of the Development and Activation of CD1d-restricted NKT Cells
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 5 of 6 Albert S. Bendelac, University of Chicago, USA NKT Cell Self-Antigens and Thymic Selection
Tuesday, February 26 \| 8:00AM - 11:15AM NKT/NK Cell Development Room: Grays 2-3 Speaker 6 of 6 Victoria J. Lawson, Institute of Cancer Research, UK Short Talk: The AP-1 Transcription Factor Fra-2 is Required for Normal NKT Cell Ontogeny and Function
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 6 * Jürg Tschopp, University of Lausanne, Switzerland The Inflammasomes
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 6 Gabriel Nuñez, University of Michigan, USA Role of NLRs in Innate Immunity and Disease
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 6 Dana Philpott, University of Toronto, Canada Title to be Determined
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 6 Mihai G. Netea, Radboud University, Netherlands Short Talk: Monocytes are not Macrophages: One-Hit Versus Two-Hit Stimulation for LPS-Driven Activation of the Human Inflammasome for IL-1beta
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 6 Marie-Cécile Michallet, INSERM, France Short Talk: Tradd is an Essential Component of the RIG-like Helicases (RLH) Antiviral Pathway
Tuesday, February 26 \| 8:00AM - 11:15AM NLR Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 6 of 6 Chris B. Moore, Arbutus Biopharma, USA Short Talk: NLRX1: a Novel Member of the NLR Family which Regulates RLH-Mediated Mitochondrial Antiviral Signaling
Tuesday, February 26 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Tuesday, February 26 \| 11:15AM - 1:00PM Poster Setup Room: Grays 1/Torreys
Tuesday, February 26 \| 1:00PM - 10:00PM Poster Viewing Room: Grays 1/Torreys
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 10 * Alan Sher, NIAID, National Institutes of Health, USA
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 10 Anna-Marie Fairhurst, Singapore Immunology Network, Singapore Yaa-Autoimmune Phenotypes are Conferred by an Overexpression of TLR7
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 10 Hsin-Jung Joyce Wu, University of Arizona, USA Inflammatory Arthritis can be Reined in by CpG-Induced DC-NK Cell Cross Talk
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 10 Sandra M. Sacre, University of Sussex, UK Toll-Like Receptor 8 is a Novel Therapeutic Target for Rheumatoid Arthritis
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 10 Liliana Schaefer, Goethe University, Germany The Matrix Component Biglycan as an Endogenous Ligand to Toll-like Receptor-4 and -2 Aggravates Inflammation and Sepsis
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 6 of 10 R. William DePaolo, University of Washington, USA Infectious Tolerance Induced by Yersinia Involves JNK2-Dependent IL-10 Production
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 7 of 10 Monica Andrea Delgado Vargas, Lovelace Respiratory Research Institute, USA Toll Like Receptors Control Autophagy
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 8 of 10 Rowan Higgs, Royal College of Surgeons in Ireland, Ireland The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-beta Gene Transcription by Initiating Proteasomal Degradation of IRF3
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 9 of 10 Ashish Banerjee, Monash University, Australia Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival
Tuesday, February 26 \| 2:00PM - 4:30PM Workshop: At the Interface between Innate Immunity and Infla mmation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 10 of 10 Neal Silverman, University of Massachusetts Medical School, USA Recognition and Signaling in the Drosophila IMD Pathway
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 1 of 10 * Sebastian Joyce, Vanderbilt University School of Medicine, USA
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 2 of 10 * Marco Colonna, Washington University School of Medicine, USA
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 3 of 10 Joanna Brzostek, Imperial College London, UK The Role of Ligand Dimensions in NK Cell Triggering
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 4 of 10 Pooja Arora, Albert Einstein College of Medicine, USA Selective Trafficking of CD1d-Glycolipid Complexes Formed with N-acyl Variants of alpha-Galactosylceramide Ligands
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 5 of 10 Deborah L. Hodge, Center for Scientific Review, NIH, USA Phenotypic Changes in IFN-gamma 3’UTR ARE Knock out Mice
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 6 of 10 Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA An Avidity Model to Explain the Vbeta use by Natural Killer TCRs
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 7 of 10 Kimberly L. Jordan, Purdue University, USA Differing Roles of AP-1 Inhibitors in the Development of NK and NKT Cells in vivo
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 8 of 10 Susanna Cardell, Göteborg University, Sweden Dependence of the Fatty Acid Chain of Sulfatide for Activation of CD1d-Restricted NK T Cells
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 9 of 10 Shouxiong Huang, University of Cincinnati, USA MR1 uses an Endocytic Pathway to Activate Mucosal-Associated Invariant T Cells
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop 2 : NKT/NK Recognition of Ligands and Antigens Room: Grays 2-3 Speaker 10 of 10 * Jenny E. Gumperz, University of Wisconsin-Madison School of Medicine and Public Health, USA Distinct Processes of Autoreactive and Foreign Antigenic Activation of NKT Cells
Tuesday, February 26 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Tuesday, February 26 \| 5:00PM - 7:00PM Activation, Inactivation and Homeostasis of NK/NKT Cells Room: Grays 2-3 Speaker 1 of 4 * Dale I. Godfrey, University of Melbourne, Australia Identification of a Novel, Developmentally Distinct, IL-17-Producing CD4-NK1.1- NKT Cell Subpopulation.
Tuesday, February 26 \| 5:00PM - 7:00PM Activation, Inactivation and Homeostasis of NK/NKT Cells Room: Grays 2-3 Speaker 2 of 4 Wayne M. Yokoyama, Washington University School of Medicine, USA Regulation of NK Cell Responses
Tuesday, February 26 \| 5:00PM - 7:00PM Activation, Inactivation and Homeostasis of NK/NKT Cells Room: Grays 2-3 Speaker 3 of 4 Werner Held, Ludwig Institute, Switzerland Short Talk: Functional Adaptation of NK Cells to Self-MHC Class I
Tuesday, February 26 \| 5:00PM - 7:00PM Activation, Inactivation and Homeostasis of NK/NKT Cells Room: Grays 2-3 Speaker 4 of 4 Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA NKT Cells Sense Bacterial Infection and Recognize Bacterial Glycolipids
Tuesday, February 26 \| 5:00PM - 7:15PM RIG-I-Like Receptors and Viral Sensing This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 5 Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan Non-Self RNA Sensing Mechanism of RIG-I-Like Helicases and Activation of Antiviral Immune Responses
Tuesday, February 26 \| 5:00PM - 7:15PM RIG-I-Like Receptors and Viral Sensing This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 5 Paula M. Pitha-Rowe, Johns Hopkins University, USA The Role of IRF-5 in the Innate Antiviral and Inflammatory Response
Tuesday, February 26 \| 5:00PM - 7:15PM RIG-I-Like Receptors and Viral Sensing This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 5 * Akira Shizuo, Osaka University, Japan TLR- and RLR-Dependent Anti-Viral Responses
Tuesday, February 26 \| 5:00PM - 7:15PM RIG-I-Like Receptors and Viral Sensing This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 5 Hiroyuki Oshiumi, Hokkaido University, Japan Short Talk: Riplet: A Novel RING Finger Protein that Activates RIG-I
Tuesday, February 26 \| 5:00PM - 7:15PM RIG-I-Like Receptors and Viral Sensing This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 5 Shohei Koyama, Research Institute for Microbial Diseases, Japan Short Talk: Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination
Tuesday, February 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Grays 1/Torreys
Tuesday, February 26 \| 7:30PM - 10:00PM Poster Session 2 Room: Grays 1/Torreys
Wednesday, February 27 \| 7:00AM - 8:00AM Breakfast Room: Grays 1/Torreys
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 1 of 6 D. Branch Moody, Brigham and Women's Hospital, USA Pathogens Provide Lipid Ligands for CD1 and Regulate CD1 Gene expression
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 2 of 6 Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK Short Talk: Activation of Liver-Resident Invariant NKT Cells Improves Outcome from Influenza Virus Infection
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 3 of 6 Luis J. Sigal, Fox Chase Cancer Center, USA Short Talk: Mechanisms of NK Cell-Mediated Resistance to Mousepox
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 4 of 6 Silvia Vidal, McGill University, Canada NK Cell Recognition of Cytomegalovirus
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 5 of 6 Eleanor M. Riley, Roslin Institute, UK NK Cell Responses to Infection: Roles of Accessory Cells and MHC Receptors
Wednesday, February 27 \| 8:00AM - 11:15AM Role of NK/NKT Cells in Infection Room: Grays 2-3 Speaker 6 of 6 * Jody L. Baron, University of California, San Francisco, USA Blockade of NKG2D on NKT Cells Prevents the Acute Immune Response to Hepatitis B Virus
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 6 * Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA NLRs at the Intersection of Death and Immunity
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 6 Jean-Laurent Casanova, Rockefeller University, USA A Genetic Dissection of Immunity to Infection in natura
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 6 Warren Strober, National Institutes of Health, USA The Molecular Basis of NOD2 Susceptibility Mutations in Crohn’s Disease
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 6 Jennifer Greene, Case Western Reserve University, USA Short Talk: A 22bp Deletion Polymorphism in the 5’ Untranslated Region of the TLR2 Gene is Associated with Protection from Cerebral Malaria
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 6 Richard I. Tapping, University of Illinois, USA Short Talk: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects Against Leprosy
Wednesday, February 27 \| 8:00AM - 11:00AM Genetic Variation in Signaling Molecules in Innate Immunity This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 6 of 6 Gordon D. Brown, University of Aberdeen, UK
Wednesday, February 27 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Wednesday, February 27 \| 11:15AM - 1:00PM Poster Setup Room: Grays 1/Torreys
Wednesday, February 27 \| 1:00PM - 10:00PM Poster Viewing Room: Grays 1/Torreys
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 1 of 9 * Luc Van Kaer, Vanderbilt University School of Medicine, USA
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 2 of 9 * Franck Housseau, Johns Hopkins School of Medicine, USA IKDCs: the other NK cells
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 3 of 9 Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA The Role of NKT Cells in Liver Disease
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 4 of 9 Kori Wallace, University of Virginia, USA The Role of NK and NK-T Cells in Pulmonary Dysfunction in a Transgenic Model of Sickle Cell Disease
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 5 of 9 Toshinori Nakayama, Chiba University, Japan Combination Therapy of In vitro Expanded Natural Killer T Cells and alpha-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 6 of 9 * Laurence Zitvogel, Institut Gustave Roussy, France Do Regulatory NK Cells Exist?
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 7 of 9 Jin Seon S. Im, MD Anderson Cancer Center, USA Mechanisms of Modulation of CD1d-Restricted NKT Cell Functions by Th2-Biasing á-Galactosylceramide Analogues
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 8 of 9 Joshua Beilke, Celgene, USA Differing NK Cell Phenotypes in Diabetic Mice
Wednesday, February 27 \| 2:30PM - 4:30PM Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu lation Room: Grays 2-3 Speaker 9 of 9 Peggy Jacques, University Ghent, Belgium iNKT Cells: Regulators of TNFá Driven Murine Spondyloarthropathy
Wednesday, February 27 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Wednesday, February 27 \| 5:00PM - 7:00PM Role of NK/NKT Cells in Tumor Immunity Room: Grays 2-3 Speaker 1 of 4 David H. Raulet, University of California, Berkeley, USA Natural Killer Cell Receptors and Tumor Immunity
Wednesday, February 27 \| 5:00PM - 7:00PM Role of NK/NKT Cells in Tumor Immunity Room: Grays 2-3 Speaker 2 of 4 Adelheid Cerwenka, University of Heidelberg, Germany Short Talk: Myeloid Derived “Suppressor” Cells Mediate NK Cell Activation
Wednesday, February 27 \| 5:00PM - 7:00PM Role of NK/NKT Cells in Tumor Immunity Room: Grays 2-3 Speaker 3 of 4 * Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia Role of NK and NKT Cells in Tumor Immune Surveillance and Immunotherapy
Wednesday, February 27 \| 5:00PM - 7:00PM Role of NK/NKT Cells in Tumor Immunity Room: Grays 2-3 Speaker 4 of 4 Andrea Velardi, University of Perugia, Italy Impact of NK Cell Alloreactivity on Human Hematopoietic Stem Cell Transplantation
Wednesday, February 27 \| 5:00PM - 7:15PM Signaling: Biophysical and Structural Aspects This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 5 * Nick Gay, University of Cambridge, UK Molecular Mechanism of Signal Transduction by the Toll and Toll-Like Receptors
Wednesday, February 27 \| 5:00PM - 7:15PM Signaling: Biophysical and Structural Aspects This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 5 Douglas Golenbock, University of Massachusetts Medical School, USA How TLRs Achieve an Active State: Implications for Disease
Wednesday, February 27 \| 5:00PM - 7:15PM Signaling: Biophysical and Structural Aspects This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 5 Joshua N. Leonard, National Institutes of Health, National Cancer Institute, USA The Signaling Complex of TLR3
Wednesday, February 27 \| 5:00PM - 7:15PM Signaling: Biophysical and Structural Aspects This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 5 James Michael Elliott, Genentech, USA Short Talk: Crystal Structure of Procaspase-1 and its Implications for Activation
Wednesday, February 27 \| 5:00PM - 7:15PM Signaling: Biophysical and Structural Aspects This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 5 Clare E. Bryant, University of Cambridge, UK Short Talk: Elucidation of the MD-2/TLR4 Interface Required for Signalling by Lipid IVa
Wednesday, February 27 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Grays 1/Torreys
Wednesday, February 27 \| 7:30PM - 10:00PM Poster Session 3 Room: Grays 1/Torreys
Thursday, February 28 \| 7:00AM - 8:00AM Breakfast Room: Grays 1/Torreys
Thursday, February 28 \| 8:00AM - 11:00AM Role of NK/NKT Cells in Autoimmunity and Immunopathology Room: Grays 2-3 Speaker 1 of 4 * Lewis L. Lanier, University of California, San Francisco, USA NK Cell Receptors in Immunity and Autoimmunity
Thursday, February 28 \| 8:00AM - 11:00AM Role of NK/NKT Cells in Autoimmunity and Immunopathology Room: Grays 2-3 Speaker 2 of 4 Gennaro De Libero, University Hospital Basel, Switzerland CD1 Restricted Self-Reactive T Cells
Thursday, February 28 \| 8:00AM - 11:00AM Role of NK/NKT Cells in Autoimmunity and Immunopathology Room: Grays 2-3 Speaker 3 of 4 Rene de Waal Malefyt, Merck Research Labs, USA Short Talk: IL-25 is a Growth and Activation Factor for NKT Cells
Thursday, February 28 \| 8:00AM - 11:00AM Role of NK/NKT Cells in Autoimmunity and Immunopathology Room: Grays 2-3 Speaker 4 of 4 Philip W. Askenase, Yale University School of Medicine, USA Role of NK and NKT Cells in Immunopathology
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 6 * Anthony J. Coyle, Pfizer, USA Danger Signals and Interferons in Autoimmune Disease
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 6 Mary Collins, Wyeth Research, USA IL-22: A Th17 cytokine contributes to chronic inflammation
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 6 Anthony M. Manning, Momenta Pharmaceuticals, USA Drug Discovery Targeting MAP Kinases: From Innate Immunity to Clinical Benefit
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 6 Jie-Oh Lee, Korea Advanced Institute of Science and Technology, South Korea Ligand Recognition by the TLR Complexes
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 6 Lani R. San Mateo, WWDA, Johnson & Johnson, USA Short Talk: Down Modulation of Human TLR3 Function by a Monoclonal Antibody
Thursday, February 28 \| 8:00AM - 11:15AM Drug Targets in Innate Signaling This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 6 of 6 Karen Colbjørn Larsen, University of Oxford, UK Short Talk: Combining TLR Signaling Molecules as Vaccine Adjuvants
Thursday, February 28 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Thursday, February 28 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Thursday, February 28 \| 5:00PM - 7:00PM Interaction of NKT and NK Cells with APC and Modulation of A daptive Immunity Room: Grays 2-3 Speaker 1 of 4 Vincenzo Cerundolo, University of Oxford, UK Role of NKT Cells in Modulation of Adaptive Immunity
Thursday, February 28 \| 5:00PM - 7:00PM Interaction of NKT and NK Cells with APC and Modulation of A daptive Immunity Room: Grays 2-3 Speaker 2 of 4 Steven A. Porcelli, Albert Einstein College of Medicine, USA Modulation of Immunoregulatory Activities of CD1d-Restricted NKT Cells by Modified Glycosylceramide Analogues
Thursday, February 28 \| 5:00PM - 7:00PM Interaction of NKT and NK Cells with APC and Modulation of A daptive Immunity Room: Grays 2-3 Speaker 3 of 4 Silke Paust, Baylor College of Medicine, USA Short Talk: T and B cell Independent Adaptive Immune Responses Mediated by Natural Killer Cells
Thursday, February 28 \| 5:00PM - 7:00PM Interaction of NKT and NK Cells with APC and Modulation of A daptive Immunity Room: Grays 2-3 Speaker 4 of 4 * Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia Interplay between Mouse NK Cells and Dendritic Cells
Thursday, February 28 \| 5:00PM - 7:15PM Pathogen Manipulation of Signaling and Immunomodulation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 1 of 5 * Andrew G. Bowie, Trinity College Dublin, Ireland Insights into Innate Immune Signaling Afforded by Viral Evasion and Subversion
Thursday, February 28 \| 5:00PM - 7:15PM Pathogen Manipulation of Signaling and Immunomodulation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 2 of 5 Anne O'Garra, Francis Crick Institute, UK Regulation of IL-10 Expression in Dendritic Cells and Macrophages and Implications for Regulation of the Immune Response to Pathogens
Thursday, February 28 \| 5:00PM - 7:15PM Pathogen Manipulation of Signaling and Immunomodulation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 3 of 5 David E. Levy, New York University School of Medicine, USA Transcriptional and Post-Transcriptional Regulation of Gene Expression in the IFN Innate Immune Response
Thursday, February 28 \| 5:00PM - 7:15PM Pathogen Manipulation of Signaling and Immunomodulation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 4 of 5 Tsukasa Seya, Graduate School of Medicine, Hokkaido University, Japan Functional Evolution of the TRIF/TLCAM-1 Pathway
Thursday, February 28 \| 5:00PM - 7:15PM Pathogen Manipulation of Signaling and Immunomodulation This session is from Innate Immunity Room: Red Cloud/Shavano Speaker 5 of 5 Amanda Mercedes Jamieson, Max F. Perutz Laboratories, University of Vienna, Austria Short Talk: Modulation of the Innate Immune Response to Bacteria by Viral Infection
Thursday, February 28 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Grays 1/Torreys
Thursday, February 28 \| 7:15PM - 7:15PM Concluding Remarks This session is from Innate Immunity Speaker 1 of 1 * Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Thursday, February 28 \| 8:00PM - 11:00PM Entertainment Room: Grays 1/Torreys
Thursday, February 28 \| 8:00PM - 11:00PM Cash Bar Room: Grays 1/Torreys
Friday, February 29 \| 10:25AM - 10:25AM Departure *Session Chair.