Web Desc
Innate Immunity: Signaling Mechanisms
joint with NK and NKT Cell Biology
Organizer(s): Luke A.J. O'Neill, Jürg Tschopp and Shizuo Akira
Date: February 24 - 29, 2008
Location: Keystone Resort, Keystone, CO, USA
Sponsored by sanofi-aventis
For important information on the coronavirus, please click here
Summary of Meeting:
The past 5 years has seen remarkable progress in our understanding of the molecular basis for innate immunity. New families of receptors have been discovered that sense microbial products, including Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors. In addition, signaling mechanisms activated by these receptor families have been described, with new adapter proteins, protein kinases and transcription factors being found. Breakthroughs in our understanding of signaling mechanisms is a key aspect for this field, with much excitement and insight being generated. This Keystone Symposia meeting will assemble the world’s leading investigators in cell signaling during innate immunity, to present recent data and discuss the importance of signaling in the more general context of innate immunity. We can expect a compelling and informative meeting that will bring together basic researchers in the area but also those more generally interested in leading edge research in innate immunity.
Scholarship Deadline: October 29 2007
Discounted Abstract Deadline: October 29 2007
Abstract Deadline: November 27 2007
Discounted Registration Deadline: December 27 2007
We gratefully acknowledge additional support for this conference from:
Sanofi US
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI077250-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5U13AI60000-05
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Sunday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Sunday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud/Shavano

Speaker 1 of 2
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Sunday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud/Shavano

Speaker 2 of 2
Michael Karin, University of California, San Diego, USA
IKK-NF-kappaB Signaling and the Control of Caspase Activation and Cell Survival

Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Grays 1/Torreys


Monday, February 25 | 8:00AM - 11:45AM
TLR Signaling: Role of Adapters
Room: Red Cloud/Shavano

Speaker 1 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Cell Biology of TLR Signal Transduction

Monday, February 25 | 8:00AM - 11:45AM
TLR Signaling: Role of Adapters
Room: Red Cloud/Shavano

Speaker 2 of 5
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Novel Regulators of Toll-like Receptor Signaling

Monday, February 25 | 8:00AM - 11:45AM
TLR Signaling: Role of Adapters
Room: Red Cloud/Shavano

Speaker 3 of 5
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Negative Regulation of Innate Immunity

Monday, February 25 | 8:00AM - 11:45AM
TLR Signaling: Role of Adapters
Room: Red Cloud/Shavano

Speaker 4 of 5
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Monday, February 25 | 8:00AM - 11:45AM
TLR Signaling: Role of Adapters
Room: Red Cloud/Shavano

Speaker 5 of 5
Abigail M. Spear, Defence Science and Technology Laboratory, UK
Short Talk: Identification and Characterization of Toll/Interleukin-1 Receptor Family Proteins in a Range of Pathogenic Bacteria

Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 7
Lewis L. Lanier, University of California, San Francisco, USA
Introduction & Welcome


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 7
Michael B. Brenner, Harvard Medical School, USA
and


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 7
Peter D. Sun, NIAID, National Institutes of Health, USA
Ligand Recognition by NK Receptors


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Structural Analysis of Potent NKT Cell Agonists


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 7
* Yvonne Yvonne Jones, University of Oxford, UK
Structure of CD1 Molecules and the TCRs that Recognize them


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 7
Roland Strong, Fred Hutchinson Cancer Research Center, USA
The NKG2A/CD94/HLA-E Complex


Monday, February 25 | 8:00AM - 11:00AM
Structure of NK and NKT Cell Recognition Molecules
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 7 of 7
Natalie A. Borg, Monash University, Australia
Short Talk: Glycolipid Recognition by an NKT Cell


Monday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Grays 1/Torreys


Monday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays 1/Torreys


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 10
* Moriya Tsuji, Aaron Diamond AIDS Research Center, Rockefeller University, USA


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 10
* Marcus Altfeld, Heinrich-Pette-Institute, Germany


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 10
Laurent Brossay, Brown University, USA
Valpha14i NK T Cells Participate to the Early Response to MCMV Infection


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 10
* Eric Vivier, Aix Marseille University, France
Natural Killer Cell Trafficking and Function


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 10
Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
iNK T Cells Provide Cognate Help for Lipid Antigen Specific B Cells


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 10
Vasileios Bekiaris, USA
Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection: Cues for Reciprocal NK-Stroma interactions


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 7 of 10
Galit Alter, MIT and Harvard University, USA
Ligand Dependent Expansion of Clonal NK Cell Populations in Acute HIV-1 Infection


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 8 of 10
Agnès C. Lehuen, Institut Cochin, France
iNKT Cells Prevent Virus-Induced Diabetes by Promoting Plasmacytoid Dendritic Cell Function in the Pancreas


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 9 of 10
Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Tolerance of NK Cells Encountering their Viral Ligand during Development


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1 : Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 10 of 10
Sandeep K. Tripathy, Washington University School of Medicine, USA
Self-MHC-Specific Inhibitory Receptor effects on Natural Killer Cell Tolerance Induced by Self-Specific Activation Receptor Engagement


Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, February 25 | 5:00PM - 7:15PM
TLR Signaling: Role of Protein Kinases
Room: Red Cloud/Shavano

Speaker 1 of 4
Alexander Tarakhovsky, Rockefeller University, USA
Essential Role of Histone Lysine Methyltransferase G9a in Innate Antiviral Response

Monday, February 25 | 5:00PM - 7:15PM
TLR Signaling: Role of Protein Kinases
Room: Red Cloud/Shavano

Speaker 2 of 4
* Sankar Ghosh, Columbia University, USA
TLR-Mediated Signaling to NF-kappaB

Monday, February 25 | 5:00PM - 7:15PM
TLR Signaling: Role of Protein Kinases
Room: Red Cloud/Shavano

Speaker 3 of 4
Carla V. Rothlin, Yale University, USA
Short Talk: TAM Receptors are Pleiotropic Inhibitors of the Innate Immune Response

Monday, February 25 | 5:00PM - 7:15PM
TLR Signaling: Role of Protein Kinases
Room: Red Cloud/Shavano

Speaker 4 of 4
Sinead Keating, Trinity College Dublin, Ireland
Short Talk: IRAK-2 Participates in Multiple Toll-Like Receptor Signalling Pathways to NF-kappaB via Activation of TRAF6 Ubiquitination

Monday, February 25 | 5:00PM - 7:00PM
Pathways of Ligand Presentation and Immune Evasion
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 4
* Michael B. Brenner, Harvard Medical School, USA
Antigen Presentation by CD1 Results in both Innate and Adaptive Immunity


Monday, February 25 | 5:00PM - 7:00PM
Pathways of Ligand Presentation and Immune Evasion
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 4
Randy R. Brutkiewicz, Indiana University School of Medicine, USA
Viral Immune Evasion of NKT Cells


Monday, February 25 | 5:00PM - 7:00PM
Pathways of Ligand Presentation and Immune Evasion
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 4
Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia
NK Cell Immune Evasion by Murine Cytomegalovirus


Monday, February 25 | 5:00PM - 7:00PM
Pathways of Ligand Presentation and Immune Evasion
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 4
Seung-Hwan Lee, University of Ottawa, Canada
Short Talk: A Role for Ly49H Receptor in Controlling NK Cell Proliferation during MCMV Infection


Monday, February 25 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Grays 1/Torreys


Monday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays 1/Torreys


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Grays 1/Torreys


Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 1 of 6
* Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasomes

Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 2 of 6
Gabriel Nuñez, University of Michigan, USA
Role of NLRs in Innate Immunity and Disease

Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 3 of 6
Dana Philpott, University of Toronto, Canada
Title to be Determined

Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 4 of 6
Mihai G. Netea, Radboud University, Netherlands
Short Talk: Monocytes are not Macrophages: One-Hit Versus Two-Hit Stimulation for LPS-Driven Activation of the Human Inflammasome for IL-1beta

Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 5 of 6
Marie-Cécile Michallet, INSERM, France
Short Talk: Tradd is an Essential Component of the RIG-like Helicases (RLH) Antiviral Pathway

Tuesday, February 26 | 8:00AM - 11:15AM
NLR Signaling
Room: Red Cloud/Shavano

Speaker 6 of 6
Chris B. Moore, Arbutus Biopharma, USA
Short Talk: NLRX1: a Novel Member of the NLR Family which Regulates RLH-Mediated Mitochondrial Antiviral Signaling

Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 6
* James P. Di Santo, Institut Pasteur, France
NK Cell Developmental Pathways


Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 6
Markus Boos, University of Chicago, USA
Short Talk: Differential Requirements for Id2 in Natural Killer Cell Development in Distinct Microenvironments


Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 6
Michael Caligiuri, Ohio State University, USA
Development of NK Cells in Humans


Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 6
Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA
Analysis of the Development and Activation of CD1d-restricted NKT Cells


Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 6
Albert S. Bendelac, University of Chicago, USA
NKT Cell Self-Antigens and Thymic Selection


Tuesday, February 26 | 8:00AM - 11:15AM
NKT/NK Cell Development
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 6
Victoria J. Lawson, Institute of Cancer Research, UK
Short Talk: The AP-1 Transcription Factor Fra-2 is Required for Normal NKT Cell Ontogeny and Function


Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Grays 1/Torreys


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays 1/Torreys


Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 1 of 10
* Alan Sher, NIAID, National Institutes of Health, USA

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 2 of 10
Anna-Marie Fairhurst, Singapore Immunology Network, Singapore
Yaa-Autoimmune Phenotypes are Conferred by an Overexpression of TLR7

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 3 of 10
Hsin-Jung Joyce Wu, University of Arizona, USA
Inflammatory Arthritis can be Reined in by CpG-Induced DC-NK Cell Cross Talk

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 4 of 10
Sandra M. Sacre, University of Sussex, UK
Toll-Like Receptor 8 is a Novel Therapeutic Target for Rheumatoid Arthritis

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 5 of 10
Liliana Schaefer, Goethe University, Germany
The Matrix Component Biglycan as an Endogenous Ligand to Toll-like Receptor-4 and -2 Aggravates Inflammation and Sepsis

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 6 of 10
R. William DePaolo, University of Washington, USA
Infectious Tolerance Induced by Yersinia Involves JNK2-Dependent IL-10 Production

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 7 of 10
Monica Andrea Delgado Vargas, Lovelace Respiratory Research Institute, USA
Toll Like Receptors Control Autophagy

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 8 of 10
Rowan Higgs, Royal College of Surgeons in Ireland, Ireland
The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-beta Gene Transcription by Initiating Proteasomal Degradation of IRF3

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 9 of 10
Ashish Banerjee, Monash University, Australia
Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival

Tuesday, February 26 | 2:00PM - 4:30PM
Workshop: At the Interface between Innate Immunity and Infla
mmation
Room: Red Cloud/Shavano

Speaker 10 of 10
Neal Silverman, University of Massachusetts Medical School, USA
Recognition and Signaling in the Drosophila IMD Pathway

Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 10
* Sebastian Joyce, Vanderbilt University School of Medicine, USA


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 10
* Marco Colonna, Washington University School of Medicine, USA


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 10
Joanna Brzostek, Imperial College London, UK
The Role of Ligand Dimensions in NK Cell Triggering


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 10
Pooja Arora, Albert Einstein College of Medicine, USA
Selective Trafficking of CD1d-Glycolipid Complexes Formed with N-acyl Variants of alpha-Galactosylceramide Ligands


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 10
Deborah L. Hodge, Center for Scientific Review, NIH, USA
Phenotypic Changes in IFN-gamma 3’UTR ARE Knock out Mice


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 10
Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA
An Avidity Model to Explain the Vbeta use by Natural Killer TCRs


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 7 of 10
Kimberly L. Jordan, Purdue University, USA
Differing Roles of AP-1 Inhibitors in the Development of NK and NKT Cells in vivo


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 8 of 10
Susanna Cardell, Göteborg University, Sweden
Dependence of the Fatty Acid Chain of Sulfatide for Activation of CD1d-Restricted NK T Cells


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 9 of 10
Shouxiong Huang, University of Cincinnati, USA
MR1 uses an Endocytic Pathway to Activate Mucosal-Associated Invariant T Cells


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop 2 : NKT/NK Recognition of Ligands and Antigens
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 10 of 10
* Jenny E. Gumperz, University of Wisconsin-Madison School of Medicine and Public Health, USA
Distinct Processes of Autoreactive and Foreign Antigenic Activation of NKT Cells


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, February 26 | 5:00PM - 7:15PM
RIG-I-Like Receptors and Viral Sensing
Room: Red Cloud/Shavano

Speaker 1 of 5
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Non-Self RNA Sensing Mechanism of RIG-I-Like Helicases and Activation of Antiviral Immune Responses

Tuesday, February 26 | 5:00PM - 7:15PM
RIG-I-Like Receptors and Viral Sensing
Room: Red Cloud/Shavano

Speaker 2 of 5
Paula M. Pitha-Rowe, Johns Hopkins University, USA
The Role of IRF-5 in the Innate Antiviral and Inflammatory Response

Tuesday, February 26 | 5:00PM - 7:15PM
RIG-I-Like Receptors and Viral Sensing
Room: Red Cloud/Shavano

Speaker 3 of 5
* Akira Shizuo, Osaka University, Japan
TLR- and RLR-Dependent Anti-Viral Responses

Tuesday, February 26 | 5:00PM - 7:15PM
RIG-I-Like Receptors and Viral Sensing
Room: Red Cloud/Shavano

Speaker 4 of 5
Hiroyuki Oshiumi, Hokkaido University, Japan
Short Talk: Riplet: A Novel RING Finger Protein that Activates RIG-I

Tuesday, February 26 | 5:00PM - 7:15PM
RIG-I-Like Receptors and Viral Sensing
Room: Red Cloud/Shavano

Speaker 5 of 5
Shohei Koyama, Research Institute for Microbial Diseases, Japan
Short Talk: Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Tuesday, February 26 | 5:00PM - 7:00PM
Activation, Inactivation and Homeostasis of NK/NKT Cells
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 4
* Dale I. Godfrey, University of Melbourne, Australia
Identification of a Novel, Developmentally Distinct, IL-17-Producing CD4-NK1.1- NKT Cell Subpopulation.


Tuesday, February 26 | 5:00PM - 7:00PM
Activation, Inactivation and Homeostasis of NK/NKT Cells
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 4
Wayne M. Yokoyama, Washington University School of Medicine, USA
Regulation of NK Cell Responses


Tuesday, February 26 | 5:00PM - 7:00PM
Activation, Inactivation and Homeostasis of NK/NKT Cells
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 4
Werner Held, Ludwig Institute, Switzerland
Short Talk: Functional Adaptation of NK Cells to Self-MHC Class I


Tuesday, February 26 | 5:00PM - 7:00PM
Activation, Inactivation and Homeostasis of NK/NKT Cells
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 4
Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
NKT Cells Sense Bacterial Infection and Recognize Bacterial Glycolipids


Tuesday, February 26 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Grays 1/Torreys


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays 1/Torreys


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Grays 1/Torreys


Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 1 of 6
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs at the Intersection of Death and Immunity

Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 2 of 6
Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Immunity to Infection in natura

Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 3 of 6
Warren Strober, National Institutes of Health, USA
The Molecular Basis of NOD2 Susceptibility Mutations in Crohn’s Disease

Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 4 of 6
Jennifer Greene, Case Western Reserve University, USA
Short Talk: A 22bp Deletion Polymorphism in the 5’ Untranslated Region of the TLR2 Gene is Associated with Protection from Cerebral Malaria

Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 5 of 6
Richard I. Tapping, University of Illinois, USA
Short Talk: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects Against Leprosy

Wednesday, February 27 | 8:00AM - 11:00AM
Genetic Variation in Signaling Molecules in Innate Immunity
Room: Red Cloud/Shavano

Speaker 6 of 6
Gordon D. Brown, University of Aberdeen, UK

Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 6
D. Branch Moody, Brigham and Women's Hospital, USA
Pathogens Provide Lipid Ligands for CD1 and Regulate CD1 Gene expression


Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 6
Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short Talk: Activation of Liver-Resident Invariant NKT Cells Improves Outcome from Influenza Virus Infection


Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 6
Luis J. Sigal, Fox Chase Cancer Center, USA
Short Talk: Mechanisms of NK Cell-Mediated Resistance to Mousepox


Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 6
Silvia Vidal, McGill University, Canada
NK Cell Recognition of Cytomegalovirus


Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 6
Eleanor M. Riley, Roslin Institute, UK
NK Cell Responses to Infection: Roles of Accessory Cells and MHC Receptors


Wednesday, February 27 | 8:00AM - 11:15AM
Role of NK/NKT Cells in Infection
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 6
* Jody L. Baron, University of California, San Francisco, USA
Blockade of NKG2D on NKT Cells Prevents the Acute Immune Response to Hepatitis B Virus


Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Grays 1/Torreys


Wednesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays 1/Torreys


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 9
* Luc Van Kaer, Vanderbilt University School of Medicine, USA


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 9
* Franck Housseau, Johns Hopkins School of Medicine, USA
IKDCs: the other NK cells


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 9
Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA
The Role of NKT Cells in Liver Disease


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 9
Kori Wallace, University of Virginia, USA
The Role of NK and NK-T Cells in Pulmonary Dysfunction in a Transgenic Model of Sickle Cell Disease


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 5 of 9
Toshinori Nakayama, Chiba University, Japan
Combination Therapy of In vitro Expanded Natural Killer T Cells and alpha-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 6 of 9
* Laurence Zitvogel, Institut Gustave Roussy, France
Do Regulatory NK Cells Exist?


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 7 of 9
Jin Seon S. Im, MD Anderson Cancer Center, USA
Mechanisms of Modulation of CD1d-Restricted NKT Cell Functions by Th2-Biasing á-Galactosylceramide Analogues


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 8 of 9
Joshua Beilke, Celgene, USA
Differing NK Cell Phenotypes in Diabetic Mice


Wednesday, February 27 | 2:30PM - 4:30PM
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregu
lation
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 9 of 9
Peggy Jacques, University Ghent, Belgium
iNKT Cells: Regulators of TNFá Driven Murine Spondyloarthropathy


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, February 27 | 5:00PM - 7:15PM
Signaling: Biophysical and Structural Aspects
Room: Red Cloud/Shavano

Speaker 1 of 5
* Nick Gay, University of Cambridge, UK
Molecular Mechanism of Signal Transduction by the Toll and Toll-Like Receptors

Wednesday, February 27 | 5:00PM - 7:15PM
Signaling: Biophysical and Structural Aspects
Room: Red Cloud/Shavano

Speaker 2 of 5
Douglas Golenbock, University of Massachusetts Medical School, USA
How TLRs Achieve an Active State: Implications for Disease

Wednesday, February 27 | 5:00PM - 7:15PM
Signaling: Biophysical and Structural Aspects
Room: Red Cloud/Shavano

Speaker 3 of 5
Joshua N. Leonard, National Institutes of Health, National Cancer Institute, USA
The Signaling Complex of TLR3

Wednesday, February 27 | 5:00PM - 7:15PM
Signaling: Biophysical and Structural Aspects
Room: Red Cloud/Shavano

Speaker 4 of 5
James Michael Elliott, Genentech, USA
Short Talk: Crystal Structure of Procaspase-1 and its Implications for Activation

Wednesday, February 27 | 5:00PM - 7:15PM
Signaling: Biophysical and Structural Aspects
Room: Red Cloud/Shavano

Speaker 5 of 5
Clare E. Bryant, University of Cambridge, UK
Short Talk: Elucidation of the MD-2/TLR4 Interface Required for Signalling by Lipid IVa

Wednesday, February 27 | 5:00PM - 7:00PM
Role of NK/NKT Cells in Tumor Immunity
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 4
David H. Raulet, University of California, Berkeley, USA
Natural Killer Cell Receptors and Tumor Immunity


Wednesday, February 27 | 5:00PM - 7:00PM
Role of NK/NKT Cells in Tumor Immunity
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 4
Adelheid Cerwenka, University of Heidelberg, Germany
Short Talk: Myeloid Derived “Suppressor” Cells Mediate NK Cell Activation


Wednesday, February 27 | 5:00PM - 7:00PM
Role of NK/NKT Cells in Tumor Immunity
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 4
* Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Role of NK and NKT Cells in Tumor Immune Surveillance and Immunotherapy


Wednesday, February 27 | 5:00PM - 7:00PM
Role of NK/NKT Cells in Tumor Immunity
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 4
Andrea Velardi, University of Perugia, Italy
Impact of NK Cell Alloreactivity on Human Hematopoietic Stem Cell Transplantation


Wednesday, February 27 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Grays 1/Torreys


Wednesday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays 1/Torreys


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Grays 1/Torreys


Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 1 of 6
* Anthony J. Coyle, Pfizer, USA
Danger Signals and Interferons in Autoimmune Disease

Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 2 of 6
Mary Collins, Wyeth Research, USA
IL-22: A Th17 cytokine contributes to chronic inflammation

Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 3 of 6
Anthony M. Manning, Momenta Pharmaceuticals, USA
Drug Discovery Targeting MAP Kinases: From Innate Immunity to Clinical Benefit

Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 4 of 6
Jie-Oh Lee, Korea Advanced Institute of Science and Technology, South Korea
Ligand Recognition by the TLR Complexes

Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 5 of 6
Lani R. San Mateo, Janssen R&D, USA
Short Talk: Down Modulation of Human TLR3 Function by a Monoclonal Antibody

Thursday, February 28 | 8:00AM - 11:15AM
Drug Targets in Innate Signaling
Room: Red Cloud/Shavano

Speaker 6 of 6
Karen Colbjørn Larsen, University of Oxford, UK
Short Talk: Combining TLR Signaling Molecules as Vaccine Adjuvants

Thursday, February 28 | 8:00AM - 11:00AM
Role of NK/NKT Cells in Autoimmunity and Immunopathology
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 1 of 4
* Lewis L. Lanier, University of California, San Francisco, USA
NK Cell Receptors in Immunity and Autoimmunity


Thursday, February 28 | 8:00AM - 11:00AM
Role of NK/NKT Cells in Autoimmunity and Immunopathology
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 2 of 4
Gennaro De Libero, University Hospital Basel, Switzerland
CD1 Restricted Self-Reactive T Cells




Thursday, February 28 | 8:00AM - 11:00AM
Role of NK/NKT Cells in Autoimmunity and Immunopathology
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 3 of 4
Rene de Waal Malefyt, Merck Research Labs, USA
Short Talk: IL-25 is a Growth and Activation Factor for NKT Cells


Thursday, February 28 | 8:00AM - 11:00AM
Role of NK/NKT Cells in Autoimmunity and Immunopathology
This session is from NK and NKT Cell Biology
Room: Grays 2-3

Speaker 4 of 4
Philip W. Askenase, Yale University School of Medicine, USA
Role of NK and NKT Cells in Immunopathology


Thursday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Thursday, February 28 | 5:00PM - 7:15PM
Pathogen Manipulation of Signaling and Immunomodulation
Room: Red Cloud/Shavano

Speaker 1 of 5
* Andrew G. Bowie, Trinity College Dublin, Ireland
Insights into Innate Immune Signaling Afforded by Viral Evasion and Subversion

Thursday, February 28 | 5:00PM - 7:15PM
Pathogen Manipulation of Signaling and Immunomodulation
Room: Red Cloud/Shavano

Speaker 2 of 5
Anne O'Garra, Francis Crick Institute, UK
Regulation of IL-10 Expression in Dendritic Cells and Macrophages and Implications for Regulation of the Immune Response to Pathogens

Thursday, February 28 | 5:00PM - 7:15PM
Pathogen Manipulation of Signaling and Immunomodulation
Room: Red Cloud/Shavano

Speaker 3 of 5
David E. Levy, New York University School of Medicine, USA
Transcriptional and Post-Transcriptional Regulation of Gene Expression in the IFN Innate Immune Response

Thursday, February 28 | 5:00PM - 7:15PM
Pathogen Manipulation of Signaling and Immunomodulation
Room: Red Cloud/Shavano

Speaker 4 of 5
Tsukasa Seya, Graduate School of Medicine, Hokkaido University, Japan
Functional Evolution of the TRIF/TLCAM-1 Pathway

Thursday, February 28 | 5:00PM - 7:15PM
Pathogen Manipulation of Signaling and Immunomodulation
Room: Red Cloud/Shavano

Speaker 5 of 5
Amanda Mercedes Jamieson, Max F. Perutz Laboratories, University of Vienna, Austria
Short Talk: Modulation of the Innate Immune Response to Bacteria by Viral Infection

Thursday, February 28 | 5:00PM - 7:00PM
Interaction of NKT and NK Cells with APC and Modulation of A
daptive Immunity
This session is from NK and NKT Cell Biology

Room: Grays 2-3

Speaker 1 of 4
Vincenzo Cerundolo, University of Oxford, UK
Role of NKT Cells in Modulation of Adaptive Immunity


Thursday, February 28 | 5:00PM - 7:00PM
Interaction of NKT and NK Cells with APC and Modulation of A
daptive Immunity
This session is from NK and NKT Cell Biology

Room: Grays 2-3

Speaker 2 of 4
Steven A. Porcelli, Albert Einstein College of Medicine, USA
Modulation of Immunoregulatory Activities of CD1d-Restricted NKT Cells by Modified Glycosylceramide Analogues


Thursday, February 28 | 5:00PM - 7:00PM
Interaction of NKT and NK Cells with APC and Modulation of A
daptive Immunity
This session is from NK and NKT Cell Biology

Room: Grays 2-3

Speaker 3 of 4
Silke Paust, Baylor College of Medicine, USA
Short Talk: T and B cell Independent Adaptive Immune Responses Mediated by Natural Killer Cells


Thursday, February 28 | 5:00PM - 7:00PM
Interaction of NKT and NK Cells with APC and Modulation of A
daptive Immunity
This session is from NK and NKT Cell Biology

Room: Grays 2-3

Speaker 4 of 4
* Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia
Interplay between Mouse NK Cells and Dendritic Cells


Thursday, February 28 | 7:15PM - 7:15PM
Concluding Remarks

Speaker 1 of 1
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Thursday, February 28 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Grays 1/Torreys


Thursday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Grays 1/Torreys


Thursday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Grays 1/Torreys


Friday, February 29 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.