Web Desc
HIV Vaccines: Progress and Prospects
joint with HIV Pathogenesis
Organizer(s): Dan H. Barouch, John R. Mascola and M. Juliana McElrath
Date: March 27 - April 01, 2008
Location: Fairmont Banff Springs, Banff, AB, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation; Sponsored by Wyeth Vaccines Research
Summary of Meeting:
The development of a safe and effective HIV-1 vaccine remains one of the highest research priorities. Several vaccine candidates are currently being evaluated in large-scale clinical trials, but numerous challenges remain. Immunogens that elicit broadly reactive neutralizing antibodies remain elusive. Vaccine vectors that induce cellular immune responses will likely require considerable improvement. Immune correlates of protection are not clearly defined, and the challenges of extensive worldwide viral sequence diversity remain. In this Keystone Symposia meeting, leading experts in the field will discuss recent advances in novel vaccine approaches, humoral and cellular immunity, immune correlates of protection, and early and late phase clinical trials. Vaccine-elicited immunity, translational vaccine development, and the Global HIV/AIDS Vaccine Enterprise will be highlighted.
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates Foundation
GenVec, Inc.
Intercell AGInternational AIDS Vaccine Initiative (IAVI)Merck Research LaboratoriesOffice of AIDS Research, NIHWyeth Vaccines Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

Roche Molecular Systems
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5R13AI068371-03
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 27 | 3:00PM - 7:30PM
Registration
Room: Van Horne Ballroom Foyer


Thursday, March 27 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Ballroom Foyer


Thursday, March 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Steven Wolinsky, Northwestern University, USA

Thursday, March 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom AB

Speaker 2 of 4
Henry A. Erlich, Roche Molecular Systems, USA
HLA Allelic and Haplotypic Diversity and Host Immunity


Thursday, March 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom AB

Speaker 3 of 4
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA

Thursday, March 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom AB

Speaker 4 of 4
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
HIV Vaccines: The Way Forward

Friday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 1 of 6
* Steven Wolinsky, Northwestern University, USA

Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 2 of 6
Ashley T. Haase, University of Minnesota, USA
Sexual Mucosal Transmission

Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 3 of 6
Daniel C. Douek, NIAID, National Institutes of Health, USA
Immune Events in the HIV-Infected Gut

Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 4 of 6
Thomas J. Hope, Northwestern University, USA
Analysis of the Early Interactions of HIV with Human Cervical Explants and the Rhesus Macaque Female Genital Tract: The First 4 Hours of Virus Exposure

Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 5 of 6
James Arthos, NIAID, National Institutes of Health, USA
Short Talk: HIV-1 Envelope Binds to and Signals through alpha4beta7 Integrin, the Gut Mucosal Homing Receptor for Peripheral T Cells

Friday, March 28 | 8:00AM - 11:00AM
Biology of Transmission (Joint)
Room: Van Horne Ballroom AB

Speaker 6 of 6
Frank Wegmann, Janssen, Netherlands
Short Talk: Combining HIV Antigens and Polyanionic Microbicides to Induce High Levels of Mucosal Env-Specific Antibodies

Friday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Friday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Friday, March 28 | 12:00PM - 1:30PM
Hands-on Computer Session on Los Alamos Sequence Database
This session is from HIV Pathogenesis
Room: Beatty/Coleman
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 1 of 2
Thomas K. Leitner, Los Alamos National Laboratory, USA


Friday, March 28 | 12:00PM - 1:30PM
Hands-on Computer Session on Los Alamos Sequence Database
This session is from HIV Pathogenesis
Room: Beatty/Coleman
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 2 of 2
Bette Tina Marie Korber, Los Alamos National Laboratory, USA


Friday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 1 of 9
* Rama Rao Amara, Emory University, USA

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 2 of 9
* Robert A. Seder, NIAID, National Institutes of Health, USA

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 3 of 9
Tomas Hanke, University of Oxford, UK
Development of a Universal T Cell Vaccine

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 4 of 9
Antu K. Dey, International AIDS Vaccine Initiative, USA
N-Terminal Substitutions in HIV-1 gp41 Reduce the Expression of non-Trimeric Envelope Glycoproteins on the Virus

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 5 of 9
Gerald Kimani Chege, South African Medical Research Council, South Africa
A Pantothenate Auxotrophic Strain of BCG Expressing HIV-1 Gag Induces Cellular Responses in Baboons, which are Efficiently Boosted by HIV-1 Pr55gag VLPs

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 6 of 9
Mario Roederer, NIAID, National Institutes of Health, USA
Fine Aerosol Adenovirus Vaccination against SIV and Tuberculosis in Rhesus Macaque

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 7 of 9
David B. Weiner, Wistar Institute, USA
Induction of Potent T Cell Immunity in Macaques by EP DNA + Molecular Adjuvants, Comparison of -Specific Responses Induced by Co-Vaccination of SIV DNA + Plasmid IL-12, IL-15 or RANTES in Rhesus Macaques

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 8 of 9
† Sean X. Du, Maxygen, USA
Directed Molecular Evolution Created Genetic and Antigenic Diversity and Improved Overall Immunogenicity of HIV-1 gp120 Immunogen

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1 : Novel Vaccines and Adjuvants
Room: Van Horne Ballroom C

Speaker 9 of 9
Mattias Forsell, Umeå University, Sweden
Elicitation of Co-Receptor Site Directed Antibodies against HIV-1 is caused by Primary Receptor Binding to the Viral Envelope Glycoproteins

Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 8
* Cristian Apetrei, University of Pittsburgh, USA
Experimentally-Induced Immune Activation in Natural Hosts of SIVs Results in Significant Increases in Viral Replication


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 8
* Genoveffa Franchini, NCI, National Institutes of Health, USA
Preferential Loss of Th17 T Cells at Mucosal Sites and Immune Activation Predicts AIDS Progression


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 8
Mirko Paiardini, Emory University, YNPRC, USA
Th17 Cells in the Gut of Naturally SIV-Infected Sooty Mangabeys


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 8
Satya Dandekar, University of California, Davis, USA
Early Onset of Enteropathic Changes in SIV Infection Lead to Impaired IL-17 Orchestrated Gut Mucosal Immune Response Against Salmonella and cause its Systemic Dissemination from the Gut


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 8
Joern E. Schmitz, Beth Israel Deaconess Medical Center, USA
Adaptive Immune Responses Appear to Contribute Little to Viral Containment of SIVagm infection in African Green Monkeys


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 6 of 8
Thaidra A. Gaufin, Tulane National Primate Research Center, USA
Humoral Immune Responses have Little Impact on Controlling Viremia during SIVagm Infection of African Green Monkeys (AGMs)


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 7 of 8
Andre Durudas, Seattle Biomedical Research Institute, USA
Tissue Specific Inflammatory Responses are Associated with Disease Outcome Following Oral SIV Transmission


Friday, March 28 | 2:30PM - 4:30PM
Workshop 1: Pathogenic and Non-Pathogenic Pathways
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 8 of 8
S. Rochelle Mikkelsen, North Carolina State University, USA
Transient Depletion of CD4+CD25+ Regulatory T Cells in Cats Chronically Infected with Feline Immunodeficiency Virus Improves Anti-Viral and Novel Immune Responses


Friday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 1 of 7
* Peggy Johnston, NIAID, National Institutes of Health, USA

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 2 of 7
Susan P. Buchbinder, San Francisco Department of Public Health, USA
Primary Efficacy Results from the STEP Study (Merck V520 Protocol 023/HVTN 502)—a Phase II Test-of-Concept Trial of the MRKAd5 HIV-1 gag/pol/nef Trivalent Vaccine

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 3 of 7
M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
T Lymphocyte Responses Elicited by Current Vaccines

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 4 of 7
Gary J. Nabel, Sanofi, USA
Criteria for Advancement of Novel Vaccine Candidates

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 5 of 7
William Snow, AIDS Vaccine Advocacy Coalition, USA
Short Talk: STEP-ing Forward: Community Perspectives on Communication and Decision-Making in the MRK-Ad5 Trials

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 6 of 7
Harriet L. Robinson, GeoVax Inc., USA
Short Talk: GeoVax Clade B DNA/MVA HIV/AIDS Vaccine is well Tolerated and Immunogenic when Administered to Healthy Seronegative Adults (HVTN 065 part A)

Friday, March 28 | 5:00PM - 7:30PM
Progress in Clinical Trials of HIV Vaccines
Room: Van Horne Ballroom C

Speaker 7 of 7
Laura Papagno, INSERM U543 Laboratoire d'Immunologie Cellulaire, France
Short Talk: Comprehensive Analysis of Virus-Specific CD8+ and CD4+ T Cells Provides Clues for the Failure of Therapeutic Immunization with ALVAC-HIV (vCP1452) Vaccine

Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 6
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA


Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 6
Sunil K. Ahuja, University of Texas Health Science Center, USA
Host Factors and Pathogenesis


Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 6
Mary Carrington, NCI, National Institutes of Health, USA
The Influence of HLA Class I and KIR on HIV-1 Disease


Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 6
Beatrice H. Hahn, University of Pennsylvania, USA
HIV-1 Transmission and Early Viral Evolution


Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 6
Christine M. Rousseau, University of Washington, USA
Short Talk: HLA-Driven Evolution of HIV-1 Subtype C: Immune Escape and Viral Fitness Costs


Friday, March 28 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 6 of 6
Athe M.N. Tsibris, Massachusetts General Hospital, USA
Short Talk: V3 Loop Sequence Dynamics in Subjects Failing CCR5 Antagonist Therapy


Friday, March 28 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Friday, March 28 | 7:30PM - 10:00PM
Poster Session 1
Room: New Brunswick, Alberta, Cascade


Saturday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Saturday, March 29 | 8:00AM - 11:00AM
Intracellular Events
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 5
* Robert W. Doms, University of Pennsylvania School of Medicine, USA
HIV Entry and its Inhibition


Saturday, March 29 | 8:00AM - 11:00AM
Intracellular Events
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 5
Katherine A. Jones, The Salk Institute, USA
Transcription Elongation by HIV-1 Tat Links to Histone Methylation


Saturday, March 29 | 8:00AM - 11:00AM
Intracellular Events
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 5
Frederic D. Bushman, University of Pennsylvania, USA
Retroviral DNA Integration: Mechanism and Consequences


Saturday, March 29 | 8:00AM - 11:00AM
Intracellular Events
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 5
Daria J. Hazuda, Merck Research Laboratories, USA
Inhibitors of HIV-1 Integrase: Lessons from the Analysis of Resistance Derived in vivo and in vitro


Saturday, March 29 | 8:00AM - 11:00AM
Intracellular Events
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 5
Eiji Morita, Hirosaki University, Japan
Short Talk: Identification of ESCRT-I Binding Factors Required for Efficient HIV-1 Release


Saturday, March 29 | 8:00AM - 8:20AM
Special Lecture
Room: Van Horne Ballroom C

Speaker 1 of 1
Alan Bernstein, Canadian Institute for Advanced Research, Canada
Special Lecture

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 1 of 6
* Nina D. Russell, Bill & Melinda Gates Foundation, USA

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 2 of 6
Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
Novel Poxvirus Vectors

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 3 of 6
Danilo R. Casimiro, Aeras, USA
What's Next After STEP? Implications on Vaccine Design

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 4 of 6
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Novel Adenovirus Vector-Based Vaccines for HIV-1

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 5 of 6
Stephen C. De Rosa, University of Washington, Fred Hutchinson Cancer Research Center, USA
Short Talk: Kinetics of T Cell Responses to Vaccination for HIV with Heterologous DNA Prime-rAd5 Boost Contrasted with Homologous rAd5 Prime-Boost

Saturday, March 29 | 8:00AM - 11:00AM
Optimization of Vectors and T Lymphocyte Responses
Room: Van Horne Ballroom C

Speaker 6 of 6
Rama Rao Amara, Emory University, USA
Short Talk: Preexisting Immunity to Vaccinia Reduces the Frequency of SIV-Specific CCR-5+ve but not CCR-7+ve CD4 T Cells Elicited by a DNA/MVA Vaccine and Enhances the Control of SIV251 Challenge

Saturday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Saturday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Saturday, March 29 | 12:00PM - 1:30PM
Hands-on Computer Session on Los Alamos Sequence/Immunology
Databases
This session is from HIV Pathogenesis
Room: Beatty/Coleman
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 1 of 2
Thomas K. Leitner, Los Alamos National Laboratory, USA


Saturday, March 29 | 12:00PM - 1:30PM
Hands-on Computer Session on Los Alamos Sequence/Immunology
Databases
This session is from HIV Pathogenesis
Room: Beatty/Coleman
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 2 of 2
Bette Tina Marie Korber, Los Alamos National Laboratory, USA


Saturday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 1 of 9
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 2 of 9
* Karin Loré, Karolinska Institutet, Sweden

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 3 of 9
Kimberly Ann Schoenly, University of Pennsylvania, USA
Systemic and Mucosal Immune Responses Elicited by Electroporation Delivered Mucosal Targeting Chemokine DNA Vaccines in Mice and Macaques

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 4 of 9
David R. Kaufman, Merck Research Laboratories, USA
Systemic Vaccination with Hetrologous Recombinant Adenovirus Prime-Boost Regimens Elicits Potent and Durable Mucosal Immunity

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 5 of 9
Cornelia Gujer, Karolinska Institutet, Sweden
Dendritic Cell Mediated Support of Human B Cell Responses Via Toll-Like Receptor Ligands

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 6 of 9
Kathlyn Santos, NIAID, National Institutes of Health, USA
Immunomodulation of Human Dendritic Cells by MVA and Ad5 Vaccine Vectors

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 7 of 9
Elizabeth Rhee, Beth Israel Deaconess Medical Center, USA
Rare Serotype Recombinant Adenovirus Vaccine Vectors Elicit Expression of Type I Interferon

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 8 of 9
Salix Boulet, Université de Montréal, Canada
Increased Expression of KIR3DL1 Subtypes and HLA-B57 in HIV Exposed Uninfected (EU) versus HIV Susceptible Individuals

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Mucosal/Innate Immunity
Room: Van Horne Ballroom C

Speaker 9 of 9
Patrice Debré, Hopital Pitie Salpetriere, France
A New Concept for HIV Vaccine Preventing CD4 T Cell Depletion

Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 1 of 7
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 2 of 7
Jason Ho, NIAID, National Institutes of Health, USA
HIV-Specific B Cells Are Enriched in a Dysfunctional Tissue-like Memory B-Cell Compartment in HIV-Infected Viremic Individuals


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 3 of 7
David M. Kuhrt, Maine Medical Center Research Institute, USA
Phenotypic Perturbation of the B Cell Compartment During Acute Simian Immunodeficiency Virus Infection


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 4 of 7
* Jason M. Brenchley, NIAID, National Institutes of Health, USA
Th17 Cells are Preferentially Depleted from GI Tract, but not BAL or Blood, of HIV-Infected Individuals


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 5 of 7
Pratip K. Chattopadhyay, National Institutes of Health, USA
Does T-Cell Function during Acute/Early HIV Predict Outcome?


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 6 of 7
Peter W. Hunt, University of California, San Francisco, USA
Inflammatory Consequences of Viral Control in HIV-infected Patients with Undetectable Plasma HIV RNA Levels in the Absence of Therapy


Saturday, March 29 | 2:30PM - 4:30PM
Workshop 2: Aspects of Progression
This session is from HIV Pathogenesis

Speaker 7 of 7
Paul de Bakker, Vertex Pharmaceuticals, USA
A Genome-Wide Association Study in HIV Elite Controllers to Identify Host Genetic Factors that Influence Viral Control in the Absence of Anti-Retroviral Therapy


Saturday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 1 of 6
* John R. Mascola, NIAID, National Institutes of Health, USA

Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
CD4-Binding-Site Antibodies: Prospects, Complications and Crystallographic Analyses

Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 3 of 6
Munir Alam, Duke Human Vaccine Institute, USA
The Role of Hydrophobic CDRH3 Loops of the Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 in Binding gp41, Lipids and in HIV-1 Neutralization

Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 4 of 6
Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Novel Formulation, Adjuvantation and Delivery Strategies for Inducing Env-Specific Antibodies

Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 5 of 6
James E. Robinson, Tulane University Health Sciences Center, USA
Short Talk: SHIV-Infected Rhesus Macaques Develop Antibodies Recognizing Quaternary Epitope(s) Exposed on Autologous Virus Particles

Saturday, March 29 | 5:00PM - 7:15PM
Prospects for Generating Broad Neutralizing Antibody Respons
es

Room: Van Horne Ballroom C

Speaker 6 of 6
Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA
Short Talk: Frequency and Phenotype of HIV gp120-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies

Saturday, March 29 | 5:00PM - 7:15PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 5
Felipe DiazGriffero, Einstein, USA
Blocking Early Events in HIV-1 Infection


Saturday, March 29 | 5:00PM - 7:15PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 5
Ruzena Stranska, University of Massachusetts Medical School, USA
Short Talk: Heterokaryon Analysis Suggests the Existence of a Dominant Restriction to SIV Infection in Macrophages


Saturday, March 29 | 5:00PM - 7:15PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 5
* Michael H. Malim, King's College London, UK
APOBEC Proteins and Intrinsic Resistance to HIV Infection


Saturday, March 29 | 5:00PM - 7:15PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 5
Stuart J. Neil, King's College London, UK
Short Talk: Tetherin, A Novel Antiviral Inhibitpr of Retrovirus Release that is Targeted by the HIV-1 VPU Protein


Saturday, March 29 | 5:00PM - 7:15PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 5
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Viral Restriction: Evolutionary Signatures of the Arms-Race between Host and Virus


Saturday, March 29 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Saturday, March 29 | 7:30PM - 10:00PM
Poster Session 2
Room: New Brunswick, Alberta, Cascade


Sunday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 1 of 6
* Mario Roederer, NIAID, National Institutes of Health, USA

Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 2 of 6
Janine T. Bryan, Merck, USA
HPV Vaccine

Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 3 of 6
Harry B. Greenberg, Stanford University, USA
Rotavirus Pathogenesis and Vaccination-The Second Time is a Charm

Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 4 of 6
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
The HSV-HIV Connection: What Similarities Exist for Vaccine Development

Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 5 of 6
Maria Grazia Pau, Johnson & Johnson Inc., USA
Flu, TB

Sunday, March 30 | 8:00AM - 11:00AM
Protection Against Transmission of Mucosal Viruses: What Can
Be Learned?

Room: Van Horne Ballroom C

Speaker 6 of 6
Meritxell Genescà, Health Sciences Research Institute Germans Trias i Pujol Foundation, Spain
Short Talk: SIV-specific CD8+ T Cells Mediated Protection from Uncontrolled Viral Replication after Vaginal Challenge in Live-Attenuated Immunized Rhesus Macaques

Sunday, March 30 | 8:00AM - 11:00AM
Structure
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 5
Ian A. Wilson, The Scripps Research Institute, USA
HIV Neutralizing Antibody Structures


Sunday, March 30 | 8:00AM - 11:00AM
Structure
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 5
Kenneth H. Roux, Florida State University, USA
HIV Envelope Glycoproteins


Sunday, March 30 | 8:00AM - 11:00AM
Structure
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 5
Sriram Subramaniam, University of British Columbia, Canada
Electron Tomography of HIV-1 and SIV: Spike Architecture and Entry Mechanisms


Sunday, March 30 | 8:00AM - 11:00AM
Structure
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 5
* Wesley I. Sundquist, University of Utah School of Medicine, USA
Retroviral Budding


Sunday, March 30 | 8:00AM - 11:00AM
Structure
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 5
Reuben S. Harris, University of Minnesota, USA
Short Talk: Structure of the DNA Deaminase Domain of the HIV-1 Restriction Factor APOBEC3G


Sunday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Sunday, March 30 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Sunday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 8
* Galit Alter, MIT and Harvard University, USA


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 8
* John P. Moore, Weill Medical College of Cornell University, USA
The Mannose Moieties of gp120 Glycans Suppress the Antibody Response to gp120 in Mice via an MCLR- and IL-10-Dependent Mechanism


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 8
Elias A. Said, Université de Montréal, Canada
PD-1 Expression in Monocytes: Up-Regulated during HIV Infection and Induces IL10 Production


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 8
Appakkudal Anand, Ohio State University Medical Center, USA
HIV-1 Macrophage-Tropic gp120-Induced Migration of Dendritic Cells is Regulated by the Tyrosine Kinase, Pyk2


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 5 of 8
Shahin Ranjbar, Immune Disease Institute, USA
HIV-1 Replication is Differentially Regulated by Different Clinical Strains of Mycobacterium Tuberculosis


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 6 of 8
Evan S. Jacobs, Blood Systems Research Institute, USA
PDC Interaction with HIV-Infected Cells Results in Fusion and Loss of Function Leading to the Potential Depletion of PDC in vivo


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 7 of 8
Angela Meier, Harvard Medical School, Massachusetts General Hospital, USA
Gender Differences in the Activation of pDCs in Response to HIV-1-Encoded TLR7/8 Ligands


Sunday, March 30 | 2:30PM - 4:30PM
Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 8 of 8
Joseph N. Brown, University of Florida, USA
HIV-1 Activates Macrophages Independent of Toll-like Receptors, a Potential Mechanism for Dysregulation of Innate Immunity


Sunday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Sunday, March 30 | 5:00PM - 7:00PM
Viral Control (Joint)
Room: Van Horne Ballroom

Speaker 1 of 5
* Dan H. Barouch, Beth Israel Deaconess Medical Center, USA

Sunday, March 30 | 5:00PM - 7:00PM
Viral Control (Joint)
Room: Van Horne Ballroom

Speaker 2 of 5
Andrew J. McMichael, Oxford University, UK
Cellular Immune Responses before and during Early HIV Infection

Sunday, March 30 | 5:00PM - 7:00PM
Viral Control (Joint)
Room: Van Horne Ballroom

Speaker 3 of 5
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Durable Control of HIV Replication

Sunday, March 30 | 5:00PM - 7:00PM
Viral Control (Joint)
Room: Van Horne Ballroom

Speaker 4 of 5
Douglas D. Richman, University of California, San Diego, USA
Neutralizing Antibody in the Control of HIV Infection

Sunday, March 30 | 5:00PM - 7:00PM
Viral Control (Joint)
Room: Van Horne Ballroom

Speaker 5 of 5
Galit Alter, MIT and Harvard University, USA
Short Talk: Specific Expansion of Highly Functional KIR+ NK Cells during Acute HIV-1 Infection

Sunday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Sunday, March 30 | 7:30PM - 10:00PM
Poster Session 3
Room: New Brunswick, Alberta, Cascade


Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 1 of 7
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 2 of 7
Rafi Ahmed, Emory University School of Medicine, USA
CD8 T Cell Memory

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 3 of 7
David I. Watkins, University of Miami, USA
The Thorny Issue of Heterologous Challenge

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 4 of 7
Bali Pulendran, Stanford University School of Medicine, USA
Modulating Vaccine Responses with Innate Immunity

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 5 of 7
Claire A. Chougnet, Cincinnati Children's Hospital Medical Center, USA
Interactions between Regulatory T Cells and HIV: A Complex Balancing Act

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 6 of 7
April L. Ferre, University of California, Davis, USA
Short Talk: Polyfunctional T-Cells in the Rectal Mucosa of HIV Controllers

Monday, March 31 | 8:00AM - 11:15AM
Interface Between Immunology and Vaccine Design (Joint)
Room: Van Horne Ballroom

Speaker 7 of 7
Natalie A. Hutnick, University of Pennsylvania, USA
Short Talk: T-Cell Responses in Healthy Adults to Replication Deficient AdHu5 Vector

Monday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Monday, March 31 | 5:00PM - 7:00PM
Correlates of Immune Protection
Room: Van Horne Ballroom C

Speaker 1 of 5
* John R. Mascola, NIAID, National Institutes of Health, USA

Monday, March 31 | 5:00PM - 7:00PM
Correlates of Immune Protection
Room: Van Horne Ballroom C

Speaker 2 of 5
Louis J. Picker, Oregon Health & Science University, USA
Live Attenuated Vaccines

Monday, March 31 | 5:00PM - 7:00PM
Correlates of Immune Protection
Room: Van Horne Ballroom C

Speaker 3 of 5
R. Paul Johnson, Harvard Medical School, USA
Protection Against Mucosal SIV Transmission

Monday, March 31 | 5:00PM - 7:00PM
Correlates of Immune Protection
Room: Van Horne Ballroom C

Speaker 4 of 5
Rafick Sekaly, Emory University, USA
Systems Biology Approaches to Understanding Memory T Cells Development and Defects

Monday, March 31 | 5:00PM - 7:00PM
Correlates of Immune Protection
Room: Van Horne Ballroom C

Speaker 5 of 5
Qingsheng Li, University of Nebraska Center for Virology, USA
Short Talk: Divergent Host Transcriptional Profiles in Lymphatic Tissues of Sooty Mangabeys and Rhesus Macaques Infected with Simian Immunodeficiency Viruses

Monday, March 31 | 5:00PM - 7:15PM
Drugs and Drug Resistance
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Lasting Beneficial Consequences of Pharmacological Alteration of Virus/Host Balance in Primary SIV Infection


Monday, March 31 | 5:00PM - 7:15PM
Drugs and Drug Resistance
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 2 of 4
Joseph K. Wong, University of California, San Francisco, USA
Drug Resistance


Monday, March 31 | 5:00PM - 7:15PM
Drugs and Drug Resistance
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 3 of 4
Robin Shattock, Imperial College London, UK
New Developments in Design of Effective Microbicides


Monday, March 31 | 5:00PM - 7:15PM
Drugs and Drug Resistance
This session is from HIV Pathogenesis
Room: Van Horne Ballroom AB

Speaker 4 of 4
Nicoli Nattrass, University of Cape Town, South Africa
The Economics of Drug Delivery


Monday, March 31 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Monday, March 31 | 8:00PM - 11:00PM
Entertainment
Room: New Brunswick, Alberta, Cascade


Monday, March 31 | 8:00PM - 11:00PM
Cash Bar
Room: New Brunswick, Alberta, Cascade


Tuesday, April 01 | 10:25AM - 10:25AM
Departure


*Session Chair.