Web Desc
Nuclear Receptors: Orphan Brothers
joint with Nuclear Receptors: Steroid Sisters
Organizer(s): Peter Tontonoz, Thomas Perlmann and Timothy M. Willson
Date: March 30 - April 04, 2008
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Director's Fund
Summary of Meeting:
The nuclear hormone receptors are a superfamily of transcription factors that play important roles in both physiology and disease. Orphan receptors are a subset of receptors that were cloned prior to the discovery of their endogenous ligands. The identification of ligands for orphan receptors and the elucidation of their biological functions have led to the discovery of new hormone signaling pathways that control growth, development, and cell and tissue homeostasis. Topics presented in this meeting will include structure function relationships, the role of orphan receptors in development and metabolism, genome-wide analysis of receptor function, coactivators and corepressors, and drug discovery. This meeting will also highlight the potential for orphan receptor signaling pathways to serve as therapeutic targets for human diseases.
Scholarship Deadline: December 3 2007
Discounted Abstract Deadline: December 3 2007
Abstract Deadline: January 2 2008
Discounted Registration Deadline: January 30 2008
We gratefully acknowledge additional support for this conference from:
Isis Pharmaceuticals, Inc.Merck & Co., Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

The Endocrine Society
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 30 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, March 30 | 6:30PM - 7:30PM
Refreshments
Room: Grand Foyer


Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 3
* Peter Tontonoz, University of California, Los Angeles, USA

Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 3
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 3
Eric N. Olson, University of Texas Southwestern Medical Center, USA
A MicroRNA Network that Governs Growth and Thyroid Hormone Responsiveness of the Heart

Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Lower Level


Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden

Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 2 of 6
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Regulation of Nutrient Metabolism by Lipid-Sensing Nuclear Receptors

Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany
Nuclear Receptor Regulation of microRNAs in the C. elegans Heterochronic Circuit

Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Metabolism by Drosophila Nuclear Receptors

Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
The Nuclear Receptors, PPARgamma, VDR and RAR Link Lipid Metabolism And Immune Function In Developing Human Dendritic Cells

Monday, March 31 | 8:00AM - 11:15AM
Differentiation and Development
Room: Sea to Sky Ballroom B

Speaker 6 of 6
Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA
HNF4 Gene Regulation and Physiology in C. elegans

Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Benita S. Katzenellenbogen, University of Illinois, USA


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 7
Donald P. McDonnell, Duke University School of Medicine, USA
Nuclear Receptor-Coactivator Interactions as Targets for New Drug Discovery


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Dean P. Edwards, Baylor College of Medicine, USA
The Role and Mechanisms of Progesterone Receptor Cross Talk with Signal Transduction Pathways


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 7
J. Wesley Pike, University of Wisconsin-Madison, USA
Regulation of Target Genes by The Vitamin D Receptor: Paradigms for Distal Enhancer Control


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Peter E. Wright, The Scripps Research Institute, USA
Role of Protein Folding in Coactivator Function


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Martin L. Privalsky, University of California, Davis, USA
Short Talk: Selective Impairment of Thyroid Hormone Receptor (TR)beta2 in Resistance to Thyroid Hormone Syndrome: Mutations Associated with Pituitary Resistance Disrupt Cooperative Contacts that Normally Enhance Coactivator Recruitment


Monday, March 31 | 8:00AM - 11:15AM
Steroid Receptor and Coregulator Structure and Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Sebastiaan H. Meijsing, Max Planck Institute for Molecular Genetics, Germany
Short Talk: The Binding Site Code: The effect of DNA Binding Site Sequence Variation on Transcriptional Regulation by the Glucocorticoid Receptor


Monday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 31 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 31 | 11:15AM - 11:15AM
On Own for Lunch


Monday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Wen Xie, University of Pittsburgh, USA

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 2 of 6
† Hong Soon Kang, NIEHS, National Institutes of Health, USA
Physiological Functions of Retinoid-Related Orphan Receptor alpha (RORalpha) in Adipose Tissue

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Pamela R. Moll, University of Toronto, Canada
Ligand Identification Using Live Zebrafish

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Juliette Rambaud, Institut de Recherches Cliniques de Montreal, Canada
TIF1beta is a Coactivator of NGFI-B (Nur77), Nurr1 and NOR1

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Chun-Li Zhang, University of Texas Southwestern Medical Center, USA
Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells and Animal Behavior

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 6 of 6
Michael L. Goodson, University of California, Davis, USA
Corepressor Isoform Diversity, Receptor Selectivity and Adipogenesis

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 6
* Donald P. McDonnell, Duke University School of Medicine, USA


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 6
Joyce Slingerland, UM Sylvester Comprehensive Cancer Center, USA
Src Promotes Estrogen Dependent ERa Proteolysis in Human Breast Cancer


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 6
Jerome C. Nwachukwu, New York University School of Medicine, USA
Roles of the Androgen Receptor Cofactor, ART-27 in Prostate Cancer


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 6
Sudipan Karmakar, Food & Drug Administration, USA
Depletion of SMRT Expression Inhibits the Proliferation of MCF-7 Breast Cancer Cell and Expression of Estrogen Receptor-alpha Target Genes


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 6
Jae-Kyung Myung, British Columbia Cancer Agency, Canada
Large Scale Analysis of the Phosphoproteome in Response to Rapid Signaling by Androgen


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1 - Hot Topics: Cancer/Signaling
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 6
Muriel Le Romancer, INSERM, France
Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 31 | 5:00PM - 7:00PM
Nuclear Receptor Structure/Function
Room: Sea to Sky Ballroom B

Speaker 1 of 4
* Fraydoon Rastinejad, University of Oxford, UK

Monday, March 31 | 5:00PM - 7:00PM
Nuclear Receptor Structure/Function
Room: Sea to Sky Ballroom B

Speaker 2 of 4
Eric A. Ortlund, Emory University, USA
Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

Monday, March 31 | 5:00PM - 7:00PM
Nuclear Receptor Structure/Function
Room: Sea to Sky Ballroom B

Speaker 3 of 4
H. Eric Xu, Van Andel Institute, USA
Structural Insights into Ligand-Dependent and -Independent Regulation of Nuclear Receptors

Monday, March 31 | 5:00PM - 7:00PM
Nuclear Receptor Structure/Function
Room: Sea to Sky Ballroom B

Speaker 4 of 4
John W. R. Schwabe, University of Leicester, UK
From Novel Paradigms for Regulation of PPARgamma ƒnto Structures of the SMRT Repression Complex

Monday, March 31 | 5:00PM - 7:00PM
Steroid Receptor Signaling and Dynamics
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 5
* Dean P. Edwards, Baylor College of Medicine, USA


Monday, March 31 | 5:00PM - 7:00PM
Steroid Receptor Signaling and Dynamics
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 5
Gordon L. Hager, NCI, National Institutes of Health, USA
Glucocorticoid Receptor Dynamics and Global Chromatin Structure


Monday, March 31 | 5:00PM - 7:00PM
Steroid Receptor Signaling and Dynamics
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 5
Boris J. Cheskis, Wyeth Research, USA
The Role of MNAR in Steroid Receptor Signaling


Monday, March 31 | 5:00PM - 7:00PM
Steroid Receptor Signaling and Dynamics
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 5
Stephen R. Hammes, University of Rochester Medical Center, USA
Extranuclear Steroid Signaling in the Ovary


Monday, March 31 | 5:00PM - 7:00PM
Steroid Receptor Signaling and Dynamics
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 5
Carol A. Lange, University of Minnesota, USA
Short Talk: Progesterone Receptor Rapid Signaling Mediates Ser345 Phosphorylation and Tethering to Sp1 Transcription Factors


Monday, March 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Lower Level


Tuesday, April 01 | 7:00AM - 8:00AM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Timothy M. Willson, GlaxoSmithKline, USA

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Dennis L. Sprecher, GlaxoSmithKline, USA
PPARdelta: The Human Experience

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Sunil Nagpal, Wyeth Research, USA

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Konstantin Petrukhin, Columbia University, USA
NR2E3 Activators for the Treatment of Ophthalmic Diseases

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy
Clinical Translation of FXR Agonists for the Treatment of Liver and Metabolic Disorders

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Henry M. Krause, University of Toronto, Canada
Structural Basis of Gas Regulation of REV-ERB Activity

Tuesday, April 01 | 8:00AM - 11:15AM
Drug Development
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Thomas P. Burris, Washington University School of Medicine, USA
Short Talk: Identification of Heme as the Ligand for the Orphan Nuclear Receptors REV-ERBalpha and REV-ERBbeta

Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Myles Brown, Dana-Farber Cancer Institute, USA


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 7
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Transcriptional Regulation by Estrogen Receptors in the Chromatin Environment of the Nucleus


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Trevor K. Archer, NIEHS, National Institutes of Health, USA
Regulating Nuclear Receptors with Chromatin


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Targeting SWI/SNF in Prostate Cancer: Implications for AR Signaling and Regulated Proliferation


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Robert G. Roeder, Rockefeller University, USA
Nuclear Receptors, Coactivators, and Chromatin


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: A GRIP1-Associated SET Domain Methyl Transferase in Glucocorticoid Receptor Target Gene Expression


Tuesday, April 01 | 8:00AM - 11:15AM
Steroid Receptors and Chromatin
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Didier Picard, University of Geneva, Switzerland
Short Talk: Mechanism of Activation of Unliganded ERalpha by cAMP and its Consequences for Target Gene Selection and Regulation


Tuesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, April 01 | 11:00AM - 12:00PM
Lunch
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 01 | 12:00PM - 2:30PM
Poster Session 2
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Carlie J. M. de Vries, University of Amsterdam, Netherlands

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 2 of 6
Eric Schoenmakers, University of Cambridge, UK
A Mutation in the Human PPARgamma Ligand Binding Domain in Severe Insulin Resistance

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Lillian J. Eichner, The Salk Institute, USA
miRNA Regulation of the ERR/PGC-1 Pathway

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Thijs Pols, University of Amsterdam, Netherlands
Nur77 Modulates Hepatic Lipid Metabolism through Suppression of SREBP1c Activity

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 5 of 6
David W. Granger, GlaxoSmithKline, UK
Characterisation of a Novel Nuclear Receptor-like Protein

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 6 of 6
J. H. M. Stroeve, TNO Quality of Life, Netherlands
The Intestinal FXR-Mediated Fgf-15 Pathway Contributes to the Control of Hepatic Bile Acid Synthesis and Bile Formation in Chow Fed Mice but its Contribution is Overruled during Bile Acid Feeding and Bile Acid Sequestration

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 6
* J. Wesley Pike, University of Wisconsin-Madison, USA


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 6
Ian M. Adcock, Imperial College London, UK
Glucocorticoid-Mediated Suppression of NF-kappaB-Stimulated TGFbeta1 Expression Requires the Methylase Suv39H1


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 6
Shilpa Chooniedass-Kothari, University of Manitoba, Canada
The Steroid Receptor RNA Activator Protein (SRAP) Acts as a Transcriptional Repressor


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 6
Peter J. Leedman, Western Australian Institute for Medical Research, Australia
PACT, TRBP, PKR and Dicer: Novel SRA-binding Coregulators that Modulate Nuclear Receptor Signaling


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 6
Deepa Chotai, Imperial College, UK
The Repression of Androgen Receptor Activity by Prohibitin


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re
ceptor Function
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 6
Beatrice D. Darimont, Merck Research Laboratories, USA
Recognition of the Glucocorticoid Receptor by Hsp90


Tuesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, April 01 | 5:00PM - 7:00PM
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 5
* W. Lee Kraus, University of Texas Southwestern Medical Center, USA

Tuesday, April 01 | 5:00PM - 7:00PM
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 5
Henk G. Stunnenberg, Radboud University, Netherlands
ChIP-seq Analyses of ER and GR Uncovers an Elaborate Ligand Dependent Interaction Network, the Interactome

Tuesday, April 01 | 5:00PM - 7:00PM
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 5
Myles Brown, Dana-Farber Cancer Institute, USA
Defining the Nuclear Receptor Cistrome

Tuesday, April 01 | 5:00PM - 7:00PM
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 5
Benita S. Katzenellenbogen, University of Illinois, USA
Integration of Nuclear and Extranuclear Signaling in Global Gene Regulation By Estrogen Receptors

Tuesday, April 01 | 5:00PM - 7:00PM
Analyses of Nuclear Receptor-Dependent Transcription (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 5
Edwin Cheung, University of Macau, Macau
Short Talk: Global Analysis of Estrogen Receptor-Mediated Chromatin Interactions

Tuesday, April 01 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Lower Level


Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Peter Tontonoz, University of California, Los Angeles, USA

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Fasting by the PPARalpha-FGF21 Pathway

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
LRH-1 Actions Along the Enterohepatic Axis

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Wen Xie, University of Pittsburgh, USA
PXR, CAR and LXR in Xeno- and Endobiotic Metabolism

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Pancreatic Beta Cells

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Kaoru Saijo, University of California, Berkeley, USA
Short Talk: A Nurr1/CoREST Transrepression Pathway Antagonizes Neurotoxicity of Activated Microglia

Wednesday, April 02 | 8:00AM - 11:15AM
Orphan Receptors In Metabolism
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Steven J. Bensinger, University of California, Los Angeles, USA
Short Talk: An LXR-Dependent Sterol Signaling Pathway Couples Proliferation to Metabolism in the Acquired Immune Response

Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 7
Nancy Lynn Weigel, Baylor College of Medicine, USA
Androgen Receptor Action in Prostate Cancer


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Patricia V. Elizalde, Instituto de Biología y Medicina Experimental, Argentina
Progesterone Receptor Signaling in Breast Cancer


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
Steroid Hormones and Hormone Dependent Breast Cancer Metastasis


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA
Estrogen Receptor and Coregulators in Breast Cancer


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Suzanne AW Fuqua, Baylor College of Medicine, USA
Short Talk: A Model of Estrogen Receptor (ER) alpha-Positive Breast Cancer Metastasis


Wednesday, April 02 | 8:00AM - 11:15AM
Steroid Receptors and Cancer
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Nicola J. Clegg, Genentech, Inc., USA
Short Talk: Androgen Receptor Antagonists with a Novel Mechanism of Action


Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, April 02 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 02 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Joyce J. Repa, University of Texas Southwestern Medical Center, USA

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 2 of 6
Tomas Jakobsson, Karolinska Institutet, Sweden
RAP250 is a Coactivator in the TGF-beta Signaling Pathway that Interacts with SMAD2 and SMAD3

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Arjen Koppen, University Medical Centre Utrecht, Netherlands
Micro Array Assay for Real-Time Analysis of Coregulator-Nuclear Receptor Interactions

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Federica Gilardi, University of Lausanne, Switzerland
Impact of Histone Deacetylases Modulating Nuclear Receptor Activity on Lipid Metabolism

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Ouliana Ziouzenkova, Ohio State University, USA
Proteomic Studies on Retinaldehyde Functions in Adipose Tissue

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics
Room: Sea to Sky Ballroom B

Speaker 6 of 6
Elizabeth M. Simpson, University of British Columbia, Canada
Initial Association of NR2E1 with Bipolar Disorder and Identification of Candidate Mutations in Bipolar Disorder, Schizophrenia, and Aggression through Resequencing

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 8
* Trevor K. Archer, NIEHS, National Institutes of Health, USA


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 8
Nina Heldring, Cornell University, USA
Molecular Mechanisms of Estrogen Receptor-Mediated Transcription Through the Activating Protein-1-Dependent 'Tethering' Pathway


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 8
Mathieu Lupien, University Health Network, Canada
FoxA1 Translates Epigenetic Signatures into Enhancer Driven Lineage-Specific Transcription


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 8
Steven K. Nordeen, University of Colorado Health Sciences Center, USA
Progesterone Receptor Binds to an Estrogen Response Element, and Antagonizes Estrogen Receptor-Mediated Gene Induction. The Role of DNA as a Functional Ligand


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 8
Raj Kumar, Commonwealth Medical College, USA
Effects of Site-Specific Phosphorylation on the Structure and Functions of the Glucocorticoid Receptor AF1 Domain


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 8
Yang Sui Brooks, Medical College of Georgia, USA
Alternative Splicing of Nuclear Receptor Coactivator CoAA in Stem Cells


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 7 of 8
Martin E. van Royen, Erasmus Medical Center, Netherlands
Spatiotemporal Organization of AR intra- and Intermolecular Domain Interactions in Living Cells


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 3 - Hot Topics: Chromatin/Transcription
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 8 of 8
Hong-Wu Chen, University of California, Davis, USA
Novel AAA+ ATPase Chromatin Coregulators are Key Integrators of Hormone Signaling and Cell Proliferation Control


Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, April 02 | 5:00PM - 7:15PM
Nuclear Receptor and Coregulator Structure and Function (Joi
nt)

Room: Sea to Sky Ballroom B,C

Speaker 1 of 5
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Wednesday, April 02 | 5:00PM - 7:15PM
Nuclear Receptor and Coregulator Structure and Function (Joi
nt)

Room: Sea to Sky Ballroom B,C

Speaker 2 of 5
Bert W. O'Malley, Baylor College of Medicine, USA
Roles of Nuclear Receptor Coactivators in Physiology and Disease.

Wednesday, April 02 | 5:00PM - 7:15PM
Nuclear Receptor and Coregulator Structure and Function (Joi
nt)

Room: Sea to Sky Ballroom B,C

Speaker 3 of 5
Orla M. Conneely, Baylor College of Medicine, USA
Orphan Receptors in Cell Growth and Tumorigenesis

Wednesday, April 02 | 5:00PM - 7:15PM
Nuclear Receptor and Coregulator Structure and Function (Joi
nt)

Room: Sea to Sky Ballroom B,C

Speaker 4 of 5
Holly A. Ingraham, University of California, San Francisco, USA
Modulating Target Gene Recognition via Sumoylation of SF- 1 (NR5A1) as Revealed by Biochemical and Mouse Mutant

Wednesday, April 02 | 5:00PM - 7:15PM
Nuclear Receptor and Coregulator Structure and Function (Joi
nt)

Room: Sea to Sky Ballroom B,C

Speaker 5 of 5
Fraydoon Rastinejad, University of Oxford, UK
Structural Organization of the Intact PPARƒ×-RXR Complex

Wednesday, April 02 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Lower Level


Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Physiology of Repression by Nuclear Receptors

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 3 of 7
David D. Moore, Baylor College of Medicine, USA
New Ligands for LRH-1 and SF-1

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Control of Metabolism through the PGC-1 and SIRT1 Cofactors

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Li Wang, University of Connecticut, USA
SHP, Metabolism, Epigenetics, and Cancer

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Jiandie Lin, University of Michigan Medical School, USA
Short Talk: Decoding the PGC-1 Transcriptional Network through Genome-Wide Coactivation Analyses

Thursday, April 03 | 8:00AM - 11:15AM
Mechanisms of Receptor Action
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Susanne Mandrup, University of Southern Denmark, Denmark
Short Talk: Genome-wide ChIP-seq Profiling of PPAR/RXR Target Sites in 3T3-L1 Adipocytes

Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Adriana Maggi, University of Milan, Italy


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 2 of 7
James T. Dalton, University of Michigan, USA
Therapeutic Promise of Selective Androgen Receptor Modulators (SARMs): Preclinical and Clinical Proof-of-Concept Studies.


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Francesco J. DeMayo, Baylor College of Medicine, USA
In Vivo Studies of Progesterone Receptor Action in the Uterus


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Estrogen Receptor Action in vivo


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Edwin R. Sanchez, University of Toledo College of Medicine, USA
Selective Targeting of Steroid Physiology in TPR Protein Ablated Mice


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Inna I. Astapova, Beth Israel Deaconess Medical Center, USA
Short Talk: Nuclear CoRepressor (NCoR) Regulates Hepatic Thyroid Hormone Receptor Function In Vivo


Thursday, April 03 | 8:00AM - 11:15AM
Steroid Receptor Biology
This session is from Nuclear Receptors: Steroids
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Frank A. Claessens, KULeuven- Molecular Endocrinology Laboratory, Belgium
Short Talk: Loss of Androgen Receptor Binding to Selective Androgen Response Elements causes a Reproductive Phenotype in the Transgenic SPARKI Mice


Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 03 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, April 03 | 5:00PM - 7:00PM
Nuclear Receptor Biology (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 5
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Thursday, April 03 | 5:00PM - 7:00PM
Nuclear Receptor Biology (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
PPARs: Bone Up on Metabolism

Thursday, April 03 | 5:00PM - 7:00PM
Nuclear Receptor Biology (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 5
Adriana Maggi, University of Milan, Italy
Estrogen, Nutrition and Fertility

Thursday, April 03 | 5:00PM - 7:00PM
Nuclear Receptor Biology (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 5
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown Fat Determination of Brown Fat Cells by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors

Thursday, April 03 | 5:00PM - 7:00PM
Nuclear Receptor Biology (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 5
Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: The Nuclear Receptor Signaling Atlas (Nursa): A Resource for the NR Community

Thursday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 03 | 8:00PM - 11:00PM
Cash Bar
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Friday, April 04 | 10:25AM - 10:25AM
Departure


*Session Chair.