Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Nuclear Receptors: Full Throttle (2016J1)
Nuclear Receptors: Biological Networks, Genome Dynamics and Disease (2014A3)
Nuclear Receptor Matrix: Reloaded (2012D3)
Nuclear Receptors: Development, Physiology and Disease (2010X8)

Web Desc
Nuclear Receptors: Orphan Brothers joint with Nuclear Receptors: Steroid Sisters Organizer(s): Peter Tontonoz, Thomas Perlmann and Timothy M. Willson Date: March 30 - April 04, 2008 Location: Whistler Conference Centre, Whistler, BC, Canada Supported by the Director's Fund Summary of Meeting: The nuclear hormone receptors are a superfamily of transcription factors that play important roles in both physiology and disease. Orphan receptors are a subset of receptors that were cloned prior to the discovery of their endogenous ligands. The identification of ligands for orphan receptors and the elucidation of their biological functions have led to the discovery of new hormone signaling pathways that control growth, development, and cell and tissue homeostasis. Topics presented in this meeting will include structure function relationships, the role of orphan receptors in development and metabolism, genome-wide analysis of receptor function, coactivators and corepressors, and drug discovery. This meeting will also highlight the potential for orphan receptor signaling pathways to serve as therapeutic targets for human diseases. Scholarship Deadline: December 3 2007 Discounted Abstract Deadline: December 3 2007 Abstract Deadline: January 2 2008 Discounted Registration Deadline: January 30 2008 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: The Endocrine Society We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 5R13DK076500-02 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Nuclear Receptors: Orphan Brothers

joint with Nuclear Receptors: Steroid Sisters

Organizer(s): Peter Tontonoz, Thomas Perlmann and Timothy M. Willson

Date: March 30 - April 04, 2008
Location: Whistler Conference Centre, Whistler, BC, Canada

Supported by the Director's Fund

Summary of Meeting:

The nuclear hormone receptors are a superfamily of transcription factors that play important roles in both physiology and disease. Orphan receptors are a subset of receptors that were cloned prior to the discovery of their endogenous ligands. The identification of ligands for orphan receptors and the elucidation of their biological functions have led to the discovery of new hormone signaling pathways that control growth, development, and cell and tissue homeostasis. Topics presented in this meeting will include structure function relationships, the role of orphan receptors in development and metabolism, genome-wide analysis of receptor function, coactivators and corepressors, and drug discovery. This meeting will also highlight the potential for orphan receptor signaling pathways to serve as therapeutic targets for human diseases.

Scholarship Deadline: December 3 2007

Discounted Abstract Deadline: December 3 2007

Abstract Deadline: January 2 2008

Discounted Registration Deadline: January 30 2008

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

The Endocrine Society

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-02

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 30 \| 3:00PM - 7:30PM Registration Room: Foyer
Sunday, March 30 \| 6:30PM - 7:30PM Refreshments Room: Grand Foyer
Sunday, March 30 \| 7:30PM - 8:30PM Keynote Address (Joint) Room: Sea to Sky Ballroom B,C Speaker 1 of 3 * Peter Tontonoz, University of California, Los Angeles, USA
Sunday, March 30 \| 7:30PM - 8:30PM Keynote Address (Joint) Room: Sea to Sky Ballroom B,C Speaker 2 of 3 * Nancy Lynn Weigel, Baylor College of Medicine, USA
Sunday, March 30 \| 7:30PM - 8:30PM Keynote Address (Joint) Room: Sea to Sky Ballroom B,C Speaker 3 of 3 Eric N. Olson, University of Texas Southwestern Medical Center, USA A MicroRNA Network that Governs Growth and Thyroid Hormone Responsiveness of the Heart
Monday, March 31 \| 7:00AM - 8:00AM Breakfast Room: Lower Level
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 1 of 6 * Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 2 of 6 David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA Regulation of Nutrient Metabolism by Lipid-Sensing Nuclear Receptors
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 3 of 6 Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany Nuclear Receptor Regulation of microRNAs in the C. elegans Heterochronic Circuit
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 4 of 6 Carl S. Thummel, University of Utah School of Medicine, USA Regulation of Metabolism by Drosophila Nuclear Receptors
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 5 of 6 Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA The Nuclear Receptors, PPARgamma, VDR and RAR Link Lipid Metabolism And Immune Function In Developing Human Dendritic Cells
Monday, March 31 \| 8:00AM - 11:15AM Differentiation and Development Room: Sea to Sky Ballroom B Speaker 6 of 6 Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA HNF4 Gene Regulation and Physiology in C. elegans
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 7 * Benita S. Katzenellenbogen, University of Illinois, USA
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 7 Donald P. McDonnell, Duke University School of Medicine, USA Nuclear Receptor-Coactivator Interactions as Targets for New Drug Discovery
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 7 Dean P. Edwards, Baylor College of Medicine, USA The Role and Mechanisms of Progesterone Receptor Cross Talk with Signal Transduction Pathways
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 7 J. Wesley Pike, University of Wisconsin-Madison, USA Regulation of Target Genes by The Vitamin D Receptor: Paradigms for Distal Enhancer Control
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 7 Peter E. Wright, The Scripps Research Institute, USA Role of Protein Folding in Coactivator Function
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 7 Martin L. Privalsky, University of California, Davis, USA Short Talk: Selective Impairment of Thyroid Hormone Receptor (TR)beta2 in Resistance to Thyroid Hormone Syndrome: Mutations Associated with Pituitary Resistance Disrupt Cooperative Contacts that Normally Enhance Coactivator Recruitment
Monday, March 31 \| 8:00AM - 11:15AM Steroid Receptor and Coregulator Structure and Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 7 of 7 Sebastiaan H. Meijsing, Max Planck Institute for Molecular Genetics, Germany Short Talk: The Binding Site Code: The effect of DNA Binding Site Sequence Variation on Transcriptional Regulation by the Glucocorticoid Receptor
Monday, March 31 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Monday, March 31 \| 11:15AM - 1:00PM Poster Setup Room: Foyer/Mountain View/Sea to Sky Ballroom A
Monday, March 31 \| 11:15AM - 11:15AM On Own for Lunch
Monday, March 31 \| 1:00PM - 10:00PM Poster Viewing Room: Foyer/Mountain View/Sea to Sky Ballroom A
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 1 of 6 * Wen Xie, University of Pittsburgh, USA
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 2 of 6 † Hong Soon Kang, NIEHS, National Institutes of Health, USA Physiological Functions of Retinoid-Related Orphan Receptor alpha (RORalpha) in Adipose Tissue
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 3 of 6 Pamela R. Moll, University of Toronto, Canada Ligand Identification Using Live Zebrafish
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 4 of 6 Juliette Rambaud, Institut de Recherches Cliniques de Montreal, Canada TIF1beta is a Coactivator of NGFI-B (Nur77), Nurr1 and NOR1
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 5 of 6 Chun-Li Zhang, University of Texas Southwestern Medical Center, USA Function of Orphan Nuclear Receptor TLX in Adult Neural Stem Cells and Animal Behavior
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics Room: Sea to Sky Ballroom B Speaker 6 of 6 Michael L. Goodson, University of California, Davis, USA Corepressor Isoform Diversity, Receptor Selectivity and Adipogenesis
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 6 * Donald P. McDonnell, Duke University School of Medicine, USA
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 6 Joyce Slingerland, UM Sylvester Comprehensive Cancer Center, USA Src Promotes Estrogen Dependent ERa Proteolysis in Human Breast Cancer
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 6 Jerome C. Nwachukwu, New York University School of Medicine, USA Roles of the Androgen Receptor Cofactor, ART-27 in Prostate Cancer
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 6 Sudipan Karmakar, Food & Drug Administration, USA Depletion of SMRT Expression Inhibits the Proliferation of MCF-7 Breast Cancer Cell and Expression of Estrogen Receptor-alpha Target Genes
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 6 Jae-Kyung Myung, British Columbia Cancer Agency, Canada Large Scale Analysis of the Phosphoproteome in Response to Rapid Signaling by Androgen
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 - Hot Topics: Cancer/Signaling This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 6 Muriel Le Romancer, INSERM, France Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1
Monday, March 31 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Monday, March 31 \| 5:00PM - 7:00PM Nuclear Receptor Structure/Function Room: Sea to Sky Ballroom B Speaker 1 of 4 * Fraydoon Rastinejad, University of Oxford, UK
Monday, March 31 \| 5:00PM - 7:00PM Nuclear Receptor Structure/Function Room: Sea to Sky Ballroom B Speaker 2 of 4 Eric A. Ortlund, Emory University, USA Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis
Monday, March 31 \| 5:00PM - 7:00PM Nuclear Receptor Structure/Function Room: Sea to Sky Ballroom B Speaker 3 of 4 H. Eric Xu, Van Andel Institute, USA Structural Insights into Ligand-Dependent and -Independent Regulation of Nuclear Receptors
Monday, March 31 \| 5:00PM - 7:00PM Nuclear Receptor Structure/Function Room: Sea to Sky Ballroom B Speaker 4 of 4 John W. R. Schwabe, University of Leicester, UK From Novel Paradigms for Regulation of PPARgamma ƒnto Structures of the SMRT Repression Complex
Monday, March 31 \| 5:00PM - 7:00PM Steroid Receptor Signaling and Dynamics This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 5 * Dean P. Edwards, Baylor College of Medicine, USA
Monday, March 31 \| 5:00PM - 7:00PM Steroid Receptor Signaling and Dynamics This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 5 Gordon L. Hager, NCI, National Institutes of Health, USA Glucocorticoid Receptor Dynamics and Global Chromatin Structure
Monday, March 31 \| 5:00PM - 7:00PM Steroid Receptor Signaling and Dynamics This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 5 Boris J. Cheskis, Wyeth Research, USA The Role of MNAR in Steroid Receptor Signaling
Monday, March 31 \| 5:00PM - 7:00PM Steroid Receptor Signaling and Dynamics This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 5 Stephen R. Hammes, University of Rochester Medical Center, USA Extranuclear Steroid Signaling in the Ovary
Monday, March 31 \| 5:00PM - 7:00PM Steroid Receptor Signaling and Dynamics This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 5 Carol A. Lange, University of Minnesota, USA Short Talk: Progesterone Receptor Rapid Signaling Mediates Ser345 Phosphorylation and Tethering to Sp1 Transcription Factors
Monday, March 31 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Foyer/Mountain View/Sea to Sky Ballroom A
Monday, March 31 \| 7:30PM - 10:00PM Poster Session 1 Room: Foyer/Mountain View/Sea to Sky Ballroom A
Tuesday, April 01 \| 7:00AM - 8:00AM Breakfast Room: Lower Level
Tuesday, April 01 \| 7:00AM - 8:00AM Poster Setup Room: Foyer/Mountain View/Sea to Sky Ballroom A
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 1 of 7 * Timothy M. Willson, GlaxoSmithKline, USA
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 2 of 7 Dennis L. Sprecher, GlaxoSmithKline, USA PPARdelta: The Human Experience
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 3 of 7 Sunil Nagpal, Wyeth Research, USA
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 4 of 7 Konstantin Petrukhin, Columbia University, USA NR2E3 Activators for the Treatment of Ophthalmic Diseases
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 5 of 7 Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy Clinical Translation of FXR Agonists for the Treatment of Liver and Metabolic Disorders
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 6 of 7 Henry M. Krause, University of Toronto, Canada Structural Basis of Gas Regulation of REV-ERB Activity
Tuesday, April 01 \| 8:00AM - 11:15AM Drug Development Room: Sea to Sky Ballroom B Speaker 7 of 7 Thomas P. Burris, Washington University School of Medicine, USA Short Talk: Identification of Heme as the Ligand for the Orphan Nuclear Receptors REV-ERBalpha and REV-ERBbeta
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 7 * Myles Brown, Dana-Farber Cancer Institute, USA
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 7 W. Lee Kraus, University of Texas Southwestern Medical Center, USA Transcriptional Regulation by Estrogen Receptors in the Chromatin Environment of the Nucleus
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 7 Trevor K. Archer, NIEHS, National Institutes of Health, USA Regulating Nuclear Receptors with Chromatin
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 7 Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA Targeting SWI/SNF in Prostate Cancer: Implications for AR Signaling and Regulated Proliferation
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 7 Robert G. Roeder, Rockefeller University, USA Nuclear Receptors, Coactivators, and Chromatin
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 7 Inez Rogatsky, Weill Medical College of Cornell University, USA Short Talk: A GRIP1-Associated SET Domain Methyl Transferase in Glucocorticoid Receptor Target Gene Expression
Tuesday, April 01 \| 8:00AM - 11:15AM Steroid Receptors and Chromatin This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 7 of 7 Didier Picard, University of Geneva, Switzerland Short Talk: Mechanism of Activation of Unliganded ERalpha by cAMP and its Consequences for Target Gene Selection and Regulation
Tuesday, April 01 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Tuesday, April 01 \| 11:00AM - 12:00PM Lunch Room: Foyer/Mountain View/Sea to Sky Ballroom A
Tuesday, April 01 \| 12:00PM - 2:30PM Poster Session 2 Room: Foyer/Mountain View/Sea to Sky Ballroom A
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 1 of 6 * Carlie J. M. de Vries, University of Amsterdam, Netherlands
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 2 of 6 Eric Schoenmakers, University of Cambridge, UK A Mutation in the Human PPARgamma Ligand Binding Domain in Severe Insulin Resistance
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 3 of 6 Lillian J. Eichner, The Salk Institute, USA miRNA Regulation of the ERR/PGC-1 Pathway
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 4 of 6 Thijs Pols, University of Amsterdam, Netherlands Nur77 Modulates Hepatic Lipid Metabolism through Suppression of SREBP1c Activity
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 5 of 6 David W. Granger, GlaxoSmithKline, UK Characterisation of a Novel Nuclear Receptor-like Protein
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics Room: Sea to Sky Ballroom B Speaker 6 of 6 J. H. M. Stroeve, TNO Quality of Life, Netherlands The Intestinal FXR-Mediated Fgf-15 Pathway Contributes to the Control of Hepatic Bile Acid Synthesis and Bile Formation in Chow Fed Mice but its Contribution is Overruled during Bile Acid Feeding and Bile Acid Sequestration
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 6 * J. Wesley Pike, University of Wisconsin-Madison, USA
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 6 Ian M. Adcock, Imperial College London, UK Glucocorticoid-Mediated Suppression of NF-kappaB-Stimulated TGFbeta1 Expression Requires the Methylase Suv39H1
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 6 Shilpa Chooniedass-Kothari, University of Manitoba, Canada The Steroid Receptor RNA Activator Protein (SRAP) Acts as a Transcriptional Repressor
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 6 Peter J. Leedman, Western Australian Institute for Medical Research, Australia PACT, TRBP, PKR and Dicer: Novel SRA-binding Coregulators that Modulate Nuclear Receptor Signaling
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 6 Deepa Chotai, Imperial College, UK The Repression of Androgen Receptor Activity by Prohibitin
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Re ceptor Function This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 6 Beatrice D. Darimont, Merck Research Laboratories, USA Recognition of the Glucocorticoid Receptor by Hsp90
Tuesday, April 01 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Tuesday, April 01 \| 5:00PM - 7:00PM Analyses of Nuclear Receptor-Dependent Transcription (Joint) Room: Sea to Sky Ballroom B,C Speaker 1 of 5 * W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Tuesday, April 01 \| 5:00PM - 7:00PM Analyses of Nuclear Receptor-Dependent Transcription (Joint) Room: Sea to Sky Ballroom B,C Speaker 2 of 5 Henk G. Stunnenberg, Radboud University, Netherlands ChIP-seq Analyses of ER and GR Uncovers an Elaborate Ligand Dependent Interaction Network, the Interactome
Tuesday, April 01 \| 5:00PM - 7:00PM Analyses of Nuclear Receptor-Dependent Transcription (Joint) Room: Sea to Sky Ballroom B,C Speaker 3 of 5 Myles Brown, Dana-Farber Cancer Institute, USA Defining the Nuclear Receptor Cistrome
Tuesday, April 01 \| 5:00PM - 7:00PM Analyses of Nuclear Receptor-Dependent Transcription (Joint) Room: Sea to Sky Ballroom B,C Speaker 4 of 5 Benita S. Katzenellenbogen, University of Illinois, USA Integration of Nuclear and Extranuclear Signaling in Global Gene Regulation By Estrogen Receptors
Tuesday, April 01 \| 5:00PM - 7:00PM Analyses of Nuclear Receptor-Dependent Transcription (Joint) Room: Sea to Sky Ballroom B,C Speaker 5 of 5 Edwin Cheung, University of Macau, Macau Short Talk: Global Analysis of Estrogen Receptor-Mediated Chromatin Interactions
Tuesday, April 01 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, April 02 \| 7:00AM - 8:00AM Breakfast Room: Lower Level
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 1 of 7 * Peter Tontonoz, University of California, Los Angeles, USA
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 2 of 7 Steven A. Kliewer, University of Texas Southwestern Medical Center, USA Regulation of Fasting by the PPARalpha-FGF21 Pathway
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 3 of 7 Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland LRH-1 Actions Along the Enterohepatic Axis
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 4 of 7 Wen Xie, University of Pittsburgh, USA PXR, CAR and LXR in Xeno- and Endobiotic Metabolism
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 5 of 7 Joyce J. Repa, University of Texas Southwestern Medical Center, USA Nuclear Receptors in Pancreatic Beta Cells
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 6 of 7 Kaoru Saijo, University of California, Berkeley, USA Short Talk: A Nurr1/CoREST Transrepression Pathway Antagonizes Neurotoxicity of Activated Microglia
Wednesday, April 02 \| 8:00AM - 11:15AM Orphan Receptors In Metabolism Room: Sea to Sky Ballroom B Speaker 7 of 7 Steven J. Bensinger, University of California, Los Angeles, USA Short Talk: An LXR-Dependent Sterol Signaling Pathway Couples Proliferation to Metabolism in the Acquired Immune Response
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 7 * Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 7 Nancy Lynn Weigel, Baylor College of Medicine, USA Androgen Receptor Action in Prostate Cancer
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 7 Patricia V. Elizalde, Instituto de Biología y Medicina Experimental, Argentina Progesterone Receptor Signaling in Breast Cancer
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 7 Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA Steroid Hormones and Hormone Dependent Breast Cancer Metastasis
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 7 Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA Estrogen Receptor and Coregulators in Breast Cancer
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 7 Suzanne AW Fuqua, Baylor College of Medicine, USA Short Talk: A Model of Estrogen Receptor (ER) alpha-Positive Breast Cancer Metastasis
Wednesday, April 02 \| 8:00AM - 11:15AM Steroid Receptors and Cancer This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 7 of 7 Nicola J. Clegg, Genentech, Inc., USA Short Talk: Androgen Receptor Antagonists with a Novel Mechanism of Action
Wednesday, April 02 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Wednesday, April 02 \| 11:15AM - 1:00PM Poster Setup Room: Foyer/Mountain View/Sea to Sky Ballroom A
Wednesday, April 02 \| 11:15AM - 11:15AM On Own for Lunch
Wednesday, April 02 \| 1:00PM - 10:00PM Poster Viewing Room: Foyer/Mountain View/Sea to Sky Ballroom A
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 1 of 6 * Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 2 of 6 Tomas Jakobsson, Karolinska Institutet, Sweden RAP250 is a Coactivator in the TGF-beta Signaling Pathway that Interacts with SMAD2 and SMAD3
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 3 of 6 Arjen Koppen, University Medical Centre Utrecht, Netherlands Micro Array Assay for Real-Time Analysis of Coregulator-Nuclear Receptor Interactions
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 4 of 6 Federica Gilardi, University of Lausanne, Switzerland Impact of Histone Deacetylases Modulating Nuclear Receptor Activity on Lipid Metabolism
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 5 of 6 Ouliana Ziouzenkova, Ohio State University, USA Proteomic Studies on Retinaldehyde Functions in Adipose Tissue
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics Room: Sea to Sky Ballroom B Speaker 6 of 6 Elizabeth M. Simpson, University of British Columbia, Canada Initial Association of NR2E1 with Bipolar Disorder and Identification of Candidate Mutations in Bipolar Disorder, Schizophrenia, and Aggression through Resequencing
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 8 * Trevor K. Archer, NIEHS, National Institutes of Health, USA
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 8 Nina Heldring, Cornell University, USA Molecular Mechanisms of Estrogen Receptor-Mediated Transcription Through the Activating Protein-1-Dependent 'Tethering' Pathway
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 8 Mathieu Lupien, University Health Network, Canada FoxA1 Translates Epigenetic Signatures into Enhancer Driven Lineage-Specific Transcription
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 8 Steven K. Nordeen, University of Colorado Health Sciences Center, USA Progesterone Receptor Binds to an Estrogen Response Element, and Antagonizes Estrogen Receptor-Mediated Gene Induction. The Role of DNA as a Functional Ligand
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 8 Raj Kumar, Commonwealth Medical College, USA Effects of Site-Specific Phosphorylation on the Structure and Functions of the Glucocorticoid Receptor AF1 Domain
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 8 Yang Sui Brooks, Medical College of Georgia, USA Alternative Splicing of Nuclear Receptor Coactivator CoAA in Stem Cells
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 7 of 8 Martin E. van Royen, Erasmus Medical Center, Netherlands Spatiotemporal Organization of AR intra- and Intermolecular Domain Interactions in Living Cells
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 3 - Hot Topics: Chromatin/Transcription This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 8 of 8 Hong-Wu Chen, University of California, Davis, USA Novel AAA+ ATPase Chromatin Coregulators are Key Integrators of Hormone Signaling and Cell Proliferation Control
Wednesday, April 02 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Wednesday, April 02 \| 5:00PM - 7:15PM Nuclear Receptor and Coregulator Structure and Function (Joi nt) Room: Sea to Sky Ballroom B,C Speaker 1 of 5 * Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Wednesday, April 02 \| 5:00PM - 7:15PM Nuclear Receptor and Coregulator Structure and Function (Joi nt) Room: Sea to Sky Ballroom B,C Speaker 2 of 5 Bert W. O'Malley, Baylor College of Medicine, USA Roles of Nuclear Receptor Coactivators in Physiology and Disease.
Wednesday, April 02 \| 5:00PM - 7:15PM Nuclear Receptor and Coregulator Structure and Function (Joi nt) Room: Sea to Sky Ballroom B,C Speaker 3 of 5 Orla M. Conneely, Baylor College of Medicine, USA Orphan Receptors in Cell Growth and Tumorigenesis
Wednesday, April 02 \| 5:00PM - 7:15PM Nuclear Receptor and Coregulator Structure and Function (Joi nt) Room: Sea to Sky Ballroom B,C Speaker 4 of 5 Holly A. Ingraham, University of California, San Francisco, USA Modulating Target Gene Recognition via Sumoylation of SF- 1 (NR5A1) as Revealed by Biochemical and Mouse Mutant
Wednesday, April 02 \| 5:00PM - 7:15PM Nuclear Receptor and Coregulator Structure and Function (Joi nt) Room: Sea to Sky Ballroom B,C Speaker 5 of 5 Fraydoon Rastinejad, University of Oxford, UK Structural Organization of the Intact PPARƒ×-RXR Complex
Wednesday, April 02 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Foyer/Mountain View/Sea to Sky Ballroom A
Wednesday, April 02 \| 7:30PM - 10:00PM Poster Session 3 Room: Foyer/Mountain View/Sea to Sky Ballroom A
Thursday, April 03 \| 7:00AM - 8:00AM Breakfast Room: Lower Level
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 1 of 7 * Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 2 of 7 Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA Physiology of Repression by Nuclear Receptors
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 3 of 7 David D. Moore, Baylor College of Medicine, USA New Ligands for LRH-1 and SF-1
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 4 of 7 Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA Nutrient Control of Metabolism through the PGC-1 and SIRT1 Cofactors
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 5 of 7 Li Wang, University of Connecticut, USA SHP, Metabolism, Epigenetics, and Cancer
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 6 of 7 Jiandie Lin, University of Michigan Medical School, USA Short Talk: Decoding the PGC-1 Transcriptional Network through Genome-Wide Coactivation Analyses
Thursday, April 03 \| 8:00AM - 11:15AM Mechanisms of Receptor Action Room: Sea to Sky Ballroom B Speaker 7 of 7 Susanne Mandrup, University of Southern Denmark, Denmark Short Talk: Genome-wide ChIP-seq Profiling of PPAR/RXR Target Sites in 3T3-L1 Adipocytes
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 1 of 7 * Adriana Maggi, University of Milan, Italy
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 2 of 7 James T. Dalton, University of Michigan, USA Therapeutic Promise of Selective Androgen Receptor Modulators (SARMs): Preclinical and Clinical Proof-of-Concept Studies.
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 3 of 7 Francesco J. DeMayo, Baylor College of Medicine, USA In Vivo Studies of Progesterone Receptor Action in the Uterus
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 4 of 7 Kenneth S. Korach, NIEHS, National Institutes of Health, USA Estrogen Receptor Action in vivo
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 5 of 7 Edwin R. Sanchez, University of Toledo College of Medicine, USA Selective Targeting of Steroid Physiology in TPR Protein Ablated Mice
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 6 of 7 Inna I. Astapova, Beth Israel Deaconess Medical Center, USA Short Talk: Nuclear CoRepressor (NCoR) Regulates Hepatic Thyroid Hormone Receptor Function In Vivo
Thursday, April 03 \| 8:00AM - 11:15AM Steroid Receptor Biology This session is from Nuclear Receptors: Steroids Room: Sea to Sky Ballroom C Speaker 7 of 7 Frank A. Claessens, KULeuven- Molecular Endocrinology Laboratory, Belgium Short Talk: Loss of Androgen Receptor Binding to Selective Androgen Response Elements causes a Reproductive Phenotype in the Transgenic SPARKI Mice
Thursday, April 03 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Thursday, April 03 \| 11:15AM - 11:15AM On Own for Lunch
Thursday, April 03 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Thursday, April 03 \| 5:00PM - 7:00PM Nuclear Receptor Biology (Joint) Room: Sea to Sky Ballroom B,C Speaker 1 of 5 * Nancy Lynn Weigel, Baylor College of Medicine, USA
Thursday, April 03 \| 5:00PM - 7:00PM Nuclear Receptor Biology (Joint) Room: Sea to Sky Ballroom B,C Speaker 2 of 5 Ronald M. Evans, HHMI/The Salk Institute, USA PPARs: Bone Up on Metabolism
Thursday, April 03 \| 5:00PM - 7:00PM Nuclear Receptor Biology (Joint) Room: Sea to Sky Ballroom B,C Speaker 3 of 5 Adriana Maggi, University of Milan, Italy Estrogen, Nutrition and Fertility
Thursday, April 03 \| 5:00PM - 7:00PM Nuclear Receptor Biology (Joint) Room: Sea to Sky Ballroom B,C Speaker 4 of 5 Bruce M. Spiegelman, Harvard Medical School, USA Transcriptional Control of Brown Fat Determination of Brown Fat Cells by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors
Thursday, April 03 \| 5:00PM - 7:00PM Nuclear Receptor Biology (Joint) Room: Sea to Sky Ballroom B,C Speaker 5 of 5 Ronald N. Margolis, NIDDK, National Institutes of Health, USA Short Talk: The Nuclear Receptor Signaling Atlas (Nursa): A Resource for the NR Community
Thursday, April 03 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Foyer/Mountain View/Sea to Sky Ballroom A
Thursday, April 03 \| 8:00PM - 11:00PM Entertainment Room: Foyer/Mountain View/Sea to Sky Ballroom A
Thursday, April 03 \| 8:00PM - 11:00PM Cash Bar Room: Foyer/Mountain View/Sea to Sky Ballroom A
Friday, April 04 \| 10:25AM - 10:25AM Departure *Session Chair.