Web Desc
Islet and Beta Cell Biology
joint with Islet and Beta Cell Development and Transplantation
Organizer(s): Christopher B. Newgard, Frances M. Ashcroft and Roland W. Stein
Date: April 06 - 11, 2008
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Despite many decades of research, important aspects of the molecular, biochemical and metabolic mechanisms that control the function of the islets of Langerhans have remained unresolved, due in part to the sequestration of these cells in the bowels of the exocrine pancreas. Nevertheless the key role of the islets in the pathogenesis of both major forms of diabetes has maintained the resolve of islet investigators at a high level, and has led to recent full-scale application of the tools of genetics, transcriptomics, genetic engineering, metabolomics, and informatics for understanding of normal islets and their loss of function in diabetes. Major progress has occurred in understanding of transcriptional networks that control islet function, growth and survival, and revealed that several factors thought of previously only as regulators of beta-cell development (e.g. Nkx6.1, Nkx2.2, Foxa1, Foxa2, MafA) are also key modulators of adult beta-cell function and growth. In addition, merger of genetic and metabolic analysis tools have allowed major inroads into identification of mitochondrially-derived mediators of insulin secretion that complement the classical KATP-channel dependent pathway. Finally, genetic studies have identified new diabetes candidate genes (e.g., the transcription factor Tcf712) that appear to play important roles in the islets—this field is just emerging and will likely be a cresting wave at the time of this proposed meeting. Major remaining problems are to test hypotheses about key genes and pathways emerging from application of 'omics' technologies to islet research, and the identification of attractive targets for improving islet function and survival in both major forms of diabetes. The key meeting goals are: • To provide a forum for investigators of the field to hear of the latest insights from application of state-of-the-art technologies to the islet field. • To allow islet biologists to hear new findings from the areas of transcription factor biology, metabolism, intracellular trafficking and signaling, and drug target identification leading to synthesis of new and integrated ideas. • To provide stimulation and inspiration for young scientists who are training in the field via the opportunity to interact freely with senior scientists and present their own work in invited abstract talks and posters.
Scholarship Deadline: December 6 2007
Discounted Abstract Deadline: December 6 2007
Abstract Deadline: January 9 2008
Discounted Registration Deadline: February 6 2008
We gratefully acknowledge additional support for this conference from:
JDRF
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 06 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, April 06 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Lobby


Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 1 of 4
* Chris Wright, Vanderbilt University Medical Center, USA

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 2 of 4
* Christopher B. Newgard, Duke University Medical Center, USA

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 3 of 4
Mark A. Magnuson, Vanderbilt School of Medicine, USA
Beta Cells, Technology Convergence and Team Science

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 4 of 4
Andrew Hattersley, University of Exeter Medical School, UK
What can Genetics Teach us about the Beta-Cell?

Monday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 1 of 6
* Chris Wright, Vanderbilt University Medical Center, USA

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 2 of 6
* Christopher B. Newgard, Duke University Medical Center, USA

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 3 of 6
Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK
Ion Channels and Diabetes

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 4 of 6
Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Integration of Beta-Cell Transcription and Metabolic Regulation

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 5 of 6
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Using Functional Genomics to Identify Targets for Beta-Cell Expansion

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 6 of 6
Douglas A. Melton, Harvard University, USA
Making Beta Cells

Monday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Monday, April 07 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
Room: Ballroom 2

Speaker 1 of 4
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Pdx1 Partners and Targets in ß Cell Development

Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
Room: Ballroom 2

Speaker 2 of 4
Roland W. Stein, Vanderbilt University Medical Center, USA
Transcriptional Control of Beta-Cell Function

Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
Room: Ballroom 2

Speaker 3 of 4
Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Constructing a Functional Beta Cell, One Histone at a Time

Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
Room: Ballroom 2

Speaker 4 of 4
Chutima Noi Talchai, Columbia University, USA
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1

Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 5
* David M. Harlan, National Institutes of Health, NIDDK, USA


Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 5
E. William St. Clair, Duke University Medical Center, USA
Targeting B Cells in Autoimmune Disease


Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 5
Arlene H. Sharpe, Harvard Medical School, USA
PD-L1 for Maintenance of Self-Tolerance


Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 5
Thomas Kay, St. Vincent's Institute of Medical Research, Australia
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice


Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 5
Shira Y. Perl, National Institutes of Health, USA
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans


Monday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 1 of 6
* Marc Prentki, Montreal Diabetes Research Center, Canada

Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 2 of 6
Alan D. Attie, University of Wisconsin-Madison, USA
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 3 of 6
Charles A. Stanley, Children's Hospital of Philadelphia, USA
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 4 of 6
Guy A. Rutter, Imperial College London, UK
Genetic Associations and the Regulation Late Events in Insulin Exocytosis

Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 5 of 6
Richard G. Kibbey, Yale University, USA
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion

Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
Room: Ballroom 2

Speaker 6 of 6
Christopher B. Newgard, Duke University Medical Center, USA
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 6
* Harry Heimberg, Vrije Universiteit Brussel, Belgium


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 6
Ray MacDonald, University of Texas Southwestern Medical Center, USA
Transcriptional Control of Early Pancreatic Development


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 6
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 6
Helena Edlund, Umeå University, Sweden
Signaling and Transcription Factors in the Pancreas


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 6
Chris Wright, Vanderbilt University Medical Center, USA
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development – Transcription / Factors
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 6 of 6
Victoria E. Prince, University of Chicago, USA
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4


Tuesday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Tuesday, April 08 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
Room: Ballroom 2

Speaker 1 of 5
* R. Paul Robertson, Pacific Northwest Research Institute, USA

Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
Room: Ballroom 2

Speaker 2 of 5
Sheila Collins, Vanderbilt University Medical Center, USA
Oxidative Stress, UCP2 and beta-Cell Function

Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
Room: Ballroom 2

Speaker 3 of 5
Feroz R. Papa, University of California, San Francisco, USA
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress

Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
Room: Ballroom 2

Speaker 4 of 5
Roger D. Cox, Medical Research Council Harwell Institute, UK
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2

Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
Room: Ballroom 2

Speaker 5 of 5
Andreas C. Wiederkehr, University of Geneva, Switzerland
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell

Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 5
* Douglas A. Melton, Harvard University, USA


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 5
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction and Specification of Endoderm from Embryonic Stem Cells


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 5
Markus Grompe, Oregon Health & Science University, USA
Characterization and Behavior of Liver and Pancreas Stem Cells


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 5
Maike Sander, University of California, San Diego, USA
Transcriptional Regulators of Stem-Cellness


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 5
Jackie E. Lee, Living Cell Technologies Limited, New Zealand
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells


Tuesday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 1 of 8
* Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 2 of 8
Sara C. Kozma, University of Cincinnati, USA
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 3 of 8
Tadao Shibasaki, Kobe University Graduate School of Medicine, Japan
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 4 of 8
Debbie C. Thurmond, Indiana University School of Medicine, USA
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 5 of 8
Tye Deering, University of Texas Southwestern Medical Center, USA
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 6 of 8
Hainan Chen, Icahn School of Medicine at Mount Sinai, USA
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 7 of 8
Leslie Ann Caromile, University of Connecticut Health Center, USA
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
Room: Ballroom 2

Speaker 8 of 8
Samuel B. Stephens, Duke University Medical Center, USA
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 7
* Ray MacDonald, University of Texas Southwestern Medical Center, USA


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 7
Klaus Ulrich Pechhold, University of Massachusetts, USA
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 7
Alvin C. Powers, Vanderbilt University School of Medicine, USA
Imaging Approaches to Follow Beta Cells in Vivo


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 7
Yuval Dor, Hebrew University-Hadassah Medical School, Israel
Determinants of Pancreatic Beta Cell Regeneration


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 7
Holger Andreas Russ, University of California, San Francisco, USA
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 6 of 7
Jake A. Kushner, Baylor College of Medicine, USA
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 7 of 7
Emmanuel E. Baetge, Nestlé Institute of Health Sciences, Switzerland
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm


Wednesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Wednesday, April 09 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
Room: Ballroom 2

Speaker 1 of 5
* Roland W. Stein, Vanderbilt University Medical Center, USA

Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
Room: Ballroom 2

Speaker 2 of 5
Ali Mortazavi, California Institute of Technology, USA

Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
Room: Ballroom 2

Speaker 3 of 5
Thomas Kodadek, The Scripps Research Institute, USA
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
Room: Ballroom 2

Speaker 4 of 5
Per-Olof Berggren, Karolinska Institutet, Sweden
Insight into Pancreatic Beta Cell Function and Survival

Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
Room: Ballroom 2

Speaker 5 of 5
Thue W. Schwartz, University of Copenhagen, Denmark
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man

Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development – Intercellular Signaling
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 5
* Maike Sander, University of California, San Diego, USA


Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development – Intercellular Signaling
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 5
Matthias Hebrok, University of California, San Francisco, USA
Wnt and Hedgehog Signaling


Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development – Intercellular Signaling
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 5
Steven D. Leach, Memorial Sloan Kettering, USA
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish


Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development – Intercellular Signaling
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 5
Ondine Cleaver, University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development


Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development – Intercellular Signaling
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 5
Palle Serup, University of Copenhagen, Denmark
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps


Wednesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Maybird/Wasatch


Thursday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 1 of 7
* Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 2 of 7
Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Fuel Sensing in Islet Non-Beta Cells

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 3 of 7
Randy J. Seeley, University of Michigan, USA
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 4 of 7
Johan M. Thevelein, KU Leuven and VIB, Belgium
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 5 of 7
Fiona M. Gribble, University of Cambridge, UK
Fuel-Sensing in the L-Cell

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 6 of 7
Nils Wierup, Lund University, Sweden
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
Room: Ballroom 2

Speaker 7 of 7
Kathryn Claiborn, USA
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 6
Kevan C. Herold, Yale University, USA
Effects of Immune Modulation on Beta Cells


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 6
David M. Harlan, National Institutes of Health, NIDDK, USA
Status of Clinical Trials Testing Beta Cell Regeneration


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 6
* Christian P. Larsen, Emory University School of Medicine, USA
Costimulatory Pathway Based Clinical Trials


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 6
Patrik Brundin, Van Andel Institute, USA
Neural Cell Grafting for Clinical Brain Repair


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 6
Keren Francis, Technion - Israel Institute of Technology, Israel
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 6 of 6
Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades


Thursday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Thursday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets

Room: Ballroom 2

Speaker 1 of 4
* Paul K. Burn, Sanford Research & Sanford School of Medicine, USA

Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets

Room: Ballroom 2

Speaker 2 of 4
Nancy A. Thornberry, Kallyope, Inc., USA
GLP-1 and Next Generation Insulin Secretagogues

Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets

Room: Ballroom 2

Speaker 3 of 4
Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?

Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets

Room: Ballroom 2

Speaker 4 of 4
Jens Zehetner, ETH Zurich, Switzerland, Switzerland
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis

Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 1 of 5
* Helena Edlund, Umeå University, Sweden


Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 2 of 5
Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist


Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 3 of 5
Harry Heimberg, Vrije Universiteit Brussel, Belgium
Beta Cell Progenitors in Adult Mouse Pancreas


Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 4 of 5
Seung K. Kim, Stanford University, USA
Control of Pancreas Cell Proliferation


Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
This session is from Islet & Beta Cell Devel & Tran
Room: Ballroom 3

Speaker 5 of 5
Sonya G. Fonseca, Novartis, USA
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1


Thursday, April 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2


Thursday, April 10 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2


Thursday, April 10 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Friday, April 11 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.