Web Desc
Islet and Beta Cell Development and Transplantation
joint with Islet and Beta Cell Biology
Organizer(s): Chris Wright, Helena Edlund, David M. Harlan and Ray MacDonald
Date: April 06 - 11, 2008
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Director's Fund
Summary of Meeting:
This meeting presents an integrated program on pancreatic islet developmental biology, islet transplantation, and immunity. It is designed to interdigitate with and to augment the companion parallel conference “Islet and Beta-Cell Biology”. The meeting will encompass pioneering science in several disciplines, including development, regeneration, stem cells, transcription factors, transplantation, cell biology, gene regulation, immunity, and diabetes. Islet transplantation as an emergent therapy for diabetes is severely hampered by an insufficient islet supply, gradually decreasing islet function post-transplantation, and by toxic immuno-suppression. Understanding the rules that guide pancreas development in vivo will promote methods to generate new islets from adult or embryonic stem cells, and yet our knowledge remains inadequate as it pertains to the mechanisms controlling normal islet development and function, or of the maintenance of the islet cell differentiated state, survival, and physiological function after transplantation. Similarly, the means elude us to safely, effectively, and reliably prevent recurrent immune attack on the transplanted islets. The meeting program focuses on these challenges by covering the most recent progress in these rapidly moving fields and discussing strategies to overcome major obstacles. The meeting builds upon the extremely strong foundation laid by the 2006 Keystone meeting on “Pancreatic Islets”, which very effectively brought together the fields of islet transplantation and basic pancreatic development. A most important aspect of the meeting will be the instructions given to the speakers to identify specific caveats and problems with the current state of research, to define short and long term goals for the field and, moreover, to orient their presentation in a manner that maximizes accessibility to attendees from the other research areas.
Scholarship Deadline: December 6 2007
Discounted Abstract Deadline: December 6 2007
Abstract Deadline: January 9 2008
Discounted Registration Deadline: February 6 2008
We gratefully acknowledge additional support for this conference from:
JDRFMerck & Co., Inc.ViaCyte, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 06 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, April 06 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Lobby


Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 1 of 4
* Chris Wright, Vanderbilt University Medical Center, USA

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 2 of 4
* Christopher B. Newgard, Duke University Medical Center, USA

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 3 of 4
Mark A. Magnuson, Vanderbilt School of Medicine, USA
Beta Cells, Technology Convergence and Team Science

Sunday, April 06 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom 2-3

Speaker 4 of 4
Andrew Hattersley, University of Exeter Medical School, UK
What can Genetics Teach us about the Beta-Cell?

Monday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 1 of 6
* Chris Wright, Vanderbilt University Medical Center, USA

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 2 of 6
* Christopher B. Newgard, Duke University Medical Center, USA

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 3 of 6
Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK
Ion Channels and Diabetes

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 4 of 6
Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Integration of Beta-Cell Transcription and Metabolic Regulation

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 5 of 6
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Using Functional Genomics to Identify Targets for Beta-Cell Expansion

Monday, April 07 | 8:00AM - 11:00AM
Stem Cells and Optimization of Beta Cell Function to Transpl
antation (Joint)

Room: Ballroom 2-3

Speaker 6 of 6
Douglas A. Melton, Harvard University, USA
Making Beta Cells

Monday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Monday, April 07 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
Room: Ballroom 3

Speaker 1 of 5
* David M. Harlan, National Institutes of Health, NIDDK, USA

Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
Room: Ballroom 3

Speaker 2 of 5
E. William St. Clair, Duke University Medical Center, USA
Targeting B Cells in Autoimmune Disease

Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
Room: Ballroom 3

Speaker 3 of 5
Arlene H. Sharpe, Harvard Medical School, USA
PD-L1 for Maintenance of Self-Tolerance

Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
Room: Ballroom 3

Speaker 4 of 5
Thomas Kay, St. Vincent's Institute of Medical Research, Australia
Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice

Monday, April 07 | 5:00PM - 7:00PM
Understanding and Controlling Autoimmunity
Room: Ballroom 3

Speaker 5 of 5
Shira Y. Perl, National Institutes of Health, USA
Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans

Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 4
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Pdx1 Partners and Targets in ß Cell Development


Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 4
Roland W. Stein, Vanderbilt University Medical Center, USA
Transcriptional Control of Beta-Cell Function


Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 4
Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Constructing a Functional Beta Cell, One Histone at a Time


Monday, April 07 | 5:00PM - 7:00PM
Transcriptional Networks that Regulate Islet Function
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 4
Chutima Noi Talchai, Columbia University, USA
Short Talk: Regulation of Pancreatic Endocrine Progenitors and beta Cell Function by Transcription Factor Foxo1


Monday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Monday, April 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 1 of 6
* Harry Heimberg, Vrije Universiteit Brussel, Belgium

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 2 of 6
Ray MacDonald, University of Texas Southwestern Medical Center, USA
Transcriptional Control of Early Pancreatic Development

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 3 of 6
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Nkx2.2: Transcriptional regulation of pancreatic islet differentiation

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 4 of 6
Helena Edlund, Umeå University, Sweden
Signaling and Transcription Factors in the Pancreas

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 5 of 6
Chris Wright, Vanderbilt University Medical Center, USA
Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation

Tuesday, April 08 | 8:00AM - 11:00AM
Pancreas Development - Transcription / Factors
Room: Ballroom 3

Speaker 6 of 6
Victoria E. Prince, University of Chicago, USA
Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4

Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 6
* Marc Prentki, Montreal Diabetes Research Center, Canada


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 6
Alan D. Attie, University of Wisconsin-Madison, USA
Multi-Dimensional Approaches to Identification of Genes Involved in Diabetes and Insulin Resistance


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 6
Charles A. Stanley, Children's Hospital of Philadelphia, USA
Human Genetic Syndromes of Hyperinsulinism: Insights into Relevant Metabolic Pathways


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 6
Guy A. Rutter, Imperial College London, UK
Genetic Associations and the Regulation Late Events in Insulin Exocytosis


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 5 of 6
Richard G. Kibbey, Yale University, USA
Metabolic Coupling between Mitochondrial GTP Synthesis and Insulin Secretion


Tuesday, April 08 | 8:00AM - 11:15AM
Metabolic Control of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 6 of 6
Christopher B. Newgard, Duke University Medical Center, USA
Integration of Metabolic and Transcriptional Profiling for Understanding Regulation of Insulin Secretion


Tuesday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Tuesday, April 08 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
Room: Ballroom 3

Speaker 1 of 5
* Douglas A. Melton, Harvard University, USA

Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
Room: Ballroom 3

Speaker 2 of 5
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction and Specification of Endoderm from Embryonic Stem Cells

Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
Room: Ballroom 3

Speaker 3 of 5
Markus Grompe, Oregon Health & Science University, USA
Characterization and Behavior of Liver and Pancreas Stem Cells


Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
Room: Ballroom 3

Speaker 4 of 5
Maike Sander, University of California, San Diego, USA
Transcriptional Regulators of Stem-Cellness

Tuesday, April 08 | 5:00PM - 7:00PM
Stem Cells and Pancreatic Islets
Room: Ballroom 3

Speaker 5 of 5
Jackie E. Lee, Living Cell Technologies Limited, New Zealand
Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells

Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 5
* R. Paul Robertson, Pacific Northwest Research Institute, USA


Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 5
Sheila Collins, Vanderbilt University Medical Center, USA
Oxidative Stress, UCP2 and beta-Cell Function


Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 5
Feroz R. Papa, University of California, San Francisco, USA
New Tools to Adjust a Life-Death Switch in Cells Under ER Stress


Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 5
Roger D. Cox, Medical Research Council Harwell Institute, UK
Mitochondrial Nicotinamide Nucleotide Transhydrogenase (NNT) Impairs Insulin Secretion through UCP2


Tuesday, April 08 | 5:00PM - 7:00PM
Mediators of Beta Cell Stress
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 5 of 5
Andreas C. Wiederkehr, University of Geneva, Switzerland
Short Talk: Nutrient-Induced Mitochondrial Matrix Alkalinization Contributes to Signal Generation in the Pancreatic Beta Cell


Tuesday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Tuesday, April 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 1 of 7
* Ray MacDonald, University of Texas Southwestern Medical Center, USA

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 2 of 7
Klaus Ulrich Pechhold, University of Massachusetts, USA
Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 3 of 7
Alvin C. Powers, Vanderbilt University School of Medicine, USA
Imaging Approaches to Follow Beta Cells in Vivo


Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 4 of 7
Yuval Dor, Hebrew University-Hadassah Medical School, Israel
Determinants of Pancreatic Beta Cell Regeneration

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 5 of 7
Holger Andreas Russ, University of California, San Francisco, USA
Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 6 of 7
Jake A. Kushner, Baylor College of Medicine, USA
Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age

Wednesday, April 09 | 8:00AM - 11:15AM
Model Systems for Assessing Beta Cell Replacements
Room: Ballroom 3

Speaker 7 of 7
Emmanuel E. Baetge, Nestlé Institute of Health Sciences, Switzerland
In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm

Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 8
* Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 8
Sara C. Kozma, University of Cincinnati, USA
The Role of S6K1 in Beta-cell Growth is Independent of its Effects on the Development of Extra Embryonic Tissue


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 8
Tadao Shibasaki, Kobe University Graduate School of Medicine, Japan
Roles of Exocytosis-Associated Proteins in Pancreatic Beta-Cells


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 8
Debbie C. Thurmond, Indiana University School of Medicine, USA
Regulation of Second-Phase Insulin Secretion by Cdc42, Syntaxin 4 and Munc18c


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 5 of 8
Tye Deering, University of Texas Southwestern Medical Center, USA
Short Talk: The Protein Methyltransferase Set7/9 is Required for the Maintenance of Transcription and Euchromatin Structure at Islet-Enriched Genes


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 6 of 8
Hainan Chen, Icahn School of Medicine at Mount Sinai, USA
Short Talk: The Polycomb Group Protein Ezh2 Controls Pancreatic beta Cell Growth by Repressing Ink4a/Arf


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 7 of 8
Leslie Ann Caromile, University of Connecticut Health Center, USA
Short Talk: The Neurosecretory Vesicle Protein Phogrin is a Phosphatidylinositol Phosphatase Whose Activity Regulates Insulin Secretion


Wednesday, April 09 | 8:00AM - 11:15AM
The Molecular Machinery of Insulin Secretion
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 8 of 8
Samuel B. Stephens, Duke University Medical Center, USA
Short Talk: Potentiation of Glucose-Stimulated Insulin Secretion by a VGF-Derived Peptide


Wednesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Wednesday, April 09 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development - Intercellular Signaling
Room: Ballroom 3

Speaker 1 of 5
* Maike Sander, University of California, San Diego, USA

Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development - Intercellular Signaling
Room: Ballroom 3

Speaker 2 of 5
Matthias Hebrok, University of California, San Francisco, USA
Wnt and Hedgehog Signaling

Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development - Intercellular Signaling
Room: Ballroom 3

Speaker 3 of 5
Steven D. Leach, Memorial Sloan Kettering, USA
Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish

Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development - Intercellular Signaling
Room: Ballroom 3

Speaker 4 of 5
Ondine Cleaver, University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development

Wednesday, April 09 | 5:00PM - 7:00PM
Pancreatic Development - Intercellular Signaling
Room: Ballroom 3

Speaker 5 of 5
Palle Serup, University of Copenhagen, Denmark
Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps

Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 5
* Roland W. Stein, Vanderbilt University Medical Center, USA


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 5
Ali Mortazavi, California Institute of Technology, USA

Mapping Mammalian Gene Regulatory Networks with ChIP-seq and RNA-seq


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 5
Thomas Kodadek, The Scripps Research Institute, USA
Synthetic Transactivator Mimics for Specific Activation of Beta-Cell Genes


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 5
Per-Olof Berggren, Karolinska Institutet, Sweden
Insight into Pancreatic Beta Cell Function and Survival


Wednesday, April 09 | 5:00PM - 7:00PM
Emerging Technologies for Beta-Cell Research
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 5 of 5
Thue W. Schwartz, University of Copenhagen, Denmark
Short Talk: GPR39 Deficiency is Associated with Pancreatic beta Cell Dysfunction in Mice and Man


Wednesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Wednesday, April 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Maybird/Wasatch


Thursday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 1 of 6
Kevan C. Herold, Yale University, USA
Effects of Immune Modulation on Beta Cells

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 2 of 6
David M. Harlan, National Institutes of Health, NIDDK, USA
Status of Clinical Trials Testing Beta Cell Regeneration

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 3 of 6
* Christian P. Larsen, Emory University School of Medicine, USA
Costimulatory Pathway Based Clinical Trials

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 4 of 6
Patrik Brundin, Van Andel Institute, USA
Neural Cell Grafting for Clinical Brain Repair

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 5 of 6
Keren Francis, Technion - Israel Institute of Technology, Israel
Short Talk: Engineering Vascularized Pancreatic Islets In Vitro

Thursday, April 10 | 8:00AM - 11:15AM
Moving Towards Clinical Application
Room: Ballroom 3

Speaker 6 of 6
Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades

Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 1 of 7
* Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford, UK


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 2 of 7
Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Fuel Sensing in Islet Non-Beta Cells


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 3 of 7
Randy J. Seeley, University of Michigan, USA
Fuel Sensing Mechanisms in the Brain: mTOR and the Regulation of Energy Balance


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 4 of 7
Johan M. Thevelein, KU Leuven and VIB, Belgium
Novel Mechanisms in Sensing of Glucose and Other Essential Nutrients in Yeast


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 5 of 7
Fiona M. Gribble, University of Cambridge, UK
Fuel-Sensing in the L-Cell


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 6 of 7
Nils Wierup, Lund University, Sweden
Short Talk: Cart is a Regulator of Islet Function and a Possible Incretin Hormone


Thursday, April 10 | 8:00AM - 11:15AM
Beta-Cell Mechanisms: Lessons from Other Systems
This session is from Islets & Beta Cells
Room: Ballroom 2

Speaker 7 of 7
Kathryn Claiborn, USA
Short Talk: PCIF1 Regulates PDX1 Protein Stability, Glucose Homeostasis, and the Development of Pancreatic Beta Cell Mass


Thursday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Thursday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
Room: Ballroom 3

Speaker 1 of 5
* Helena Edlund, Umeå University, Sweden

Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
Room: Ballroom 3

Speaker 2 of 5
Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist

Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
Room: Ballroom 3

Speaker 3 of 5
Harry Heimberg, Vrije Universiteit Brussel, Belgium
Beta Cell Progenitors in Adult Mouse Pancreas

Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
Room: Ballroom 3

Speaker 4 of 5
Seung K. Kim, Stanford University, USA
Control of Pancreas Cell Proliferation

Thursday, April 10 | 5:00PM - 7:00PM
Islet Proliferation and Survival
Room: Ballroom 3

Speaker 5 of 5
Sonya G. Fonseca, Novartis, USA
Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1

Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets
This session is from Islets & Beta Cells

Room: Ballroom 2

Speaker 1 of 4
* Paul K. Burn, Sanford Research & Sanford School of Medicine, USA


Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets
This session is from Islets & Beta Cells

Room: Ballroom 2

Speaker 2 of 4
Nancy A. Thornberry, Kallyope, Inc., USA
GLP-1 and Next Generation Insulin Secretagogues


Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets
This session is from Islets & Beta Cells

Room: Ballroom 2

Speaker 3 of 4
Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Mass, a Therapeutic Target or the Cards you are Dealt?


Thursday, April 10 | 5:00PM - 7:00PM
Mechanisms of Beta-Cell Failure In Disease and Possible Drug
Targets
This session is from Islets & Beta Cells

Room: Ballroom 2

Speaker 4 of 4
Jens Zehetner, ETH Zurich, Switzerland, Switzerland
Short Talk: Regulation of Insulin Secretion and Glucose Homeostasis by the pVHL-HIF1a Axis


Thursday, April 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird/Wasatch


Thursday, April 10 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 10 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 11 | 10:25AM - 10:25AM
Departure


*Session Chair.