Web Desc
Angiogenesis and Lymphangiogenesis in Cancer
Organizer(s): Lee M. Ellis and Luisa Iruela-Arispe
Date: January 06 - 11, 2009
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored by Genentech BioOncology, ImClone Systems Corporation and sanofi-aventis
For important information on the coronavirus, please click here
Summary of Meeting:
A concrete understanding of the mechanisms that regulate tumor angiogenesis has led to advances in the clinic; however multiple challenges remain. First, not all tumors or tumor types respond equally well to anti-VEGF therapy. And for those that do, many, if not all, eventually become refractory to anti-VEGF therapies. It is essential to understand the various factors that lead to the development and function of the neovascular network in tumors in order to improve therapies and identify predictive markers. In addition, understanding basic mechanisms of angiogenesis will lead to insights into other diseases where neovascularization is an important factor in the progression or resolution of the pathology. This symposium will provide a forum to discuss the current status of anti-angiogenic therapy, new insights into the molecular and morphologic abnormalities of the tumor vascular network, methods to investigate mechanisms of angiogenesis, the relationship of the tumor microenvironment to vascular and tumor stem cells, and elucidation of recently discovered mediators of angiogenesis.
Scholarship Deadline: September 15 2008
Discounted Abstract Deadline: September 15 2008
Abstract Deadline: October 9 2008
Discounted Registration Deadline: November 6 2008
We gratefully acknowledge additional support for this conference from:
Genentech BioOncology
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genzyme Corporation

Regeneron Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA135834-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 06 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Tuesday, January 06 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Tuesday, January 06 | 7:30PM - 8:30PM
Keynote Lecture
Room: Gallatin

Speaker 1 of 3
* Lee M. Ellis, University of Texas MD Anderson Cancer Center, USA

Tuesday, January 06 | 7:30PM - 8:30PM
Keynote Lecture
Room: Gallatin

Speaker 2 of 3
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Tuesday, January 06 | 7:30PM - 8:30PM
Keynote Lecture
Room: Gallatin

Speaker 3 of 3
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Angiogenesis in Cancer

Wednesday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Wednesday, January 07 | 8:00AM - 11:00AM
Current Clinical Status of Anti-Angiogenic Therapy for Cance
r

Room: Gallatin

Speaker 1 of 5
* Lee M. Ellis, University of Texas MD Anderson Cancer Center, USA
Anti-VEGF Therapy: Successes and Failures in the Clinic

Wednesday, January 07 | 8:00AM - 11:00AM
Current Clinical Status of Anti-Angiogenic Therapy for Cance
r

Room: Gallatin

Speaker 2 of 5
Axel Grothey, Mayo Clinic College of Medicine, USA
Clinical Toxicities of Anti-VEGF Therapy - Focus on Bevacizumab

Wednesday, January 07 | 8:00AM - 11:00AM
Current Clinical Status of Anti-Angiogenic Therapy for Cance
r

Room: Gallatin

Speaker 3 of 5
John V. Heymach, University of Texas MD Anderson Cancer Center, USA
Circulating Endothelial Precursors as Surrogate Markers of Activity of Anti-VEGF Therapy

Wednesday, January 07 | 8:00AM - 11:00AM
Current Clinical Status of Anti-Angiogenic Therapy for Cance
r

Room: Gallatin

Speaker 4 of 5
Emile E. Voest, University Medical Center Utrecht, Netherlands
Short Talk: Kinetics of Endothelial (Progenitor) Cell Release from the Bone Marrow in Patients Receiving Chemotherapy Predicts Response and Survival

Wednesday, January 07 | 8:00AM - 11:00AM
Current Clinical Status of Anti-Angiogenic Therapy for Cance
r

Room: Gallatin

Speaker 5 of 5
Mark A. Rosen, University of Pennsylvania, USA
Non-Invasive Imaging of the Tumor Vascular Phenotype in Humans Undergoing Anti-Vascular and Anti-Angiogenic Therapies

Wednesday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 07 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Wednesday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Wednesday, January 07 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 07 | 5:00PM - 7:00PM
Abnormalities of the Tumor Microvascular Network
Room: Gallatin

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Wednesday, January 07 | 5:00PM - 7:00PM
Abnormalities of the Tumor Microvascular Network
Room: Gallatin

Speaker 2 of 5
Laura E. Benjamin, ImClone Systems, USA
Akt Signaling in the Tumor Microenvironment

Wednesday, January 07 | 5:00PM - 7:00PM
Abnormalities of the Tumor Microvascular Network
Room: Gallatin

Speaker 3 of 5
David A. Cheresh, University of California, San Diego, USA
A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation

Wednesday, January 07 | 5:00PM - 7:00PM
Abnormalities of the Tumor Microvascular Network
Room: Gallatin

Speaker 4 of 5
Ombretta Salvucci, NCI, National Institutes of Health, USA
Short Talk: Requirement for EphrinB Activation in Mural Cells Association with Endothelial Cells during New Vessel Formation

Wednesday, January 07 | 5:00PM - 7:00PM
Abnormalities of the Tumor Microvascular Network
Room: Gallatin

Speaker 5 of 5
Robert S. Kerbel, Sunnybrook Research Institute, Canada
Rapid Systemic Induction of Proangiogenic/Vasculogenic Factors by Chemotherapy or Antiangiogenic Drugs: Implications for Tumor Progression and Response to Therapy

Wednesday, January 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Wednesday, January 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson/Madison


Thursday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 1 of 6
* Laura E. Benjamin, ImClone Systems, USA

Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 2 of 6
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Intracrine VEGF Signaling and Tumor Growth

Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 3 of 6
Raymond N. DuBois, Arizona State University, USA
Inflammatory Mediators and Tumor Progression

Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 4 of 6
Kristian Pietras, Lund University, Sweden
Exploring New Strategies to Target the Pro-Angiogenic Tumor Stroma

Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 5 of 6
Calvin Kuo, Stanford University, USA
Short Talk: Angiogenic Phenotypes of the Egfl7 Locus are Attributable to the Embedded MicroRNA miR-126

Thursday, January 08 | 8:00AM - 11:00AM
Tumor Angiogenesis, Inflammation and the Microenvironment
Room: Gallatin

Speaker 6 of 6
J. Silvio Gutkind, University of California, San Diego, USA
Semaphorin-Regulated Signaling Networks and Tumor-Induced Angiogenesis

Thursday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, January 08 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Thursday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Thursday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, January 08 | 5:00PM - 7:00PM
Vascular Stem and Progenitor Cells
Room: Gallatin

Speaker 1 of 5
* Robert S. Kerbel, Sunnybrook Research Institute, Canada

Thursday, January 08 | 5:00PM - 7:00PM
Vascular Stem and Progenitor Cells
Room: Gallatin

Speaker 2 of 5
Richard J. Gilbertson, University of Cambridge, UK
The Perivascular Niche for Tumor Stem Cells

Thursday, January 08 | 5:00PM - 7:00PM
Vascular Stem and Progenitor Cells
Room: Gallatin

Speaker 3 of 5
Robert Benezra, Memorial Sloan-Kettering Cancer Center, USA
Id Proteins and Vascular Mobilization

Thursday, January 08 | 5:00PM - 7:00PM
Vascular Stem and Progenitor Cells
Room: Gallatin

Speaker 4 of 5
Avner Adini, Children's Hospital, Boston, USA
Short Talk: Prominin-1/CD133, is More than a Marker of Premature Hematopoietic Cells

Thursday, January 08 | 5:00PM - 7:00PM
Vascular Stem and Progenitor Cells
Room: Gallatin

Speaker 5 of 5
M. Celeste Simon, University of Pennsylvania, USA
Hypoxia, HIF and Stem Cells

Thursday, January 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Thursday, January 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson/Madison


Friday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 1 of 6
* Robert Benezra, Memorial Sloan-Kettering Cancer Center, USA

Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 2 of 6
Barbara H. Garmy-Susini, University of California, San Diego, USA
Central Requirement for Integrin Signaling in Lymphangiogenesis and Metastasis

Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 3 of 6
Michael J. Detmar, ETH - Zürich, Switzerland
Molecular Control of Lymphangiogenesis

Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 4 of 6
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Collective Invasion and Radioresistance at the Tumor-Vessel Interface

Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 5 of 6
Yusuke Mizukami, Asahikawa Medical College, Japan
Short Talk: Hedgehog Signaling Regulates Angiogenesis in Pancreatic Cancer

Friday, January 09 | 8:00AM - 11:00AM
Tumor Lymphangiogenesis
Room: Gallatin

Speaker 6 of 6
Tuomas Tammela, Koch Institute for Integrative Cancer Research at MIT, USA
VEGFR-3 Pathway as a Target to Inhibit Angiogenesis, Lymphangiogenesis and Tumor Metastasis

Friday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Friday, January 09 | 11:00AM - 5:00PM
On Own for Lunch


Friday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Friday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Friday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Friday, January 09 | 5:00PM - 7:00PM
Imaging Angiogenesis: Histopathologic and Non-Invasive Imagi
ng of Live Animals

Room: Gallatin

Speaker 1 of 4
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Proteomic Imaging of Tumor Microenvironment and Angiogenesis in vivo for Enhancing Targeted Therapies

Friday, January 09 | 5:00PM - 7:00PM
Imaging Angiogenesis: Histopathologic and Non-Invasive Imagi
ng of Live Animals

Room: Gallatin

Speaker 2 of 4
Lily Wu, University of California, Los Angeles, USA
Functional Molecular Imaging of Prostate Cancer Lymphatic Metastasis

Friday, January 09 | 5:00PM - 7:00PM
Imaging Angiogenesis: Histopathologic and Non-Invasive Imagi
ng of Live Animals

Room: Gallatin

Speaker 3 of 4
Myunghwan Choi, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Dynamic Fluorescence Imaging for Multiparametric Measurement of Tumor Vasculature

Friday, January 09 | 5:00PM - 7:00PM
Imaging Angiogenesis: Histopathologic and Non-Invasive Imagi
ng of Live Animals

Room: Gallatin

Speaker 4 of 4
* Donald M. McDonald, University of California, San Francisco, USA
Imaging of Cellular Actions of Angiogenesis Inhibitors

Friday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Friday, January 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Jefferson/Madison


Saturday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Saturday, January 10 | 8:00AM - 11:00AM
Emerging Targets and Endothelial Cell Biology
Room: Gallatin

Speaker 1 of 5
* Gregory D. Plowman, Eli Lilly and Company, USA

Saturday, January 10 | 8:00AM - 11:00AM
Emerging Targets and Endothelial Cell Biology
Room: Gallatin

Speaker 2 of 5
Richard O. Hynes, Massachusetts Institute of Technology, USA
Cell-Matrix Interactions in Vascular Development

Saturday, January 10 | 8:00AM - 11:00AM
Emerging Targets and Endothelial Cell Biology
Room: Gallatin

Speaker 3 of 5
Hellmut G. Augustin, DKFZ & Heidelberg University, Germany
Angiopoietins and Tie-2

Saturday, January 10 | 8:00AM - 11:00AM
Emerging Targets and Endothelial Cell Biology
Room: Gallatin

Speaker 4 of 5
Beverly A. Teicher, Genzyme Corporation, USA
Endosialin/CD248: The Evolution of a Target

Saturday, January 10 | 8:00AM - 11:00AM
Emerging Targets and Endothelial Cell Biology
Room: Gallatin

Speaker 5 of 5
Napoleone Ferrara, University of California, San Diego, USA
Myeloid Dependent Tumor Angiogenesis and Bv8

Saturday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Saturday, January 10 | 11:00AM - 5:00PM
On Own for Lunch


Saturday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Saturday, January 10 | 5:00PM - 7:00PM
Notch Signaling
Room: Gallatin

Speaker 1 of 4
* Jan K. Kitajewski, Columbia University, USA
Notch Signaling in Tumor Angiogenesis

Saturday, January 10 | 5:00PM - 7:00PM
Notch Signaling
Room: Gallatin

Speaker 2 of 4
Nicholas W. Gale, Regeneron Pharmaceuticals Inc., USA
Targeting Tumor Microvasculature via the VEGF and Delta/Notch Pathways

Saturday, January 10 | 5:00PM - 7:00PM
Notch Signaling
Room: Gallatin

Speaker 3 of 4
Ji-Liang Li, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Short Talk: DLL4 Enhances Tumour Growth and Mediates Tumour Resistance to Anti-VEGF Therapy in vivo

Saturday, January 10 | 5:00PM - 7:00PM
Notch Signaling
Room: Gallatin

Speaker 4 of 4
Gregory D. Plowman, Eli Lilly and Company, USA
Contrasting Roles of VEGF and DLL4 in Vascular Biology

Saturday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Saturday, January 10 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson/Madison


Saturday, January 10 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson/Madison


Sunday, January 11 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.