Web Desc
The Many Faces of Ubiquitin
Organizer(s): Simona Polo, Christopher D. Lima and Vishva M. Dixit
Date: January 11 - 16, 2009
Location: Copper Mountain Resort, Copper Mountain, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
The ubiquitin (Ub) pathway controls many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death. The covalent attachment of Ub to proteins can alter their localization, activities, and ultimate fate. One of the most intriguing features of the ubiquitin pathway is its emerging involvement in functions not directly related to protein degradation. In addition, some half-dozen related ubiquitin-like (Ubl) proteins, such as SUMO, are also revealing themselves as regulators of numerous cellular pathways. The existence of this vast and dynamic array of Ub and Ubl signals raises the central question of how specificity is achieved during conjugation, recognition, and signal transduction. Indeed, the molecular requirements for generating and recognizing various Ub signals are poorly understood and form a central unresolved issue in the field. This meeting will focus attention on the biology associated with Ub/Ubl-mediated signal transduction, including its role in human disease and cancer. The goal of this meeting is to gather a diverse array of scientists, not just “ubiquitinologists”, but also biologists whose work has been touched in some way by ubiquitin or ubiquitin-like pathways. By bringing together scientists from different backgrounds who work on a wide range of systems that are regulated by Ub and Ubl conjugation, this meeting will create a fertile ground for exchange of ideas on non-conventional functions for Ub and Ubl proteins in signal transduction.
Scholarship Deadline: September 17 2008
Discounted Abstract Deadline: September 17 2008
Abstract Deadline: October 14 2008
Discounted Registration Deadline: November 11 2008
We gratefully acknowledge additional support for this conference from:
Boston Biochem, an R&D Systems Company
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company

ENZO LIFE SCIENCES INTERNATIONAL, INC.

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 11 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Sunday, January 11 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Sunday, January 11 | 7:30PM - 7:45PM
Opening Remarks

Speaker 1 of 1
* Vishva M. Dixit, Genentech, Inc., USA

Sunday, January 11 | 7:45PM - 8:45PM
The Cecile Pickart Memorial Lecture
Room: Big Horn B

Speaker 1 of 1
Daniel J. Finley, Harvard University, USA
Regulation of Substrate Processing by the Proteasome

Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 1 of 7
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 2 of 7
Vishva M. Dixit, Genentech, Inc., USA
Usp9x: A Stabilizing Deubiquitinase for Mcl-1

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 3 of 7
David O. Morgan, University of California, San Francisco, USA
Substrate Recognition by the Anaphase-Promoting Complex

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 4 of 7
J. Wade Harper, Harvard Medical School, USA
Genetic and Proteomic Analysis of the Ubiquitin System

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 5 of 7
Claudio A. P. Joazeiro, University of Heidelberg, Germany
Mitochondria and the Ubiquitin System

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 6 of 7
Sirio Dupont, University of Padova, Italy
Short Talk: A Deubiquitinating Enzyme Essential for TGFbeta Signaling Controls Smad4 Monoubiquitination

Monday, January 12 | 8:00AM - 11:15AM
Signal Transduction by Ub (I)
Room: Big Horn B

Speaker 7 of 7
Peter Kaiser, University of California, Irvine, USA
Short Talk: Inactivation of SCF by Signal-Induced Disassembly

Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, January 12 | 11:15AM - 1:00PM
Poster Setup
Room: Big Horn C


Monday, January 12 | 11:15AM - 11:15AM
On Own for Lunch


Monday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Monday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 1 of 6
* Ronald T. Hay, University of Dundee, UK

Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 2 of 6
Simona Polo, FIRC Institute of Molecular Oncology, Italy
Ubiquitin in Endocytosis and Signaling of EGFR

Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 3 of 6
Morag Park, McGill University, Canada
Met Receptor Tyrosine Kinase: Intracellular Trafficking, Signal Polarisation and Transformation

Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 4 of 6
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
and

Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 5 of 6
Ming Xu, University of Texas Southwestern Medical Center, USA
Ubiquitin in the NF-kappaB Pathway

Monday, January 12 | 5:00PM - 7:00PM
Signal Transduction by Ub (II)
Room: Big Horn B

Speaker 6 of 6
Mads Gyrd-Hansen, University of Oxford, UK
Short Talk: IAPs Contain an Evolutionarily Conserved Ubiquitin-Binding Domain that is Essential for NF-kappaB Regulation and Oncogenesis

Monday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Monday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Big Horn C


Tuesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 1 of 7
* Morag Park, McGill University, Canada

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 2 of 7
Raymond J. Deshaies, Amgen, Inc., USA
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 3 of 7
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Mechanisms and Specificity of NEDD8ylation

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 4 of 7
Anindya Dutta, University of Virginia, USA
CRL4-Cdt2 in the Maintenance of Genome Stability

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 5 of 7
Jonathon Pines, University of Cambridge, UK
Short Talk: How is the APC/C-Cdc20 Complex Regulated in Mitosis?

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 6 of 7
Yang Xie, Yale University, USA
Short Talk: Proteolytic Regulation of the Yeast MATalpha2 Transcription Factor by a SUMO-Targeted Ubiquitin Ligase (STUbL)

Tuesday, January 13 | 8:00AM - 11:15AM
Enzymes Regulation
Room: Big Horn B

Speaker 7 of 7
R. Andrew Byrd, NCI, National Institutes of Health, USA
Short Talk: Allosteric Activation of Ubiquitin Ligase Activity by a Novel E2 Binding Region

Tuesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, January 13 | 11:15AM - 1:00PM
Poster Setup
Room: Big Horn C


Tuesday, January 13 | 11:15AM - 11:15AM
On Own for Lunch


Tuesday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 1 of 6
* Paul W. Sheppard, Vacye Associates Limited, UK
State of the Art

Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 2 of 6
Christopher Tsu, Takeda Pharmaceuticals International Co., USA
Development of a Novel Charcoal Paper ATP: Pyrophosphate Exchange Assay: Kinetic Characterization of NEDD8 Activating Enzyme

Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 3 of 6
Karen M. Kleman-Leyer, Bellbrook Labs, USA
Monitoring AMP Flux through the SUMOylation Cascade Using the Transcreener AMP/GMP Assay

Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 4 of 6
Michael H. Tatham, University of Dundee, UK
System-Wide Analysis of Changes to the SUMO Proteome in Response to External Stimuli

Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 5 of 6
Paul S. Andrews, Amgen Inc, USA
Identification of SMURF1 Substrates Utilizing Protein Microarrays

Tuesday, January 13 | 2:30PM - 4:30PM
Workshop 1: Tools and Reagents Development
Room: Big Horn B

Speaker 6 of 6
Birte Kalveram, University of Constance, Germany
Generation and Characterization of Monoclonal Antibodies Against the Ubiquitin-Like Modifier FAT10

Tuesday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Tuesday, January 13 | 5:00PM - 7:00PM
Various Chains, Various Signals
Room: Big Horn B

Speaker 1 of 4
* Raymond J. Deshaies, Amgen, Inc., USA

Tuesday, January 13 | 5:00PM - 7:00PM
Various Chains, Various Signals
Room: Big Horn B

Speaker 2 of 4
Kazuhiro Iwai, Osaka University, Japan
Physiological Function of Linear Polyubiquitin Chains

Tuesday, January 13 | 5:00PM - 7:00PM
Various Chains, Various Signals
Room: Big Horn B

Speaker 3 of 4
Michael Rape, University of California, Berkeley, USA
The Assembly of K11-linked Ubiquitin Chains during Mitosis

Tuesday, January 13 | 5:00PM - 7:00PM
Various Chains, Various Signals
Room: Big Horn B

Speaker 4 of 4
Junmin Peng, Emory University, USA
Analysis of Ubiquitinated Proteins and PolyUb Linkages by Quantitative Mass Spectrometry

Tuesday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Tuesday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Big Horn C


Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 1 of 7
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 2 of 7
Ivan Dikic, Goethe University Medical School, Germany
Specificity in UbiquitinSignaling Networks

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 3 of 7
Kylie J. Walters, NCI, National Institutes of Health, USA
The Proteasome‘s Ubiquitin Receptors

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 4 of 7
Heran Darwin, New York University School of Medicine, USA
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 5 of 7
Frauke Melchior, Universität Heidelberg, Germany
Characterisation of the RanBP2 / RanGAP1*SUMO1 E3 Ligase Complex

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 6 of 7
Christian D. Schlieker, Whitehead Institute for Biomedical Research, USA
Short Talk: A Functional Proteomics Approach Links the Ubiquitin-Related Modifier Urm1 to a RNA Modification Pathway

Wednesday, January 14 | 8:00AM - 11:15AM
UBDs and UBLs Function and Specificity
Room: Big Horn B

Speaker 7 of 7
Kate E. Stoll, University of Washington, USA
Short Talk: Interaction of the E2s yeast Ubc4 and Human UbcH5 with Ub: Functional Consequence.

Wednesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Wednesday, January 14 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Big Horn C


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 1 of 7
* Ron R. Kopito, Stanford University, USA
Ubiquitin Homeostasis on the Edge: Lessons from Polyubiquitin Knockout Mice

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 2 of 7
Pengbo Zhou, Weill Cornell Medical College, USA
CULLIN 4A Knockout Mice

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 3 of 7
Nicholas John van Buuren, Stanford University, USA
A Novel Family Of Viral Ankyrin/F-Box Proteins Interact With The SCF Complex

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 4 of 7
Maud Demarque, Pasteur Institute, France
A Mouse Model for the Study of Sumo E2 Function

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 5 of 7
Michael R. Kuehn, National Cancer Institute, National Institutes of Health, USA
Loss of SUMO-1 in Mice is not Lethal Due to Compensation by SUMO-2/3

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 6 of 7
Jongdae Lee, University of California, San Diego, USA
STAT3 Maintains Intestinal Epithelial Barrier by Induction of Ubiquitin-Mediated Degradation of SNAI

Wednesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Animal Models
Room: Big Horn B

Speaker 7 of 7
Birgit Aerne, Cancer Research UK, UK
A Uiquitin-Related RNAi Screen in Drosophila

Wednesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Wednesday, January 14 | 5:00PM - 7:00PM
Signal Transduction by UbIs
Room: Big Horn B

Speaker 1 of 5
* Frauke Melchior, Universität Heidelberg, Germany

Wednesday, January 14 | 5:00PM - 7:00PM
Signal Transduction by UbIs
Room: Big Horn B

Speaker 2 of 5
Deborah J. Lenschow, Washington University School of Medicine, USA
Regulation of the Host Antiviral Response by ISG15

Wednesday, January 14 | 5:00PM - 7:00PM
Signal Transduction by UbIs
Room: Big Horn B

Speaker 3 of 5
Edward T.H. Yeh, University of Texas MD Anderson Cancer Center, USA
Role of Sentrin/SUMO-Specific Protease 1 (SENP1) in Angiogenesis

Wednesday, January 14 | 5:00PM - 7:00PM
Signal Transduction by UbIs
Room: Big Horn B

Speaker 4 of 5
Ronald T. Hay, University of Dundee, UK
Regulation of Promyelocytic Leukaemia Protein by SUMO

Wednesday, January 14 | 5:00PM - 7:00PM
Signal Transduction by UbIs
Room: Big Horn B

Speaker 5 of 5
Michael N. Boddy, The Scripps Research Institute, USA
Short Talk: New Interactions of SUMO Pathway Enzymes in Genome Stability

Wednesday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Big Horn C


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 1 of 7
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 2 of 7
Ingrid E. Wertz, Genentech, Inc., USA
Ubiquitin Editing

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 3 of 7
Marcus Groettrup, University of Konstanz, Germany
The Role of FAT10 in Cancer

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 4 of 7
Lawrence R. Dick, USA
Targeting the NEDD8 Conjugation Pathway for Cancer Chemotherapy

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 5 of 7
Roger Greenberg, University of Pennsylvania, USA
Ubiquitin Recognition and Turnover in BRCA1-Dependent DNA Repair and Tumor Suppression

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 6 of 7
Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The Fbw7 E3 Ubiquitin Ligase Controls Hematopoietic Stem Cell Self-Renewal and Transformation

Thursday, January 15 | 8:00AM - 11:15AM
Ubiquitin and UbIs in Cancer
Room: Big Horn B

Speaker 7 of 7
Lian Li, Emory University School of Medicine, USA
Short Talk: Parkin-Mediated Ubiquitin Signaling in Regulation of the Aggresome-Autophagy Pathway

Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Thursday, January 15 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Thursday, January 15 | 5:00PM - 6:25PM
Regulation by Ub and UbIs in the Nucleus
Room: Big Horn B

Speaker 1 of 4
* Edward T.H. Yeh, University of Texas MD Anderson Cancer Center, USA

Thursday, January 15 | 5:00PM - 6:25PM
Regulation by Ub and UbIs in the Nucleus
Room: Big Horn B

Speaker 2 of 4
Jesper Q. Svejstrup, Francis Crick Institute, UK
Ubiquitylation of RNA Polymerase II

Thursday, January 15 | 5:00PM - 6:25PM
Regulation by Ub and UbIs in the Nucleus
Room: Big Horn B

Speaker 3 of 4
Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Regulation of DNA Repair by Monoubiquitination

Thursday, January 15 | 5:00PM - 6:25PM
Regulation by Ub and UbIs in the Nucleus
Room: Big Horn B

Speaker 4 of 4
Valentina Perissi, Boston University School of Medicine, USA
Short Talk: Dismissal of Distinct Corepressor Complexes from Regulated Gene Promoters is Regulated by Specific Phosphorylation of the TBL1 and TBLR1 Exchange Factors

Thursday, January 15 | 6:25PM - 7:15PM
Translational Research Lecture
Room: Big Horn B

Speaker 1 of 1
Giulio F. Draetta, University of Texas MD Anderson Cancer Center, USA
Druggable Targets in the Ubiquitin Field

Thursday, January 15 | 7:15PM - 7:30PM
Closing Remarks

Speaker 1 of 1
Simona Polo, FIRC Institute of Molecular Oncology, Italy

Thursday, January 15 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Kokopelli's


Thursday, January 15 | 8:30PM - 11:30PM
Entertainment
Room: Big Horn C


Thursday, January 15 | 8:30PM - 11:30PM
Cash Bar
Room: Big Horn C


Friday, January 16 | 10:25AM - 10:25AM
Departure


*Session Chair.