Web Desc
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota
Organizer(s): R. Balfour Sartor, Lloyd F. Mayer, Charles O. Elson and Scott Plevy
Date: January 13 - 18, 2009
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Directors' Fund
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Summary of Meeting:
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.
Scholarship Deadline: September 18 2008
Discounted Abstract Deadline: September 18 2008
Abstract Deadline: October 15 2008
Discounted Registration Deadline: November 13 2008
We gratefully acknowledge additional support for this conference from:
Crohn
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Schering-Plough Research Institute
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell PressUnited European Gastroenterology Federation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079896-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 13 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, January 13 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Ballroom 2


Tuesday, January 13 | 7:30PM - 8:00PM
Welcoming Remarks
Room: Chamisa Ballroom 2

Speaker 1 of 1
R Balfour Balfour Sartor, University of North Carolina - Chapel Hill, USA
Welcoming Remarks: An Overview of the Intestinal Microbiota and Mechanisms of Host/ Microbial Interactions

Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 1 of 7
* Lloyd F. Mayer, Mount Sinai Medical Center, USA

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 2 of 7
Scott Plevy, Janssen, USA
Protective Role of Heme Oxygenase and PI3 Kinase Isoforms

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 3 of 7
Maria T. Abreu, University of Miami, Miller School of Medicine, USA
Mucosal TLR Regulation of Epithelial Integrity and Malignancy

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 4 of 7
Eyal Raz, University of California, San Diego, USA
Gut, Germs and Genes: The Tumorigenic Triad

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 5 of 7
Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 6 of 7
Sergio A. Lira, Mount Sinai School of Medicine, USA
Short Talk: TLRs, Chemokines and Intestinal Homeostasis

Wednesday, January 14 | 8:00AM - 11:15AM
Protective Role of Innate Mucosal Immune Responses to Commen
sal Microbiota

Room: Chamisa Ballroom 1

Speaker 7 of 7
Nouara Lhocine, Institut Pasteur, France
Short Talk: PIMS Modulates Immune Tolerance to Commensal Bacteria by Regulating Drosophila Imd Pathway

Wednesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, January 14 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Maria T. Abreu, University of Miami, Miller School of Medicine, USA

Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 2 of 6
Christian Jobin, University of Florida, USA
Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System

Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 3 of 6
Averil I. Ma, University of California, San Francisco, USA
Ubiquitin and Innate Immunity: ABIN-1 and TNF Responses

Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 4 of 6
Maria del Carmen Alonso Cotoner, Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors

Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 5 of 6
Wen Zhou, University of Texas Southwestern Medical Center, USA
Short Talk: Deletion of FoxO4 Elevates Susceptibility of Mice to Trinitrobenzene Sulfonic Acid-Induced Colitis

Wednesday, January 14 | 5:00PM - 7:00PM
Activation and Regulation of Mucosal NF-kappaB
Room: Chamisa Ballroom 1

Speaker 6 of 6
Jun Sun, University of Rochester, USA
Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation

Wednesday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 1 of 7
* R Balfour Balfour Sartor, University of North Carolina - Chapel Hill, USA

Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 2 of 7
Ramnik Xavier, Massachusetts General Hospital, USA
Autophagy – Defender of the Cytoplasm

Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 3 of 7
Jan Wehkamp, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Germany
Antimicrobial Host Defense: from Epithelial Stem Cells to Chronic Inflammation

Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 4 of 7
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Innate Defense of Gut Epithelial Surfaces

Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 5 of 7
Arlette Darfeuille-Michaud, Université d'Auvergne, France
Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation

Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 6 of 7
Ye Yang, University of Oregon, USA
Short Talk: IAP (Intestinal Alkaline Phosphatase) Up-Regulated by LPS Detoxifies LPS to Prevent Inflammation in Response to the Gut Microbiota


Thursday, January 15 | 8:00AM - 11:15AM
Mechanisms of Bacterial Killing by Epithelial and Phagocytic
Cells

Room: Chamisa Ballroom 1

Speaker 7 of 7
Ajay S. Gulati, University of North Carolina, Chapel Hill, USA
Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression

Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, January 15 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Scott Plevy, Janssen, USA

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 2 of 7
Hans-Christian Reinecker, Massachusetts General Hospital, USA
Dendritic Cell Function at the Mucosal Surfaces

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 3 of 7
Peter Velázquez, Indiana University School of Medicine - South Bend, USA
Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 4 of 7
Jacqueline Perrigoue, University of Pennsylvania, USA
Short Talk: Delineating Requirements for Antigen Presentation in the Intestine: Dendritic Cells and Beyond

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 5 of 7
Ting Feng, Harvard Medical School, USA
Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 6 of 7
R. William DePaolo, University of Washington, USA
Short Talk: Regulation of Intestinal Immunity to Yersinia Enterocolitica by TLR1&TLR6

Thursday, January 15 | 5:00PM - 7:00PM
Dendritic Cell Function at Mucosal Surfaces
Room: Chamisa Ballroom 1

Speaker 7 of 7
InYoung Kim, University of Chicago, USA
Short Talk: The Role of Hsp70 in Intestinal Immune Homeostasis

Thursday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Charles O. Elson, University of Alabama, USA

Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 2 of 7
Casey T. Weaver, University of Alabama at Birmingham, USA
Late Plasticity in Th17 Development: a Basis for Revised Models of Intestinal Inflammtion

Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 3 of 7
Fiona M. Powrie, University of Oxford, UK
IL-23 and Intestinal Homeostasis

Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 4 of 7
Bana Jabri, University of Chicago, USA
Innate-Mediated Tolerance by TLR6: a Journey from Yersinia Pestis in the Gut

Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 5 of 7
Jesús Rivera-Nieves, Inflammatory Bowel Disease Center, USA
Recruitment of T Cells to Chronically Inflamed Small Intestine

Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 6 of 7
Anisa S. Ismail, Princeton University, USA
Short Talk: Reciprocal Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury


Friday, January 16 | 8:00AM - 11:15AM
Effector T Cell Responses in Intestinal Inflammation
Room: Chamisa Ballroom 1

Speaker 7 of 7
Kim Phung Le Nguyen, University of California, San Diego, USA
Short Talk: Induction of Th17: Is It too Early for a Paradigm?

Friday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, January 16 | 11:15AM - 11:15AM
On Own for Lunch


Friday, January 16 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, January 16 | 5:00PM - 7:00PM
Microbial Activation of Immune-Mediated Intestinal Inflammat
ion

Room: Chamisa Ballroom 1

Speaker 1 of 5
* Casey T. Weaver, University of Alabama at Birmingham, USA

Friday, January 16 | 5:00PM - 7:00PM
Microbial Activation of Immune-Mediated Intestinal Inflammat
ion

Room: Chamisa Ballroom 1

Speaker 2 of 5
Charles O. Elson, University of Alabama, USA
Flagellin-Specific T Cell Responses in Experimental Colitis

Friday, January 16 | 5:00PM - 7:00PM
Microbial Activation of Immune-Mediated Intestinal Inflammat
ion

Room: Chamisa Ballroom 1

Speaker 3 of 5
Sandra Kim, University of North Carolina, Chapel Hill, USA
Functional Characteristics of Escherichia Coli in Immune-Mediated Experimental Colitis

Friday, January 16 | 5:00PM - 7:00PM
Microbial Activation of Immune-Mediated Intestinal Inflammat
ion

Room: Chamisa Ballroom 1

Speaker 4 of 5
Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA
The Role of Alphaproteobacteria in the Induction of Autoimmunity

Friday, January 16 | 5:00PM - 7:00PM
Microbial Activation of Immune-Mediated Intestinal Inflammat
ion

Room: Chamisa Ballroom 1

Speaker 5 of 5
Wendy S. Garrett, Harvard School of Public Health, USA
Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System

Friday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Friday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Saturday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 1 of 6
* Bana Jabri, University of Chicago, USA

Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 2 of 6
Craig L. Maynard, University of Alabama at Birmingham, USA
Development of Gut-Protective Regulatory T Cells

Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 3 of 6
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Tregs and Th17 Cells: Role of Induction and Regulation of Tissue Inflammation

Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 4 of 6
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Modulation of Foxp3+ Regulatory T Cells by Microbes

Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 5 of 6
William A. Faubion, Mayo Clinic, USA
PRR Inhibition of Treg Apoptosis and the Pathigenesis of Crohn’s Disease

Saturday, January 17 | 8:00AM - 11:15AM
Regulation of Mucosal Immune Response to Microbial Component
s

Room: Chamisa Ballroom 1

Speaker 6 of 6
Betsy C. Taylor, University of Pennsylvania, USA
Short Talk: TSLP Regulates Intestinal Immunity and Inflammation

Saturday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, January 17 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, January 17 | 5:00PM - 7:00PM
Translation of Basic Research to Biomedical Applications
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Scott Plevy, Janssen, USA

Saturday, January 17 | 5:00PM - 7:00PM
Translation of Basic Research to Biomedical Applications
Room: Chamisa Ballroom 1

Speaker 2 of 5
Rene de Waal Malefyt, Merck Research Labs, USA
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

Saturday, January 17 | 5:00PM - 7:00PM
Translation of Basic Research to Biomedical Applications
Room: Chamisa Ballroom 1

Speaker 3 of 5
Kevan C. Herold, Yale University, USA
Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody

Saturday, January 17 | 5:00PM - 7:00PM
Translation of Basic Research to Biomedical Applications
Room: Chamisa Ballroom 1

Speaker 4 of 5
Huabao Xiong, Mount Sinai School of Medicine, USA
Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis

Saturday, January 17 | 5:00PM - 7:00PM
Translation of Basic Research to Biomedical Applications
Room: Chamisa Ballroom 1

Speaker 5 of 5
Edwin F. de Zoeten, Children's Hospital of Philadelphia, USA
Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models

Saturday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, January 18 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.