Web Desc
Mechanotransduction in Physiology and Disease
Organizer(s): Martin A. Schwartz, Alpha Yap and Christopher S. Chen
Date: January 18 - 23, 2009
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Directors' Fund
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Summary of Meeting:
Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; and (2) to foster multidisciplinary interactions. The meeting will address major mechanistic questions in the context of relevant clinical problems, integrating engineering/biophysics, cell biology, and physiology/disease into each session whenever possible.
Scholarship Deadline: September 18 2008
Discounted Abstract Deadline: September 18 2008
Abstract Deadline: October 21 2008
Discounted Registration Deadline: November 18 2008
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Cell Press
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 18 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Sunday, January 18 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Sunday, January 18 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Martin Lee Chalfie, Columbia University, USA
A Protein-Lipid Complex Transduces Touch in C. elegans

Sunday, January 18 | 8:30PM - 9:00PM
Orientation for New Attendees and New Investigators
Room: Chamisa Ballroom I


Monday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, January 19 | 8:00AM - 11:00AM
Atherosclerosis and Flow
Room: Chamisa Ballroom 1

Speaker 1 of 5
Bradford C. Berk, University of Rochester Medical Center, USA
Atheroprotective Mechanisms Activated by Flow

Monday, January 19 | 8:00AM - 11:00AM
Atherosclerosis and Flow
Room: Chamisa Ballroom 1

Speaker 2 of 5
Hanjoong Jo, Emory University, USA
Flow Regulation of Vascular Inflammation and Atherosclerosis by the BMP4 and BMPRII Signaling Axis

Monday, January 19 | 8:00AM - 11:00AM
Atherosclerosis and Flow
Room: Chamisa Ballroom 1

Speaker 3 of 5
Stephanie Lehoux, McGill University - Jewish General Hospital, Canada
Pro-and Anti-atherosclerotic Signaling in Whole Vessels

Monday, January 19 | 8:00AM - 11:00AM
Atherosclerosis and Flow
Room: Chamisa Ballroom 1

Speaker 4 of 5
Benoit Ladoux, University Paris Diderot, France
Short Talk: A Useful Tool for Studying Cell Forces and Transmigration Mechanisms

Monday, January 19 | 8:00AM - 11:00AM
Atherosclerosis and Flow
Room: Chamisa Ballroom 1

Speaker 5 of 5
* Martin Schwartz, Yale School of Medicine, USA
Measuring Forces across Specific Molecules

Monday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Monday, January 19 | 11:00AM - 11:00AM
On Own for Lunch


Monday, January 19 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, January 19 | 5:00PM - 7:00PM
Osteoporosis and Bone
Room: Chamisa Ballroom 1

Speaker 1 of 4
Charles H. Turner, Indiana University-Purdue University Indianapolis, USA
Mechanobiology of the Skeleton

Monday, January 19 | 5:00PM - 7:00PM
Osteoporosis and Bone
Room: Chamisa Ballroom 1

Speaker 2 of 4
Sheldon Weinbaum, City College of New York, USA
How Do Bone Cells Feel? Flow Induced Mechanotransduction in Osteocytes

Monday, January 19 | 5:00PM - 7:00PM
Osteoporosis and Bone
Room: Chamisa Ballroom 1

Speaker 3 of 4
Olivier Collin, Curie Institute, France
Short Talk: Self-Organized Podosomes Are Dynamic Mechanosensors

Monday, January 19 | 5:00PM - 7:00PM
Osteoporosis and Bone
Room: Chamisa Ballroom 1

Speaker 4 of 4
* Lynda F. Bonewald, University of Missouri-Kansas City School of Dentistry, USA
Osteocytes, Mechanotransduction, and Osteoporosis

Monday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Monday, January 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Tuesday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, January 20 | 8:00AM - 11:00AM
Hypertension and Stretch
Room: Chamisa Ballroom 1

Speaker 1 of 4
Steffen-Sebastian Bolz, University of Toronto, Canada
Regulation of Sphingosine-1-Phosphate Signaling as a Key Element of the Myogenic Response

Tuesday, January 20 | 8:00AM - 11:00AM
Hypertension and Stretch
Room: Chamisa Ballroom 1

Speaker 2 of 4
Jeffrey J. Fredberg, Harvard School of Public Health, USA
Missing the Signal: Force, Fluidization, and Physical Biology

Tuesday, January 20 | 8:00AM - 11:00AM
Hypertension and Stretch
Room: Chamisa Ballroom 1

Speaker 3 of 4
Kimberly P. Gannon, University of Mississippi Medical Center, USA
Short Talk: ASIC2 Protein is Required for Pressure-Induced Constriction in Mouse Renal Interlobar Artery

Tuesday, January 20 | 8:00AM - 11:00AM
Hypertension and Stretch
Room: Chamisa Ballroom 1

Speaker 4 of 4
* Heather A. Drummond, University of Mississippi Medical Center, USA
Role of the ENaC Proteins in Vascular Smooth Muscle Sensing

Tuesday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, January 20 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, January 20 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, January 20 | 5:00PM - 7:15PM
Transmembrane Receptors in Force Transduction
Room: Chamisa Ballroom 1

Speaker 1 of 5
Alexander Bershadsky, Weizmann Institute of Science, Israel
Forces and Force-sensation in the Crosstalk between Cell Adhesion and the Actin Cytoskeleton

Tuesday, January 20 | 5:00PM - 7:15PM
Transmembrane Receptors in Force Transduction
Room: Chamisa Ballroom 1

Speaker 2 of 5
Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
The Shaping of Cells by Force and Rigidity through Protein Stretching

Tuesday, January 20 | 5:00PM - 7:15PM
Transmembrane Receptors in Force Transduction
Room: Chamisa Ballroom 1

Speaker 3 of 5
Cheng Zhu, Georgia Institute of Technology, USA
Short Talk: Can Catch Bonds Provide a Mechanosensing Mechanism for Integrins?

Tuesday, January 20 | 5:00PM - 7:15PM
Transmembrane Receptors in Force Transduction
Room: Chamisa Ballroom 1

Speaker 4 of 5
Deborah E. Leckband, University of Illinois at Urbana-Champaign, USA
Adhesion and Mechanosensing at Cell-Cell Junctions

Tuesday, January 20 | 5:00PM - 7:15PM
Transmembrane Receptors in Force Transduction
Room: Chamisa Ballroom 1

Speaker 5 of 5
* Alpha Yap, Institute for Molecular Bioscience, Australia
Cadherins and Myosins: Regulating the Cortical Actin Cytoskeletal at Cell-Cell Adhesions

Tuesday, January 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Tuesday, January 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Wednesday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, January 21 | 8:00AM - 11:00AM
Hearing, Touch and Ion Channels
Room: Chamisa Ballroom 1

Speaker 1 of 5
Jeffrey R. Holt, Boston Children's Hospital, USA
Transduction and Adaptation in Mechanosensory Hair Cells of the Mouse Inner Ear

Wednesday, January 21 | 8:00AM - 11:00AM
Hearing, Touch and Ion Channels
Room: Chamisa Ballroom 1

Speaker 2 of 5
Owen P. Hamill, University of Texas Medical Branch, USA
Role of Stretch Activated Channels and TRPC channels in Prostate Cancer and Cell Migration

Wednesday, January 21 | 8:00AM - 11:00AM
Hearing, Touch and Ion Channels
Room: Chamisa Ballroom 1

Speaker 3 of 5
Valeria Vásquez, University of Chicago, USA
Structural Basis of Gating in Prokaryotic Mechanosensitive Channels

Wednesday, January 21 | 8:00AM - 11:00AM
Hearing, Touch and Ion Channels
Room: Chamisa Ballroom 1

Speaker 4 of 5
Ginger L. Hunter, Duke University, USA
Short Talk: Mechanically Gated Ion Channels in Drosophila Morphogenesis

Wednesday, January 21 | 8:00AM - 11:00AM
Hearing, Touch and Ion Channels
Room: Chamisa Ballroom 1

Speaker 5 of 5
* Miriam Goodman, Stanford University School of Medicine, USA
A Tale of Mechanoreceptor Neurons and Two Mechanotransduction Channels

Wednesday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, January 21 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 21 | 5:00PM - 7:00PM
Development and Differentiation
Room: Chamisa Ballroom 1

Speaker 1 of 4
Dennis E. Discher, University of Pennsylvania, USA
Forces, Matrix and Stem Cell Differentiation Kinetics

Wednesday, January 21 | 5:00PM - 7:00PM
Development and Differentiation
Room: Chamisa Ballroom 1

Speaker 2 of 4
Emmanuel Farge, Institut Curie, France
Mechanical Cues in Development

Wednesday, January 21 | 5:00PM - 7:00PM
Development and Differentiation
Room: Chamisa Ballroom 1

Speaker 3 of 4
Rodrigo Fernandez-Gonzalez, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Actomyosin Cables Promote Directional Cell Behaviors during Axis Elongation

Wednesday, January 21 | 5:00PM - 7:00PM
Development and Differentiation
Room: Chamisa Ballroom 1

Speaker 4 of 4
* Douglas W. DeSimone, University of Virginia, USA
Adhesions-Dependent Mechanosensitive Cell Signaling and the Regulation of Morphogenesis

Wednesday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, January 22 | 8:00AM - 11:00AM
Matrix, Force Transduction and Disease
Room: Chamisa Ballroom 1

Speaker 1 of 5
Yingxiao Wang, University of California, San Diego, USA
Live-Cell Imaging of Signaling Transduction in MechanoBiology

Thursday, January 22 | 8:00AM - 11:00AM
Matrix, Force Transduction and Disease
Room: Chamisa Ballroom 1

Speaker 2 of 5
Melody A. Swartz, University of Chicago, USA
Mechano-Chemical Signal Integration in Lymphatic Transport Function

Thursday, January 22 | 8:00AM - 11:00AM
Matrix, Force Transduction and Disease
Room: Chamisa Ballroom 1

Speaker 3 of 5
Viola Vogel, ETH, Swiss Federal Institute of Technology, Switzerland
Fibronectin as a Mechanotransducer

Thursday, January 22 | 8:00AM - 11:00AM
Matrix, Force Transduction and Disease
Room: Chamisa Ballroom 1

Speaker 4 of 5
Shang-You Tee, University of Pennsylvania, USA
Short Talk: Establishing the Mechanism of Substrate Rigidity Sensing

Thursday, January 22 | 8:00AM - 11:00AM
Matrix, Force Transduction and Disease
Room: Chamisa Ballroom 1

Speaker 5 of 5
* Valerie M. Weaver, University of California, San Francisco, USA
Matrix-Crosslinking, Mechanotransduction and Tumor Progression

Thursday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, January 22 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, January 22 | 5:00PM - 7:00PM
Cytoskeletal and Nuclear Events in Mechanotransduction
Room: Chamisa Ballroom 1

Speaker 1 of 4
Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Tensegrity and Mechanotransduction

Thursday, January 22 | 5:00PM - 7:00PM
Cytoskeletal and Nuclear Events in Mechanotransduction
Room: Chamisa Ballroom 1

Speaker 2 of 4
Jan Lammerding, Cornell University, USA
The Role of Nuclear Mechanisms and Nuclear Mechanical Coupling in Human Disease

Thursday, January 22 | 5:00PM - 7:00PM
Cytoskeletal and Nuclear Events in Mechanotransduction
Room: Chamisa Ballroom 1

Speaker 3 of 4
Chao-Min Cheng, Carnegie Mellon University, USA
Short Talk: Probing Mechanotransduction through Syndecan-4 using Surface Modified Elastomeric Matrices

Thursday, January 22 | 5:00PM - 7:00PM
Cytoskeletal and Nuclear Events in Mechanotransduction
Room: Chamisa Ballroom 1

Speaker 4 of 4
* Christopher S. Chen, Boston University, USA
Mechanotransduction at the Cellular and Multi-Cellular Level

Thursday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, January 22 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Thursday, January 22 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Friday, January 23 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.