Web Desc
Multiple Sclerosis
Organizer(s): James L. Salzer, Anne H. Cross and John Fleming
Date: January 21 - 26, 2009
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by the National Multiple Sclerosis Society
Summary of Meeting:
Despite important recent progress, the etiology of Multiple Sclerosis (MS) remains unknown and important therapeutic needs are unmet. This conference will discuss advances in basic pathogenetic mechanisms and emergent therapies for MS. Emphasis will be on the immunopathogenesis of MS, including mechanisms of lymphocyte activation and trafficking across the blood brain barrier, on sources of axonal pathology, and genetic risk factors. New imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. An important challenge in MS research is to integrate emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.
Scholarship Deadline: September 24 2008
Discounted Abstract Deadline: September 24 2008
Abstract Deadline: October 24 2008
Discounted Registration Deadline: November 21 2008
We gratefully acknowledge additional support for this conference from:
National Multiple Sclerosis Society
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Elan Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS063455-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, January 21 | 3:00PM - 7:30PM
Registration
Room: Promenade


Wednesday, January 21 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Wednesday, January 21 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa Ballroom

Speaker 1 of 1
Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Role of the Innate Immune System in Multiple Sclerosis

Wednesday, January 21 | 8:30PM - 9:00PM
Orientation for New Attendees and New Investigators
Room: Mesa Ballroom
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.

Thursday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 1 of 6
* John Fleming, University of Wisconsin, Madison, USA
Overview of MS and Major Challenges; and The Hygiene Hypothesis and Multiple Sclerosis

Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 2 of 6
Alberto Ascherio, Harvard School of Public Health, USA
Epidemiology of MS: Could MS be Prevented?

Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 3 of 6
Claudia Lucchinetti, Mayo Clinic, USA
Evolution of Pathogenic Concepts in Multiple Sclerosis

Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 4 of 6
Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland
Short Talk: Characterization of Molecular Alterations in Normal Appearing Grey Matter of Multiple Sclerosis Brain Tissues

Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 5 of 6
Stephen D. Miller, Northwestern University Medical School, USA
Pathogenic Mechanisms and Regulation of Susceptibility/Resistance to Theiler’s Virus-Induced Demyelination by CD4+CD25+ Regulatory T Cells

Thursday, January 22 | 8:00AM - 11:15AM
Pathogenetic Mechanisms of Demyelination and MS
Room: Mesa Ballroom

Speaker 6 of 6
Alison L. Christy, Northwestern University, USA
Short Talk: Mast Cells Regulate BBB Permeability in EAE

Thursday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, January 22 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, January 22 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa/Ortiz


Thursday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa/Ortiz


Thursday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, January 22 | 5:00PM - 7:00PM
Biology and Pathobiology of the Myelinated Axon
Room: Mesa Ballroom

Speaker 1 of 4
* James L. Salzer, New York University School of Medicine, USA
Assembly and Molecular Architecture of Myelinated Axons

Thursday, January 22 | 5:00PM - 7:00PM
Biology and Pathobiology of the Myelinated Axon
Room: Mesa Ballroom

Speaker 2 of 4
Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany
An Emerging Role of Oligodendrocytes in Maintaining Axonal Integrity

Thursday, January 22 | 5:00PM - 7:00PM
Biology and Pathobiology of the Myelinated Axon
Room: Mesa Ballroom

Speaker 3 of 4
Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA
Mechanisms of Axonal Degeneration in Chronic MS Lesions

Thursday, January 22 | 5:00PM - 7:00PM
Biology and Pathobiology of the Myelinated Axon
Room: Mesa Ballroom

Speaker 4 of 4
Volker Siffrin, Charité University Medicine Berlin, Germany
Short Talk: Intravital Imaging of Immune-Neuronal Interaction in Experimental Autoimmune Encephalomyelitis

Thursday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Thursday, January 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa/Ortiz


Friday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Friday, January 23 | 7:00AM - 8:00AM
Poster Setup
Room: Chamisa/Ortiz


Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 1 of 6
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
T-regs and Th17 Cells: Role in Induction and Regulation of Tissue Inflammation

Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 2 of 6
Zsuzsanna Fabry, University of Wisconsin, USA
Short Talk: Intracerebral Dendritic Cells Modulate Encephalitogenic Versus Regulatory Immune Responses in the CNS

Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 3 of 6
Dan R. Littman, HHMI/New York University School of Medicine, USA
Transcriptional Regulation of Th17 Cell Differentiation

Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 4 of 6
Izumi Kawachi, Brain Research Institute, Niigata University, Japan
Short Talk: The Distinct Lineage: Double Negative T Cells Expressing IL-17 in MS

Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 5 of 6
Colleen E. Hayes, University of Wisconsin-Madison, USA
Regulatory Role of Vitamin D in Autoimmune Demyelination

Friday, January 23 | 8:00AM - 11:15AM
Immunopathogenetic Mechanisms in MS
Room: Mesa Ballroom

Speaker 6 of 6
* Joan Goverman, University of Washington, USA
Triggering CD8+ T Cells to Mediate CNS Autoimmunity

Friday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Friday, January 23 | 11:15AM - 12:00PM
Lunch
Room: Ortiz/Chamisa


Friday, January 23 | 12:00PM - 2:30PM
Poster Session 2
Room: Chamisa/Ortiz


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 1 of 7
* Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 2 of 7
Maria Traka, University Of Chicago, USA
Development of a Mouse Model for Adult Onset Ablation of Oligodendrocytes

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 3 of 7
Jayshree Samanta, New York University, USA
Role of Sonic Hedgehog in Remyelination

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 4 of 7
Kevin S. Carbajal, University of California, Irvine, USA
CXCL12 Enhances Migration of Implanted Glial-Committed Progenitor Cells in a Viral Model of Multiple Sclerosis

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 5 of 7
Angeliki Mela, Columbia University, USA
KAI1/CD82 is Required for CNS Myelination by Oligodendrocyte Progenitors

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 6 of 7
Patrick Kuery, University of Duesseldorf, Germany
CXCL12-Dependent Oligodendroglial Differentiation

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Myelination and Remyelination Cell
s
Room: Mesa Ballroom

Speaker 7 of 7
Manzoor Bhat, University of North Carolina, Chapel Hill, USA
Formation and Maintenance of the Paranodal Axo-glial Junctions in Myelinated Axons

Friday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Friday, January 23 | 5:00PM - 7:00PM
Mechanisms of T Cell Trafficking into the CNS
Room: Mesa Ballroom

Speaker 1 of 4
* Richard M. Ransohoff, Third Rock Ventures, USA
MS Pathogenesis from the Outside-In: A New Perspective

Friday, January 23 | 5:00PM - 7:00PM
Mechanisms of T Cell Trafficking into the CNS
Room: Mesa Ballroom

Speaker 2 of 4
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Imaging Leukocyte Recruitment across the Blood Brain Barrier

Friday, January 23 | 5:00PM - 7:00PM
Mechanisms of T Cell Trafficking into the CNS
Room: Mesa Ballroom

Speaker 3 of 4
Robyn S. Klein, Washington University School of Medicine, USA
Blood-Brain Barrier Dysfunction During MS: Signals that Promote T Cell Entry

Friday, January 23 | 5:00PM - 7:00PM
Mechanisms of T Cell Trafficking into the CNS
Room: Mesa Ballroom

Speaker 4 of 4
Harald F. Langer, National Cancer Institute, National Institutes of Health, USA
Short Talk: A Novel Function of Platelets in the Pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE)


Friday, January 23 | 7:00PM - 7:00PM
On Own for Dinner


Saturday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Saturday, January 24 | 8:00AM - 11:00AM
Identification of Genetic Risk Factors for MS and Autoimmune
Diseases

Room: Mesa Ballroom

Speaker 1 of 5
* David A. Hafler, Yale University School of Medicine, USA
Common Risk Alleles Associated with Multiple Sclerosis

Saturday, January 24 | 8:00AM - 11:00AM
Identification of Genetic Risk Factors for MS and Autoimmune
Diseases

Room: Mesa Ballroom

Speaker 2 of 5
Jacob McCauley, University of Miami, USA
Interleukin-7 Receptor (IL7R) Pathway Genes as Risk Factors for MS

Saturday, January 24 | 8:00AM - 11:00AM
Identification of Genetic Risk Factors for MS and Autoimmune
Diseases

Room: Mesa Ballroom

Speaker 3 of 5
Sergio E. Baranzini, University of California, San Francisco, USA
Genomic Approaches in MS

Saturday, January 24 | 8:00AM - 11:00AM
Identification of Genetic Risk Factors for MS and Autoimmune
Diseases

Room: Mesa Ballroom

Speaker 4 of 5
Allan James Bieber, Mayo Clinic, USA
Short Talk: Genetic Determinants of CNS Repair

Saturday, January 24 | 8:00AM - 11:00AM
Identification of Genetic Risk Factors for MS and Autoimmune
Diseases

Room: Mesa Ballroom

Speaker 5 of 5
Mario Clerici, Dipartimento di Fisiologia Medico-Chirurgica e dei Trapianti, Italy
Short Talk: RAC2 Gene Single Nucleotide Polymorphisms Modulate
MBP-Specific Immune Responses and Correlate with Disease Progression in MS


Saturday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, January 24 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, January 24 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa/Ortiz


Saturday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa/Ortiz


Saturday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Saturday, January 24 | 5:00PM - 7:00PM
Evaluation of MS Lesions and Axonal Pathology
Room: Mesa Ballroom

Speaker 1 of 4
Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK
Biomarkers in Multiple Sclerosis

Saturday, January 24 | 5:00PM - 7:00PM
Evaluation of MS Lesions and Axonal Pathology
Room: Mesa Ballroom

Speaker 2 of 4
Yanming Wang, Case Western Reserve University, USA
Short Talk: Direct Quantification of Myelin Changes in the Vertebrate Nervous System

Saturday, January 24 | 5:00PM - 7:00PM
Evaluation of MS Lesions and Axonal Pathology
Room: Mesa Ballroom

Speaker 3 of 4
Sheng-Kwei Song, Washington University School of Medicine, USA
Distinguishing Axonal from Myelin Pathology by DTI

Saturday, January 24 | 5:00PM - 7:00PM
Evaluation of MS Lesions and Axonal Pathology
Room: Mesa Ballroom

Speaker 4 of 4
* Paul M. Matthews, Imperial College London, UK
Using fMRI to Study MS: Understanding Plasticity

Saturday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Saturday, January 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa/Ortiz


Sunday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 1 of 6
Lawrence Steinman, Stanford University, USA
Antigen Specific Tolerance in MS

Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 2 of 6
Gordon Francis, Novartis, USA
Natalizumab Therapy in MS

Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 3 of 6
Lisa M. Mendoza, Bayer Healthcare Pharmaceuticals, USA
Short Talk: A Role for Leukotriene A4 Hydrolase in Disease Progression in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 4 of 6
* Anne H. Cross, Washington University, USA
B Cell Depletion in MS Patients using Rituximab (antiCD20)

Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 5 of 6
Mehrdad Matloubian, University of California, San Francisco, USA
Regulation of Lymphocyte Egress by Innate and Adaptive Immune Responses


Sunday, January 25 | 8:00AM - 11:15AM
Emergent Immunotherapeutics: What Do They Teach Us About MS?
Room: Mesa Ballroom

Speaker 6 of 6
Patrizia De Sarno, University of Alabama at Birmingham, USA
Short Talk: Targeting GSK3 is Therapeutic in EAE: Effects on Dendritic Cells and Encephalitogenic Activity of T Cells

Sunday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, January 25 | 11:15AM - 11:15AM
On Own for Lunch


Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 1 of 8
* Lawrence Steinman, Stanford University, USA

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 2 of 8
* Henry McFarland, NINDS, National Institutes of Health, USA

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 3 of 8
Jacqueline Kirchner, Bill & Melinda Gates Foundation, USA
Prophylactic or Therapeutic Administration of Anti-GM-CSF-M250 Inhibits Disease in Multiple Experimental Autoimmune Models of MS

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 4 of 8
Jennifer S. Lam, SRI International, USA
SR16951, a New Small Molecule for the Treatment of Multiple Sclerosis

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 5 of 8
V. Wee Yong, University of Calgary, Canada
EMMPRIN: A New Regulator of Neuroinflammation in Multiple Sclerosis

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 6 of 8
Jochen Schmitz, Lilly Research Laboratories, USA
The Orally Bioavailable Portein Kinase C Inhibitor RGE-80 can Abrogate EAE Disease Induction and Ameliorates Disease in a Therapeutic Setting

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 7 of 8
Chandra Deb, Mayo Clinic College of Medicine, USA
Neuronal Stress Sensitizes Axons to Immune-Mediated Injury

Sunday, January 25 | 2:30PM - 4:30PM
Workshop 2: New Therapeutic Approaches to MS
Room: Mesa Ballroom

Speaker 8 of 8
Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
NKT Cell-Dependent Amelioration of EAE by Altering Gut Flora

Sunday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Sunday, January 25 | 5:00PM - 7:00PM
Neural Protection and Remyelination
Room: Mesa Ballroom

Speaker 1 of 4
* Robin Franklin, University of Cambridge, UK
The Biology of CNS Remyelination – the Key to Therapeutic Advances

Sunday, January 25 | 5:00PM - 7:00PM
Neural Protection and Remyelination
Room: Mesa Ballroom

Speaker 2 of 4
Sha Mi, Biogen Idec, Inc., USA
Remyelination and Repair of the CNS by anti-LINGO1 Antibody

Sunday, January 25 | 5:00PM - 7:00PM
Neural Protection and Remyelination
Room: Mesa Ballroom

Speaker 3 of 4
Rhonda R. Voskuhl, University of California, Los Angeles, USA
Hormone Treatment in MS

Sunday, January 25 | 5:00PM - 7:00PM
Neural Protection and Remyelination
Room: Mesa Ballroom

Speaker 4 of 4
Marnie Preston, Oregon National Primate Research Center, USA
Short Talk: Hyaluronidase Activity Prevents Remyelination and Inhibits Neural Stem Cell and Oligodendrocyte Progenitor Differentiation

Sunday, January 25 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Mesa C


Sunday, January 25 | 8:00PM - 11:00PM
Entertainment
Room: Mesa C


Sunday, January 25 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa C


Monday, January 26 | 10:25AM - 10:25AM
Departure


*Session Chair.