Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Multiple Sclerosis (2013A1)
Genetics, Immunology and Repair in Multiple Sclerosis (2011B8)

Web Desc
Multiple Sclerosis Organizer(s): James L. Salzer, Anne H. Cross and John Fleming Date: January 21 - 26, 2009 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Sponsored by the National Multiple Sclerosis Society Summary of Meeting: Despite important recent progress, the etiology of Multiple Sclerosis (MS) remains unknown and important therapeutic needs are unmet. This conference will discuss advances in basic pathogenetic mechanisms and emergent therapies for MS. Emphasis will be on the immunopathogenesis of MS, including mechanisms of lymphocyte activation and trafficking across the blood brain barrier, on sources of axonal pathology, and genetic risk factors. New imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. An important challenge in MS research is to integrate emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations. Scholarship Deadline: September 24 2008 Discounted Abstract Deadline: September 24 2008 Abstract Deadline: October 24 2008 Discounted Registration Deadline: November 21 2008 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Elan Pharmaceuticals, Inc. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS063455-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Multiple Sclerosis

Organizer(s): James L. Salzer, Anne H. Cross and John Fleming

Date: January 21 - 26, 2009
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Sponsored by the National Multiple Sclerosis Society

Summary of Meeting:

Despite important recent progress, the etiology of Multiple Sclerosis (MS) remains unknown and important therapeutic needs are unmet. This conference will discuss advances in basic pathogenetic mechanisms and emergent therapies for MS. Emphasis will be on the immunopathogenesis of MS, including mechanisms of lymphocyte activation and trafficking across the blood brain barrier, on sources of axonal pathology, and genetic risk factors. New imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. An important challenge in MS research is to integrate emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.

Scholarship Deadline: September 24 2008

Discounted Abstract Deadline: September 24 2008

Abstract Deadline: October 24 2008

Discounted Registration Deadline: November 21 2008

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Elan Pharmaceuticals, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS063455-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Wednesday, January 21 \| 3:00PM - 7:30PM Registration Room: Promenade
Wednesday, January 21 \| 6:30PM - 7:30PM Refreshments Room: Promenade
Wednesday, January 21 \| 7:30PM - 8:30PM Keynote Address Room: Mesa Ballroom Speaker 1 of 1 Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA Role of the Innate Immune System in Multiple Sclerosis
Wednesday, January 21 \| 8:30PM - 9:00PM Orientation for New Attendees and New Investigators Room: Mesa Ballroom Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.
Thursday, January 22 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 1 of 6 * John Fleming, University of Wisconsin, Madison, USA Overview of MS and Major Challenges; and The Hygiene Hypothesis and Multiple Sclerosis
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 2 of 6 Alberto Ascherio, Harvard School of Public Health, USA Epidemiology of MS: Could MS be Prevented?
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 3 of 6 Claudia Lucchinetti, Mayo Clinic, USA Evolution of Pathogenic Concepts in Multiple Sclerosis
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 4 of 6 Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland Short Talk: Characterization of Molecular Alterations in Normal Appearing Grey Matter of Multiple Sclerosis Brain Tissues
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 5 of 6 Stephen D. Miller, Northwestern University Medical School, USA Pathogenic Mechanisms and Regulation of Susceptibility/Resistance to Theiler’s Virus-Induced Demyelination by CD4+CD25+ Regulatory T Cells
Thursday, January 22 \| 8:00AM - 11:15AM Pathogenetic Mechanisms of Demyelination and MS Room: Mesa Ballroom Speaker 6 of 6 Alison L. Christy, Northwestern University, USA Short Talk: Mast Cells Regulate BBB Permeability in EAE
Thursday, January 22 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Thursday, January 22 \| 11:15AM - 11:15AM On Own for Lunch
Thursday, January 22 \| 11:15AM - 1:00PM Poster Setup Room: Chamisa/Ortiz
Thursday, January 22 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa/Ortiz
Thursday, January 22 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Thursday, January 22 \| 5:00PM - 7:00PM Biology and Pathobiology of the Myelinated Axon Room: Mesa Ballroom Speaker 1 of 4 * James L. Salzer, New York University School of Medicine, USA Assembly and Molecular Architecture of Myelinated Axons
Thursday, January 22 \| 5:00PM - 7:00PM Biology and Pathobiology of the Myelinated Axon Room: Mesa Ballroom Speaker 2 of 4 Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany An Emerging Role of Oligodendrocytes in Maintaining Axonal Integrity
Thursday, January 22 \| 5:00PM - 7:00PM Biology and Pathobiology of the Myelinated Axon Room: Mesa Ballroom Speaker 3 of 4 Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA Mechanisms of Axonal Degeneration in Chronic MS Lesions
Thursday, January 22 \| 5:00PM - 7:00PM Biology and Pathobiology of the Myelinated Axon Room: Mesa Ballroom Speaker 4 of 4 Volker Siffrin, Charité University Medicine Berlin, Germany Short Talk: Intravital Imaging of Immune-Neuronal Interaction in Experimental Autoimmune Encephalomyelitis
Thursday, January 22 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa/Ortiz
Thursday, January 22 \| 7:30PM - 10:00PM Poster Session 1 Room: Chamisa/Ortiz
Friday, January 23 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Friday, January 23 \| 7:00AM - 8:00AM Poster Setup Room: Chamisa/Ortiz
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 1 of 6 Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA T-regs and Th17 Cells: Role in Induction and Regulation of Tissue Inflammation
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 2 of 6 Zsuzsanna Fabry, University of Wisconsin, USA Short Talk: Intracerebral Dendritic Cells Modulate Encephalitogenic Versus Regulatory Immune Responses in the CNS
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 3 of 6 Dan R. Littman, HHMI/New York University School of Medicine, USA Transcriptional Regulation of Th17 Cell Differentiation
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 4 of 6 Izumi Kawachi, Brain Research Institute, Niigata University, Japan Short Talk: The Distinct Lineage: Double Negative T Cells Expressing IL-17 in MS
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 5 of 6 Colleen E. Hayes, University of Wisconsin-Madison, USA Regulatory Role of Vitamin D in Autoimmune Demyelination
Friday, January 23 \| 8:00AM - 11:15AM Immunopathogenetic Mechanisms in MS Room: Mesa Ballroom Speaker 6 of 6 * Joan Goverman, University of Washington, USA Triggering CD8+ T Cells to Mediate CNS Autoimmunity
Friday, January 23 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Friday, January 23 \| 11:15AM - 12:00PM Lunch Room: Ortiz/Chamisa
Friday, January 23 \| 12:00PM - 2:30PM Poster Session 2 Room: Chamisa/Ortiz
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 1 of 7 * Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 2 of 7 Maria Traka, University Of Chicago, USA Development of a Mouse Model for Adult Onset Ablation of Oligodendrocytes
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 3 of 7 Jayshree Samanta, New York University, USA Role of Sonic Hedgehog in Remyelination
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 4 of 7 Kevin S. Carbajal, University of California, Irvine, USA CXCL12 Enhances Migration of Implanted Glial-Committed Progenitor Cells in a Viral Model of Multiple Sclerosis
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 5 of 7 Angeliki Mela, Columbia University, USA KAI1/CD82 is Required for CNS Myelination by Oligodendrocyte Progenitors
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 6 of 7 Patrick Kuery, University of Duesseldorf, Germany CXCL12-Dependent Oligodendroglial Differentiation
Friday, January 23 \| 2:30PM - 4:30PM Workshop 1: Mechanisms of Myelination and Remyelination Cell s Room: Mesa Ballroom Speaker 7 of 7 Manzoor Bhat, University of North Carolina, Chapel Hill, USA Formation and Maintenance of the Paranodal Axo-glial Junctions in Myelinated Axons
Friday, January 23 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Friday, January 23 \| 5:00PM - 7:00PM Mechanisms of T Cell Trafficking into the CNS Room: Mesa Ballroom Speaker 1 of 4 * Richard M. Ransohoff, Third Rock Ventures, USA MS Pathogenesis from the Outside-In: A New Perspective
Friday, January 23 \| 5:00PM - 7:00PM Mechanisms of T Cell Trafficking into the CNS Room: Mesa Ballroom Speaker 2 of 4 Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland Imaging Leukocyte Recruitment across the Blood Brain Barrier
Friday, January 23 \| 5:00PM - 7:00PM Mechanisms of T Cell Trafficking into the CNS Room: Mesa Ballroom Speaker 3 of 4 Robyn S. Klein, Washington University School of Medicine, USA Blood-Brain Barrier Dysfunction During MS: Signals that Promote T Cell Entry
Friday, January 23 \| 5:00PM - 7:00PM Mechanisms of T Cell Trafficking into the CNS Room: Mesa Ballroom Speaker 4 of 4 Harald F. Langer, National Cancer Institute, National Institutes of Health, USA Short Talk: A Novel Function of Platelets in the Pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE)
Friday, January 23 \| 7:00PM - 7:00PM On Own for Dinner
Saturday, January 24 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Saturday, January 24 \| 8:00AM - 11:00AM Identification of Genetic Risk Factors for MS and Autoimmune Diseases Room: Mesa Ballroom Speaker 1 of 5 * David A. Hafler, Yale University School of Medicine, USA Common Risk Alleles Associated with Multiple Sclerosis
Saturday, January 24 \| 8:00AM - 11:00AM Identification of Genetic Risk Factors for MS and Autoimmune Diseases Room: Mesa Ballroom Speaker 2 of 5 Jacob McCauley, University of Miami, USA Interleukin-7 Receptor (IL7R) Pathway Genes as Risk Factors for MS
Saturday, January 24 \| 8:00AM - 11:00AM Identification of Genetic Risk Factors for MS and Autoimmune Diseases Room: Mesa Ballroom Speaker 3 of 5 Sergio E. Baranzini, University of California, San Francisco, USA Genomic Approaches in MS
Saturday, January 24 \| 8:00AM - 11:00AM Identification of Genetic Risk Factors for MS and Autoimmune Diseases Room: Mesa Ballroom Speaker 4 of 5 Allan James Bieber, Mayo Clinic, USA Short Talk: Genetic Determinants of CNS Repair
Saturday, January 24 \| 8:00AM - 11:00AM Identification of Genetic Risk Factors for MS and Autoimmune Diseases Room: Mesa Ballroom Speaker 5 of 5 Mario Clerici, Dipartimento di Fisiologia Medico-Chirurgica e dei Trapianti, Italy Short Talk: RAC2 Gene Single Nucleotide Polymorphisms Modulate MBP-Specific Immune Responses and Correlate with Disease Progression in MS
Saturday, January 24 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Saturday, January 24 \| 11:00AM - 11:00AM On Own for Lunch
Saturday, January 24 \| 11:00AM - 1:00PM Poster Setup Room: Chamisa/Ortiz
Saturday, January 24 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa/Ortiz
Saturday, January 24 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Saturday, January 24 \| 5:00PM - 7:00PM Evaluation of MS Lesions and Axonal Pathology Room: Mesa Ballroom Speaker 1 of 4 Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK Biomarkers in Multiple Sclerosis
Saturday, January 24 \| 5:00PM - 7:00PM Evaluation of MS Lesions and Axonal Pathology Room: Mesa Ballroom Speaker 2 of 4 Yanming Wang, Case Western Reserve University, USA Short Talk: Direct Quantification of Myelin Changes in the Vertebrate Nervous System
Saturday, January 24 \| 5:00PM - 7:00PM Evaluation of MS Lesions and Axonal Pathology Room: Mesa Ballroom Speaker 3 of 4 Sheng-Kwei Song, Washington University School of Medicine, USA Distinguishing Axonal from Myelin Pathology by DTI
Saturday, January 24 \| 5:00PM - 7:00PM Evaluation of MS Lesions and Axonal Pathology Room: Mesa Ballroom Speaker 4 of 4 * Paul M. Matthews, Imperial College London, UK Using fMRI to Study MS: Understanding Plasticity
Saturday, January 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa/Ortiz
Saturday, January 24 \| 7:30PM - 10:00PM Poster Session 3 Room: Chamisa/Ortiz
Sunday, January 25 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 1 of 6 Lawrence Steinman, Stanford University, USA Antigen Specific Tolerance in MS
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 2 of 6 Gordon Francis, Novartis, USA Natalizumab Therapy in MS
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 3 of 6 Lisa M. Mendoza, Bayer Healthcare Pharmaceuticals, USA Short Talk: A Role for Leukotriene A4 Hydrolase in Disease Progression in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 4 of 6 * Anne H. Cross, Washington University, USA B Cell Depletion in MS Patients using Rituximab (antiCD20)
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 5 of 6 Mehrdad Matloubian, University of California, San Francisco, USA Regulation of Lymphocyte Egress by Innate and Adaptive Immune Responses
Sunday, January 25 \| 8:00AM - 11:15AM Emergent Immunotherapeutics: What Do They Teach Us About MS? Room: Mesa Ballroom Speaker 6 of 6 Patrizia De Sarno, University of Alabama at Birmingham, USA Short Talk: Targeting GSK3 is Therapeutic in EAE: Effects on Dendritic Cells and Encephalitogenic Activity of T Cells
Sunday, January 25 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Sunday, January 25 \| 11:15AM - 11:15AM On Own for Lunch
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 1 of 8 * Lawrence Steinman, Stanford University, USA
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 2 of 8 * Henry McFarland, NINDS, National Institutes of Health, USA
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 3 of 8 Jacqueline Kirchner, Bill & Melinda Gates Foundation, USA Prophylactic or Therapeutic Administration of Anti-GM-CSF-M250 Inhibits Disease in Multiple Experimental Autoimmune Models of MS
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 4 of 8 Jennifer S. Lam, SRI International, USA SR16951, a New Small Molecule for the Treatment of Multiple Sclerosis
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 5 of 8 V. Wee Yong, University of Calgary, Canada EMMPRIN: A New Regulator of Neuroinflammation in Multiple Sclerosis
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 6 of 8 Jochen Schmitz, Lilly Research Laboratories, USA The Orally Bioavailable Portein Kinase C Inhibitor RGE-80 can Abrogate EAE Disease Induction and Ameliorates Disease in a Therapeutic Setting
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 7 of 8 Chandra Deb, Mayo Clinic College of Medicine, USA Neuronal Stress Sensitizes Axons to Immune-Mediated Injury
Sunday, January 25 \| 2:30PM - 4:30PM Workshop 2: New Therapeutic Approaches to MS Room: Mesa Ballroom Speaker 8 of 8 Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan NKT Cell-Dependent Amelioration of EAE by Altering Gut Flora
Sunday, January 25 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Sunday, January 25 \| 5:00PM - 7:00PM Neural Protection and Remyelination Room: Mesa Ballroom Speaker 1 of 4 * Robin Franklin, University of Cambridge, UK The Biology of CNS Remyelination – the Key to Therapeutic Advances
Sunday, January 25 \| 5:00PM - 7:00PM Neural Protection and Remyelination Room: Mesa Ballroom Speaker 2 of 4 Sha Mi, Biogen Idec, Inc., USA Remyelination and Repair of the CNS by anti-LINGO1 Antibody
Sunday, January 25 \| 5:00PM - 7:00PM Neural Protection and Remyelination Room: Mesa Ballroom Speaker 3 of 4 Rhonda R. Voskuhl, University of California, Los Angeles, USA Hormone Treatment in MS
Sunday, January 25 \| 5:00PM - 7:00PM Neural Protection and Remyelination Room: Mesa Ballroom Speaker 4 of 4 Marnie Preston, Oregon National Primate Research Center, USA Short Talk: Hyaluronidase Activity Prevents Remyelination and Inhibits Neural Stem Cell and Oligodendrocyte Progenitor Differentiation
Sunday, January 25 \| 8:00PM - 9:00PM Social Hour with Lite Bites Room: Mesa C
Sunday, January 25 \| 8:00PM - 11:00PM Entertainment Room: Mesa C
Sunday, January 25 \| 8:00PM - 11:00PM Cash Bar Room: Mesa C
Monday, January 26 \| 10:25AM - 10:25AM Departure *Session Chair.