Web Desc
Emerging Themes in Tumor Suppressors: Function and Clinical Implications in the Post-Genomic Era
Organizer(s): Kun-Liang Guan, Eric R. Fearon and Stephen H. Friend
Date: January 25 - 30, 2009
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakers’ laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct.
Scholarship Deadline: September 25 2008
Discounted Abstract Deadline: September 25 2008
Abstract Deadline: October 28 2008
Discounted Registration Deadline: November 25 2008
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA135833-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 25 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Sunday, January 25 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Sunday, January 25 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Stephen H. Friend, Sage Bionetworks, USA

Sunday, January 25 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Eric Schadt, Mount Sinai School of Medicine, USA
Networks as the Sensors and Drivers of Disease

Monday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 2 of 7
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Identifying New Tumor Suppressors through in vivo RNA Interference Screens

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 3 of 7
Yukiko Hasumi, National Cancer Institute, National Institutes of Health, USA
Short Talk: Investigating the Role of the BHD Tumor Suppressor Gene in vivo; Early Embryonic Lethality and Increased Incidence of Kidney Tumor in BHD Heterozygous Null Mice

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 4 of 7
Charles J. Sherr, St. Jude Children's Research Hospital, USA
The Arf Tumor Suppressor: Gating Cellular Self-Renewal

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 5 of 7
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Autophagy and Cancer - Cell Survival vs. Cell Death

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 6 of 7
Veronique T. Baron, vaccine research institute of sand iego, USA
Short Talk: Gain-of-Function Mutation of p53 Initiates a Positive Feedback Loop Involving EGR-1, EGF-R, and the ERK1/2 Pathway in Prostate Cancer Cells

Monday, January 26 | 8:00AM - 11:15AM
p53 and ARF
Room: Chamisa Ballroom 1

Speaker 7 of 7
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Aberrant PTEN/PI3K Signaling in Tumorigenesis

Monday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Monday, January 26 | 11:00AM - 11:00AM
On Own for Lunch


Monday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, January 26 | 5:00PM - 7:00PM
Epigenetics, Chromatin Modification and Tumor Suppressors
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA

Monday, January 26 | 5:00PM - 7:00PM
Epigenetics, Chromatin Modification and Tumor Suppressors
Room: Chamisa Ballroom 1

Speaker 2 of 4
Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Epigenetic Mechanisms of Tumor Suppressor Gene Inactivation

Monday, January 26 | 5:00PM - 7:00PM
Epigenetics, Chromatin Modification and Tumor Suppressors
Room: Chamisa Ballroom 1

Speaker 3 of 4
Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Histone Methylation

Monday, January 26 | 5:00PM - 7:00PM
Epigenetics, Chromatin Modification and Tumor Suppressors
Room: Chamisa Ballroom 1

Speaker 4 of 4
Manel Esteller, Josep Carreras Leukaemia Research Institute, Spain
Cancer Epigenomics

Monday, January 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Monday, January 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Tuesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Michael B. Kastan, St. Jude Children's Research Hospital, USA

Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 2 of 7
Jihye Paik, Dana Farber Cancer Institute/ Harvard Medical School, USA
FoxOs in Cancer and Stem Cells

Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 3 of 7
Bin Zhao, Zhejiang University, China
Short Talk: Tead Binding and WW Domains are both Required for the Growth Stimulation and Oncogenic Transformation Activity of YAP


Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 4 of 7
Elizabeth Petri Henske, Brigham and Women's Hospital, USA
LAM and TSC Pathogenesis

Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 5 of 7
Yang Liu, University of Michigan, Ann Arbor, USA
FOXP3 is an X-Linked Cancer Suppressor Gene

Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 6 of 7
Arti Santhanam, National Cancer Institute at Frederick, USA
Short Talk: Novel Tumor Suppressor Pdcd4 Inhibits mRNA Translation Initiation to Prevent Tumorigenesis and Invasion

Tuesday, January 27 | 8:00AM - 11:15AM
PTEN/FOXO/TSC/LKB
Room: Chamisa Ballroom 1

Speaker 7 of 7
Senthil K. Muthuswamy, Harvard Medical School, USA
Cell Polarity and Tumor Suppression

Tuesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, January 27 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, January 27 | 5:00PM - 7:00PM
Tumor Suppressors, Checkpoints and Genetic Instability
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Elizabeth Petri Henske, Brigham and Women's Hospital, USA

Tuesday, January 27 | 5:00PM - 7:00PM
Tumor Suppressors, Checkpoints and Genetic Instability
Room: Chamisa Ballroom 1

Speaker 2 of 4
Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Translating the Cancer Genome

Tuesday, January 27 | 5:00PM - 7:00PM
Tumor Suppressors, Checkpoints and Genetic Instability
Room: Chamisa Ballroom 1

Speaker 3 of 4
Dina Dikovskaya, College of Life Sciences, University of Dundee, UK
Mechanisms for Tumour Predisposition by Mutations in Adenomatous Polyposis Coli

Tuesday, January 27 | 5:00PM - 7:00PM
Tumor Suppressors, Checkpoints and Genetic Instability
Room: Chamisa Ballroom 1

Speaker 4 of 4
Michael B. Kastan, St. Jude Children's Research Hospital, USA
Molecular Controls of the ATM-p53 Pathway

Tuesday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Tuesday, January 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Wednesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 2 of 7
Reuven Agami, Netherlands Cancer Institute, Netherlands
Cofactor Regulating p53 Tumor Suppressor Activity

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 3 of 7
Xiaotao Li, Baylor College of Medicine, USA
Short Talk: Regulation of p53 by the Proteasome Activator REGgamma

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 4 of 7
Carlo M. Croce, Ohio State University, USA
Non-Coding RNA in Oncogene and Tumor Suppression Function

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 5 of 7
Randall S. Johnson, University of Cambridge, UK
Inflammatory Cell VEGF Release: Angiogenesis as a Tumor Suppressor

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 6 of 7
Martijn Kedde, Netherlands Cancer Institute, Netherlands
Short Talk: Interplay between microRNAs and RNA Binding Proteins Regulate the p27 Tumor Suppressor

Wednesday, January 28 | 8:00AM - 11:00AM
Non-Coding RNAs in Tumor Suppression
Room: Chamisa Ballroom 1

Speaker 7 of 7
Yue Xiong, University of North Carolina at Chapel Hill, USA
Control of Stem and Progenitor Cell Cycle by INK4 Genes

Wednesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, January 28 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 28 | 5:00PM - 7:00PM
Cancer Stem Cells and Tumor Suppressor Pathways
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Carlo M. Croce, Ohio State University, USA

Wednesday, January 28 | 5:00PM - 7:00PM
Cancer Stem Cells and Tumor Suppressor Pathways
Room: Chamisa Ballroom 1

Speaker 2 of 4
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hmga2 Increases the Self-Renewal of Fetal and Young Adult Stem Cells as Compared to Old Adult Stem Cells by Negatively Regulating p16Ink4a and p19Arf Expression

Wednesday, January 28 | 5:00PM - 7:00PM
Cancer Stem Cells and Tumor Suppressor Pathways
Room: Chamisa Ballroom 1

Speaker 3 of 4
David Bilder, University of California, Berkeley, USA
New Insights into Drosophila Tumor Suppression

Wednesday, January 28 | 5:00PM - 7:00PM
Cancer Stem Cells and Tumor Suppressor Pathways
Room: Chamisa Ballroom 1

Speaker 4 of 4
Ariel Ruiz i Altaba, University of Geneva Medical School, Switzerland
HEDGEHOG-GLI Signaling in Stem Cells and Cancer

Wednesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, January 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Thursday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Yue Xiong, University of North Carolina at Chapel Hill, USA

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 2 of 8
Colleen A. Fordyce, University of California, San Francisco, USA
Epithelial-Stromal Interactions and Tumor Suppressors

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 3 of 8
Alice Hawley Berger, Beth Israel Deaconess Medical Center, USA
Short Talk: Identification of DOK Family Proteins as Lung Tumor Suppressors

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 4 of 8
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy, Metabolic Stress and Genome Damage

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 5 of 8
Tian Xu, Yale University School of Medicine, USA
Cell Polarity and JNK Signaling in Drosophila Tumor Progression and Metastasis

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 6 of 8
Gutian Xiao, University of Pittsburgh Medical Center, USA
Short Talk: Epigenetic Repression of PDLIM2 in Cancer

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 7 of 8
Andrea I. McClatchey, Massachusetts General Hospital, USA
Membrane Organization in Receptor Tyrosine Kinase Signaling and Tissue Homeostasis

Thursday, January 29 | 8:00AM - 11:15AM
Tissue Context and Tumor Suppressor Function
Room: Chamisa Ballroom 1

Speaker 8 of 8
Kun-Liang Guan, University of California, San Diego, USA
The TSC-mTOR Pathway in Cell Growth Regulation

Thursday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, January 29 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, January 29 | 5:00PM - 7:00PM
Metabolism and Cancer
Room: Chamisa Ballroom 1

Speaker 1 of 1
* Tian Xu, Yale University School of Medicine, USA

Thursday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Thursday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Friday, January 30 | 10:25AM - 10:25AM
Departure


*Session Chair.