Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Tuberculosis: Science Aimed at Ending the Epidemic (2021EK10)
Tuberculosis: Immunity and Immune Evasion (2020A2)
Tuberculosis Co-Morbidities and Immunopathogenesis (2016B6)
Host Response in Tuberculosis (2015J3)
Novel Therapeutic Approaches to Tuberculosis (2014C7)
Tuberculosis: Understanding the Enemy (2013X8)
Host Response in Tuberculosis (2013X7)
Drug Resistance and Persistence in Tuberculosis (2012E1)
Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (2011J4)
Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies (2011J3)

Web Desc
Tuberculosis: Biology, Pathology and Therapy Organizer(s): JoAnne L. Flynn, David G. Russell and Thomas N.A. Dick Date: January 25 - 30, 2009 Location: Keystone Resort, Keystone, CO, USA Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline. Summary of Meeting: Tuberculosis kills 2 million people per year worldwide. Although great strides have been made in the past decade in understanding Mycobacterium tuberculosis, the complexity of the disease necessitates a multi-pronged approach. Translating insights related to host-pathogen interplay and bacterial physiology into treatments is complex, requiring academics and industrial scientists to come together in new and creative ways. In humans the infection is persistent and chronic, yet reactivates into fulminating progressive disease. This, and the shortage of appropriate animal models, form major obstacles to identifying factors that determine disease progression and the extensive pathology associated with transmission. This meeting will focus on basic mechanisms of pathogenesis of Mycobacterium tuberculosis, and how the balance of control of infection within the granuloma is influenced by host and bacterial factors. We will also focus on translating basic mechanistic findings to the development of therapies, and a workshop highlighting academic-industrial partnerships is planned. Global Health Travel Award Deadline: August 25 2008 Scholarship Deadline: September 29 2008 Discounted Abstract Deadline: September 29 2008 Abstract Deadline: October 29 2008 Discounted Registration Deadline: November 25 2008 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Novartis Institute for Tropical Diseases Pte Ltd We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI079894-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Tuberculosis: Biology, Pathology and Therapy

Organizer(s): JoAnne L. Flynn, David G. Russell and Thomas N.A. Dick

Date: January 25 - 30, 2009
Location: Keystone Resort, Keystone, CO, USA

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline.

Summary of Meeting:

Tuberculosis kills 2 million people per year worldwide. Although great strides have been made in the past decade in understanding Mycobacterium tuberculosis, the complexity of the disease necessitates a multi-pronged approach. Translating insights related to host-pathogen interplay and bacterial physiology into treatments is complex, requiring academics and industrial scientists to come together in new and creative ways. In humans the infection is persistent and chronic, yet reactivates into fulminating progressive disease. This, and the shortage of appropriate animal models, form major obstacles to identifying factors that determine disease progression and the extensive pathology associated with transmission. This meeting will focus on basic mechanisms of pathogenesis of Mycobacterium tuberculosis, and how the balance of control of infection within the granuloma is influenced by host and bacterial factors. We will also focus on translating basic mechanistic findings to the development of therapies, and a workshop highlighting academic-industrial partnerships is planned.

Global Health Travel Award Deadline: August 25 2008

Scholarship Deadline: September 29 2008

Discounted Abstract Deadline: September 29 2008

Abstract Deadline: October 29 2008

Discounted Registration Deadline: November 25 2008

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institute for Tropical Diseases Pte Ltd

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079894-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 25 \| 3:00PM - 7:30PM Registration Room: Longs Peak Foyer
Sunday, January 25 \| 6:30PM - 7:30PM Refreshments Room: Longs Peak Foyer
Sunday, January 25 \| 7:30PM - 8:30PM Keynote Address Room: Grays Peak Speaker 1 of 2 * JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Sunday, January 25 \| 7:30PM - 8:30PM Keynote Address Room: Grays Peak Speaker 2 of 2 Douglas B. Young, Imperial College London, UK The Best Laid Schemes of Mice and Men . . .
Sunday, January 25 \| 8:30PM - 9:00PM Orientation for New Attendees and New Investigators Room: Grays Peak/Longs Peak Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.
Monday, January 26 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 1 of 6 Vojo Deretic, University of New Mexico Health Sciences Center, USA Autophagy: a Cell Sanitation, Survival and Death Process
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 2 of 6 * David G. Russell, Cornell University, USA Mycobacterium Tuberculosis and the Intracellular Environment
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 3 of 6 Ulrich E. Schaible, Research Center Borstel, Germany Host Innate Defense and Mycobacterial Virulence
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 4 of 6 Sabine Ehrt, Weill Cornell Medical College, USA Mycobacterial Survival Strategies in the Phagosome
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 5 of 6 Volker Briken, University of Maryland, USA Short Talk: Molecular Mechanism of Mycobacterium tuberculosis nuoG Mediated Host Macrophage Apoptosis Inhibition
Monday, January 26 \| 8:00AM - 11:15AM Life and Death within the Phagocyte Room: Grays Peak/Longs Peak Speaker 6 of 6 Frédéric Altare, INSERM U892, France Short Talk: Nutrient-Rich Reservoir for M. Tuberculosis Persistence
Monday, January 26 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Monday, January 26 \| 11:15AM - 11:15AM On Own for Lunch
Monday, January 26 \| 11:15AM - 1:00PM Poster Setup Room: Red Cloud/Shavano
Monday, January 26 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano
Monday, January 26 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 26 \| 5:00PM - 7:00PM Early/Innate Immune Responses to TB Room: Grays Peak/Longs Peak Speaker 1 of 4 * Valerie F. Quesniaux, Centre National de la Recherche Scientifique, France Toll-Like Receptors in Tuberculosis
Monday, January 26 \| 5:00PM - 7:00PM Early/Innate Immune Responses to TB Room: Grays Peak/Longs Peak Speaker 2 of 4 Clifford V. Harding, Case Western Reserve University, USA Regulation of APCs and Class II MHC by TLR2 and Mycobacterium tuberculosis
Monday, January 26 \| 5:00PM - 7:00PM Early/Innate Immune Responses to TB Room: Grays Peak/Longs Peak Speaker 3 of 4 Stefan Ehlers, Research Center Borstel, Germany Short Talk: Non-Classical Macrophage Activation in Experimental TB – Consequences for Reactivation and Lung Pathology
Monday, January 26 \| 5:00PM - 7:00PM Early/Innate Immune Responses to TB Room: Grays Peak/Longs Peak Speaker 4 of 4 Padmini Salgame, Rutgers University, USA Short Talk: Coexisting Helminth Infection Induces Inhibition of Pulmonary Anti-Tuberculosis Defense
Monday, January 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano
Monday, January 26 \| 7:30PM - 10:00PM Poster Session 1 Room: Red Cloud/Shavano
Tuesday, January 27 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano
Tuesday, January 27 \| 8:00AM - 11:00AM Key Pathways in Bacterial Metabolism Room: Grays Peak/Longs Peak Speaker 1 of 5 Christopher M. Sassetti, University of Massachusetts Medical School, USA Carbon Metabolism Comes Full Circle
Tuesday, January 27 \| 8:00AM - 11:00AM Key Pathways in Bacterial Metabolism Room: Grays Peak/Longs Peak Speaker 2 of 5 * Valerie Mizrahi, University of Cape Town, South Africa Novel and Vulnerable Pathways of DNA Metabolism in Mycobacteria
Tuesday, January 27 \| 8:00AM - 11:00AM Key Pathways in Bacterial Metabolism Room: Grays Peak/Longs Peak Speaker 3 of 5 Jeffery S. Cox, University of California, Berkeley, USA Protein Secretion, Novel and Conserved Systems
Tuesday, January 27 \| 8:00AM - 11:00AM Key Pathways in Bacterial Metabolism Room: Grays Peak/Longs Peak Speaker 4 of 5 Carolyn R. Bertozzi, Stanford University, USA Mycobacterial Sulfation Pathways
Tuesday, January 27 \| 8:00AM - 11:00AM Key Pathways in Bacterial Metabolism Room: Grays Peak/Longs Peak Speaker 5 of 5 Koen Andries, Tibotec, Belgium Short Talk: ATP Synthase, A New Validated Target for TB Treatment
Tuesday, January 27 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, January 27 \| 11:00AM - 11:00AM On Own for Lunch
Tuesday, January 27 \| 11:15AM - 1:00PM Poster Setup Room: Red Cloud/Shavano
Tuesday, January 27 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 1 of 10 * Thomas Dick, Hackensack Meridian Health, USA Introduction: Connecting Academia and Industry
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 2 of 10 * Ken Duncan, Bill & Melinda Gates Foundation, USA
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 3 of 10 Koen Andries, Tibotec, Belgium Filling the Gap: What can YOU do?
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 4 of 10 Christopher D. Earl, BIO Ventures for Global Health, USA Building Biotech Solutions for Diseases of the Developing World
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 5 of 10 Jose F. Garcia-Bustos, GlaxoSmithKline, Spain and
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 6 of 10 Clifton E. Barry III, NIAID, National Institutes of Health, USA and
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 7 of 10 James C. Sacchettini, Texas A & M University, USA How Can We Improve Academia - Industry Interaction 2: Views from Academia
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 8 of 10 M. Gerard Waters, Novartis, USA
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 9 of 10 Makoto Matsumoto, Otsuka Pharmaceutical Co. Ltd., Japan
Tuesday, January 27 \| 2:30PM - 4:30PM Workshop on TB Drug Discovery: Connecting Academia and Indus try Room: Grays Peak / Longs Peak Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion. Speaker 10 of 10 Veronique Anne Dartois, Hackensack Meridian Health, USA
Tuesday, January 27 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 27 \| 5:00PM - 7:00PM Pathology and Transmission of Tuberculosis Room: Grays Peak/Longs Peak Speaker 1 of 4 * Gilla Kaplan, University of Cape Town, South Africa
Tuesday, January 27 \| 5:00PM - 7:00PM Pathology and Transmission of Tuberculosis Room: Grays Peak/Longs Peak Speaker 2 of 4 Elizabeth L. Corbett, London School of Hygiene & Tropical Med / MLW Trust Clinical Research Programme, Malawi TB Transmission and Susceptibility
Tuesday, January 27 \| 5:00PM - 7:00PM Pathology and Transmission of Tuberculosis Room: Grays Peak/Longs Peak Speaker 3 of 4 Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK Conditions in the Human Lung during Active Tuberculosis
Tuesday, January 27 \| 5:00PM - 7:00PM Pathology and Transmission of Tuberculosis Room: Grays Peak/Longs Peak Speaker 4 of 4 Denise Kirschner, University of Michigan, USA A Multi-Scale Peek at Granuloma Formation in TB
Tuesday, January 27 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano
Tuesday, January 27 \| 7:30PM - 10:00PM Poster Session 2 Room: Red Cloud/Shavano
Wednesday, January 28 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano
Wednesday, January 28 \| 8:00AM - 11:00AM Insights from Animal Models: New Approaches Room: Grays Peak/Longs Peak Speaker 1 of 4 Lalita Ramakrishnan, University of Cambridge, UK A Forward Genetic Screen in the Zebrafish Reveals a Human TB Susceptibility Locus
Wednesday, January 28 \| 8:00AM - 11:00AM Insights from Animal Models: New Approaches Room: Grays Peak/Longs Peak Speaker 2 of 4 David S. Schneider, Stanford University School of Medicine, USA Balancing Resistance and Tolerance During Infections in the Fly
Wednesday, January 28 \| 8:00AM - 11:00AM Insights from Animal Models: New Approaches Room: Grays Peak/Longs Peak Speaker 3 of 4 * JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA Non-Human Primate Model of Tuberculosis. What can we learn about TB?
Wednesday, January 28 \| 8:00AM - 11:00AM Insights from Animal Models: New Approaches Room: Grays Peak/Longs Peak Speaker 4 of 4 Gilla Kaplan, University of Cape Town, South Africa Host and Pathogen Contribution to Pathology
Wednesday, January 28 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, January 28 \| 11:00AM - 1:00PM Poster Setup Room: Red Cloud/Shavano
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 1 of 9 * Gary K. Schoolnik, Stanford University, USA Welcome, Workshop Goals
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 2 of 9 Adamandia Kapopoulou, Ecole Polytechnique Federale de Lausanne, Switzerland Tuberculist
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 3 of 9 James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA TBDatabase: A Database that Integrates Expression and Genomics Data and which Provides Suites of Bioinformatics Tools
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 4 of 9 Barry A. Bunin, CDD, USA Collaborative Drug Discovery Database
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 5 of 9 Thomas R. Holton, University of California, Los Angeles, USA WebTB.org and the TB Structural Genomics Consortium: Tools for searching and annotating the TB genome
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 6 of 9 Shubhada Godbole, University of Texas Southwestern Medical Center, USA BioHealthBase: A Comprehensive Integrated Database and Analysis Resource for TB Research
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 7 of 9 Kristin Kremer, National Institute of Public Health and the Environment, Netherlands Usefulness of DNA Fingerprint Databases to Study the Epidemiology and Phylogeny of TB
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 8 of 9 Stefan Niemann, Research Center Borstel, Germany MIRU-VNTRplus Database: Online Identification of Clinical Isolates Based on Reference Collections and Analysis of Molecular Typing Data
Wednesday, January 28 \| 11:00AM - 2:00PM Symposium on Tuberculosis Databases and Bioinformatics Tools Room: Grays Peak/Longs Peak Speaker 9 of 9 * Gary K. Schoolnik, Stanford University, USA Discussion: Unmet Bioinformatic Needs; How can they be Addressed?
Wednesday, January 28 \| 1:00PM - 10:00PM Poster Viewing Room: Red Cloud/Shavano
Wednesday, January 28 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 28 \| 5:00PM - 7:00PM Bacterial Response to the Evolving Host Environments Room: Grays Peak/Longs Peak Speaker 1 of 4 * Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA The Essential Irony of Tuberculosis
Wednesday, January 28 \| 5:00PM - 7:00PM Bacterial Response to the Evolving Host Environments Room: Grays Peak/Longs Peak Speaker 2 of 4 Helena I. M. Boshoff, NIAID, National Institutes of Health, USA Nitroimidazoles for TB: Mechanism of Killing
Wednesday, January 28 \| 5:00PM - 7:00PM Bacterial Response to the Evolving Host Environments Room: Grays Peak/Longs Peak Speaker 3 of 4 William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA Slipping the Host a Mycobacterial Mickey Finn
Wednesday, January 28 \| 5:00PM - 7:00PM Bacterial Response to the Evolving Host Environments Room: Grays Peak/Longs Peak Speaker 4 of 4 Adrie J. C. Steyn, Africa Health Research Institute & UAB, South Africa Short Talk: Mycobacterium tuberculosis WhiB3 maintains Intrabacterial Redox Homeostasis by Modulating Virulence Lipid Anabolism to Subvert Macrophage Function
Wednesday, January 28 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano
Wednesday, January 28 \| 7:30PM - 10:00PM Poster Session 3 Room: Red Cloud/Shavano
Thursday, January 29 \| 7:00AM - 8:00AM Breakfast Room: Red Cloud/Shavano
Thursday, January 29 \| 7:00AM - 8:00AM Poster Setup Room: Red Cloud/Shavano
Thursday, January 29 \| 8:00AM - 11:00AM Action and Reaction in the Immune Control of Tuberculosis Room: Grays Peak/Longs Peak Speaker 1 of 5 * Michael Stephen Glickman, Memorial Sloan-Kettering Institute, USA Discovery of a Novel Pathway that Integrates rRNA Transcription with DNA damage
Thursday, January 29 \| 8:00AM - 11:00AM Action and Reaction in the Immune Control of Tuberculosis Room: Grays Peak/Longs Peak Speaker 2 of 5 Gary K. Schoolnik, Stanford University, USA Mycobacterium tuberculosis (Mtb)Expression Signatures of Host Immune Status
Thursday, January 29 \| 8:00AM - 11:00AM Action and Reaction in the Immune Control of Tuberculosis Room: Grays Peak/Longs Peak Speaker 3 of 5 Heran Darwin, New York University School of Medicine, USA Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis
Thursday, January 29 \| 8:00AM - 11:00AM Action and Reaction in the Immune Control of Tuberculosis Room: Grays Peak/Longs Peak Speaker 4 of 5 Shahin Shafiani, Center for Infectious Disease Research, USA Short Talk: Pathogen-Specific Regulatory T Cells Impair Protective Immunity in Tuberculosis
Thursday, January 29 \| 8:00AM - 11:00AM Action and Reaction in the Immune Control of Tuberculosis Room: Grays Peak/Longs Peak Speaker 5 of 5 Tige R. Rustad, Seattle BioMed, USA Short Talk: The DosR Regulon and the Enduring Hypoxic Response: Identification, Regulation and In Vivo Relevance
Thursday, January 29 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, January 29 \| 11:00AM - 12:00PM Lunch Room: Quandary Peaks
Thursday, January 29 \| 12:00PM - 2:30PM Poster Session 4 Room: Red Cloud/Shavano
Thursday, January 29 \| 12:00PM - 5:00PM Poster Viewing Room: Red Cloud/Shavano
Thursday, January 29 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, January 29 \| 5:00PM - 7:00PM Bacterial Physiology and Drug Targets Room: Grays Peak/Longs Peak Speaker 1 of 3 Thomas Dick, Hackensack Meridian Health, USA One Plus One does not Equal Two: In Vitro – in Vivo Disconnect in TB Drug Discovery
Thursday, January 29 \| 5:00PM - 7:00PM Bacterial Physiology and Drug Targets Room: Grays Peak/Longs Peak Speaker 2 of 3 * James C. Sacchettini, Texas A & M University, USA Mtb Whole Genome Sequencing: Detecting Drug-Pathogen Interactions
Thursday, January 29 \| 5:00PM - 7:00PM Bacterial Physiology and Drug Targets Room: Grays Peak/Longs Peak Speaker 3 of 3 Clifton E. Barry III, NIAID, National Institutes of Health, USA Rethinking the Concept of a Good TB Drug “Target”
Thursday, January 29 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Red Cloud/Shavano
Thursday, January 29 \| 8:00PM - 11:00PM Entertainment Room: Red Cloud/Shavano
Thursday, January 29 \| 8:00PM - 11:00PM Cash Bar Room: Red Cloud/Shavano
Friday, January 30 \| 10:25AM - 10:25AM Departure *Session Chair.