Web Desc
Tuberculosis: Biology, Pathology and Therapy
Organizer(s): JoAnne L. Flynn, David G. Russell and Thomas N.A. Dick
Date: January 25 - 30, 2009
Location: Keystone Resort, Keystone, CO, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline.
Summary of Meeting:
Tuberculosis kills 2 million people per year worldwide. Although great strides have been made in the past decade in understanding Mycobacterium tuberculosis, the complexity of the disease necessitates a multi-pronged approach. Translating insights related to host-pathogen interplay and bacterial physiology into treatments is complex, requiring academics and industrial scientists to come together in new and creative ways. In humans the infection is persistent and chronic, yet reactivates into fulminating progressive disease. This, and the shortage of appropriate animal models, form major obstacles to identifying factors that determine disease progression and the extensive pathology associated with transmission. This meeting will focus on basic mechanisms of pathogenesis of Mycobacterium tuberculosis, and how the balance of control of infection within the granuloma is influenced by host and bacterial factors. We will also focus on translating basic mechanistic findings to the development of therapies, and a workshop highlighting academic-industrial partnerships is planned.
Global Health Travel Award Deadline: August 25 2008
Scholarship Deadline: September 29 2008
Discounted Abstract Deadline: September 29 2008
Abstract Deadline: October 29 2008
Discounted Registration Deadline: November 25 2008
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationGlaxoSmithKlineTibotec, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institute for Tropical Diseases Pte Ltd
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079894-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 25 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, January 25 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 25 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak

Speaker 1 of 2
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA

Sunday, January 25 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak

Speaker 2 of 2
Douglas B. Young, Imperial College London, UK
The Best Laid Schemes of Mice and Men . . .

Sunday, January 25 | 8:30PM - 9:00PM
Orientation for New Attendees and New Investigators
Room: Grays Peak/Longs Peak
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.

Monday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano


Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 1 of 6
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: a Cell Sanitation, Survival and Death Process

Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 2 of 6
* David G. Russell, Cornell University, USA
Mycobacterium Tuberculosis and the Intracellular Environment

Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 3 of 6
Ulrich E. Schaible, Research Center Borstel, Germany
Host Innate Defense and Mycobacterial Virulence

Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 4 of 6
Sabine Ehrt, Weill Cornell Medical College, USA
Mycobacterial Survival Strategies in the Phagosome

Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 5 of 6
Volker Briken, University of Maryland, USA
Short Talk: Molecular Mechanism of Mycobacterium tuberculosis nuoG Mediated Host Macrophage Apoptosis Inhibition

Monday, January 26 | 8:00AM - 11:15AM
Life and Death within the Phagocyte
Room: Grays Peak/Longs Peak

Speaker 6 of 6
Frédéric Altare, INSERM U892, France
Short Talk: Nutrient-Rich Reservoir for M. Tuberculosis Persistence

Monday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 26 | 11:15AM - 11:15AM
On Own for Lunch


Monday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano


Monday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano


Monday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 26 | 5:00PM - 7:00PM
Early/Innate Immune Responses to TB
Room: Grays Peak/Longs Peak

Speaker 1 of 4
* Valerie F. Quesniaux, Centre National de la Recherche Scientifique, France
Toll-Like Receptors in Tuberculosis

Monday, January 26 | 5:00PM - 7:00PM
Early/Innate Immune Responses to TB
Room: Grays Peak/Longs Peak

Speaker 2 of 4
Clifford V. Harding, Case Western Reserve University, USA
Regulation of APCs and Class II MHC by TLR2 and Mycobacterium tuberculosis

Monday, January 26 | 5:00PM - 7:00PM
Early/Innate Immune Responses to TB
Room: Grays Peak/Longs Peak

Speaker 3 of 4
Stefan Ehlers, Research Center Borstel, Germany
Short Talk: Non-Classical Macrophage Activation in Experimental TB – Consequences for Reactivation and Lung Pathology

Monday, January 26 | 5:00PM - 7:00PM
Early/Innate Immune Responses to TB
Room: Grays Peak/Longs Peak

Speaker 4 of 4
Padmini Salgame, Rutgers University, USA
Short Talk: Coexisting Helminth Infection Induces Inhibition of Pulmonary Anti-Tuberculosis Defense

Monday, January 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano


Monday, January 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano


Tuesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano


Tuesday, January 27 | 8:00AM - 11:00AM
Key Pathways in Bacterial Metabolism
Room: Grays Peak/Longs Peak

Speaker 1 of 5
Christopher M. Sassetti, University of Massachusetts Medical School, USA
Carbon Metabolism Comes Full Circle

Tuesday, January 27 | 8:00AM - 11:00AM
Key Pathways in Bacterial Metabolism
Room: Grays Peak/Longs Peak

Speaker 2 of 5
* Valerie Mizrahi, University of Cape Town, South Africa
Novel and Vulnerable Pathways of DNA Metabolism in Mycobacteria

Tuesday, January 27 | 8:00AM - 11:00AM
Key Pathways in Bacterial Metabolism
Room: Grays Peak/Longs Peak

Speaker 3 of 5
Jeffery S. Cox, University of California, Berkeley, USA
Protein Secretion, Novel and Conserved Systems

Tuesday, January 27 | 8:00AM - 11:00AM
Key Pathways in Bacterial Metabolism
Room: Grays Peak/Longs Peak

Speaker 4 of 5
Carolyn R. Bertozzi, Stanford University, USA
Mycobacterial Sulfation Pathways

Tuesday, January 27 | 8:00AM - 11:00AM
Key Pathways in Bacterial Metabolism
Room: Grays Peak/Longs Peak

Speaker 5 of 5
Koen Andries, Tibotec, Belgium
Short Talk: ATP Synthase, A New Validated Target for TB Treatment



Tuesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 27 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano


Tuesday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano


Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 1 of 10
* Thomas Dick, Hackensack Meridian Health, USA
Introduction: Connecting Academia and Industry

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 2 of 10
* Ken Duncan, Bill & Melinda Gates Foundation, USA

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 3 of 10
Koen Andries, Tibotec, Belgium
Filling the Gap: What can YOU do?

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 4 of 10
Christopher D. Earl, BIO Ventures for Global Health, USA
Building Biotech Solutions for Diseases of the Developing World

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 5 of 10
Jose F. Garcia-Bustos, GlaxoSmithKline, Spain
and

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 6 of 10
Clifton E. Barry III, NIAID, National Institutes of Health, USA
and

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 7 of 10
James C. Sacchettini, Texas A & M University, USA
How Can We Improve Academia - Industry Interaction 2: Views from Academia

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 8 of 10
M. Gerard Waters, Novartis, USA

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 9 of 10
Makoto Matsumoto, Otsuka Pharmaceutical Co. Ltd., Japan

Tuesday, January 27 | 2:30PM - 4:30PM
Workshop on TB Drug Discovery: Connecting Academia and Indus
try
Room: Grays Peak / Longs Peak
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Speaker 10 of 10
Veronique Anne Dartois, Hackensack Meridian Health, USA

Tuesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 27 | 5:00PM - 7:00PM
Pathology and Transmission of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 1 of 4
* Gilla Kaplan, University of Cape Town, South Africa

Tuesday, January 27 | 5:00PM - 7:00PM
Pathology and Transmission of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 2 of 4
Elizabeth L. Corbett, London School of Hygiene & Tropical Med / MLW Trust Clinical Research Programme, Malawi
TB Transmission and Susceptibility

Tuesday, January 27 | 5:00PM - 7:00PM
Pathology and Transmission of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 3 of 4
Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK
Conditions in the Human Lung during Active Tuberculosis

Tuesday, January 27 | 5:00PM - 7:00PM
Pathology and Transmission of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 4 of 4
Denise Kirschner, University of Michigan, USA
A Multi-Scale Peek at Granuloma Formation in TB

Tuesday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano


Tuesday, January 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano


Wednesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano


Wednesday, January 28 | 8:00AM - 11:00AM
Insights from Animal Models: New Approaches
Room: Grays Peak/Longs Peak

Speaker 1 of 4
Lalita Ramakrishnan, University of Cambridge, UK
A Forward Genetic Screen in the Zebrafish Reveals a Human TB Susceptibility Locus

Wednesday, January 28 | 8:00AM - 11:00AM
Insights from Animal Models: New Approaches
Room: Grays Peak/Longs Peak

Speaker 2 of 4
David S. Schneider, Stanford University School of Medicine, USA
Balancing Resistance and Tolerance During Infections in the Fly

Wednesday, January 28 | 8:00AM - 11:00AM
Insights from Animal Models: New Approaches
Room: Grays Peak/Longs Peak

Speaker 3 of 4
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Non-Human Primate Model of Tuberculosis. What can we learn about TB?

Wednesday, January 28 | 8:00AM - 11:00AM
Insights from Animal Models: New Approaches
Room: Grays Peak/Longs Peak

Speaker 4 of 4
Gilla Kaplan, University of Cape Town, South Africa
Host and Pathogen Contribution to Pathology

Wednesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano


Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 1 of 9
* Gary K. Schoolnik, Stanford University, USA
Welcome, Workshop Goals

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 2 of 9
Adamandia Kapopoulou, Ecole Polytechnique Federale de Lausanne, Switzerland
Tuberculist

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 3 of 9
James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA
TBDatabase: A Database that Integrates Expression and Genomics Data and which Provides Suites of Bioinformatics Tools

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 4 of 9
Barry A. Bunin, CDD, USA
Collaborative Drug Discovery Database

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 5 of 9
Thomas R. Holton, University of California, Los Angeles, USA
WebTB.org and the TB Structural Genomics Consortium: Tools for searching and annotating the TB genome

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 6 of 9
Shubhada Godbole, University of Texas Southwestern Medical Center, USA
BioHealthBase: A Comprehensive Integrated Database and Analysis Resource for TB Research

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 7 of 9
Kristin Kremer, National Institute of Public Health and the Environment, Netherlands
Usefulness of DNA Fingerprint Databases to Study the Epidemiology and Phylogeny of TB

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 8 of 9
Stefan Niemann, Research Center Borstel, Germany
MIRU-VNTRplus Database: Online Identification of Clinical Isolates Based on Reference Collections and Analysis of Molecular Typing Data

Wednesday, January 28 | 11:00AM - 2:00PM
Symposium on Tuberculosis Databases and Bioinformatics Tools
Room: Grays Peak/Longs Peak

Speaker 9 of 9
* Gary K. Schoolnik, Stanford University, USA
Discussion: Unmet Bioinformatic Needs; How can they be Addressed?

Wednesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano


Wednesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 28 | 5:00PM - 7:00PM
Bacterial Response to the Evolving Host Environments
Room: Grays Peak/Longs Peak

Speaker 1 of 4
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
The Essential Irony of Tuberculosis

Wednesday, January 28 | 5:00PM - 7:00PM
Bacterial Response to the Evolving Host Environments
Room: Grays Peak/Longs Peak

Speaker 2 of 4
Helena I. M. Boshoff, NIAID, National Institutes of Health, USA
Nitroimidazoles for TB: Mechanism of Killing

Wednesday, January 28 | 5:00PM - 7:00PM
Bacterial Response to the Evolving Host Environments
Room: Grays Peak/Longs Peak

Speaker 3 of 4
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Slipping the Host a Mycobacterial Mickey Finn

Wednesday, January 28 | 5:00PM - 7:00PM
Bacterial Response to the Evolving Host Environments
Room: Grays Peak/Longs Peak

Speaker 4 of 4
Adrie J. C. Steyn, Africa Health Research Institute & UAB, South Africa
Short Talk: Mycobacterium tuberculosis WhiB3 maintains Intrabacterial Redox Homeostasis by Modulating Virulence Lipid Anabolism to Subvert Macrophage Function

Wednesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano


Wednesday, January 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano


Thursday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano


Thursday, January 29 | 7:00AM - 8:00AM
Poster Setup
Room: Red Cloud/Shavano


Thursday, January 29 | 8:00AM - 11:00AM
Action and Reaction in the Immune Control of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 1 of 5
* Michael Stephen Glickman, Memorial Sloan-Kettering Institute, USA
Discovery of a Novel Pathway that Integrates rRNA Transcription with DNA damage

Thursday, January 29 | 8:00AM - 11:00AM
Action and Reaction in the Immune Control of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 2 of 5
Gary K. Schoolnik, Stanford University, USA
Mycobacterium tuberculosis (Mtb)Expression Signatures of Host Immune Status

Thursday, January 29 | 8:00AM - 11:00AM
Action and Reaction in the Immune Control of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 3 of 5
Heran Darwin, New York University School of Medicine, USA
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

Thursday, January 29 | 8:00AM - 11:00AM
Action and Reaction in the Immune Control of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 4 of 5
Shahin Shafiani, Center for Infectious Disease Research, USA
Short Talk: Pathogen-Specific Regulatory T Cells Impair Protective Immunity in Tuberculosis

Thursday, January 29 | 8:00AM - 11:00AM
Action and Reaction in the Immune Control of Tuberculosis
Room: Grays Peak/Longs Peak

Speaker 5 of 5
Tige R. Rustad, Seattle BioMed, USA
Short Talk: The DosR Regulon and the Enduring Hypoxic Response: Identification, Regulation and In Vivo Relevance

Thursday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 29 | 11:00AM - 12:00PM
Lunch
Room: Quandary Peaks


Thursday, January 29 | 12:00PM - 2:30PM
Poster Session 4
Room: Red Cloud/Shavano


Thursday, January 29 | 12:00PM - 5:00PM
Poster Viewing
Room: Red Cloud/Shavano


Thursday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 29 | 5:00PM - 7:00PM
Bacterial Physiology and Drug Targets
Room: Grays Peak/Longs Peak

Speaker 1 of 3
Thomas Dick, Hackensack Meridian Health, USA
One Plus One does not Equal Two: In Vitro – in Vivo Disconnect in TB Drug Discovery

Thursday, January 29 | 5:00PM - 7:00PM
Bacterial Physiology and Drug Targets
Room: Grays Peak/Longs Peak

Speaker 2 of 3
* James C. Sacchettini, Texas A & M University, USA
Mtb Whole Genome Sequencing: Detecting Drug-Pathogen Interactions

Thursday, January 29 | 5:00PM - 7:00PM
Bacterial Physiology and Drug Targets
Room: Grays Peak/Longs Peak

Speaker 3 of 3
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Rethinking the Concept of a Good TB Drug “Target”

Thursday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano


Thursday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano


Thursday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano


Friday, January 30 | 10:25AM - 10:25AM
Departure


*Session Chair.