Web Desc
Pathogenesis and Immune Regulation in Helminth Infections
Organizer(s): Rick M. Maizels, Maria Yazdanbakhsh and Thomas A. Wynn
Date: February 01 - 05, 2009
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
The immunology of parasitic helminths is now attracting intense interest, due to the exciting and intricate relationship between immunity and pathogenesis, the proposed significance of regulatory immune controls in modulating both infection and disease, including allergies and autoimmunity, and the application of new molecular tools to the field situation. Currently, research aims to trace how helminths manipulate host immune cell populations, identify molecular mediators and receptor pathways involved in the host-pathogen dialogue, and design new interventions for control of infection in both human and animal contexts. This meeting will bring together scientists from many different countries (particularly those highly prevalent for helminth diseases), bridging from reductionist model systems, which offer proof of principle, to the epidemiological scale in which major insights are gained from natural infection settings. New questions from field and laboratory research will be generated, promoting the integration of different strands of inquiry and paving the way for new strategies for disease control.
Global Health Travel Award Deadline: September 9 2008
Scholarship Deadline: October 1 2008
Discounted Abstract Deadline: October 1 2008
Abstract Deadline: October 30 2008
Discounted Registration Deadline: December 1 2008
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome FundScynexis, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell PressUnited European Gastroenterology Federation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI081464-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 01 | 3:00PM - 7:30PM
Registration
Room: Pre Function


Sunday, February 01 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Daniel G. Colley, University of Georgia, USA
Helminth Research in the 21st Century: 8 Down - 92 to Go

Monday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 7 of 7
Peter J. Hotez, Baylor College of Medicine, USA
Vaccination Against Human Helminth Parasites

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 6 of 7
Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
The Impact of Maternal Helminth Infection and of De-Worming in Pregnancy on Infant Response to BCG and tetanus immunisation

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 5 of 7
Markus Mohrs, Regeneron Pharmaceuticals, USA
Short Talk: Omega-1, a Glycoprotein Secreted by Schistosoma mansoni Eggs, Drives Th2 Responses

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 4 of 7
Philip J. Cooper, St George's, University of London, UK
Short Talk: Human Chronic Infections with Ascaris lumbricoides Affect Cytokine Production and Gene Expression

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 3 of 7
* Thomas B. Nutman, NIAID, National Institutes of Health, USA
Clinically Inapparent but Immunologically Measurable Bystander Effects of Tissue-Invasive Helminth Infections on other Infectious Diseases of Humans

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 2 of 7
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Regulatory Network in Human Helminth Infections

Monday, February 02 | 8:00AM - 11:15AM
New Developments in Immunology of Helminth Diseases
Room: Mountain/Lake

Speaker 1 of 7
* Murray E. Selkirk, Imperial College London, UK

Monday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, February 02 | 11:15AM - 11:15AM
On Own for Lunch


Monday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 9 of 9
* Mark John Taylor, Liverpool School of Tropical Medicine, UK
Wolbachia Lipoproteins as Drivers of Innate and Adaptive Inflammatory Pathogenesis of Lymphatic Filariasis and Onchocerciasis

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 8 of 9
Rachel A. Lawrence, Royal Veterinary College, UK
Deficiency in Mannose-Binding Lectin -A and/or -C Prevents Parasite Clearance and Development of Anti-Parasite IgM

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 7 of 9
David Voehringer, University Hospital of Erlangen, Germany
Basophil Effector Function and Homeostasis during Helminth Infection

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 6 of 9
Jacqueline Perrigoue, University of Pennsylvania, USA
Innate Immunity to Intestinal Helminths: Looking Beyond Dendritic Cells

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 5 of 9
Katie Smith, Cardiff Institute of Infection and Immunity, UK
Tolerogenic Dendritic Cells in Chronic Helminth Infection

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 4 of 9
Caroline M.W. van Stijn, VU Medical Center, Netherlands
Schistosoma mansoni Adult Worm Glycolipids Induce Maturation of Human Monocytes Derived Dendritic Cells

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 3 of 9
Carmen Aranzamendi, Rijksinstituut voor Volksgezondheid en Milieu, Netherlands
Trichinella spiralis Excretory/Secretory Antigen Inhibits DC Maturation: A Role of for TLR4 and CD14

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 2 of 9
Ayola A. Adegnika, Albert Schweitzer Hospital, of Lambaréné, Gabon
Schistosoma haematobium Infection Impairs Human Blood Dendritic Cell Function

Monday, February 02 | 2:30PM - 4:30PM
Workshop 1: Stimulation of Anti-Helminth Responsiveness
Room: Mountain/Lake

Speaker 1 of 9
* Taniawati Supali, Faculty of Medicine University of Indonesia, Indonesia

Monday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 02 | 5:00PM - 7:00PM
Helminth Stimulation of the Immune System
Room: Mountain/Lake

Speaker 1 of 4
Achim M. Hoerauf, University Hospital Bonn, Germany
Stimulation of the Host Immune System by Filariae and their Wolbachia endosymbionts

Monday, February 02 | 5:00PM - 7:00PM
Helminth Stimulation of the Immune System
Room: Mountain/Lake

Speaker 2 of 4
Nicola L. Harris, Monash University, Australia
Short Talk: Parasite Products Bypass the Need for TSLP in TH2 Immune Responses by Directly Modulating Dendritic Cell Function

Monday, February 02 | 5:00PM - 7:00PM
Helminth Stimulation of the Immune System
Room: Mountain/Lake

Speaker 3 of 4
Padraic Fallon, Trinity College Dublin, Ireland
Helminth Drivers of Innate and Adaptive Immunity

Monday, February 02 | 5:00PM - 7:00PM
Helminth Stimulation of the Immune System
Room: Mountain/Lake

Speaker 4 of 4
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Tracking the Host Response in Helminth Immunity

Monday, February 02 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, February 02 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay


Monday, February 02 | 8:00PM - 9:00PM
Social Hour
Room: Pre-Function


Tuesday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 1 of 7
* Rachel A. Lawrence, Royal Veterinary College, UK

Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 2 of 7
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Induction and Regulation of the Th2 Response to Helminths

Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 3 of 7
Graham S. Le Gros, Malaghan Institute of Medical Research, New Zealand
Rewriting the Paradigm for IL4/STAT6 in Th2 Differentiation and Protective Immunity against Helminth Infection

Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 4 of 7
Nienke van der Werf, University of Edinburgh, UK
Short Talk: Induction and Maintenance of Regulatory and Effector T Cell Responses during chronic helminth infection


Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 5 of 7
Marc Peter Hübner, Uniformed Services University, USA
Short Talk: Inhibition of Type I Diabetes in Filaria Infected NOD Mice is Associated with a Th2 Shift and Induction of Regulatory T Cells

Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 6 of 7
William C. Gause, Rutgers New Jersey Medical School, USA
Characterization of Effector Mechanisms Leading to Resistance during a Peripheral Memory Th2 Type Response

Tuesday, February 03 | 8:00AM - 11:15AM
Helminth Modulation of T Cell Activity
Room: Mountain/Lake

Speaker 7 of 7
Richard M. Maizels, University of Glasgow, UK
Regulatory Cells Induced by Helminth Parasites

Tuesday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, February 03 | 11:15AM - 11:15AM
On Own for Lunch


Tuesday, February 03 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, February 03 | 5:00PM - 7:00PM
Pathogenesis and Immunity in Helminth Infection
Room: Mountain/Lake

Speaker 1 of 5
* Richard M. Locksley, HHMI/University of California, San Francisco, USA

Tuesday, February 03 | 5:00PM - 7:00PM
Pathogenesis and Immunity in Helminth Infection
Room: Mountain/Lake

Speaker 2 of 5
Thomas A. Wynn, Pfizer, USA
Dissecting 'Alternative' Activation: The Role of Macrophages and Other Targets of IL-4/IL-13 Signaling

Tuesday, February 03 | 5:00PM - 7:00PM
Pathogenesis and Immunity in Helminth Infection
Room: Mountain/Lake

Speaker 3 of 5
Miguel J. Stadecker, Tufts University School of Medicine, USA
Induction and Regulation of the Pathogenic Th17 Response in Schistosomiasis

Tuesday, February 03 | 5:00PM - 7:00PM
Pathogenesis and Immunity in Helminth Infection
Room: Mountain/Lake

Speaker 4 of 5
Mara Shainheit, Tufts University-Sackler School, USA
Short Talk: Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology

Tuesday, February 03 | 5:00PM - 7:00PM
Pathogenesis and Immunity in Helminth Infection
Room: Mountain/Lake

Speaker 5 of 5
David Artis, Weill Cornell Medical College, USA
Regulation of Immunity and Infection following Gastrointestinal Nematode Infection

Tuesday, February 03 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, February 03 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, February 03 | 8:00PM - 9:00PM
Social Hour
Room: Pre-Function


Wednesday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 1 of 7
* Sabine Specht, University Hospital Bonn, Germany

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 2 of 7
Anne Cooke, University of Cambridge, UK
Helminth Modulation of Autoimmune Diabetes

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 3 of 7
Cathryn R. Nagler, University of Chicago, USA
Intestinal Helminth Infection Compromises Oral and Parenteral Vaccine Efficacy

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 4 of 7
De' Broski R. Herbert, University of Pennsylvania, USA
Short Talk: Essential Role for IL-4/13 Activated Epithelia in Host Protection Against GI Nematodes

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 5 of 7
P'ng Loke, New York University School of Medicine, USA
Short Talk: Characterization of the Colon for Th17/Th22 Cells and by Transcriptional Profiling during Trichuris trichiura Infection in a Patient with Ulcerative Colitis

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 6 of 7
Klaus J. Erb, Boehringer Ingelheim, Germany
How can Infection with Helmintths Protect from Allergic Disorders?

Wednesday, February 04 | 8:00AM - 11:15AM
Inflammatory Diseases and Helminth Infection
Room: Mountain/Lake

Speaker 7 of 7
* Judith E. Allen, University of Manchester, UK
Helminth-Elicited Macrophages in Th2-Mediated Inflammation

Wednesday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, February 04 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 1 of 8
Alvaro Juan Díaz, Facultad de Quimica, Universidad de la Republica, Uruguay, Uruguay
Surface Mucins of Larval Echinococcus Granulosus: Carbohydrate Structural Elucidation and Effects on Macrophage Phenotype

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 2 of 8
* Irma M. Van Die, VU University Medical Center, Netherlands
Schistosome Glycans Modulate Dendritic Cell Function

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 3 of 8
Irma Schabussova, Center for Physiology, Pathophysiology & Immunology, Austria
Novel O-Methylated Glycans from Toxocara Activate Dendritic Cells via TLR2, Selectively Inhibiting TLR4 Responsiveness and IL-12p70 Production

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 4 of 8
Moniek H J Meevissen, Leiden University Medical Centre, Netherlands
The GalNAcbeta1-4GlcNAc-Containing Glycoprotein kappa5 from S. Mansoni Egg Secretions Induces Granuloma Formation in a Pulmonary Mouse Model

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 5 of 8
Jose Lozano-Torres, Wageningen University, Netherlands
A Nematode Venom Allergen/ASP-Like Protein Interacts with a Cathepsin-Like Protein in the Host and is Required for Plant-Parasitism

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 6 of 8
Sara Lustigman, New York Blood Center, USA
The Onchocerca volvulus Recombinant Ov-ASP-1 Protein has Immunostimulatory Properties in vivo and in vitro

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 7 of 8
Soraya Gaze Jangola, Fiocruz - Instituto Rene Rahcou, Brazil
Excretory/Secretory Products from Necator americanus that Bind to Natural Killer Cells and Induce IFN-gamma Secretion

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 2: Helminth Genomes: Promise and Practise
Room: Mountain/Lake

Speaker 8 of 8
* Kleoniki Gounaris, Imperial College London, UK
Secreted Proteins of Trichinella spiralis Modulate Purinergic Signalling and Leukocyte Function

Wednesday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, February 04 | 5:00PM - 7:00PM
Helminths and Defined Products in Therapy of Disease
Room: Mountain/Lake

Speaker 1 of 5
* Cornelis H. Hokke, Leiden University Medical Center, Netherlands

Wednesday, February 04 | 5:00PM - 7:00PM
Helminths and Defined Products in Therapy of Disease
Room: Mountain/Lake

Speaker 2 of 5
Daniel G. Blount, University of Nottingham, UK
The Costs and Potential Benefits of Hookworm Infection

Wednesday, February 04 | 5:00PM - 7:00PM
Helminths and Defined Products in Therapy of Disease
Room: Mountain/Lake

Speaker 3 of 5
Danielle Smyth, Queensland Institute of Medical Research, Australia
Short Talk: New Lessons from Old Parasites: Using Hookworm Antigen to Treat IBD

Wednesday, February 04 | 5:00PM - 7:00PM
Helminths and Defined Products in Therapy of Disease
Room: Mountain/Lake

Speaker 4 of 5
Joel V. Weinstock, Tufts Medical Center, USA
Helminth Suppression of Antigenic T Cell Responses in the Gut of Murine Colitis

Wednesday, February 04 | 5:00PM - 7:00PM
Helminths and Defined Products in Therapy of Disease
Room: Mountain/Lake

Speaker 5 of 5
William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62

Wednesday, February 04 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Wednesday, February 04 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Wednesday, February 04 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Thursday, February 05 | 10:25AM - 10:25AM
Departure


*Session Chair.