Past Meeting | Keystone Symposia

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Helminths: New Insights from Immunity to Global Health (2020T4)

Web Desc
Pathogenesis and Immune Regulation in Helminth Infections Organizer(s): Rick M. Maizels, Maria Yazdanbakhsh and Thomas A. Wynn Date: February 01 - 05, 2009 Location: Granlibakken Tahoe, Tahoe City, CA, USA Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation Summary of Meeting: The immunology of parasitic helminths is now attracting intense interest, due to the exciting and intricate relationship between immunity and pathogenesis, the proposed significance of regulatory immune controls in modulating both infection and disease, including allergies and autoimmunity, and the application of new molecular tools to the field situation. Currently, research aims to trace how helminths manipulate host immune cell populations, identify molecular mediators and receptor pathways involved in the host-pathogen dialogue, and design new interventions for control of infection in both human and animal contexts. This meeting will bring together scientists from many different countries (particularly those highly prevalent for helminth diseases), bridging from reductionist model systems, which offer proof of principle, to the epidemiological scale in which major insights are gained from natural infection settings. New questions from field and laboratory research will be generated, promoting the integration of different strands of inquiry and paving the way for new strategies for disease control. Global Health Travel Award Deadline: September 9 2008 Scholarship Deadline: October 1 2008 Discounted Abstract Deadline: October 1 2008 Abstract Deadline: October 30 2008 Discounted Registration Deadline: December 1 2008 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI081464-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Pathogenesis and Immune Regulation in Helminth Infections

Organizer(s): Rick M. Maizels, Maria Yazdanbakhsh and Thomas A. Wynn

Date: February 01 - 05, 2009
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:

The immunology of parasitic helminths is now attracting intense interest, due to the exciting and intricate relationship between immunity and pathogenesis, the proposed significance of regulatory immune controls in modulating both infection and disease, including allergies and autoimmunity, and the application of new molecular tools to the field situation. Currently, research aims to trace how helminths manipulate host immune cell populations, identify molecular mediators and receptor pathways involved in the host-pathogen dialogue, and design new interventions for control of infection in both human and animal contexts. This meeting will bring together scientists from many different countries (particularly those highly prevalent for helminth diseases), bridging from reductionist model systems, which offer proof of principle, to the epidemiological scale in which major insights are gained from natural infection settings. New questions from field and laboratory research will be generated, promoting the integration of different strands of inquiry and paving the way for new strategies for disease control.

Global Health Travel Award Deadline: September 9 2008

Scholarship Deadline: October 1 2008

Discounted Abstract Deadline: October 1 2008

Abstract Deadline: October 30 2008

Discounted Registration Deadline: December 1 2008

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

United European Gastroenterology Federation

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI081464-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 01 \| 3:00PM - 7:30PM Registration Room: Pre Function
Sunday, February 01 \| 7:30PM - 8:30PM Keynote Address Room: Mountain/Lake Speaker 1 of 1 Daniel G. Colley, University of Georgia, USA Helminth Research in the 21st Century: 8 Down - 92 to Go
Monday, February 02 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 7 of 7 Peter J. Hotez, Baylor College of Medicine, USA Vaccination Against Human Helminth Parasites
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 6 of 7 Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda The Impact of Maternal Helminth Infection and of De-Worming in Pregnancy on Infant Response to BCG and tetanus immunisation
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 5 of 7 Markus Mohrs, Regeneron Pharmaceuticals, USA Short Talk: Omega-1, a Glycoprotein Secreted by Schistosoma mansoni Eggs, Drives Th2 Responses
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 4 of 7 Philip J. Cooper, St George's, University of London, UK Short Talk: Human Chronic Infections with Ascaris lumbricoides Affect Cytokine Production and Gene Expression
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 3 of 7 * Thomas B. Nutman, NIAID, National Institutes of Health, USA Clinically Inapparent but Immunologically Measurable Bystander Effects of Tissue-Invasive Helminth Infections on other Infectious Diseases of Humans
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 2 of 7 Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands The Regulatory Network in Human Helminth Infections
Monday, February 02 \| 8:00AM - 11:15AM New Developments in Immunology of Helminth Diseases Room: Mountain/Lake Speaker 1 of 7 * Murray E. Selkirk, Imperial College London, UK
Monday, February 02 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Monday, February 02 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Monday, February 02 \| 11:15AM - 11:15AM On Own for Lunch
Monday, February 02 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 9 of 9 * Mark John Taylor, Liverpool School of Tropical Medicine, UK Wolbachia Lipoproteins as Drivers of Innate and Adaptive Inflammatory Pathogenesis of Lymphatic Filariasis and Onchocerciasis
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 8 of 9 Rachel A. Lawrence, Royal Veterinary College, UK Deficiency in Mannose-Binding Lectin -A and/or -C Prevents Parasite Clearance and Development of Anti-Parasite IgM
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 7 of 9 David Voehringer, University Hospital of Erlangen, Germany Basophil Effector Function and Homeostasis during Helminth Infection
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 6 of 9 Jacqueline Perrigoue, University of Pennsylvania, USA Innate Immunity to Intestinal Helminths: Looking Beyond Dendritic Cells
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 5 of 9 Katie Smith, Cardiff Institute of Infection and Immunity, UK Tolerogenic Dendritic Cells in Chronic Helminth Infection
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 4 of 9 Caroline M.W. van Stijn, VU Medical Center, Netherlands Schistosoma mansoni Adult Worm Glycolipids Induce Maturation of Human Monocytes Derived Dendritic Cells
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 3 of 9 Carmen Aranzamendi, Rijksinstituut voor Volksgezondheid en Milieu, Netherlands Trichinella spiralis Excretory/Secretory Antigen Inhibits DC Maturation: A Role of for TLR4 and CD14
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 2 of 9 Ayola A. Adegnika, Albert Schweitzer Hospital, of Lambaréné, Gabon Schistosoma haematobium Infection Impairs Human Blood Dendritic Cell Function
Monday, February 02 \| 2:30PM - 4:30PM Workshop 1: Stimulation of Anti-Helminth Responsiveness Room: Mountain/Lake Speaker 1 of 9 * Taniawati Supali, Faculty of Medicine University of Indonesia, Indonesia
Monday, February 02 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Monday, February 02 \| 5:00PM - 7:00PM Helminth Stimulation of the Immune System Room: Mountain/Lake Speaker 1 of 4 Achim M. Hoerauf, University Hospital Bonn, Germany Stimulation of the Host Immune System by Filariae and their Wolbachia endosymbionts
Monday, February 02 \| 5:00PM - 7:00PM Helminth Stimulation of the Immune System Room: Mountain/Lake Speaker 2 of 4 Nicola L. Harris, Monash University, Australia Short Talk: Parasite Products Bypass the Need for TSLP in TH2 Immune Responses by Directly Modulating Dendritic Cell Function
Monday, February 02 \| 5:00PM - 7:00PM Helminth Stimulation of the Immune System Room: Mountain/Lake Speaker 3 of 4 Padraic Fallon, Trinity College Dublin, Ireland Helminth Drivers of Innate and Adaptive Immunity
Monday, February 02 \| 5:00PM - 7:00PM Helminth Stimulation of the Immune System Room: Mountain/Lake Speaker 4 of 4 Richard M. Locksley, HHMI/University of California, San Francisco, USA Tracking the Host Response in Helminth Immunity
Monday, February 02 \| 7:00PM - 8:00PM Dinner Room: Granhall
Monday, February 02 \| 8:00PM - 10:00PM Poster Session 1 Room: Bay
Monday, February 02 \| 8:00PM - 9:00PM Social Hour Room: Pre-Function
Tuesday, February 03 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 1 of 7 * Rachel A. Lawrence, Royal Veterinary College, UK
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 2 of 7 * Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany Induction and Regulation of the Th2 Response to Helminths
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 3 of 7 Graham S. Le Gros, Malaghan Institute of Medical Research, New Zealand Rewriting the Paradigm for IL4/STAT6 in Th2 Differentiation and Protective Immunity against Helminth Infection
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 4 of 7 Nienke van der Werf, University of Edinburgh, UK Short Talk: Induction and Maintenance of Regulatory and Effector T Cell Responses during chronic helminth infection
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 5 of 7 Marc Peter Hübner, Uniformed Services University, USA Short Talk: Inhibition of Type I Diabetes in Filaria Infected NOD Mice is Associated with a Th2 Shift and Induction of Regulatory T Cells
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 6 of 7 William C. Gause, Rutgers New Jersey Medical School, USA Characterization of Effector Mechanisms Leading to Resistance during a Peripheral Memory Th2 Type Response
Tuesday, February 03 \| 8:00AM - 11:15AM Helminth Modulation of T Cell Activity Room: Mountain/Lake Speaker 7 of 7 Richard M. Maizels, University of Glasgow, UK Regulatory Cells Induced by Helminth Parasites
Tuesday, February 03 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Tuesday, February 03 \| 11:15AM - 11:15AM On Own for Lunch
Tuesday, February 03 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Tuesday, February 03 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Tuesday, February 03 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Tuesday, February 03 \| 5:00PM - 7:00PM Pathogenesis and Immunity in Helminth Infection Room: Mountain/Lake Speaker 1 of 5 * Richard M. Locksley, HHMI/University of California, San Francisco, USA
Tuesday, February 03 \| 5:00PM - 7:00PM Pathogenesis and Immunity in Helminth Infection Room: Mountain/Lake Speaker 2 of 5 Thomas A. Wynn, Pfizer, USA Dissecting 'Alternative' Activation: The Role of Macrophages and Other Targets of IL-4/IL-13 Signaling
Tuesday, February 03 \| 5:00PM - 7:00PM Pathogenesis and Immunity in Helminth Infection Room: Mountain/Lake Speaker 3 of 5 Miguel J. Stadecker, Tufts University School of Medicine, USA Induction and Regulation of the Pathogenic Th17 Response in Schistosomiasis
Tuesday, February 03 \| 5:00PM - 7:00PM Pathogenesis and Immunity in Helminth Infection Room: Mountain/Lake Speaker 4 of 5 Mara Shainheit, Tufts University-Sackler School, USA Short Talk: Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology
Tuesday, February 03 \| 5:00PM - 7:00PM Pathogenesis and Immunity in Helminth Infection Room: Mountain/Lake Speaker 5 of 5 David Artis, Weill Cornell Medical College, USA Regulation of Immunity and Infection following Gastrointestinal Nematode Infection
Tuesday, February 03 \| 7:00PM - 8:00PM Dinner Room: Granhall
Tuesday, February 03 \| 8:00PM - 10:00PM Poster Session 2 Room: Bay
Tuesday, February 03 \| 8:00PM - 9:00PM Social Hour Room: Pre-Function
Wednesday, February 04 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 1 of 7 * Sabine Specht, University Hospital Bonn, Germany
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 2 of 7 Anne Cooke, University of Cambridge, UK Helminth Modulation of Autoimmune Diabetes
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 3 of 7 Cathryn R. Nagler, University of Chicago, USA Intestinal Helminth Infection Compromises Oral and Parenteral Vaccine Efficacy
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 4 of 7 De' Broski R. Herbert, University of Pennsylvania, USA Short Talk: Essential Role for IL-4/13 Activated Epithelia in Host Protection Against GI Nematodes
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 5 of 7 P'ng Loke, New York University School of Medicine, USA Short Talk: Characterization of the Colon for Th17/Th22 Cells and by Transcriptional Profiling during Trichuris trichiura Infection in a Patient with Ulcerative Colitis
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 6 of 7 Klaus J. Erb, Boehringer Ingelheim, Germany How can Infection with Helmintths Protect from Allergic Disorders?
Wednesday, February 04 \| 8:00AM - 11:15AM Inflammatory Diseases and Helminth Infection Room: Mountain/Lake Speaker 7 of 7 * Judith E. Allen, University of Manchester, UK Helminth-Elicited Macrophages in Th2-Mediated Inflammation
Wednesday, February 04 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Wednesday, February 04 \| 11:15AM - 11:15AM On Own for Lunch
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 1 of 8 Alvaro Juan Díaz, Facultad de Quimica, Universidad de la Republica, Uruguay, Uruguay Surface Mucins of Larval Echinococcus Granulosus: Carbohydrate Structural Elucidation and Effects on Macrophage Phenotype
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 2 of 8 * Irma M. Van Die, VU University Medical Center, Netherlands Schistosome Glycans Modulate Dendritic Cell Function
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 3 of 8 Irma Schabussova, Center for Physiology, Pathophysiology & Immunology, Austria Novel O-Methylated Glycans from Toxocara Activate Dendritic Cells via TLR2, Selectively Inhibiting TLR4 Responsiveness and IL-12p70 Production
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 4 of 8 Moniek H J Meevissen, Leiden University Medical Centre, Netherlands The GalNAcbeta1-4GlcNAc-Containing Glycoprotein kappa5 from S. Mansoni Egg Secretions Induces Granuloma Formation in a Pulmonary Mouse Model
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 5 of 8 Jose Lozano-Torres, Wageningen University, Netherlands A Nematode Venom Allergen/ASP-Like Protein Interacts with a Cathepsin-Like Protein in the Host and is Required for Plant-Parasitism
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 6 of 8 Sara Lustigman, New York Blood Center, USA The Onchocerca volvulus Recombinant Ov-ASP-1 Protein has Immunostimulatory Properties in vivo and in vitro
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 7 of 8 Soraya Gaze Jangola, Fiocruz - Instituto Rene Rahcou, Brazil Excretory/Secretory Products from Necator americanus that Bind to Natural Killer Cells and Induce IFN-gamma Secretion
Wednesday, February 04 \| 2:30PM - 4:30PM Workshop 2: Helminth Genomes: Promise and Practise Room: Mountain/Lake Speaker 8 of 8 * Kleoniki Gounaris, Imperial College London, UK Secreted Proteins of Trichinella spiralis Modulate Purinergic Signalling and Leukocyte Function
Wednesday, February 04 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Wednesday, February 04 \| 5:00PM - 7:00PM Helminths and Defined Products in Therapy of Disease Room: Mountain/Lake Speaker 1 of 5 * Cornelis H. Hokke, Leiden University Medical Center, Netherlands
Wednesday, February 04 \| 5:00PM - 7:00PM Helminths and Defined Products in Therapy of Disease Room: Mountain/Lake Speaker 2 of 5 Daniel G. Blount, University of Nottingham, UK The Costs and Potential Benefits of Hookworm Infection
Wednesday, February 04 \| 5:00PM - 7:00PM Helminths and Defined Products in Therapy of Disease Room: Mountain/Lake Speaker 3 of 5 Danielle Smyth, Queensland Institute of Medical Research, Australia Short Talk: New Lessons from Old Parasites: Using Hookworm Antigen to Treat IBD
Wednesday, February 04 \| 5:00PM - 7:00PM Helminths and Defined Products in Therapy of Disease Room: Mountain/Lake Speaker 4 of 5 Joel V. Weinstock, Tufts Medical Center, USA Helminth Suppression of Antigenic T Cell Responses in the Gut of Murine Colitis
Wednesday, February 04 \| 5:00PM - 7:00PM Helminths and Defined Products in Therapy of Disease Room: Mountain/Lake Speaker 5 of 5 William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62
Wednesday, February 04 \| 7:00PM - 8:00PM Social Hour Room: Granhall
Wednesday, February 04 \| 8:00PM - 9:00PM Dinner Room: Granhall
Wednesday, February 04 \| 8:00PM - 11:00PM Entertainment Room: Granhall
Thursday, February 05 \| 10:25AM - 10:25AM Departure *Session Chair.