Web Desc
Immunologic Memory and Host Defense
Organizer(s): Daniel C. Douek, Robert A. Seder, Stephen P. Schoenberger and Susan M. Kaech
Date: February 08 - 13, 2009
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Immune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic disease.
Scholarship Deadline: October 8 2008
Discounted Abstract Deadline: October 8 2008
Abstract Deadline: November 6 2008
Discounted Registration Deadline: December 8 2008
We gratefully acknowledge additional support for this conference from:
European Journal of ImmunologyJDRF
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079895-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 08 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 08 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 08 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak / Longs Peak

Speaker 1 of 3
* Robert A. Seder, NIAID, National Institutes of Health, USA

Sunday, February 08 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak / Longs Peak

Speaker 2 of 3
* Susan M. Kaech, The Salk Institute, USA

Sunday, February 08 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak / Longs Peak

Speaker 3 of 3
Rafi Ahmed, Emory University School of Medicine, USA
Immunologic Memory of T Cells

Monday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Quandary 1-3


Monday, February 09 | 8:00AM - 11:00AM
Innate Influence on Adaptive Memory
Room: Grays Peak / Longs Peak

Speaker 1 of 5
* Robert A. Seder, NIAID, National Institutes of Health, USA
Innate Influence on the Quality of T Cell Responses

Monday, February 09 | 8:00AM - 11:00AM
Innate Influence on Adaptive Memory
Room: Grays Peak / Longs Peak

Speaker 2 of 5
Bali Pulendran, Stanford University School of Medicine, USA
Modulating Vaccine Responses with Innate Immunity

Monday, February 09 | 8:00AM - 11:00AM
Innate Influence on Adaptive Memory
Room: Grays Peak / Longs Peak

Speaker 3 of 5
Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasome

Monday, February 09 | 8:00AM - 11:00AM
Innate Influence on Adaptive Memory
Room: Grays Peak / Longs Peak

Speaker 4 of 5
Murali Krishna Kaja, University of Washington, USA
Innate Influence on T Cells

Monday, February 09 | 8:00AM - 11:00AM
Innate Influence on Adaptive Memory
Room: Grays Peak / Longs Peak

Speaker 5 of 5
Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Adaptive Immune Features of Natural Killer Cells

Monday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 09 | 11:00AM - 11:00AM
On Own for Lunch


Monday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary 1-3


Monday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary 1-3


Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 1 of 6
* Rafick Sekaly, Emory University, USA
FOXO3A: A Critical Integrator of Signals Leading to B and T Cell Memory

Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 2 of 6
Dietmar Zehn, Technical University of Munich, Germany
CD8 Response Kinetics

Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 3 of 6
Inka Albrecht, German Rheumatism Research Center, Germany
Twist1 Acts as an Internal Brake of Th1 Induced Chronic Inflammation

Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 4 of 6
Spencer Stonier, MD Anderson Cancer Center, USA
Characterization of Cell Surface IL-15 Expression by Myeloid Cell Populations

Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 5 of 6
Michael Quigley, Gilead Sciences, Inc., USA
Gene Expression Profiling of Tetramer-sorted Human T Cells can Distinguish Functionality and Disease Outcome in HIV

Monday, February 09 | 2:30PM - 4:30PM
Workshop 1: Measuring Events in Immune Activation
Room: Grays Peak / Longs Peak

Speaker 6 of 6
David Farrar, University of Texas Southwestern Medical Center, USA
Dynamic Programming of Effector and Central Memory CD8+ T cells by IL-12 and IFN-a

Monday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 09 | 5:00PM - 7:00PM
Memory T Cell Subsets and Host Defense
Room: Grays Peak / Longs Peak

Speaker 1 of 4
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Molecular Control of Regulatory T Cells

Monday, February 09 | 5:00PM - 7:00PM
Memory T Cell Subsets and Host Defense
Room: Grays Peak / Longs Peak

Speaker 2 of 4
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Th17 Cells and Host Defense

Monday, February 09 | 5:00PM - 7:00PM
Memory T Cell Subsets and Host Defense
Room: Grays Peak / Longs Peak

Speaker 3 of 4
E. John Wherry, University of Pennsylvania, USA
Coregulation of CD8+ T Cell Exhaustion during Chronic Viral Infection by Multiple Inhibitory Receptors

Monday, February 09 | 5:00PM - 7:00PM
Memory T Cell Subsets and Host Defense
Room: Grays Peak / Longs Peak

Speaker 4 of 4
Nathan W. Schmidt, University of Louisville, USA
Short Talk: Memory CD8 T Cell Responses Exceeding a Large, but Definable Threshold Provide Long-term Immunity to Malaria

Monday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary 1-3


Monday, February 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary 1-3


Tuesday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Quandary 1-3


Tuesday, February 10 | 8:00AM - 11:00AM
T Cells: Homeostasis and Maintenance
Room: Grays Peak / Longs Peak

Speaker 1 of 5
* Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of Immune Memory by Bacterial Antigen-specific CD4+ T Cells

Tuesday, February 10 | 8:00AM - 11:00AM
T Cells: Homeostasis and Maintenance
Room: Grays Peak / Longs Peak

Speaker 2 of 5
Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research, Australia
Coordinate Regulation of Effector and Memory Expansion and Differentiation

Tuesday, February 10 | 8:00AM - 11:00AM
T Cells: Homeostasis and Maintenance
Room: Grays Peak / Longs Peak

Speaker 3 of 5
Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
T Cell Responses in Chronic Viral Infections

Tuesday, February 10 | 8:00AM - 11:00AM
T Cells: Homeostasis and Maintenance
Room: Grays Peak / Longs Peak

Speaker 4 of 5
Stephen C. Jameson, University of Minnesota Medical School, USA
Pre-existing Antigen Specific Memory Like Cells in Unprimed Mice

Tuesday, February 10 | 8:00AM - 11:00AM
T Cells: Homeostasis and Maintenance
Room: Grays Peak / Longs Peak

Speaker 5 of 5
Carmen Gerlach, Karolinska Institutet, Sweden
Short Talk: Effector and Memory CD8+ T Cells Constitute a Single Lineage

Tuesday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 10 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, February 10 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary 1-3


Tuesday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary 1-3


Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 1 of 7
* Mark K. Slifka, Oregon National Primate Research Center, Oregon Health & Science University, USA
Will Viral Virulence Dictate the Level of Immunological Memory to Orthopoxviruses?

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 2 of 7
* Mario Roederer, NIAID, National Institutes of Health, USA
The Unique Immunogenicity Profile of Aerosol Vaccination in Nonhuman Primates

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 3 of 7
Rene A. Van Lier, Academic Medical Center, Netherlands
Human CMV Infection Induces Rapid and Lasting Changes in Gene Expression in the CD8+ T Cell Compartment

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 4 of 7
Cheryl H. Rozanski, Roswell Park Cancer Institute, USA
CD28 Supports Normal Plasma Cell Survival and Interactions with the Microenvironment

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 5 of 7
Kylie Quinn, Monash University, Australia
Priming of CD4+ T Cells with Protein and Poly I:C Increases Subsequent Boosting of CD8+ but not CD4+ T Cell Responses

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 6 of 7
Derek Trobaugh, University of Massachusetts Medical School, USA
Qualitative and Quantitative Differences in Effector Functions of Virus-specific and -Cross-reactive T Cells in Mice Immunized with Related Flaviviruses

Tuesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Vaccines and T Cell Memory
Room: Grays Peak / Longs Peak

Speaker 7 of 7
Lindsay E. Edwards, University of Colorado Denver and National Jewish Health, USA
Generation of Protective CD8+ T cell Memory in CD4+ Deficient Hosts

Tuesday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 10 | 5:00PM - 7:00PM
Tissues, Traffic and Circulation
Room: Grays Peak / Longs Peak

Speaker 1 of 4
David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Site-Specific Control of T Cell Memory

Tuesday, February 10 | 5:00PM - 7:00PM
Tissues, Traffic and Circulation
Room: Grays Peak / Longs Peak

Speaker 2 of 4
Andrea Cerutti, Mount Sinai School of Medicine, USA
Role of Innate Signaling Networks in Mucosal Immunoglobulin Heavy Chain Class Switching

Tuesday, February 10 | 5:00PM - 7:00PM
Tissues, Traffic and Circulation
Room: Grays Peak / Longs Peak

Speaker 3 of 4
* Daniel C. Douek, NIAID, National Institutes of Health, USA
Tissue-Specific Differences and T Cell Loss in HIV Infection

Tuesday, February 10 | 5:00PM - 7:00PM
Tissues, Traffic and Circulation
Room: Grays Peak / Longs Peak

Speaker 4 of 4
James J. Campbell, Brigham and Women's Hospital, USA
Short Talk: Specificity and Dissemination of Antigen-Experienced, Tissue-Tropic T Lymphocytes

Tuesday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary 1-3


Tuesday, February 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary 1-3


Wednesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Quandary 1-3


Wednesday, February 11 | 8:00AM - 11:00AM
Memory B Cell Differentiation
Room: Grays Peak / Longs Peak

Speaker 1 of 5
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Cytokine Signaling in Human B Cell Differentiation

Wednesday, February 11 | 8:00AM - 11:00AM
Memory B Cell Differentiation
Room: Grays Peak / Longs Peak

Speaker 2 of 5
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Intrinsic Properties of Memory B Cells

Wednesday, February 11 | 8:00AM - 11:00AM
Memory B Cell Differentiation
Room: Grays Peak / Longs Peak

Speaker 3 of 5
John C. Cambier, University of Colorado, USA
Molecular Basis of B Cell Anergy and its Disruption by Innate and T Cell-Derived Signals

Wednesday, February 11 | 8:00AM - 11:00AM
Memory B Cell Differentiation
Room: Grays Peak / Longs Peak

Speaker 4 of 5
Ross M. Kedl, University of Colorado Denver, USA
Navigating the Boundary between Innate and Adaptive Immune Responses

Wednesday, February 11 | 8:00AM - 11:00AM
Memory B Cell Differentiation
Room: Grays Peak / Longs Peak

Speaker 5 of 5
Kim Good-Jacobson, Monash University, Australia
Short Talk: Role of PD-1 in Memory B Cell Formation and Responses

Wednesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 11 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary 1-3


Wednesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary 1-3


Wednesday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 11 | 5:00PM - 7:00PM
The Genetics and Biochemistry of Memory
Room: Grays Peak / Longs Peak

Speaker 1 of 4
Steven L. Reiner, Columbia University, USA
Inducing the T Cell Fates Required for Immunity

Wednesday, February 11 | 5:00PM - 7:00PM
The Genetics and Biochemistry of Memory
Room: Grays Peak / Longs Peak

Speaker 2 of 4
Donna L. Farber, Columbia University Medical Center, USA
Biochemical Signaling Pathways for Memory CD4 T Cell Recall and Homeostasis



Wednesday, February 11 | 5:00PM - 7:00PM
The Genetics and Biochemistry of Memory
Room: Grays Peak / Longs Peak

Speaker 3 of 4
* Susan M. Kaech, The Salk Institute, USA
Regulation of CD8 T Cell Memory Induction

Wednesday, February 11 | 5:00PM - 7:00PM
The Genetics and Biochemistry of Memory
Room: Grays Peak / Longs Peak

Speaker 4 of 4
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism

Wednesday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary 1-3


Wednesday, February 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary 1-3


Thursday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Quandary 1-3


Thursday, February 12 | 8:00AM - 11:00AM
T Cells: Differentiation and Functional Capacity
Room: Grays Peak / Longs Peak

Speaker 1 of 5
John T. Harty, University of Iowa, USA
Controlling Memory CD8 T Cell Differentiation

Thursday, February 12 | 8:00AM - 11:00AM
T Cells: Differentiation and Functional Capacity
Room: Grays Peak / Longs Peak

Speaker 2 of 5
Rose Zamoyska, University of Edinburgh, UK
The Influence of Signal Strength on the Differentiation of Effector and Memory T Cells

Thursday, February 12 | 8:00AM - 11:00AM
T Cells: Differentiation and Functional Capacity
Room: Grays Peak / Longs Peak

Speaker 3 of 5
* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
How to Make a Memory CD8 T Cell

Thursday, February 12 | 8:00AM - 11:00AM
T Cells: Differentiation and Functional Capacity
Room: Grays Peak / Longs Peak

Speaker 4 of 5
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Plasticity of Regulatory T Cells During Infection

Thursday, February 12 | 8:00AM - 11:00AM
T Cells: Differentiation and Functional Capacity
Room: Grays Peak / Longs Peak

Speaker 5 of 5
Ryan T. Sowell, Rush University Medical Center, USA
Short Talk: CD27 is Preferentially Required for Generation and Maintenance of Some Memory CD8 T Cell Subsets

Thursday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 12 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 1 of 6
* David Price, Cardiff University School of Medicine, UK
Deconvoluting Adaptive T Cell Immunity: Clonotype Selection and Biological Outcome

Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 2 of 6
* Bridie Day, University of Melbourne, Australia
Investigating the Determinants of Antigen-Specific TCR Repertoire Diversity

Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 3 of 6
Rebekka Ariane Duhen, EACRI Providence Cancer Center, USA
Repertoire Analysis of Human Naive and Memory CD4+ T Cells Reveals Affinity Maturation during the Immune Response

Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 4 of 6
Pradyot Dash, St Jude Children's Research Hospital, USA
Influenza A KbPB1703 Epitope Specific CD8 T Cell Receptor Chain Repertoire Analysis: Priming with Fewer Epitopes Broadens Recruitment of the Influenza KbPB1703 Repertoire

Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 5 of 6
Laurent Malherbe, Blood Center of Wisconsin, USA
Stability of MHC Class II:Peptide Complexes Governs Th Cell Clonal Selection

Thursday, February 12 | 2:30PM - 4:30PM
Workshop 3: Immunodominance and TCR Repertoire
Room: Grays Peak / Longs Peak

Speaker 6 of 6
Vanessa Venturi, University of New South Wales, Australia
A Molecular Basis for the Sharing of T Cell Receptor beta-Chains

Thursday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 12 | 5:00PM - 6:45PM
Why Memory Might Be Important: Cancer, Autoimmunity and Vacc
ines

Room: Grays Peak / Longs Peak

Speaker 1 of 3
* Nicholas P. Restifo, Lyell, USA
T Cell Control of Cancer

Thursday, February 12 | 5:00PM - 6:45PM
Why Memory Might Be Important: Cancer, Autoimmunity and Vacc
ines

Room: Grays Peak / Longs Peak

Speaker 2 of 3
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Memory to beta Cells - Good or Bad?

Thursday, February 12 | 5:00PM - 6:45PM
Why Memory Might Be Important: Cancer, Autoimmunity and Vacc
ines

Room: Grays Peak / Longs Peak

Speaker 3 of 3
Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Active and Passive Immunization Against Avian Influenza Viruses

Thursday, February 12 | 6:45PM - 7:30PM
Concluding Remarks
Room: Grays Peak / Longs Peak

Speaker 1 of 1
Peter C. Doherty, University of Melbourne, Australia
Looking Back at Memory

Thursday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary 1-3


Thursday, February 12 | 8:00PM - 11:00PM
Entertainment
Room: Quandary 1-3


Thursday, February 12 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary 1-3


Friday, February 13 | 10:25AM - 10:25AM
Departure


*Session Chair.