Web Desc
Frontiers of NMR in Biology
Organizer(s): Mitsuhiko Ikura, Ann E. McDermott and Ad Bax
Date: February 15 - 20, 2009
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Over the past several decades Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool in structural and molecular biology, with most recent contributions to genomics, proteomics and metabolomics. Advances in NMR technology would not be possible without our continued efforts to develop new methodologies and applications. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies. Emphasis will be placed on the investigation of large biological systems, membrane proteins, folding and dynamics, and transient states of enzymatic reactions or protein interactions. As such, those using NMR have been extending its application to more complex and challenging systems in combination with other biophysical tools such as X-ray crystallography and electron microscopy. The purpose of this symposium is to provide a forum for discussion on these and other new trends in biological NMR.
Scholarship Deadline: October 15 2008
Discounted Abstract Deadline: October 15 2008
Abstract Deadline: November 14 2008
Discounted Registration Deadline: December 15 2008
We gratefully acknowledge additional support for this conference from:

Affymetrix, Inc.
Bruker BioSpin Corp.Cambridge Isotope Laboratories
ISOTEC, a member of the Sigma-Aldrich Group
New Era Enterprises, Inc.Varian, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell PressRoyal Society of Chemistry
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM086958-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 15 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, February 15 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Sunday, February 15 | 7:30PM - 9:30PM
Keynote Session: Roles of NMR and X-ray in the Future of Bio
logy
Room: Mesa Ballroom

Speaker 3 of 3
Wayne A. Hendrickson, Columbia University, USA
Prospects and Challenges for X-ray Diffraction in Biology

Sunday, February 15 | 7:30PM - 9:30PM
Keynote Session: Roles of NMR and X-ray in the Future of Bio
logy
Room: Mesa Ballroom

Speaker 2 of 3
Peter E. Wright, The Scripps Research Institute, USA
Beyond 3D Structure: Insights from NMR into Protein Disorder, Dynamics, and Interactions

Sunday, February 15 | 7:30PM - 9:30PM
Keynote Session: Roles of NMR and X-ray in the Future of Bio
logy
Room: Mesa Ballroom

Speaker 1 of 3
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Monday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 6 of 6
Erik R. P. Zuiderweg, University of Michigan, USA
Short Talk: Structural Basis of the Allosteric Trigger of the Hsp70 Chaperone Proteins

Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 5 of 6
Robert G. Griffin, Massachusetts Institute of Technology, USA
Protein Structure Determination with Solid State NMR

Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 4 of 6
Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
Recognition Dynamics from NMR Residual Dipolar Couplings

Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 3 of 6
Stephan Grzesiek, University of Basel, Switzerland
Probing Protein Structure and Dynamics of Unfolded and Folded Proteins by NMR

Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 2 of 6
Ad Bax, NIDDK, National Institutes of Health, USA
Proteins, Membranes, and their Interaction Viewed by NMR

Monday, February 16 | 8:00AM - 11:00AM
New Methods
Room: Mesa Ballroom

Speaker 1 of 6
* Mitsu Ikura, University of Toronto, Canada

Monday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 16 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa/Mesa C


Monday, February 16 | 11:00AM - 11:00AM
On Own for Lunch


Monday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa/Mesa C


Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 6 of 6
Volker Dötsch, University of Frankfurt, Germany
Combination of Cell-Free Expression and Liquid State NMR Spectroscopy for the Structural Investigation of Membrane Proteins

Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 5 of 6
Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
Magic-Angle Spinning NMR for Membrane Protein Structure Determination

Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 4 of 6
Ichio Shimada, University of Tokyo, Japan
Interaction Analyses between Membrane Proteins and Ligands

Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 3 of 6
Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA
NMR of Membrane Proteins in Lipid Bilayers, Bicelles, and Micelles

Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 2 of 6
Mark Girvin, Albert Einstein College Of Medicine, USA
Talk Title to be Determined

Monday, February 16 | 2:30PM - 4:30PM
Workshop 1: Tackling Membrane Proteins
Room: Mesa Ballroom

Speaker 1 of 6
* Angela M. Gronenborn, University of Pittsburgh, USA

Monday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 16 | 5:00PM - 7:00PM
Protein Folding and Dynamics
Room: Mesa Ballroom

Speaker 1 of 5
* Ann E. McDermott, Columbia University, USA

Monday, February 16 | 5:00PM - 7:00PM
Protein Folding and Dynamics
Room: Mesa Ballroom

Speaker 2 of 5
Charles R. Sanders, Vanderbilt University School of Medicine, USA
NMR Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein: Does APP Function as a Cholesterol Sensor?

Monday, February 16 | 5:00PM - 7:00PM
Protein Folding and Dynamics
Room: Mesa Ballroom

Speaker 3 of 5
Brian F. Volkman, Medical College of Wisconsin, USA
Native State Interconversion between Unrelated Protein Folds

Monday, February 16 | 5:00PM - 7:00PM
Protein Folding and Dynamics
Room: Mesa Ballroom

Speaker 4 of 5
Robert Tycko, NIDDK, National Institutes of Health, USA
Solid State NMR of Amyloid Fibrils and Freeze-Trapped Protein Folding Intermediates

Monday, February 16 | 5:00PM - 7:00PM
Protein Folding and Dynamics
Room: Mesa Ballroom

Speaker 5 of 5
Anthony Mittermaier, McGill University, Canada
Short Talk: Mapping the Energy Landscape of Protein Folding and Binding Using NMR and Calorimetry

Monday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Monday, February 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa/Mesa C


Tuesday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, February 17 | 7:00AM - 8:00AM
Poster Setup
Room: Chamisa/Mesa C


Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 1 of 6
* Hideo Akutsu, Osaka University, Japan

Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 2 of 6
Ann E. McDermott, Columbia University, USA
Conformational Changes in Enzymes and Membrane Proteins

Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 3 of 6
Lukas K. Tamm, University of Virginia, USA
Structure and Dynamics of OmpG in Detergent Micelles

Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 4 of 6
Mei Hong, Massachusetts Institute of Technology, USA
Dynamic Conformation and Orientation of Membrane Proteins

Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 5 of 6
Stanley J. Opella, University of California, San Diego, USA
Membrane Proteins Studied by Solid State NMR

Tuesday, February 17 | 8:00AM - 11:00AM
Membrane Proteins
Room: Mesa Ballroom

Speaker 6 of 6
Daniel Nietlispach, University of Cambridge, UK
Short Talk: Solution-NMR Structural Studies of the 7-Helix Transmembrane Receptor Sensory Rhodopsin pSRII

Tuesday, February 17 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 17 | 11:00AM - 12:00PM
Lunch
Room: Chamisa


Tuesday, February 17 | 12:00PM - 2:30PM
Poster Session 2
Room: Chamisa/Mesa C


Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 1 of 6
* Kevin H. Gardner, CUNY Advanced Science Research Center, USA

Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 2 of 6
Angela M. Gronenborn, University of Pittsburgh, USA
Title to be Determined

Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 3 of 6
Alexander Grishaev, NIDDK, National Institutes of Health, USA
Combining RDC and Scattering Data for Structure Determination

Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 4 of 6
Lucia Banci, University of Florence, Italy
Approaches for Characterizing Metal- or Redox-Mediated Protein Complexes

Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 5 of 6
Rieko Ishima, University of Pittsburgh School of Medicine, USA
Application of F-19 NMR to Study Protein Structure and Dynamics

Tuesday, February 17 | 2:30PM - 4:30PM
Workshop 2: Paramagnetic Relaxation Enhancement and Residual
Dipolar Coupling
Room: Mesa Ballroom

Speaker 6 of 6
Rafael Brüschweiler, Ohio State University, USA
Structural Protein Dynamics Elucidated by Spin Relaxation, Dipolar Couplings, and Computation

Tuesday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 17 | 5:00PM - 7:00PM
Protein Dynamics and Transient States
Room: Mesa Ballroom

Speaker 1 of 5
* A. Joshua Wand, University of Pennsylvania, USA

Tuesday, February 17 | 5:00PM - 7:00PM
Protein Dynamics and Transient States
Room: Mesa Ballroom

Speaker 2 of 5
G. Marius Clore, NIDDK, National Institutes of Health, USA
Visualizing Lowly-Populated Regions of the Free Energy Landscape of Macromolecular Complexes by Paramagnetic Relaxation Enhancement

Tuesday, February 17 | 5:00PM - 7:00PM
Protein Dynamics and Transient States
Room: Mesa Ballroom

Speaker 3 of 5
Dorothee Kern, Brandeis University, HHMI, USA
The Climb Over the Mountain – Molecular Pathways of Conformational Transitions

Tuesday, February 17 | 5:00PM - 7:00PM
Protein Dynamics and Transient States
Room: Mesa Ballroom

Speaker 4 of 5
Gary P. Drobny, University of Washington, USA
Dynamics of Nucleic Acids

Tuesday, February 17 | 5:00PM - 7:00PM
Protein Dynamics and Transient States
Room: Mesa Ballroom

Speaker 5 of 5
Giuseppe Melacini, McMaster University, Canada
Short Talk: Understanding cAMP-Dependent Allostery by NMR Spectroscopy

Tuesday, February 17 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 1 of 6
* John L. Markley, University of Wisconsin-Madison, USA

Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 2 of 6
Torleif Härd, University of Gothenburg, Sweden
An Engineered Monomer Binding Protein Eliminates Alzheimer Amyloid-Beta Peptide Neurotoxicity


Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 3 of 6
Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Trafficking of HIV-1 and HIV-2 Proteins to Virus Assembly Sites

Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 4 of 6
Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein

Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 5 of 6
Juli Feigon, University of California, Los Angeles, USA
Structure and Function of Human Telomerase and H/ACA RNA

Wednesday, February 18 | 8:00AM - 11:00AM
Human Disease Targets
Room: Mesa Ballroom

Speaker 6 of 6
Christopher B. Marshall, University Health Network, Canada
Short Talk: Characterization of Intrinsic and TSC2 GAP-Accelerated GTPase Activity of Rheb by Real-Time NMR

Wednesday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 18 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, February 18 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa/Mesa C


Wednesday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa/Mesa C


Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 1 of 6
* Frank D. Sönnichsen, Christian Albrechts Universität, Germany

Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 2 of 6
John L. Markley, University of Wisconsin-Madison, USA
Approaches to the Investigation of More Challenging Proteins and Protein Complexes

Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 3 of 6
Masatsune Kainosho, Nagoya University, Japan
Applications of the Residue-Selective SAIL Approach for Structures and Dynamics of Proteins

Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 4 of 6
David A. Case, Rutgers University, USA
Building Better Models for Rotational Diffusion in Biomolecular NMR

Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 5 of 6
Alexandre M.J.J. Bonvin, Utrecht University, Netherlands
Information-Driven Modeling of Biomolecular Complexes

Wednesday, February 18 | 2:30PM - 4:30PM
Workshop 3: Automation and Refinement Methods
Room: Mesa Ballroom

Speaker 6 of 6
Vladislav Orekhov, Gothenburg University, Sweden
Hyper-Dimensional NMR Spectroscopy with Multi Dimensional Decomposition

Wednesday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 18 | 5:00PM - 7:00PM
Macromolecular Interactions
Room: Mesa Ballroom

Speaker 1 of 5
* Robert Kaptein, University of Utrecht, Netherlands

Wednesday, February 18 | 5:00PM - 7:00PM
Macromolecular Interactions
Room: Mesa Ballroom

Speaker 2 of 5
Robert B. Russell, University of Heidelberg, Germany
Discovery of New Peptides Mediating Interaction Networks


Wednesday, February 18 | 5:00PM - 7:00PM
Macromolecular Interactions
Room: Mesa Ballroom

Speaker 3 of 5
James Jeiwen Chou, Harvard Medical School, USA
NMR Studies of Viral Proton Channels

Wednesday, February 18 | 5:00PM - 7:00PM
Macromolecular Interactions
Room: Mesa Ballroom

Speaker 4 of 5
Gerhard Wagner, Harvard Medical School, USA
Topology and Regulation of the eIF4A/4G/4H Helicase Complex in Translation Initiation

Wednesday, February 18 | 5:00PM - 7:00PM
Macromolecular Interactions
Room: Mesa Ballroom

Speaker 5 of 5
† Masayori Inouye, University of Medicine and Dentistry of New Jersey, USA
Short Talk: Production and Isotopic Enrichment of a Single Membrane Protein in E. coli for NMR Studies without Purification

Wednesday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Wednesday, February 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa/Mesa C


Thursday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 1 of 6
* Melissa A. Starovasnik, Genentech, Inc., USA

Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 2 of 6
Maurizio Pellecchia, University of California, Riverside, USA
NMR Based Drug Discovery: Screening and Design of Novel Chemical Probes

Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 3 of 6
Patricia J. LiWang, University of California, Merced, USA
Structural and Functional Studies of Chemokines: Blocking HIV-1 and Stopping Inflammation

Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 4 of 6
Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
NMR in Drug Discovery: The Blessing and Curse of Versatility

Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 5 of 6
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Activity-Based Proteomics

Thursday, February 19 | 8:00AM - 11:00AM
Drug Discovery and Chemical Biology
Room: Mesa Ballroom

Speaker 6 of 6
Timothy A. Cross, Florida State University, USA
Short Talk: Solid State NMR: A Novel Approach for Membrane Protein Drug Screening

Thursday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 19 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 19 | 5:00PM - 7:00PM
Large Systems and New Methods
Room: Mesa Ballroom

Speaker 1 of 5
* Ad Bax, NIDDK, National Institutes of Health, USA

Thursday, February 19 | 5:00PM - 7:00PM
Large Systems and New Methods
Room: Mesa Ballroom

Speaker 2 of 5
Patrik Lundstrom, University of Toronto, Canada
Short Talk: Accurate Measurement of Protein Excited State Chemical Shifts by Relaxation Dispersion NMR Spectroscopy

Thursday, February 19 | 5:00PM - 7:00PM
Large Systems and New Methods
Room: Mesa Ballroom

Speaker 3 of 5
Charalampos Babis Kalodimos, St. Jude Children's Research Hospital, USA
NMR of the Transcription Machinery

Thursday, February 19 | 5:00PM - 7:00PM
Large Systems and New Methods
Room: Mesa Ballroom

Speaker 4 of 5
James H. Prestegard, University of Georgia, USA
Sparse Labeling and Resonance Assignments for Structural Studies of Large and Glycosylated Proteins

Thursday, February 19 | 5:00PM - 7:00PM
Large Systems and New Methods
Room: Mesa Ballroom

Speaker 5 of 5
Kurt Wüthrich, ETH Zürich, Switzerland
Automation in NMR Structure Determination of Proteins in Solution

Thursday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mesa C


Thursday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Mesa C


Thursday, February 19 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa C


Friday, February 20 | 10:25AM - 10:25AM
Departure


*Session Chair.