Web Desc
The Neurobiology of Pain and Analgesia
Organizer(s): Clifford J. Woolf, Ardem Patapoutian and Simon Tate
Date: February 22 - 27, 2009
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Abbott Laboratories and AstraZeneca Pharmaceuticals, L.P.
Summary of Meeting:
This symposium will highlight the substantial advances made in our understanding of the neurobiology and pathophysiology of pain and the enormous opportunities these present for identifying and exploiting new targets for therapy. Current therapy is largely empirical and is based on suppressing symptoms. The future offers treatment targeted at the specific neural mechanisms responsible. This requires understanding the mechanisms, being able to identify which mechanism operates in which patient, and having pharmacological tools to act on the molecular targets that drive these mechanisms. Furthermore, we need to identify which patient is at risk of developing pain and develop preventative disease-modifying treatments to abort the establishment of pain. This symposium will address how these goals can be achieved by the combined effort of academics and industry.
Scholarship Deadline: October 21 2008
Discounted Abstract Deadline: October 21 2008
Abstract Deadline: November 21 2008
Discounted Registration Deadline: December 22 2008
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesAstraZeneca Pharmaceuticals, L.P.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Lilly USA, LLC

GlaxoSmithKline

Pfizer Global Research & Development

Pfizer Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS064604-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 22 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, February 22 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Sunday, February 22 | 7:30PM - 9:30PM
Keynote Session
Room: Mesa A-B

Speaker 1 of 4
* Clifford J. Woolf, Children's Hospital, USA

Sunday, February 22 | 7:30PM - 9:30PM
Keynote Session
Room: Mesa A-B

Speaker 2 of 4
Michael J. Detke, MedAvante Research Institute, USA
New Treatments for Pain: Starting with the End in Mind – Market, Regulatory, and Development Challenges, and How These Relate to Neurobiology

Sunday, February 22 | 7:30PM - 9:30PM
Keynote Session
Room: Mesa A-B

Speaker 3 of 4
Xinzhong Dong, Johns Hopkins University, USA
Short Talk: Regulation of TRP Channels by Pirt

Sunday, February 22 | 7:30PM - 9:30PM
Keynote Session
Room: Mesa A-B

Speaker 4 of 4
Samer Eid, Merck & Co., Inc., USA
Short Talk: To Feel or not to Feel - Targeting the Heat Sensor TRPV1 for Pain Treatment

Monday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 23 | 8:00AM - 11:00AM
Nociceptor Transduction and Plasticity
Room: Mesa A-B

Speaker 1 of 5
* Ardem Patapoutian, The Scripps Research Institute, USA

Monday, February 23 | 8:00AM - 11:00AM
Nociceptor Transduction and Plasticity
Room: Mesa A-B

Speaker 2 of 5
Jon Levine, University of California, San Francisco, USA
Kinases - Nociceptors Pain Switches

Monday, February 23 | 8:00AM - 11:00AM
Nociceptor Transduction and Plasticity
Room: Mesa A-B

Speaker 3 of 5
Peter McNaughton, Kings College London, UK
Sensitization in Nociceptors

Monday, February 23 | 8:00AM - 11:00AM
Nociceptor Transduction and Plasticity
Room: Mesa A-B

Speaker 4 of 5
David Shelton, USA
NGF and Anti-NGF: The Ying and Yang of Pain

Monday, February 23 | 8:00AM - 11:00AM
Nociceptor Transduction and Plasticity
Room: Mesa A-B

Speaker 5 of 5
Stephen B. McMahon, King's College London, UK
Nociceptor Mechano-Sensitisation Induced by UVB Irradiation in Human and Rodent Skin

Monday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 23 | 11:00AM - 11:00AM
On Own for Lunch


Monday, February 23 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 23 | 5:00PM - 7:00PM
TRP Channels
Room: Mesa A-B

Speaker 1 of 5
* Stephen B. McMahon, King's College London, UK

Monday, February 23 | 5:00PM - 7:00PM
TRP Channels
Room: Mesa A-B

Speaker 2 of 5
Ardem Patapoutian, The Scripps Research Institute, USA
Molecular Mechanisms of Thermosensation

Monday, February 23 | 5:00PM - 7:00PM
TRP Channels
Room: Mesa A-B

Speaker 3 of 5
David Julius, University of California, San Francisco, USA
From Peppers to Peppermints: Natural Products as Probes of the Pain Pathway

Monday, February 23 | 5:00PM - 7:00PM
TRP Channels
Room: Mesa A-B

Speaker 4 of 5
Magdalene Moran, Hydra Biosciences, USA
TRPs as Analgesic Drug Targets

Monday, February 23 | 5:00PM - 7:00PM
TRP Channels
Room: Mesa A-B

Speaker 5 of 5
Cheryl L. Stucky, Medical College of Wisconsin, USA
Short Talk: TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons via Neuronal and Keratinocyte Expression

Monday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Monday, February 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 24 | 8:00AM - 11:00AM
Synaptic Plasticity
Room: Mesa A-B

Speaker 1 of 5
* David Julius, University of California, San Francisco, USA

Tuesday, February 24 | 8:00AM - 11:00AM
Synaptic Plasticity
Room: Mesa A-B

Speaker 2 of 5
Robert W. Gereau, Washington University Pain Center, USA
Postsynaptic Mechanisms of Plasticity in Dorsal Horn Neurons

Tuesday, February 24 | 8:00AM - 11:00AM
Synaptic Plasticity
Room: Mesa A-B

Speaker 3 of 5
Sandra Garraway, Texas A & M, USA
Activation of Neuronal ERK2 is Required for Inflammation-Induced Pain

Tuesday, February 24 | 8:00AM - 11:00AM
Synaptic Plasticity
Room: Mesa A-B

Speaker 4 of 5
Frank Porreca, University of Arizona, USA
Modulating Descending Modulation

Tuesday, February 24 | 8:00AM - 11:00AM
Synaptic Plasticity
Room: Mesa A-B

Speaker 5 of 5
Hans Ulrich Zeilhofer, University of Zurich, Switzerland
GABA-A Receptor Subunit-Specific Analgesia

Tuesday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 24 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, February 24 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 24 | 5:00PM - 7:00PM
Sodium and Calcium Channels
Room: Mesa A-B

Speaker 1 of 5
* Prisca Honore, Abbott Bioresearch Center, USA

Tuesday, February 24 | 5:00PM - 7:00PM
Sodium and Calcium Channels
Room: Mesa A-B

Speaker 2 of 5
Peter W. Reeh, University of Erlangen - Nurnberg, Germany
Nociceptor Sodium Channels – Few but Decisive

Tuesday, February 24 | 5:00PM - 7:00PM
Sodium and Calcium Channels
Room: Mesa A-B

Speaker 3 of 5
Alex Binshtok, Harvard Medical School, USA
Interleukin 1beta and Sodium Channels - From Slow Inactivation to Fast Nociception

Tuesday, February 24 | 5:00PM - 7:00PM
Sodium and Calcium Channels
Room: Mesa A-B

Speaker 4 of 5
Diane Lipscombe, Brown University, USA
Nociceptors Modulate Calcium Channel Activity by Alternative Splicing.

Tuesday, February 24 | 5:00PM - 7:00PM
Sodium and Calcium Channels
Room: Mesa A-B

Speaker 5 of 5
Sarah E. Canetta, Columbia University, USA
Short Talk: Type III Nrg1-erbB Signaling Affects Peripheral Nociception

Tuesday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Tuesday, February 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C


Wednesday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, February 25 | 8:00AM - 11:00AM
Discovering Pain Targets
Room: Mesa A-B

Speaker 1 of 5
* Simon Tate, GlaxoSmithKline, UK

Wednesday, February 25 | 8:00AM - 11:00AM
Discovering Pain Targets
Room: Mesa A-B

Speaker 2 of 5
Clifford J. Woolf, Children's Hospital, USA
Finding Novel Analgesic Targets

Wednesday, February 25 | 8:00AM - 11:00AM
Discovering Pain Targets
Room: Mesa A-B

Speaker 3 of 5
Qiufu Ma, Dana Farber Cancer Institute, USA
Regulation of Nociceptor Phenotype and Pain Behavior

Wednesday, February 25 | 8:00AM - 11:00AM
Discovering Pain Targets
Room: Mesa A-B

Speaker 4 of 5
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Modulating Pain by Blockade of Endocannabinoid Metabolism

Wednesday, February 25 | 8:00AM - 11:00AM
Discovering Pain Targets
Room: Mesa A-B

Speaker 5 of 5
Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany
Mechanostransducers as Targets for Pain Therapy

Wednesday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 25 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 25 | 5:00PM - 7:00PM
Pain Circuits
Room: Mesa A-B

Speaker 1 of 5
* Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany

Wednesday, February 25 | 5:00PM - 7:00PM
Pain Circuits
Room: Mesa A-B

Speaker 2 of 5
Mark Zylka, University of North Carolina, USA
Biochemical Modulation of Nociceptive Circuits

Wednesday, February 25 | 5:00PM - 7:00PM
Pain Circuits
Room: Mesa A-B

Speaker 3 of 5
Allan I. Basbaum, University of California, San Francisco, USA
Behaviorally Relevant Specificity of Nociceptors and Their Differential Regulation via mu and delta Opioid Receptors

Wednesday, February 25 | 5:00PM - 7:00PM
Pain Circuits
Room: Mesa A-B

Speaker 4 of 5
Joyce A. DeLeo, Dartmouth Medical School, USA
Glial-Neuronal Circuits

Wednesday, February 25 | 5:00PM - 7:00PM
Pain Circuits
Room: Mesa A-B

Speaker 5 of 5
Sarah Ross, University of Pittsburgh, USA
Short Talk: Bhlhb5 Is Critical for the Formation of Nociceptive Circuits in the Developing Spinal Cord

Wednesday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Thursday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Thursday, February 26 | 8:00AM - 11:00AM
Validating Pain Targets and Developing Analgesics
Room: Mesa A-B

Speaker 1 of 5
* Allan I. Basbaum, University of California, San Francisco, USA

Thursday, February 26 | 8:00AM - 11:00AM
Validating Pain Targets and Developing Analgesics
Room: Mesa A-B

Speaker 2 of 5
Simon Tate, GlaxoSmithKline, UK
Progressing Pain Targets: A Focus on in vitro Screening

Thursday, February 26 | 8:00AM - 11:00AM
Validating Pain Targets and Developing Analgesics
Room: Mesa A-B

Speaker 3 of 5
Rohini Kuner, University of Heidelberg, Germany
Target Validation using Genetically Modified Mice

Thursday, February 26 | 8:00AM - 11:00AM
Validating Pain Targets and Developing Analgesics
Room: Mesa A-B

Speaker 4 of 5
Prisca Honore, Abbott Bioresearch Center, USA
Pharmacological Validation for Analgesia Targets

Thursday, February 26 | 8:00AM - 11:00AM
Validating Pain Targets and Developing Analgesics
Room: Mesa A-B

Speaker 5 of 5
Kenneth M. Verburg, Pfizer Inc., USA
Pain Therapeutics: Focus on Development

Thursday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 26 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 1 of 6
* Peter W. Reeh, University of Erlangen - Nurnberg, Germany

Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 2 of 6
Annemieke Kavelaars, University of Texas MD Anderson Cancer Center, USA
Short Talk: GRK2 Deficiency Prolongs PGE2-Induced Hyperalgesia via a Switch in Signaling from PKA to ERK

Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 3 of 6
Michele Hummel, Wyeth Research, USA
Short Talk: Corticotropin Releasing Factor1 Receptors Mediate Inflammatory- and Neuropathic-Like Pain

Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 4 of 6
Achim Schmidtko, Goethe University, Germany
Short Talk: Reduced Inflammatory and Neuropathic Pain in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase

Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 5 of 6
Jeff S. Mogil, McGill University, Canada
Genetics of Pain in the Laboratory Mouse

Thursday, February 26 | 5:00PM - 7:00PM
Pain Genetics
Room: Mesa A-B

Speaker 6 of 6
Luda Diatchenko, University of North Carolina School of Dentistry, USA
Expansion of the Human mu-Opioid Receptor Gene Locus: Novel Functional Variants

Thursday, February 26 | 7:00PM - 7:15PM
Concluding Remarks
Room: Mesa A-B

Speaker 1 of 3
Clifford J. Woolf, Children's Hospital, USA

Thursday, February 26 | 7:00PM - 7:15PM
Concluding Remarks
Room: Mesa A-B

Speaker 2 of 3
Simon Tate, GlaxoSmithKline, UK

Thursday, February 26 | 7:00PM - 7:15PM
Concluding Remarks
Room: Mesa A-B

Speaker 3 of 3
Ardem Patapoutian, The Scripps Research Institute, USA

Thursday, February 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mesa A-B


Thursday, February 26 | 8:00PM - 11:00PM
Entertainment
Room: Mesa A-B


Thursday, February 26 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa A-B


Friday, February 27 | 10:25AM - 10:25AM
Departure


*Session Chair.