Web Desc
B Cells in Context
Organizer(s): Ann Marshak-Rothstein, Michael P. Cancro and Mark S. Schlissel
Date: February 24 - March 01, 2009
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools. Failures in these processes can lead to autoimmune disease and lymphoid malignancy. These events involve highly choreographed cell-cell interactions and migratory behaviors. The goal of this meeting will be to ask how the various B cell microenvironments regulate the molecular events that determine B cell fate and function, and to explore how manipulation of the microenvironment can impact the immune response, autoimmunity, transformation and vaccine development.
Scholarship Deadline: October 22 2008
Discounted Abstract Deadline: October 22 2008
Abstract Deadline: November 25 2008
Discounted Registration Deadline: December 29 2008
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI081355-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 24 | 3:00PM - 7:30PM
Registration
Room: Rio Grande D


Tuesday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: Rio Grande


Tuesday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: Bataan

Speaker 1 of 1
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Signaling Life and Lifestyle through the BCR

Wednesday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande


Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 1 of 6
Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
A Recurring Gene Regulatory Network that Orchestrates Myeloid Versus B Cell Fate Choice

Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 2 of 6
Christian Kosan, Institut de Recherches Cliniques de Montréal (IRCM), Canada
Short Talk: The POZ Domain Transcription Factor Miz-1 (Zbtb17) is Required for B Cell Lineage Commitment and Indispensable for the Formation of Mature Follicular B Cells

Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 3 of 6
Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Role of the Pre-BCR and BCR in Early B Cell Development

Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 4 of 6
Marjorie A. Oettinger, Massachusetts General Hospital, USA
RAG2 Links Histone Methylation and VDJ Recombination

Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 5 of 6
David G. Schatz, Yale University School of Medicine, USA
Short Talk: Focal Binding of RAG1 and RAG2 to Antigen Receptor loci Defines V(D)J 'Recombination Centers'

Wednesday, February 25 | 8:00AM - 11:15AM
Lineage Commitment and BCR Generation
Room: Bataan

Speaker 6 of 6
* Mark S. Schlissel, University of California, Berkeley, USA
A Role for NF-kB in Receptor Editing

Wednesday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B/C


Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 1 of 7
Sebastian D. Fugmann, Chang Gung University, Taiwan
Identification of Cis-Regulatory Elements Targeting AID-Mediated Sequence Diversification to the Chicken Immunoglobulin Light Chain Gene

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 2 of 7
Barbara K. Birshtein, Albert Einstein College Of Medicine, USA
Active DNA Demethylation in the Immunoglobulin Heavy Chain 3’ Regulatory Region during Class Switch Recombination Involves GADD45A

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 3 of 7
Rebecca K. Delker, Rockefeller University, USA
Elucidating the Mechanism of Specificity Achieved by Activation Induced Cytidine Deaminase

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 4 of 7
Urszula Nowak, Weill Cornell Graduate School of Medical Sciences, USA
AID in Class Switch Recombination

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 5 of 7
Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA
Identification of AID Interacting Proteins

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 6 of 7
Anne Durandy, Institut Imagine, France
Human PMS2 Deficiency is Associated with Impaired Immunoglobulin Class Switch Recombination

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Speaker 7 of 7
Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
Mechanistic Factors That Promote Recurrent Translocations in Peripheral B Lymphocytes

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1B: RAg Interactions, VDJ Recombination and Allelic
Exclusion

Speaker 1 of 3
Moshe J. Sadofsky, Albert Einstein College Of Medicine, USA
A New Protein Interaction Motif in the Rag1 N-Terminal Domain

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1B: RAg Interactions, VDJ Recombination and Allelic
Exclusion

Speaker 2 of 3
Jane A. Skok, New York University School of Medicine, USA
Recombinase-Dependent Homologous Pairing of Ig Alleles: A Novel Regulatory Aspect of Allelic Exclusion

Wednesday, February 25 | 10:00AM - 10:00AM
Workshop 1B: RAg Interactions, VDJ Recombination and Allelic
Exclusion

Speaker 3 of 3
Laurel A. Eckhardt, Hunter College of CUNY, USA
A Role for the IgH Intronic Enhancer, Eu, in Enforcing Allelic Exclusion

Wednesday, February 25 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Wednesday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Wednesday, February 25 | 2:00PM - 4:30PM
Workshop 1: What Targets the lgH/lgL Loci for VDJ Recombinat
ion, CSR, and SHM?
Room: Don Fernando Hall

Speaker 1 of 2
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany

Wednesday, February 25 | 2:00PM - 4:30PM
Workshop 1: What Targets the lgH/lgL Loci for VDJ Recombinat
ion, CSR, and SHM?
Room: Don Fernando Hall

Speaker 2 of 2
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 1 of 8
* Peter E. Lipsky, AMPEL Biosolutions, USA

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 2 of 8
* John F. Kearney, University of Alabama, Birmingham, USA

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 3 of 8
Michelle L. Harris, Yale University School of Medicine, USA
APRIL Promotes AM14 Rheumatoid Factor B-Cell Activation and Maturation

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 4 of 8
Andrea Bottaro, University of Rochester School of Medicine and Dentistry, USA
Accumulation and Relocation of B Cells in the Popliteal Lymph Nodes of TNF-Transgenic Mice Accompanies Development of Knee Arthritis

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 5 of 8
Sarah R. Fintushel, University of Pennsylvania, USA
B Cell Recirculation through Skin

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 6 of 8
Tineke Cantaert, Institut Pasteur Cambodia, Cambodia
Ectopic Lymphoid Neogenesis is not Functionally Competent to Drive Humoral Autoimmunity in Rheumatoid Synovitis

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 7 of 8
Julie Kujawa, Biogen Idec, USA
Abnormalities in Lymphoid Subsets and Architecture Associated with the Onset of Autoimmunity in an Interferon-Accelerated Murine Lupus Model

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 2: Dysregulated B Cells in Autoimmunity
Room: Council Chambers

Speaker 8 of 8
Magdalena A. Berkowska, Leiden University Medical Center, Netherlands
Molecular Analysis of Human Memory B-cell Subsets Suggests Different Origins and Maturation Pathways

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 1 of 8
* Ramit Mehr, Bar-Ilan University, Israel
B Cell Immunomics - From Analyzing Single Mutations to Modeling Cell Populations

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 2 of 8
Andrew M. Collins, University of New South Wales, Australia
Immunoglobulin Sequences of Different Isotypes and from Patients with Different Diseases Show Distinct Patterns of Somatic Point Mutation

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 3 of 8
Ying Li, University of Chicago, USA
Gene Regulatory Model for B Cell Fate Specification

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 4 of 8
Yoram Louzoun, Bar Ilan University, Israel
Autoantibody Repertoire Shift as Early Clinical Marker of Cancer

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 5 of 8
Kamila Karolina Matulewicz, University Hospital of Georg August University, Germany
Dissecting the Molecular Events in Burkitt’s Lymphoma

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 6 of 8
Michael Meyer-Hermann, Helmholtz Centre for Infection Research, Germany
Coherent Data, Divergent Interpretations: Mathematical Modeling Clarifies the Interpretation of Two-Photon Imaging Data of Germinal Centers

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 7 of 8
Jamie L. Duke, Yale University, USA
Computational Modeling of Genome-Wide Targeting of Somatic Hypermutation

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 3: Computation and Mathematical Modeling in the Stu
dy of B Cell Biology
Room: Bataan

Speaker 8 of 8
Thomas B. Kepler, Boston University, USA
Adjuvants and the Reorganization of Leukocytes in Humoral Immunity: A Computational Systems Approach

Wednesday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Rio Grande B/C


Wednesday, February 25 | 5:00PM - 7:00PM
Selection and Survival of Primary B Cells
Room: Bataan

Speaker 1 of 4
John F. Kearney, University of Alabama, Birmingham, USA
Primary B Cell Repertoire Determination

Wednesday, February 25 | 5:00PM - 7:00PM
Selection and Survival of Primary B Cells
Room: Bataan

Speaker 2 of 4
Sarah F. Andrews, National Institutes of Health, USA
Short Talk: Transitional B Cells Exhibit a BCR-Specific Nuclear Defect in Gene Transcription

Wednesday, February 25 | 5:00PM - 7:00PM
Selection and Survival of Primary B Cells
Room: Bataan

Speaker 3 of 4
Shiv Pillai, Massachusetts General Hospital, USA
The role of a 9-O sialylacetylesterase in peripheral B cell development and autoimmunity

Wednesday, February 25 | 5:00PM - 7:00PM
Selection and Survival of Primary B Cells
Room: Bataan

Speaker 4 of 4
* Michael P. Cancro, University of Pennsylvania, USA
Molecular and Cellular Cross-Talk in the Actions of BLyS Ligands and Receptors

Wednesday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande


Wednesday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Rio Grande


Thursday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande


Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 1 of 6
Robert C. Rickert, Pfizer Inc., USA
Short Talk: Distinct Roles for Foxo1 at Multiple Stages of B Cell Differentiation

Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 2 of 6
Eric Meffre, Yale University School of Medicine, USA
Autoreactive B Cell Counterselection in Humans

Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 3 of 6
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Activating autoreactive B Cells: Roles of T cells, Tolls and Time

Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 4 of 6
Stephen C. Jameson, University of Minnesota Medical School, USA
Short Talk: KLF2 Deficiency dysregulates multiple B Cell Subsets

Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 5 of 6
Jean-Claude Weill, Institut Necker-Enfants Malades, INSERM U1151, France
Multiple Layers of B cell memory with different effector functions

Thursday, February 26 | 8:00AM - 11:15AM
Differentiation Decisions
Room: Bataan

Speaker 6 of 6
David M. Tarlinton, Monash University, Australia
Molecular Regulation of Memory

Thursday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B/C


Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4A: Commitment to Germinal Center of Plasmablast Di
fferentiation

Speaker 1 of 4
Daniel James Hodson, NCI, National Institutes of Health, USA
The RNA Binding Protein TIS11b is Expressed in the Germinal Centre and Suppresses Immune Regulatory Genes

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4A: Commitment to Germinal Center of Plasmablast Di
fferentiation

Speaker 2 of 4
Shinu A. John, University at Buffalo, State University of New York, USA
ETS-1 Plays a Unique and Non-Redundant Role in Inhibiting Blimp-1 Activity and Preventing Plasma Cell Differentiation

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4A: Commitment to Germinal Center of Plasmablast Di
fferentiation

Speaker 3 of 4
B. Hilda Ye, Albert Einstein College Of Medicine, USA
STAT3 and NF-kappaB Synergistically Promote Plasma Cell Differentiation Through Upregulation of IRF4 and Blimp-1

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4A: Commitment to Germinal Center of Plasmablast Di
fferentiation

Speaker 4 of 4
Tyani D. Chan, Garvan Institute of Medical Research, Australia
In vivo Dynamics and Affinty Regulation of Early T-dependent B Cell Responses

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4B: B Cell Memory

Speaker 1 of 4
Jeremy Foote, University of Alabama at Birmingham, USA
Generation of B cell memory to the TI-2 antigen a 1.3-dextran

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4B: B Cell Memory

Speaker 2 of 4
Eliver Eid Bou Ghosn, Emory University, USA
Novel Properties of B-1 Memory

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4B: B Cell Memory

Speaker 3 of 4
Ismail Dogan, Hôpital Necker, France
B Cell Memory Subsets

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4B: B Cell Memory

Speaker 4 of 4
Kim Good-Jacobson, Monash University, Australia
Role of PD-1 in Memory B Cell Formation and Responses

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4C: The Regulation of Plasmblast Maturation and Sur
vival

Speaker 1 of 5
Sefat Khuda, University of Virginia, USA
Deregulated c-Myc Negatively Controls B Cell Immunity

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4C: The Regulation of Plasmblast Maturation and Sur
vival

Speaker 2 of 5
Bimba Franziska Hoyer, Charité University Medicine, Germany

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4C: The Regulation of Plasmblast Maturation and Sur
vival

Speaker 3 of 5
Bimba Franziska Hoyer, Charité University Medicine, Germany

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4C: The Regulation of Plasmblast Maturation and Sur
vival

Speaker 4 of 5
Dong-Mi Shin, NIAID, National Institutes of Health, USA
Interferon Regulatory Factor 6 (IRF6) Influences Late B Cell Differentiation

Thursday, February 26 | 10:00AM - 10:00AM
Workshop 4C: The Regulation of Plasmblast Maturation and Sur
vival

Speaker 5 of 5
Selina Chen-Kiang, Weill Medical College of Cornell University, USA
The Cdk4/6 Inhibitor p18INK4c Targets Rapidly Cycling and Apoptotic Plasma Cell Precursors for Homeostatic Control of Terminal Plasma Cell Differentiation

Thursday, February 26 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Thursday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Thursday, February 26 | 2:00PM - 4:30PM
Workshop 4: What is B Cell Memory? How are Cells Committed
to Memory or Plasma Cell Differentiation?
Room: Don Fernando Hall

Speaker 1 of 1
* Ian C.M. MacLennan, University of Birmingham, UK

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 1 of 8
* Silvia Bolland, NIAID, National Institutes of Health, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 2 of 8
* Gregg J. Silverman, New York University Langone Medical Center, USA
VH Inheritance Determines Apoptotic Cell Neo-Antigen Recognition by Antibodies that Regulate Phagocytosis and Inflammatory Responses by Immature Dendritic Cells

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 3 of 8
Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
Characterizing iNK T and B Cell Memory Responses to Lipid Antigen

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 4 of 8
Marcus R. Clark, University of Chicago, USA
Endocytic Sequestration of the B Cell Antigen Receptor and Toll-like Receptor 9 in Anergic Cells

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 5 of 8
Rebecca Anne Sweet, John Curtin School of Medical Research, Australia
Extrafollicular Activation of Autoreactive RF B Cells Leads to Memory B Cell Development

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 6 of 8
John H. Kehrl, NIAID, National Institutes of Health, USA
Toll-Like Receptor 4 Signaling Augments B lymphocyte Migratory and Proliferative Programs, and Overcomes the Restriction that Limits Access to the Dark Zones of Germinal Centers

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 7 of 8
Almut Meyer-Bahlburg, University Medicine Greifswald, Germany
Reduced c-myc Expression Levels Limit Follicular Mature B Cell Cycling in Response to TLR Signals

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 5: Interactions between B Cells and the Innate Immu
ne System
Room: Bataan

Speaker 8 of 8
Lenka L. Allan, University of British Columbia, Canada
Apolipoprotein-mediated Lipid Antigen Presentation in B cells

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 1 of 9
* Ranjan Sen, National Institute of Aging, National Institutes of Health, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 2 of 9
* Shiv Pillai, Massachusetts General Hospital, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 3 of 9
John David Colgan, University of Iowa, USA
The Justy Mutation Identifies the Gon4L Gene as an Essential regulator of B Cell Development

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 4 of 9
Qi Yang, University Of Pittsburgh, USA
E47 Controls the Developmental Integrity and Cell Cycle Quiescence of Multipotential Hematopoietic Progenitors during Progression to B Lineage

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 5 of 9
James R. Hagman, National Jewish Health, USA
Combined Haploinsufficiency of Ebf1 and Runx1 Genes Impedes B Cell Lineage Progression and Identity

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 6 of 9
Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Myb Is Critical For Early B Cell Development

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 7 of 9
Hans-Willem E. Snoeck, Columbia University Medical Center, USA
Differential Specification of Lymphoid Progenitor Populations to Distinct B Cell Development Programs

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 8 of 9
Jane Seagal, Immune Disease Institute, USA
Developmental Plasticity of Mature B Cell Populations

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 6: Regulating B Lineage Specification and Commitmen
t
Room: Council Chambers

Speaker 9 of 9
David M. Allman, University of Pennsylvania, USA
Unique Requirement for AKT1 and AKT2 in Marginal Zone B Cell Development

Thursday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Rio Grande B/C


Thursday, February 26 | 5:00PM - 7:00PM
B Cell Activation and Regulation
Room: Bataan

Speaker 1 of 4
Susan K. Pierce, NIAID, National Institutes of Health, USA
A “conformation-induced oligomerization” Model for the Initiation of B cell receptor signaling

Thursday, February 26 | 5:00PM - 7:00PM
B Cell Activation and Regulation
Room: Bataan

Speaker 2 of 4
Michael Reth, Albert-Ludwigs University Freiburg, Germany
BCR Signaling Pathways: From Autoinhibition to Activation

Thursday, February 26 | 5:00PM - 7:00PM
B Cell Activation and Regulation
Room: Bataan

Speaker 3 of 4
Thomas L. Rothstein, Western Michigan University, USA
Short Talk: Reprogramming BCR Signaling through Receptor Crosstalk

Thursday, February 26 | 5:00PM - 7:00PM
B Cell Activation and Regulation
Room: Bataan

Speaker 4 of 4
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Modulation of autoreactive B cell responses by IFNbeta and BCR engagement



Thursday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande


Thursday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Rio Grande


Friday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande


Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 1 of 7
Rita Carsetti, Bambino Gesù Children Hospital, Italy
Mucosal B Cell Ontogeny in Mouse and Man

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 2 of 7
Nicole Baumgarth, University of California, Davis, USA
Short Talk: B cells in the context of Influenca

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 3 of 7
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Directed Trafficking of Chemokines and Small Antigens into LNs via Follicular Conduits

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 4 of 7
Shiv Pillai, Massachusetts General Hospital, USA
Interlude

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 5 of 7
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
Plasma Cell Niches and Dynamics

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 6 of 7
Frances E. Lund, University of Alabama at Birmingham, USA
Effector B Cell Subsets: Multiple antibody independent roles for B cells in immunity

Friday, February 27 | 8:00AM - 11:00AM
B Cell Niches, Contacts, and Effector Function
Room: Bataan

Speaker 7 of 7
Louis B. Justement, University of Alabama, Birmingham, USA
Short Talk: Cross-Talk between Marginal Zone B Cells and Marginal Zone
Macrophages


Friday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B/C


Friday, February 27 | 11:00AM - 11:00AM
On Own for Lunch


Friday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande


Friday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 1 of 10
* Katherine L. Knight, Loyola University, USA

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 2 of 10
SangKon Oh, Baylor Research Institute, USA
A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing IgA-Secreting Plasmablasts

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 3 of 10
Douglas A. Kuperman, Northwestern University, USA
Secretory IgA is Increased in the Airways of
12/15-lipoxygenase Deficient Mice


Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 4 of 10
Bertrand Huard, Centre Medical Universitaire, Switzerland
Neutrophils Create Survival Niches Rich in APRIL for Plasma Cells

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 5 of 10
Henrik E. Mei, German Rheumatism Research Center, Germany
Blood-borne Human Plasma Cells are Derived from Mucosal Immune Responses and are Refractory to Therapeutic B Cell Depletion

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 6 of 10
HyeMee Joo, Baylor Institute Research, USA
The State of B Cell Memory in the Lung is Profoundly Influenced by the Nature of Immunization

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 7 of 10
Kristina Rothaeusler, California National Primate Research Center, USA
Evidence for Extrafollicular Foci-derived Self-renewing Lung Tissue Plasma Cells following Influenza Virus Infection

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 8 of 10
* Troy D. Randall, University of Alabama at Birmingham, USA
Milky Spots in the Omentum Independently Support T-dependent B Cell Responses to Peritoneal Antigens

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 9 of 10
Wojciech Wojciechowski, University of Rochester, USA
TNF-alpha Producing B Cells are Involved in the Generation of Protective Immunity against Intestinal Nematode Parasite Heligmosmoides Polygyrus

Friday, February 27 | 2:30PM - 4:30PM
Workshop 7: Unique Aspects of Mucosal Immunity
Room: Don Fernando Hall

Speaker 10 of 10
Venkata A. Yeramilli, Loyola University Chicago, USA
B Lymphocyte Development in GALT

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 1 of 11
* Thomas L. Rothstein, Western Michigan University, USA

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 2 of 11
* Robert T. Woodland, University of Massachusetts Medical School, USA
Introduction

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 3 of 11
Kevin L. Otipoby, Biogen Idec, USA
BCR Expression Regulates Gsk3 activation, c-Myc Protein Levels and B Cell Proliferation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 4 of 11
Josquin Nys, National Institute for Medical Research, UK
to provide comment for above presentation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 5 of 11
Shannon O'Neill, University of Colorado Denver, USA
Monophosphorylation of the Igá ITAM Initiates an Inhibitory Cascade Required for B Cell Anergy

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 6 of 11
Lenka Sinik, Array BioPharma, USA
to provide comment for above presentation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 7 of 11
H. Christine Patterson, Immune Disease Institute, USA
Negative Regulation of B Cell Antigen Receptor Signaling Strength by Ig Alpha Serine/Threonine Phosphorylation Inhibits Poly- and Autoreactive Plasma Cell Formation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 8 of 11
Corinne Lara DePersis, University of Colorado Health Science Center, USA
to provide comment for above presentation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 9 of 11
Sarah Rowland, Washington University in St. Louis, USA
Suboptimal BCR Levels and Tonic BCR Signals Prevent Differentiation of Immature B Cells

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 10 of 11
Nichol E. Holodick, WMU Medical School, USA
to provide comment for above presentation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 8: Integrating Signaling Cascades
Room: Council Chambers

Speaker 11 of 11
Bazarragchaa Damdinsuren, National Institute on Aging, National Institutes of Health, USA
Functional Consequences of Single Round Antigen Receptor Signaling in Naïve B Cells

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 1 of 10
* Ann J. Feeney, The Scripps Research Institute, USA

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 2 of 10
* Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 3 of 10
Sergei B. Koralov, New York University, USA
Role of miRNAs in B Cell Development

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 4 of 10
Stefan Kuchen, National Institutes of Health, USA
A Systems Approach Using Genome-Wide Small RNA Profiling for Studying B Cell Development, Activation, and Differentiation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 5 of 10
Giuseppe Testa, European Institute of Oncology, Italy
Functional Dissection of Histone Lysine Methylation in B Cell specification

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 6 of 10
Marieta Caganova, Fondazione Istituto Italiano di Tecnologia (IIT), Italy
The Role of the Polycomb Group Protein Ezh2 in Adaptive B Cell Immunity and Terminal Differentiation

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 7 of 10
Ramesh Subrahmanyam, National Institute on Aging, National Institutes of Health, USA
Rearrangement Associated Epigenetic Changes Distinguish DJH Junctions for VH Recombination

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 8 of 10
Chaggai E. Rosenbluh, Icahn School of Medicine at Mount Sinai, USA
Epigenetic Regulation - A Key Mediator of Allelic Exclusion

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 9 of 10
Zhixin Zhang, University of Nebraska Medical Center, USA
Association with the Nuclear Matrix is Essential for Pax5 to Fully Activate its Target Genes in Murine Pro B

Friday, February 27 | 2:30PM - 4:30PM
Workshop 9: Epigenetic Regulation and microRNA Control
Room: Bataan

Speaker 10 of 10
Julita A. Ramirez, University of Washington, USA
Opposing Effects of Swi/Snf and Mi-2 NuRD Chromatin Remodeling Complexes on Epigenetic Reprogramming by EBF and Pax5

Friday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Rio Grande B/C


Friday, February 27 | 5:00PM - 7:15PM
B Cells on the Move
Room: Bataan

Speaker 1 of 4
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Early events in B cell response to antigen

Friday, February 27 | 5:00PM - 7:15PM
B Cells on the Move
Room: Bataan

Speaker 2 of 4
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Dynamics of B Cell Antigen Encounter

Friday, February 27 | 5:00PM - 7:15PM
B Cells on the Move
Room: Bataan

Speaker 3 of 4
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing the Cell-Cell Interactions Underlying Humoral Immune Responses

Friday, February 27 | 5:00PM - 7:15PM
B Cells on the Move
Room: Bataan

Speaker 4 of 4
Marc K. Jenkins, University of Minnesota Medical School, USA
Analysis of Antigen-Specific Memory B Cell Formation in Normal Mice

Friday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande


Friday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Rio Grande


Saturday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande


Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 1 of 7
Jennifer H. Anolik, University of Rochester, USA
B Cell Subsets Targeted by Rituximab: Understanding Clinical and Immunological Outcomes After B Cell Depletion in Autoimmune Disease

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 2 of 7
* Hergen Spits, University of Amsterdam, Netherlands
Immortalization of BCR+ Antibody Producing Human B Cells by Genetic Programming

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 3 of 7
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Development of B Cell Targeted Vaccines

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 4 of 7
Barton F. Haynes, Duke University Medical Center, USA
Induction of B Cell Polyclonal Differentiation and Apoptosis With Massive Gastrointestinal Tract Germinal Center Loss In the Earliest Stages of HIV-1 Infection

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 5 of 7
Kenneth K. Yu, California Institute of Technology, USA
Short Talk: Engineering Immunity Against HIV: A Stem Cell Vaccine

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 6 of 7
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Pax5 in Normal and Neoplastic B Cell Development

Saturday, February 28 | 8:00AM - 11:30AM
Therapeutic Manipulation of B Cell Subsets
Room: Bataan

Speaker 7 of 7
Geetha P. Bansal, National Institutes of Health, USA
Short Talk: Update on NIAID Funding Opportunities

Saturday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B/C


Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10A: B Cells and Non-HIV Infections

Speaker 1 of 3
Filiz Demircik, Uniklinik, Germany
The Role of B Cells in Murine Cytomegalovirus (MCMV) Infection

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10A: B Cells and Non-HIV Infections

Speaker 2 of 3
Denise A. Kaminski, University of Rochester, USA
Nucleoprotein-Immune Antibody Protects Against Influenza Virus by a T Cell-Mediated Mechanism

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10A: B Cells and Non-HIV Infections

Speaker 3 of 3
Shane Crotty, La Jolla Institute for Immunology, USA
Characterization of Protective B Cell Responses to Vaccinia virus, the Smallpox Vaccine, and Generation of Protective Human Monoclonal Antibodies

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10B: B Cells and HIV Infections

Speaker 1 of 4
† Julien van Grevenynghe, Lady Davis Institute, Canada
Depletion of Peripheral CD19+CD27+ Memory B-cells from HIV-Infected Individuals is Associated with FOXO3a Activation

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10B: B Cells and HIV Infections

Speaker 2 of 4
Oluwadamilola Unuigbe, Malawi-Liverpool Wellcome Trust, Malawi
The Loss of B Cell Memory to Pneumococcal Protein Antigens in Malawian Children during HIV Infection

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10B: B Cells and HIV Infections

Speaker 3 of 4
Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
Enhancing the Immunogenicity of HIV-1 Envelope Glycoprotein Trimers by Fusion to CD40 Ligand

Saturday, February 28 | 10:00AM - 10:00AM
Workshop 10B: B Cells and HIV Infections

Speaker 4 of 4
Mattias Forsell, Umeå University, Sweden
Direct Interaction of a Viral Surface Protein with its Primary Receptor is Required for B Cell Receptor Recognition of a Conserved Co-Receptor Binding Surface.

Saturday, February 28 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, February 28 | 2:30PM - 4:30PM
Workshop 10: Targeted Vaccine Strategies for Chronic Infecti
on
Room: Don Fernando Hall

Speaker 1 of 1
* Nancy L. Haigwood, Oregon Health & Science University, USA

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 1 of 9
* John G. Monroe, Genentech, Inc., USA

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 2 of 9
Inbal Binsky-Ehrenreich, Weizmann Institute, Israel
CD74 Induces the Expression of TAp63, which Regulates B-CLL Survival and Migration to the Bone Marrow

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 3 of 9
* Lisa Borghesi, University of Pittsburgh, USA
Targeted Knockdown of the B Lineage Transcriptional Activator E2A in B Cell Chronic Lymphocytic Leukemia (CLL) Enhances Lenalidomide Sensitivity and Regulates Cellular Proliferation

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 4 of 9
Bridget S. Wilson, University of New Mexico Health Science Center, USA
Select gamma-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance between Constitutive Notch Signaling and Repression

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 5 of 9
Laura R. Wasil, University of Pittsburgh Graduate School of Public Health, USA
Immortalization of B Cells by Epstein-Barr Virus Requires both the Products of the Latent Membrane Protein 2 Gene

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 6 of 9
Geetha Chalasani, University of Pittsburgh, USA
B Cells Promote Development of Alloreactive Memory T Cells

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 7 of 9
Peggy L. Kendall, Vanderbilt University Medical Center, USA
Bruton’s Tyrosine Kinase Deficiency Ameliorates Type 1 Diabetes

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 8 of 9
Yue Wang, MedImmune, Inc, USA
An Afucosylated Anti-human-CD19 Antibody Exhibits Potent Depletion of Bone Marrow and Peripheral B Cells in Mice

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 11: Drug Targets for Immune Modulation
Room: Council Chambers

Speaker 9 of 9
Chung Park, NIAID, National Institutes of Health, USA
B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids Near to Lymph Node Follicles by a Mechanism Independent of S1P-Mediated Chemotaxis

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 1 of 7
* Ignacio Sanz, Emory University, School of Medicine, USA

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 2 of 7
Santi Suryani, Garvan Institute of Medical Research, Australia
Characterisation of Human Transitional B cell Subsets

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 3 of 7
Panida Sriaroon, University of South Florida, USA
Memory CD27+ B220- B Cell Subpopulation is Decreased in Human Immunodeficiency Virus Disease (HIV) on Therapy, Common Variable Immune Deficiency (CVID) and Systemic Lupus Erythematosus (SLE)

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 4 of 7
Isabelle Isnardi, Novartis Pharma, Switzerland
Defective Receptor Editing Results in the Appearance of Anergic B cells in Humans

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 5 of 7
Jonathan Michael Irish, Vanderbilt University, USA
Abnormal B cell Receptor Signaling in a Subset of Lymphoma B cells Distinguishes Follicular Lymphoma Patients with Poor Clinical Outcomes

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 6 of 7
Isabelle Bekeredjian-Ding, University of Heidelberg, Germany
Immunostimulatory DNA ODN and BAFF/BlyS Selectively Target Human IgM+ B cell Subsets

Saturday, February 28 | 2:30PM - 4:30PM
Workshop 12: Human B Cell Subsets in Health and Disease
Room: Bataan

Speaker 7 of 7
Patrick C. Wilson, University of Chicago, USA
A Memory Compartment Origin for Early Antibody-Secreting B cells during the Anti-Influenza Vaccine Response

Saturday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Rio Grande B/C


Saturday, February 28 | 5:00PM - 7:15PM
Transformation
Room: Bataan

Speaker 1 of 4
Jeffrey L. Browning, Boston University School of Medicine, USA
Blockade of the Lymphotoxin-LIGHT Pathway and the Treatment of Autoimmune Disease

Saturday, February 28 | 5:00PM - 7:15PM
Transformation
Room: Bataan

Speaker 2 of 4
Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
Short Talk: DNA double strand breaks, translocations, and B cell lymphoma

Saturday, February 28 | 5:00PM - 7:15PM
Transformation
Room: Bataan

Speaker 3 of 4
* Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA
AID tumorigenic activity

Saturday, February 28 | 5:00PM - 7:15PM
Transformation
Room: Bataan

Speaker 4 of 4
Lin He, University of California, Berkeley, USA
Mir17-92 as a putative oncogene for B cell lymphomas

Saturday, February 28 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Rio Grande


Saturday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Rio Grande


Saturday, February 28 | 8:15PM - 11:00PM
Entertainment
Room: Rio Grande


Sunday, March 01 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.