Web Desc
Chromatin Dynamics and Higher Order Organization
Organizer(s): Terumi Kohwi-Shigematsu and Patrick D. Varga-Weisz
Date: February 25 - March 02, 2009
Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA
Supported by the Directors' Fund
Summary of Meeting:
Research in the past decade has revealed the intimate link of chromatin structure at the levels of histone modifications and nucleosome remodeling to nuclear functions, especially gene regulation. Yet the molecular mechanisms of higher orders of chromatin organization beyond the nucleosomal array remain largely obscure. Evidence is emerging that chromatin folding and large-scale chromatin interactions, including trans-interactions between chromosomes, play an important role in gene regulation, recombination, and other nuclear processes. Chromatin looping may be a key component of regulatory mechanisms. New roles of non-coding RNAs in regulating chromatin function are also uprising. Furthermore, functional compartments, such as transcription factories, replication factories, and polycomb bodies have been suggested to organize the nucleus. This meeting will focus on recent breakthroughs in our understanding of the mechanisms that govern dynamics of higher-order chromatin architecture in order to gain important insights into gene regulation and disregulation, DNA repair, normal development, stem cell function, epigenetic inheritance and diseases such as cancer.
Scholarship Deadline: October 27 2008
Discounted Abstract Deadline: October 27 2008
Abstract Deadline: November 25 2008
Discounted Registration Deadline: December 30 2008
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
BioMed CentralCell Press
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Wednesday, February 25 | 3:00PM - 7:30PM
Registration
Room: Conference Center Lobby


Wednesday, February 25 | 6:30PM - 7:30PM
Refreshments
Room: Bay 4


Wednesday, February 25 | 7:30PM - 8:30PM
Keynote Address
Room: Bay 2-3

Speaker 1 of 2
* Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA

Wednesday, February 25 | 7:30PM - 8:30PM
Keynote Address
Room: Bay 2-3

Speaker 2 of 2
Michael G. Rosenfeld, University of California, San Diego, USA
Life, Death, and Translocation: Movements, Repeats, and ncRNAs

Thursday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Bay 5


Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 1 of 6
* Peter Fraser, Florida State University, USA
Inter-Chromosomal Gene Regulatory Networks

Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 2 of 6
David M. Gilbert, Florida State University, USA
Global Re-Organization of Replication Domains during Embryonic Stem Cell Differentiation

Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 3 of 6
Sarah Javaid, Merck, USA
Short Talk: Nucleosome Remodeling Catalyzed by the Human hMSH2-hMSH6 Mismatch Recognition Complex

Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 4 of 6
Craig L. Peterson, University of Massachusetts Medical School, USA
Chromatin Dynamics during DNA Repair

Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 5 of 6
Irina Solovei, Ludwig Maximilians University, Germany
Inverted Nuclear Architecture and Its Development during Differentiation of Mouse Rod Photoreceptor Cells

Thursday, February 26 | 8:00AM - 11:15AM
The Regulation of Chromatin Dynamics
Room: Bay 2-3

Speaker 6 of 6
Samantha Gail Zeitlin, University of California, San Diego, USA
Short Talk: The Centromeric H3 Variant CENP-A is Targeted by and Functions in DNA Repair

Thursday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: West Conference Center Lobb


Thursday, February 26 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Bay 4


Thursday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 4


Thursday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: West Conference Center Lobb


Thursday, February 26 | 5:00PM - 7:15PM
Chromatin Transitions Underlying Development
Room: Bay 2-3

Speaker 1 of 4
* Peter B. Becker, University of Munich, Germany
CHRAC/ACF Initiates the Stratification of the Epigenome

Thursday, February 26 | 5:00PM - 7:15PM
Chromatin Transitions Underlying Development
Room: Bay 2-3

Speaker 2 of 4
Patrick D. Varga-Weisz, Babraham Institute, UK
ATP-Dependent Chromatin Remodeling Factors: Guardians of the Epigenome

Thursday, February 26 | 5:00PM - 7:15PM
Chromatin Transitions Underlying Development
Room: Bay 2-3

Speaker 3 of 4
Sophie Rousseaux, Institut Albert Bonniot, France
Molecular Basis of Post-Meiotic Male Genome Reprogramming: Essential Role for Histone Hyperacetylation

Thursday, February 26 | 5:00PM - 7:15PM
Chromatin Transitions Underlying Development
Room: Bay 2-3

Speaker 4 of 4
Antoine H.F.M. Peters, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Role of Polycomb-Group Proteins in Higher Order Chromatin Organization and Genomic Imprinting

Thursday, February 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Bay 4


Thursday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay 4


Friday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Bay 5


Friday, February 27 | 7:00AM - 8:00AM
Poster Setup
Room: Bay 4


Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 1 of 6
* Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Chromatin Boundaries

Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 2 of 6
Job Dekker, University of Massachusetts Medical School, USA
Three-Dimensional Folding of Chromosomal Domains in Relation to Gene Expression

Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 3 of 6
Olivier Cuvier, LBME- CNRS, France
Short Talk: Chromatin Dual-Cores Define Nucleosome-Associated Cis-Regulatory Insulator Elements that Control the Deposition of H3K9 Methylation Marks in Hundreds of Promoters of Genes Regulating Chromosome Organization/Segregation

Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 4 of 6
Rolf Ohlsson, Karolinska Institute, Sweden
Imprinted Domains Form Extensive Interaction-Networks to Regulate Epigenetic States

Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 5 of 6
Gordon L. Hager, NCI, National Institutes of Health, USA
Genome-Wide Interaction of Nuclear Receptors with Chromatin

Friday, February 27 | 8:00AM - 11:15AM
Chromatin Folding and Gene Regulation
Room: Bay 2-3

Speaker 6 of 6
Joke G. van Bemmel, Netherlands Cancer Institute, Netherlands
Short Talk: The Insulator Protein Su(Hw) Marks Borders of Lamina Associated Domains

Friday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: West Conference Center Lobb


Friday, February 27 | 11:15AM - 12:00PM
Lunch
Room: Bay 4


Friday, February 27 | 12:00PM - 2:30PM
Poster Session 2
Room: Bay 4


Friday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: West Conference Center Lobb


Friday, February 27 | 5:00PM - 7:00PM
Non-Coding RNAs and Chromatin Function
Room: Bay 2-3

Speaker 1 of 4
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins

Friday, February 27 | 5:00PM - 7:00PM
Non-Coding RNAs and Chromatin Function
Room: Bay 2-3

Speaker 2 of 4
Howard Y. Chang, Stanford University, USA
Programming Chromatin States by Long Noncoding RNAs

Friday, February 27 | 5:00PM - 7:00PM
Non-Coding RNAs and Chromatin Function
Room: Bay 2-3

Speaker 3 of 4
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
New Lessons from the X-Inactivation Paradigm

Friday, February 27 | 5:00PM - 7:00PM
Non-Coding RNAs and Chromatin Function
Room: Bay 2-3

Speaker 4 of 4
Keith E. Giles, University of Alabama at Birmingham, USA
Short Talk: Histone Deacetylation and Dicer-Dependent Small RNAs Control Chromatin Condensation within Vertebrate Constitutive Heterochromatin

Friday, February 27 | 7:00PM - 7:00PM
On Own for Dinner


Saturday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Bay 5


Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 1 of 6
* Giacomo Cavalli, Institute of Human Genetics, France
Polycomb Proteins and Nuclear Organization in Drosophila

Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 2 of 6
Victor G. Corces, Emory University School of Medicine, USA
Genome Organization and Chromatin Insulators

Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 3 of 6
Matthias Merkenschlager, Imperial College London, UK
Cohesins in Gene Regulation and Genome Organization

Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 4 of 6
Keji Zhao, NHLBI, National Institutes of Health, USA
Dynamic Change of Histone Modifications during Differentiation

Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 5 of 6
Jung S. Byun, National Cancer Institute, National Institutes of Health, USA
Short Talk: p300 Facilitates the Formation of Pre-Positioned RNA Polymerase

Saturday, February 28 | 8:00AM - 11:15AM
Genome Organization and Structure
Room: Bay 2-3

Speaker 6 of 6
Dale Dorsett, St. Louis University School of Medicine, USA
Short Talk: Gene Regulation in Cohesin-Binding Chromosomal Domains

Saturday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: West Conference Center Lobb


Saturday, February 28 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Bay 4


Saturday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 4


Saturday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: West Conference Center Lobb


Saturday, February 28 | 5:00PM - 7:00PM
The Chromatin Landscape for Stem Cells and Development
Room: Bay 2-3

Speaker 1 of 4
* Wolf Reik, Babraham Institute, UK
Imprinting and Epigenetic Reprogramming in Mammalian Development

Saturday, February 28 | 5:00PM - 7:00PM
The Chromatin Landscape for Stem Cells and Development
Room: Bay 2-3

Speaker 2 of 4
Stuart H. Orkin, Dana-Farber Cancer Institute, USA
The Transcriptional Network and Chromatin Structure in ES Cells

Saturday, February 28 | 5:00PM - 7:00PM
The Chromatin Landscape for Stem Cells and Development
Room: Bay 2-3

Speaker 3 of 4
Manjari Mazumdar, Indiana University, USA
Short Talk: The Molecular Motor Chromokinesin KIF4 is a Modulator of Interphase Chromatin Structure

Saturday, February 28 | 5:00PM - 7:00PM
The Chromatin Landscape for Stem Cells and Development
Room: Bay 2-3

Speaker 4 of 4
Yukiko Gotoh, University of Tokyo, Japan
Short Talk: Temporal Regulation of Neural Precursor Cell Fate by Polycomb-Group Proteins

Saturday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Bay 4


Saturday, February 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay 4


Sunday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Bay 5


Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 1 of 6
* Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Epigenetic Control of Cancer

Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 2 of 6
Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetic Control of the Circadian Clock: SIRT1 and Metabolism

Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 3 of 6
Andrew S. Koh, Stanford University, USA
Short Talk: Essential Role for Chromatin in Aire-Mediated Tolerance to Autoimmunity

Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 4 of 6
Kyoko Yokomori, University of California, Irvine, USA
Differential Recruitment and Function of the Essential Sister Chromatid Cohesion Complex Cohesin in Gene Activation and Heterochromatin Organization

Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 5 of 6
Le Zhang, Yale University, USA
Short Talk: Prelamin A Induces Premature Senescence and Accelerated Aging by Activating Heterochromatin Formation

Sunday, March 01 | 8:00AM - 11:15AM
Chromatin Dynamics in Aging and Disease
Room: Bay 2-3

Speaker 6 of 6
Alexander Tarakhovsky, Rockefeller University, USA
Chromatin Control of Antiviral Response

Sunday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: West Conference Center Lobb


Sunday, March 01 | 11:00AM - 11:00AM
On Own for Lunch


Sunday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: West Conference Center Lobb


Sunday, March 01 | 5:00PM - 7:00PM
Altered Chromatin Structure in Disease
Room: Bay 2-3

Speaker 1 of 4
* Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA
Age-Dependent CAG Trinucleotide Expansion in Post-Mitotic Neurons

Sunday, March 01 | 5:00PM - 7:00PM
Altered Chromatin Structure in Disease
Room: Bay 2-3

Speaker 2 of 4
Siavash K. Kurdistani, University of California, Los Angeles, USA
Histone Modification Dynamics in Oncogenic Transformation

Sunday, March 01 | 5:00PM - 7:00PM
Altered Chromatin Structure in Disease
Room: Bay 2-3

Speaker 3 of 4
Colyn Crane-Robinson, University of Portsmouth, UK
Short Talk: The Chromatin of Active Genes is not in a Permanently Open Conformation

Sunday, March 01 | 5:00PM - 7:00PM
Altered Chromatin Structure in Disease
Room: Bay 2-3

Speaker 4 of 4
Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
The Genome Organizer SATB1 in Mouse Brain

Sunday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Bay 4


Sunday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Bay 4


Sunday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Bay 4


Monday, March 02 | 10:25AM - 10:25AM
Departure


*Session Chair.