Web Desc
Extrinsic Control of Tumor Genesis and Progression
Organizer(s): Thea D. Tlsty and Mary J.C. Hendrix
Date: March 15 - 20, 2009
Location: Fairmont Waterfront, Vancouver, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights.
Scholarship Deadline: November 17 2008
Discounted Abstract Deadline: November 17 2008
Abstract Deadline: December 15 2008
Discounted Registration Deadline: January 15 2009
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA138043-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 15 | 3:00PM - 7:30PM
Registration
Room: Waterfront Foyer


Sunday, March 15 | 6:30PM - 7:30PM
Refreshments
Room: Waterfront Foyer


Sunday, March 15 | 7:30PM - 8:30PM
Keynote Address
Room: Waterfront Ballroom

Speaker 1 of 1
Norman F. Boyd, University of Toronto, Canada
Mammographic Density and Breast Cancer Risk

Monday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Mackenzie Ballroom


Monday, March 16 | 8:00AM - 11:00AM
Coding Information within the ECM
Room: Waterfront Ballroom

Speaker 1 of 4
Pepper Jo Schedin, Oregon Health & Science University, USA
Information Conveyed by ECM Proteins in the Mammary Gland

Monday, March 16 | 8:00AM - 11:00AM
Coding Information within the ECM
Room: Waterfront Ballroom

Speaker 2 of 4
David V. Schaffer, University of California, Berkeley, USA
Molecular Engineering of Synthetic Stem Cell Microenvironments

Monday, March 16 | 8:00AM - 11:00AM
Coding Information within the ECM
Room: Waterfront Ballroom

Speaker 3 of 4
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Tumor Microenvironment in Cancer Progression and Metastasis

Monday, March 16 | 8:00AM - 11:00AM
Coding Information within the ECM
Room: Waterfront Ballroom

Speaker 4 of 4
Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
Reprogramming Metastatic Tumor Cells with an Embryonic Microenvironment:Convergence of Embryonic and Tumorigenic Signaling Pathways

Monday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Waterfront Foyer


Monday, March 16 | 11:00AM - 11:00AM
On Own for Lunch


Monday, March 16 | 11:00AM - 1:00PM
Poster Setup
Room: Waterfront Ballroom


Monday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Waterfront Ballroom


Monday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Waterfront Foyer


Monday, March 16 | 5:00PM - 7:00PM
Key Pathways in Extrinsic Modulation
Room: Waterfront Ballroom

Speaker 1 of 4
Sheila A. Stewart, Washington University School of Medicine, USA
Short Talk: The Tumor Microenvironment: A Role for Senescent-Derived Osteopontin

Monday, March 16 | 5:00PM - 7:00PM
Key Pathways in Extrinsic Modulation
Room: Waterfront Ballroom

Speaker 2 of 4
Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Extrinsic Control of Intrinsic DNA Damage Response and Genomic Instability

Monday, March 16 | 5:00PM - 7:00PM
Key Pathways in Extrinsic Modulation
Room: Waterfront Ballroom

Speaker 3 of 4
Valerie M. Weaver, University of California, San Francisco, USA
How Matrix Topology and Stiffness Direct Tumor Progression

Monday, March 16 | 5:00PM - 7:00PM
Key Pathways in Extrinsic Modulation
Room: Waterfront Ballroom

Speaker 4 of 4
Harold L. Moses, Vanderbilt University, USA
TGF-beta Regulation of the Tumor Microenvironment

Monday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Waterfront Ballroom


Monday, March 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Waterfront Ballroom


Tuesday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Mackenzie Ballroom


Tuesday, March 17 | 7:00AM - 8:00AM
Poster Setup
Room: Waterfront Ballroom


Tuesday, March 17 | 8:00AM - 11:00AM
Stem Cells and Their Niche
Room: Waterfront Ballroom

Speaker 1 of 4
Leanne Jones, University of California, Los Angeles, USA
Stem Cell-Niche Cell Interactions during Tumorigenesis

Tuesday, March 17 | 8:00AM - 11:00AM
Stem Cells and Their Niche
Room: Waterfront Ballroom

Speaker 2 of 4
Gilbert H. Smith, National Cancer Institute, National Institutes of Health, USA
Reprogramming Stem and Cancer Cells is a Microenvironment Task

Tuesday, March 17 | 8:00AM - 11:00AM
Stem Cells and Their Niche
Room: Waterfront Ballroom

Speaker 3 of 4
Tannishtha Reya, University of California, San Diego, USA
Imaging Asymmetric Division in Stem Cells and Cancer

Tuesday, March 17 | 8:00AM - 11:00AM
Stem Cells and Their Niche
Room: Waterfront Ballroom

Speaker 4 of 4
Elsa Quintana-Fernandez, University of Michigan, USA
Tumorigenic Potential is a Common Attribute of Melanoma Cells

Tuesday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Waterfront Foyer


Tuesday, March 17 | 11:00AM - 12:00PM
Lunch
Room: Waterfront Ballroom


Tuesday, March 17 | 12:00PM - 3:00PM
Poster Session 2
Room: Waterfront Ballroom


Tuesday, March 17 | 3:00PM - 4:30PM
Workshop 1: New Tools to Study Multicellular Interactions
Room: Waterfront Ballroom

Speaker 1 of 4
Deborah L. Holliday, Leeds Institute of Molecular Medicine, UK
Multicellular Organotypic Models of Normal and Malignant Breast

Tuesday, March 17 | 3:00PM - 4:30PM
Workshop 1: New Tools to Study Multicellular Interactions
Room: Waterfront Ballroom

Speaker 2 of 4
Maribella Domenech, University of Wisconsin, Madison, USA
Multi-Chamber Platform for the Study of Paracrine and Autocrine Interactions between Cancer Cells and the Surrounding Microenvironment

Tuesday, March 17 | 3:00PM - 4:30PM
Workshop 1: New Tools to Study Multicellular Interactions
Room: Waterfront Ballroom

Speaker 3 of 4
Edna Cukierman, Fox Chase Cancer Center, USA
Staging Tumor-Associated Stroma to Study Epithelial 3D in vivo-like Cancer Cell Responses

Tuesday, March 17 | 3:00PM - 4:30PM
Workshop 1: New Tools to Study Multicellular Interactions
Room: Waterfront Ballroom

Speaker 4 of 4
David Beebe, University of Wisconsin, USA
Exploring Stromal-Carcinoma Cell Interactions in Breast Cancer via Microscale 3-Dimensional Co-Culture Systems

Tuesday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Waterfront Foyer


Tuesday, March 17 | 5:00PM - 7:00PM
Clinical Applications
Room: Waterfront Ballroom

Speaker 1 of 4
Rosa Anna DeFilippis, University of California, San Francisco, USA
Short Talk: The Biological Basis of Mammographic Density

Tuesday, March 17 | 5:00PM - 7:00PM
Clinical Applications
Room: Waterfront Ballroom

Speaker 2 of 4
Dorothy A. Sipkins, University of Chicago, USA
Leukemic Cells Create Bone Marrow Niches that Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

Tuesday, March 17 | 5:00PM - 7:00PM
Clinical Applications
Room: Waterfront Ballroom

Speaker 3 of 4
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cell Interactions with their Microenvironment

Tuesday, March 17 | 5:00PM - 7:00PM
Clinical Applications
Room: Waterfront Ballroom

Speaker 4 of 4
Morag Park, McGill University, Canada
Profiling the Breast Tumor Microenvironment

Tuesday, March 17 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Mackenzie Ballroom


Wednesday, March 18 | 8:00AM - 11:00AM
Basic Biology: Molecular Mechanisms
Room: Waterfront Ballroom

Speaker 1 of 4
Michael J. Hendzel, University of Alberta, Canada
Force Transmission and the Nucleus

Wednesday, March 18 | 8:00AM - 11:00AM
Basic Biology: Molecular Mechanisms
Room: Waterfront Ballroom

Speaker 2 of 4
Thea D. Tlsty, University of California, San Francisco, USA
Early Events in Carcinogenesis

Wednesday, March 18 | 8:00AM - 11:00AM
Basic Biology: Molecular Mechanisms
Room: Waterfront Ballroom

Speaker 3 of 4
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Stromal Changes in Cancer Progression

Wednesday, March 18 | 8:00AM - 11:00AM
Basic Biology: Molecular Mechanisms
Room: Waterfront Ballroom

Speaker 4 of 4
Zena Werb, University of California, San Francisco, USA
Extrinsic and Intrinsic Mechanisms of Malignant Progression

Wednesday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Waterfront Foyer


Wednesday, March 18 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, March 18 | 11:00AM - 1:00PM
Poster Setup
Room: Waterfront Ballroom


Wednesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Waterfront Ballroom


Wednesday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Waterfront Foyer


Wednesday, March 18 | 5:00PM - 7:00PM
Tumor Microenvironment
Room: Waterfront Ballroom

Speaker 1 of 4
Esther N. Arwert, Francis Crick Institute, UK
Short Talk: Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate

Wednesday, March 18 | 5:00PM - 7:00PM
Tumor Microenvironment
Room: Waterfront Ballroom

Speaker 2 of 4
Nancy Dumont, University of California, San Francisco, USA
Extrinsic Control of Epigenetic Modifications Associated with Mammary Tumor Progression

Wednesday, March 18 | 5:00PM - 7:00PM
Tumor Microenvironment
Room: Waterfront Ballroom

Speaker 3 of 4
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Regulation of in Situ to Invasive Breast Carcinoma Progression

Wednesday, March 18 | 5:00PM - 7:00PM
Tumor Microenvironment
Room: Waterfront Ballroom

Speaker 4 of 4
Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
Form Dictates Function: Modeling Normal Breast to Understand Breast Cancer

Wednesday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Waterfront Ballroom


Wednesday, March 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Waterfront Ballroom


Thursday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Mackenzie Ballroom


Thursday, March 19 | 8:00AM - 11:00AM
Non-Transformed Cells Modulate Transformed Cells
Room: Waterfront Ballroom

Speaker 1 of 4
Judith Campisi, Buck Institute for Research on Aging, USA
Two Faces of Cellular Senescence

Thursday, March 19 | 8:00AM - 11:00AM
Non-Transformed Cells Modulate Transformed Cells
Room: Waterfront Ballroom

Speaker 2 of 4
Lisa M. Coussens, Oregon Health & Science University, USA
Tissue-Specific Mechanisms Regulate Pro-Tumor Immunity

Thursday, March 19 | 8:00AM - 11:00AM
Non-Transformed Cells Modulate Transformed Cells
Room: Waterfront Ballroom

Speaker 3 of 4
Sylvaine Cases, USA
Role of Adipocytes in Mammary Gland Development and Breast Cancer: Lessons form DGAT1-Deficient Mice

Thursday, March 19 | 8:00AM - 11:00AM
Non-Transformed Cells Modulate Transformed Cells
Room: Waterfront Ballroom

Speaker 4 of 4
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Signals

Thursday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Waterfront Foyer


Thursday, March 19 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, March 19 | 2:30PM - 4:30PM
Workshop 2: Potential Lingages to the Tumor Microenvironment
Network - Funding
Room: Waterfront Ballroom

Speaker 1 of 1
* † Suresh Mohla, NCI, National Institutes of Health, USA

Thursday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Waterfront Foyer


Thursday, March 19 | 5:00PM - 7:00PM
Progression to Metastasis
Room: Waterfront Ballroom

Speaker 1 of 4
Marsha R. Rosner, University of Chicago, USA
Short Talk: Identification of Signaling Pathway Signature for Metastasis Suppressor Reveals Novel Mechanism for MicroRNA Regulation of the Microenvironment.

Thursday, March 19 | 5:00PM - 7:00PM
Progression to Metastasis
Room: Waterfront Ballroom

Speaker 2 of 4
Douglas Hanahan, ISREC, Switzerland
Evasive Resistance: Switching from Tumor Angiogenesis to Invasion and Metastasis

Thursday, March 19 | 5:00PM - 7:00PM
Progression to Metastasis
Room: Waterfront Ballroom

Speaker 3 of 4
Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA
Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor-Negative Cancers

Thursday, March 19 | 5:00PM - 7:00PM
Progression to Metastasis
Room: Waterfront Ballroom

Speaker 4 of 4
Robert A. Weinberg, Massachusetts Institute of Technology, USA
Metastatic Modulation

Thursday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Waterfront Ballroom


Thursday, March 19 | 8:00PM - 11:00PM
Entertainment
Room: Waterfront Ballroom


Thursday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Waterfront Ballroom


Friday, March 20 | 10:25AM - 10:25AM
Departure


*Session Chair.