Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
There are no records.

Web Desc
Extrinsic Control of Tumor Genesis and Progression Organizer(s): Thea D. Tlsty and Mary J.C. Hendrix Date: March 15 - 20, 2009 Location: Fairmont Waterfront, Vancouver, BC, Canada Supported by the Directors' Fund Summary of Meeting: It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights. Scholarship Deadline: November 17 2008 Discounted Abstract Deadline: November 17 2008 Abstract Deadline: December 15 2008 Discounted Registration Deadline: January 15 2009 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA138043-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Extrinsic Control of Tumor Genesis and Progression

Organizer(s): Thea D. Tlsty and Mary J.C. Hendrix

Date: March 15 - 20, 2009
Location: Fairmont Waterfront, Vancouver, BC, Canada

Supported by the Directors' Fund

Summary of Meeting:

It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights.

Scholarship Deadline: November 17 2008

Discounted Abstract Deadline: November 17 2008

Abstract Deadline: December 15 2008

Discounted Registration Deadline: January 15 2009

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA138043-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 15 \| 3:00PM - 7:30PM Registration Room: Waterfront Foyer
Sunday, March 15 \| 6:30PM - 7:30PM Refreshments Room: Waterfront Foyer
Sunday, March 15 \| 7:30PM - 8:30PM Keynote Address Room: Waterfront Ballroom Speaker 1 of 1 Norman F. Boyd, University of Toronto, Canada Mammographic Density and Breast Cancer Risk
Monday, March 16 \| 7:00AM - 8:00AM Breakfast Room: Mackenzie Ballroom
Monday, March 16 \| 8:00AM - 11:00AM Coding Information within the ECM Room: Waterfront Ballroom Speaker 1 of 4 Pepper Jo Schedin, Oregon Health & Science University, USA Information Conveyed by ECM Proteins in the Mammary Gland
Monday, March 16 \| 8:00AM - 11:00AM Coding Information within the ECM Room: Waterfront Ballroom Speaker 2 of 4 David V. Schaffer, University of California, Berkeley, USA Molecular Engineering of Synthetic Stem Cell Microenvironments
Monday, March 16 \| 8:00AM - 11:00AM Coding Information within the ECM Room: Waterfront Ballroom Speaker 3 of 4 Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA Tumor Microenvironment in Cancer Progression and Metastasis
Monday, March 16 \| 8:00AM - 11:00AM Coding Information within the ECM Room: Waterfront Ballroom Speaker 4 of 4 Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA Reprogramming Metastatic Tumor Cells with an Embryonic Microenvironment:Convergence of Embryonic and Tumorigenic Signaling Pathways
Monday, March 16 \| 9:20AM - 9:40AM Coffee Break Room: Waterfront Foyer
Monday, March 16 \| 11:00AM - 11:00AM On Own for Lunch
Monday, March 16 \| 11:00AM - 1:00PM Poster Setup Room: Waterfront Ballroom
Monday, March 16 \| 1:00PM - 10:00PM Poster Viewing Room: Waterfront Ballroom
Monday, March 16 \| 4:30PM - 5:00PM Coffee Available Room: Waterfront Foyer
Monday, March 16 \| 5:00PM - 7:00PM Key Pathways in Extrinsic Modulation Room: Waterfront Ballroom Speaker 1 of 4 Sheila A. Stewart, Washington University School of Medicine, USA Short Talk: The Tumor Microenvironment: A Role for Senescent-Derived Osteopontin
Monday, March 16 \| 5:00PM - 7:00PM Key Pathways in Extrinsic Modulation Room: Waterfront Ballroom Speaker 2 of 4 Mary Helen Barcellos-Hoff, New York School of Medicine, USA Extrinsic Control of Intrinsic DNA Damage Response and Genomic Instability
Monday, March 16 \| 5:00PM - 7:00PM Key Pathways in Extrinsic Modulation Room: Waterfront Ballroom Speaker 3 of 4 Valerie M. Weaver, University of California, San Francisco, USA How Matrix Topology and Stiffness Direct Tumor Progression
Monday, March 16 \| 5:00PM - 7:00PM Key Pathways in Extrinsic Modulation Room: Waterfront Ballroom Speaker 4 of 4 Harold L. Moses, Vanderbilt University, USA TGF-beta Regulation of the Tumor Microenvironment
Monday, March 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Waterfront Ballroom
Monday, March 16 \| 7:30PM - 10:00PM Poster Session 1 Room: Waterfront Ballroom
Tuesday, March 17 \| 7:00AM - 8:00AM Breakfast Room: Mackenzie Ballroom
Tuesday, March 17 \| 7:00AM - 8:00AM Poster Setup Room: Waterfront Ballroom
Tuesday, March 17 \| 8:00AM - 11:00AM Stem Cells and Their Niche Room: Waterfront Ballroom Speaker 1 of 4 Leanne Jones, University of California, Los Angeles, USA Stem Cell-Niche Cell Interactions during Tumorigenesis
Tuesday, March 17 \| 8:00AM - 11:00AM Stem Cells and Their Niche Room: Waterfront Ballroom Speaker 2 of 4 Gilbert H. Smith, National Cancer Institute, National Institutes of Health, USA Reprogramming Stem and Cancer Cells is a Microenvironment Task
Tuesday, March 17 \| 8:00AM - 11:00AM Stem Cells and Their Niche Room: Waterfront Ballroom Speaker 3 of 4 Tannishtha Reya, University of California, San Diego, USA Imaging Asymmetric Division in Stem Cells and Cancer
Tuesday, March 17 \| 8:00AM - 11:00AM Stem Cells and Their Niche Room: Waterfront Ballroom Speaker 4 of 4 Elsa Quintana-Fernandez, University of Michigan, USA Tumorigenic Potential is a Common Attribute of Melanoma Cells
Tuesday, March 17 \| 9:20AM - 9:40AM Coffee Break Room: Waterfront Foyer
Tuesday, March 17 \| 11:00AM - 12:00PM Lunch Room: Waterfront Ballroom
Tuesday, March 17 \| 12:00PM - 3:00PM Poster Session 2 Room: Waterfront Ballroom
Tuesday, March 17 \| 3:00PM - 4:30PM Workshop 1: New Tools to Study Multicellular Interactions Room: Waterfront Ballroom Speaker 1 of 4 Deborah L. Holliday, Leeds Institute of Molecular Medicine, UK Multicellular Organotypic Models of Normal and Malignant Breast
Tuesday, March 17 \| 3:00PM - 4:30PM Workshop 1: New Tools to Study Multicellular Interactions Room: Waterfront Ballroom Speaker 2 of 4 Maribella Domenech, University of Wisconsin, Madison, USA Multi-Chamber Platform for the Study of Paracrine and Autocrine Interactions between Cancer Cells and the Surrounding Microenvironment
Tuesday, March 17 \| 3:00PM - 4:30PM Workshop 1: New Tools to Study Multicellular Interactions Room: Waterfront Ballroom Speaker 3 of 4 Edna Cukierman, Fox Chase Cancer Center, USA Staging Tumor-Associated Stroma to Study Epithelial 3D in vivo-like Cancer Cell Responses
Tuesday, March 17 \| 3:00PM - 4:30PM Workshop 1: New Tools to Study Multicellular Interactions Room: Waterfront Ballroom Speaker 4 of 4 David Beebe, University of Wisconsin, USA Exploring Stromal-Carcinoma Cell Interactions in Breast Cancer via Microscale 3-Dimensional Co-Culture Systems
Tuesday, March 17 \| 4:30PM - 5:00PM Coffee Available Room: Waterfront Foyer
Tuesday, March 17 \| 5:00PM - 7:00PM Clinical Applications Room: Waterfront Ballroom Speaker 1 of 4 Rosa Anna DeFilippis, University of California, San Francisco, USA Short Talk: The Biological Basis of Mammographic Density
Tuesday, March 17 \| 5:00PM - 7:00PM Clinical Applications Room: Waterfront Ballroom Speaker 2 of 4 Dorothy A. Sipkins, University of Chicago, USA Leukemic Cells Create Bone Marrow Niches that Disrupt the Behavior of Normal Hematopoietic Progenitor Cells
Tuesday, March 17 \| 5:00PM - 7:00PM Clinical Applications Room: Waterfront Ballroom Speaker 3 of 4 David T. Scadden, Massachusetts General Hospital and Harvard University, USA Hematopoietic Stem Cell Interactions with their Microenvironment
Tuesday, March 17 \| 5:00PM - 7:00PM Clinical Applications Room: Waterfront Ballroom Speaker 4 of 4 Morag Park, McGill University, Canada Profiling the Breast Tumor Microenvironment
Tuesday, March 17 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, March 18 \| 7:00AM - 8:00AM Breakfast Room: Mackenzie Ballroom
Wednesday, March 18 \| 8:00AM - 11:00AM Basic Biology: Molecular Mechanisms Room: Waterfront Ballroom Speaker 1 of 4 Michael J. Hendzel, University of Alberta, Canada Force Transmission and the Nucleus
Wednesday, March 18 \| 8:00AM - 11:00AM Basic Biology: Molecular Mechanisms Room: Waterfront Ballroom Speaker 2 of 4 Thea D. Tlsty, University of California, San Francisco, USA Early Events in Carcinogenesis
Wednesday, March 18 \| 8:00AM - 11:00AM Basic Biology: Molecular Mechanisms Room: Waterfront Ballroom Speaker 3 of 4 Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA Stromal Changes in Cancer Progression
Wednesday, March 18 \| 8:00AM - 11:00AM Basic Biology: Molecular Mechanisms Room: Waterfront Ballroom Speaker 4 of 4 Zena Werb, University of California, San Francisco, USA Extrinsic and Intrinsic Mechanisms of Malignant Progression
Wednesday, March 18 \| 9:20AM - 9:40AM Coffee Break Room: Waterfront Foyer
Wednesday, March 18 \| 11:00AM - 11:00AM On Own for Lunch
Wednesday, March 18 \| 11:00AM - 1:00PM Poster Setup Room: Waterfront Ballroom
Wednesday, March 18 \| 1:00PM - 10:00PM Poster Viewing Room: Waterfront Ballroom
Wednesday, March 18 \| 4:30PM - 5:00PM Coffee Available Room: Waterfront Foyer
Wednesday, March 18 \| 5:00PM - 7:00PM Tumor Microenvironment Room: Waterfront Ballroom Speaker 1 of 4 Esther N. Arwert, Francis Crick Institute, UK Short Talk: Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate
Wednesday, March 18 \| 5:00PM - 7:00PM Tumor Microenvironment Room: Waterfront Ballroom Speaker 2 of 4 Nancy Dumont, University of California, San Francisco, USA Extrinsic Control of Epigenetic Modifications Associated with Mammary Tumor Progression
Wednesday, March 18 \| 5:00PM - 7:00PM Tumor Microenvironment Room: Waterfront Ballroom Speaker 3 of 4 Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA Regulation of in Situ to Invasive Breast Carcinoma Progression
Wednesday, March 18 \| 5:00PM - 7:00PM Tumor Microenvironment Room: Waterfront Ballroom Speaker 4 of 4 Mina J. Bissell, Lawrence Berkeley National Laboratory, USA Form Dictates Function: Modeling Normal Breast to Understand Breast Cancer
Wednesday, March 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Waterfront Ballroom
Wednesday, March 18 \| 7:30PM - 10:00PM Poster Session 3 Room: Waterfront Ballroom
Thursday, March 19 \| 7:00AM - 8:00AM Breakfast Room: Mackenzie Ballroom
Thursday, March 19 \| 8:00AM - 11:00AM Non-Transformed Cells Modulate Transformed Cells Room: Waterfront Ballroom Speaker 1 of 4 Judith Campisi, Buck Institute for Research on Aging, USA Two Faces of Cellular Senescence
Thursday, March 19 \| 8:00AM - 11:00AM Non-Transformed Cells Modulate Transformed Cells Room: Waterfront Ballroom Speaker 2 of 4 Lisa M. Coussens, Oregon Health & Science University, USA Tissue-Specific Mechanisms Regulate Pro-Tumor Immunity
Thursday, March 19 \| 8:00AM - 11:00AM Non-Transformed Cells Modulate Transformed Cells Room: Waterfront Ballroom Speaker 3 of 4 Sylvaine Cases, USA Role of Adipocytes in Mammary Gland Development and Breast Cancer: Lessons form DGAT1-Deficient Mice
Thursday, March 19 \| 8:00AM - 11:00AM Non-Transformed Cells Modulate Transformed Cells Room: Waterfront Ballroom Speaker 4 of 4 Philipp E. Scherer, University of Texas Southwestern Medical Center, USA Adipocyte Signals
Thursday, March 19 \| 9:20AM - 9:40AM Coffee Break Room: Waterfront Foyer
Thursday, March 19 \| 11:00AM - 11:00AM On Own for Lunch
Thursday, March 19 \| 2:30PM - 4:30PM Workshop 2: Potential Lingages to the Tumor Microenvironment Network - Funding Room: Waterfront Ballroom Speaker 1 of 1 * † Suresh Mohla, NCI, National Institutes of Health, USA
Thursday, March 19 \| 4:30PM - 5:00PM Coffee Available Room: Waterfront Foyer
Thursday, March 19 \| 5:00PM - 7:00PM Progression to Metastasis Room: Waterfront Ballroom Speaker 1 of 4 Marsha R. Rosner, University of Chicago, USA Short Talk: Identification of Signaling Pathway Signature for Metastasis Suppressor Reveals Novel Mechanism for MicroRNA Regulation of the Microenvironment.
Thursday, March 19 \| 5:00PM - 7:00PM Progression to Metastasis Room: Waterfront Ballroom Speaker 2 of 4 Douglas Hanahan, ISREC, Switzerland Evasive Resistance: Switching from Tumor Angiogenesis to Invasion and Metastasis
Thursday, March 19 \| 5:00PM - 7:00PM Progression to Metastasis Room: Waterfront Ballroom Speaker 3 of 4 Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor-Negative Cancers
Thursday, March 19 \| 5:00PM - 7:00PM Progression to Metastasis Room: Waterfront Ballroom Speaker 4 of 4 Robert A. Weinberg, Massachusetts Institute of Technology, USA Metastatic Modulation
Thursday, March 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Waterfront Ballroom
Thursday, March 19 \| 8:00PM - 11:00PM Entertainment Room: Waterfront Ballroom
Thursday, March 19 \| 8:00PM - 11:00PM Cash Bar Room: Waterfront Ballroom
Friday, March 20 \| 10:25AM - 10:25AM Departure *Session Chair.