Web Desc
Cardiac Disease: Development, Regeneration, and Repair
Organizer(s): Michael D. Schneider and Nadia A. Rosenthal
Date: March 15 - 20, 2009
Location: Grove Park Inn Resort & Spa, Asheville, NC, USA
Supported by the Directors' Fund
Summary of Meeting:
Cardiac muscle death, without numerically equivalent myocyte creation, poses a formidable and inexorable challenge in both acute and chronic forms of heart disease. A regenerative medicine approach to rescue cardiac muscle cell number or instigate heart repair in other ways has moved from the esoteric fringe to the mainstream of both fundamental and patient-based cardiovascular research. However, notwithstanding the encouraging results from phase I and even phase II trials in this realm, the scientific foundations of cardiac repair largely remain to be proven on a basis that is more than empirical. By virtue of its orientation not merely to translation, but at least equally to the enabling sciences within stem cell biology, cardiovascular development, and genetics, this Keystone Symposia meeting addresses a critical unmet need in a high-impact field of current and foreseeable explosive growth.
Scholarship Deadline: November 18 2008
Discounted Abstract Deadline: November 18 2008
Abstract Deadline: December 15 2008
Discounted Registration Deadline: January 15 2009
We gratefully acknowledge additional support for this conference from:
American Heart Association
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL095270-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 15 | 3:00PM - 7:30PM
Registration
Room: Vanderbilt Registration


Sunday, March 15 | 6:30PM - 7:30PM
Refreshments
Room: Grand Ballroom B-C


Sunday, March 15 | 7:30PM - 8:30PM
Keynote Address
Room: Grand Ballroom A

Speaker 1 of 1
George Q. Daley, HHMI/Boston Children's Hospital, USA
Reprogramming and Stem Cells in Disease and Development

Monday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Grand Ballroom B-C


Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 1 of 6
* Gordon M. Keller, University Health Network, MaRS Centre, Canada
Regulation of Cardiovascular Development from Mouse and Human Pluripotent Stem Cells

Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 2 of 6
Sean M. Wu, Stanford School of Medicine, USA
Turning Skin into Heart: Cardiac Progenitor Cells from Induced Pluripotent Cells

Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 3 of 6
Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Mesp1 and Multipotent Cardiac Progenitor Cells

Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 4 of 6
Piero Anversa, Brigham and Women's Hospital, USA
Myocardial Regeneration

Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 5 of 6
Michel Pucéat, INSERM, France
Short Talk: Derivation of Early Human Cardiac Progenitors from Embryonic and Induced Pluripotent Stem Cells

Monday, March 16 | 8:00AM - 11:15AM
Stemness and Cell Fate in Pluripotent Cells
Room: Grand Ballroom A

Speaker 6 of 6
Li Chen, University of Houston, USA
Short Talk: Tbx1 Regulates Proliferation and Differentiation of Multipotent Heart Progenitors

Monday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Ballroom B-C


Monday, March 16 | 11:15AM - 11:15AM
On Own for Lunch


Monday, March 16 | 11:15AM - 1:00PM
Poster Setup
Room: Grand Ballroom B-C


Monday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom B-C


Monday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Monday, March 16 | 5:00PM - 7:00PM
Making Myocardium: Lessons from Organogenesis
Room: Grand Ballroom A

Speaker 1 of 4
* Margaret E. Buckingham, Institut Pasteur, France
Cardiac Progenitor Cells of the Second Heart Field

Monday, March 16 | 5:00PM - 7:00PM
Making Myocardium: Lessons from Organogenesis
Room: Grand Ballroom A

Speaker 2 of 4
Jonathan A. Epstein, University of Pennsylvania, USA
Jagged1/Notch Signaling and Outflow Tract Development

Monday, March 16 | 5:00PM - 7:00PM
Making Myocardium: Lessons from Organogenesis
Room: Grand Ballroom A

Speaker 3 of 4
Deepak Srivastava, Gladstone Institutes, USA
MicroRNA Regulation of Cardiac Cell Fate and Morphogenesis

Monday, March 16 | 5:00PM - 7:00PM
Making Myocardium: Lessons from Organogenesis
Room: Grand Ballroom A

Speaker 4 of 4
Caroline E. Burns, Harvard Medical School, Boston Children's Hospital, USA
Short Talk: Cardiac Chamber Morphogenesis is Regulated by the miR143-adducin3 Pathway

Monday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Monday, March 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Grand Ballroom B-C


Tuesday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Grand Ballroom B-C


Tuesday, March 17 | 7:00AM - 8:00AM
Poster Setup
Room: Grand Ballroom B-C


Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 1 of 6
Michael D. Schneider, Imperial College London, UK
The Sox17-Hhex-Cer1 Circuit Drives Heart Muscle Cell Creation in Embryonic Stem Cells

Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 2 of 6
* Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Cardiac Progenitor Cell Behaviour in Development and Congenital Heart Disease

Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 3 of 6
Ibrahim J. Domian, Massachusetts General Hospital, USA
Assembly of Mature Ventricular Muscle from Embryonic Stem Cell derived Progenitors

Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 4 of 6
Mark Mercola, Stanford University, USA
A Chemical Genomics Strategy for Generating Cardiac Myocytes

Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 5 of 6
Michael Kühl, Ulm University, Germany
Short Talk: DM-GRASP/ALCAM/CD166 in Cardiogenesis of Xenopus

Tuesday, March 17 | 8:00AM - 11:15AM
Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Emb
ryonic Cells

Room: Grand Ballroom A

Speaker 6 of 6
Frank L. Conlon, University of North Carolina at Chapel Hill, USA
Short Talk: CASTOR Is Required for the Differentiation of Cardiomyocyte Progenitors at the Ventral Midline

Tuesday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Ballroom B-C


Tuesday, March 17 | 11:00AM - 12:00PM
Lunch
Room: Grand Ballroom B-C


Tuesday, March 17 | 12:00PM - 2:30PM
Poster Session 2
Room: Grand Ballroom B-C


Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 1: Human ES Cell Update
Room: Grand Ballroom A

Speaker 1 of 3
Joseph Gold, Beckman Research Institute, City of Hope, USA
Large-Scale Generation and Characterization of hESC-Derived Cardiomyocytes for Cell Therapy

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 1: Human ES Cell Update
Room: Grand Ballroom A

Speaker 2 of 3
* Lior Gepstein, Technion-Israel Institute of Technology, Israel
Myocardial Regeneration Using Human Embryonic Stem Cells

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 1: Human ES Cell Update
Room: Grand Ballroom A

Speaker 3 of 3
Wei-Zhong Zhu, University of Washington, USA
Induction of Human Embryonic Stem Cell Derived Cardiac Pacemaker Cells by Neuregulin Blockade

Tuesday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Tuesday, March 17 | 5:00PM - 7:00PM
Injury and Inflammation in Muscle Regeneration
Room: Grand Ballroom A

Speaker 1 of 4
Nadia A. Rosenthal, The Jackson Laboratory, USA
Enhancing Cardiac Regeneration

Tuesday, March 17 | 5:00PM - 7:00PM
Injury and Inflammation in Muscle Regeneration
Room: Grand Ballroom A

Speaker 2 of 4
Kenneth D. Poss, Duke University Medical Center, USA
Mechanisms of Cardiac Regeneration in Zebrafish

Tuesday, March 17 | 5:00PM - 7:00PM
Injury and Inflammation in Muscle Regeneration
Room: Grand Ballroom A

Speaker 3 of 4
* Elizabeth M. McNally, Northwestern University, USA
Regeneration and Repair in Muscle

Tuesday, March 17 | 5:00PM - 7:00PM
Injury and Inflammation in Muscle Regeneration
Room: Grand Ballroom A

Speaker 4 of 4
Santhosh Kumar Ghadge, Max-Delbruck Center for Molecular Medicine, Germany
Short Talk: Impaired Cardiac Function in Cardiomyocyte Specific SDF-1/CXCL12 Knockout Mice

Tuesday, March 17 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Grand Ballroom B-C


Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 1 of 6
Robert J. Schwartz, Texas A&M University, USA
The sumoylation Pathway: A Global Regulator of Cardiac Development

Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 2 of 6
Mary Dickinson, Baylor College of Medicine, USA
Form Follows Flow: Where Biomechanics and Genetics Meet

Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 3 of 6
Paul R. Riley, University of Oxford, UK
Epicardium-Derived Progenitors: A Source of Neovascular Repair of the Injured Adult Heart

Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 4 of 6
* Brian L. Black, University of California, San Francisco, USA
A Combinatorial Transcriptional Code for Endothelial Development

Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 5 of 6
Kimberly R. Cordes, Gladstone Institute, USA
Short Talk: miR-143/145 Regulates Smooth Muscle Cell Fate

Wednesday, March 18 | 8:00AM - 11:15AM
Vasculogenesis and Angiogenesis: Developmental Insights and
Therapeutic Targets

Room: Grand Ballroom A

Speaker 6 of 6
Marc Tjwa, University of Frankfurt, Center for Molecular Medicine, Germany
Short Talk: Mobilization of Bone Marrow Progenitors by Ischemic Tissues Requires an Interplay between Hematopoietic Cytokines and Placental Growth Factor (PlGF)

Wednesday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Ballroom B-C


Wednesday, March 18 | 11:00AM - 1:00PM
Poster Setup
Room: Grand Ballroom B-C


Wednesday, March 18 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom B-C


Wednesday, March 18 | 3:30PM - 4:30PM
Workshop 2: 'The Vision Thing:' Imaging Sciences and Cell T
racking for Cardiac Repair
Room: Grand Ballroom A

Speaker 1 of 2
Karl H. Schuleri, Johns Hopkins Hospital, USA
Tomographic Imaging Applications for Myocardial Phenotyping in Cardiac Stem Cell Therapy

Wednesday, March 18 | 3:30PM - 4:30PM
Workshop 2: 'The Vision Thing:' Imaging Sciences and Cell T
racking for Cardiac Repair
Room: Grand Ballroom A

Speaker 2 of 2
Joseph C. Wu, Stanford University School of Medicine, USA
Molecular Imaging of hESC Biology

Wednesday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Wednesday, March 18 | 5:00PM - 7:00PM
Myocyte Death and Dysfunction in Heart Failure
Room: Grand Ballroom A

Speaker 1 of 4
Richard N. Kitsis, Albert Einstein College of Medicine, USA
Mechanisms of Cell Death in Human Disease

Wednesday, March 18 | 5:00PM - 7:00PM
Myocyte Death and Dysfunction in Heart Failure
Room: Grand Ballroom A

Speaker 2 of 4
Jonathan G. Seidman, Harvard Medical School, USA
Mechanisms and Modifiers of the Hereditary Cardiomyopathies

Wednesday, March 18 | 5:00PM - 7:00PM
Myocyte Death and Dysfunction in Heart Failure
Room: Grand Ballroom A

Speaker 3 of 4
* Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Molecular Logic of Cardiac Development and Disease

Wednesday, March 18 | 5:00PM - 7:00PM
Myocyte Death and Dysfunction in Heart Failure
Room: Grand Ballroom A

Speaker 4 of 4
Ching-Pin Chang, Indiana University, USA
Short Talk: Control of Cardiac Growth, Differentiation and Hypertrophy by the BAF Complex

Wednesday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Wednesday, March 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Grand Ballroom B-C


Thursday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Grand Ballroom B-C


Thursday, March 19 | 8:00AM - 11:15AM
Cardiac Repair in Human Trials: The Half-Full Cup?
Room: Grand Ballroom A

Speaker 1 of 5
Andreas M. Zeiher, University Frankfurt, Germany
Bone Marrow for Cardiac Repair: Molecular Insights and Clinical Deployment

Thursday, March 19 | 8:00AM - 11:15AM
Cardiac Repair in Human Trials: The Half-Full Cup?
Room: Grand Ballroom A

Speaker 2 of 5
Douglas W. Losordo, Caladrius Biosciences, Inc., USA
Targeting the Microvasculature for Ischemic Tissue Repair

Thursday, March 19 | 8:00AM - 11:15AM
Cardiac Repair in Human Trials: The Half-Full Cup?
Room: Grand Ballroom A

Speaker 3 of 5
Joshua M. Hare, University of Miami Miller School of Medicine, USA
Mechanisms of Action and Clinical Utility of Mesenchymal Stem Cells to Treat Ischemic Cardiomyopathy

Thursday, March 19 | 8:00AM - 11:15AM
Cardiac Repair in Human Trials: The Half-Full Cup?
Room: Grand Ballroom A

Speaker 4 of 5
Robert D. Simari, Mayo Clinic, USA
Bone Marrow and The Heart: Opportunities for Discovery

Thursday, March 19 | 8:00AM - 11:15AM
Cardiac Repair in Human Trials: The Half-Full Cup?
Room: Grand Ballroom A

Speaker 5 of 5
* Stefanie Dimmeler, University of Frankfurt, Germany
Control of Angiogenesis by microRNA

Thursday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Ballroom B-C


Thursday, March 19 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, March 19 | 2:30PM - 4:30PM
Workshop 3: Alternative Visions of the Therapeutic Landscape
: Tissue Engineering, Stem Cell Mobilization, and Stem Cell Proteins
Room: Grand Ballroom A

Speaker 1 of 3
* Victor J. Dzau, Duke University Medical Center, USA
Paracrine Mediators of Stem Cell Reparative Action

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 3: Alternative Visions of the Therapeutic Landscape
: Tissue Engineering, Stem Cell Mobilization, and Stem Cell Proteins
Room: Grand Ballroom A

Speaker 2 of 3
Doris A. Taylor, Texas Heart Institute, USA
The Power of Engineering Organs: When Cells aren't Enough

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 3: Alternative Visions of the Therapeutic Landscape
: Tissue Engineering, Stem Cell Mobilization, and Stem Cell Proteins
Room: Grand Ballroom A

Speaker 3 of 3
Sara M. Rankin, Imperial College School of Medicine, UK
Progress Toward Selective Stem Cell Mobilization

Thursday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Thursday, March 19 | 5:00PM - 7:00PM
'Get with the System:' How Systems Biology is Transforming
Biomedicine

Room: Grand Ballroom A

Speaker 1 of 4
* Shoumo Bhattacharya, University of Oxford, UK
Coupling ENU Mutagenesis and High-Throughput MRI to Unmask Essential Genes that Fashion the Mouse Heart

Thursday, March 19 | 5:00PM - 7:00PM
'Get with the System:' How Systems Biology is Transforming
Biomedicine

Room: Grand Ballroom A

Speaker 2 of 4
David Hill, Dana Farber Cancer Institute, USA
The Human Interactome Project and Molecular Network Analysis

Thursday, March 19 | 5:00PM - 7:00PM
'Get with the System:' How Systems Biology is Transforming
Biomedicine

Room: Grand Ballroom A

Speaker 3 of 4
Stuart Cook, Duke-NUS, Singapore
Genomic Approaches to Heart Disease

Thursday, March 19 | 5:00PM - 7:00PM
'Get with the System:' How Systems Biology is Transforming
Biomedicine

Room: Grand Ballroom A

Speaker 4 of 4
Tao P. Zhong, East China Normal University, China
Short Talk: Chemical Genetics Approach to elucidate Cardiomyocyte Generation and Development

Thursday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Thursday, March 19 | 8:00PM - 11:00PM
Entertainment
Room: Grand Ballroom B-C


Thursday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Grand Ballroom B-C


Friday, March 20 | 10:25AM - 10:25AM
Departure


*Session Chair.