Web Desc
Common Mechanisms in Arrhythmias and Heart Failure
Organizer(s): Alfred L. George, Jeffrey A. Towbin and Elizabeth M. McNally
Date: April 02 - 07, 2009
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets.
Scholarship Deadline: December 3 2008
Discounted Abstract Deadline: December 3 2008
Abstract Deadline: January 5 2009
Discounted Registration Deadline: February 2 2009
We gratefully acknowledge additional support for this conference from:
American Heart AssociationMedtronic
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL096236-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, April 02 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Thursday, April 02 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Thursday, April 02 | 7:30PM - 8:30PM
Keynote Address
Room: Shavano Peak

Speaker 1 of 2
* Alfred L. George, Jr., Vanderbilt University, USA

Thursday, April 02 | 7:30PM - 8:30PM
Keynote Address
Room: Shavano Peak

Speaker 2 of 2
Christine E. Seidman, Harvard Medical School, USA
Molecular Genetics of Familial Cardiomyopathies

Friday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak 1-4


Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 1 of 6
* Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA

Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 2 of 6
Connie R. Bezzina, Academic Medical Center, Netherlands
Modifier Genes in Cardiac Sodium Channelopathy

Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 3 of 6
Dan Arking, Johns Hopkins School of Medicine, USA
QT Interval Genes as Modifiers of Sudden Cardiac Death

Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 4 of 6
Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Modifier Genes in the Cardiomyopathies

Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 5 of 6
Howard A. Rockman, Duke University Medical Center, USA
Mapping Modifiers in Drosophila

Friday, April 03 | 8:00AM - 11:00AM
Genetic Modifiers
Room: Shavano Peak

Speaker 6 of 6
Sharlene M. Day, University of Pennsylvania, USA
Short Talk: Genetic and Phenotypic Complexity in a Unique Family with Arrhythmogenic Right Ventricular Cardiomyopathy

Friday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Torreys Peak 1-4


Friday, April 03 | 11:00AM - 11:00AM
On Own for Lunch


Friday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Friday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Friday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Torreys Peak 1-4


Friday, April 03 | 5:00PM - 7:00PM
Transcriptional Remodeling
Room: Shavano Peak

Speaker 1 of 5
* Howard A. Rockman, Duke University Medical Center, USA

Friday, April 03 | 5:00PM - 7:00PM
Transcriptional Remodeling
Room: Shavano Peak

Speaker 2 of 5
Katherine T. Murray, Vanderbilt University Medical Center, USA
Transcriptional Profiles in Healthy and Arrhythmic Heart

Friday, April 03 | 5:00PM - 7:00PM
Transcriptional Remodeling
Room: Shavano Peak

Speaker 3 of 5
Nikhil V. Munshi, University of Texas Southwestern Medical Center, USA
A GATA4-Dependent Transcriptional Pathway Regulates Normal Atrioventricular Delay

Friday, April 03 | 5:00PM - 7:00PM
Transcriptional Remodeling
Room: Shavano Peak

Speaker 4 of 5
Fikru B. Bedada, University of Minnesota, USA
Short Talk: MiR208 Prevents Phenylephrine Induced Hypertrophy in Adult Rat Cardiac Myocytes

Friday, April 03 | 5:00PM - 7:00PM
Transcriptional Remodeling
Room: Shavano Peak

Speaker 5 of 5
Farah Sheikh, University of California, San Diego, USA
Short Talk: Early Defects in Connexin Signaling Underlie Arrhythmogenic Right Ventricular Cardiomyopathy in a Novel Mouse Model

Friday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Friday, April 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak 1-4


Saturday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak 1-4


Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 1 of 7
* Alfred L. George, Jr., Vanderbilt University, USA

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 2 of 7
Penelope A. Boyden, Columbia University, USA
Ionic Mechanisms Influencing Regional Action Potentials and Conduction

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 3 of 7
Marc A. Vos, UMC Utrecht, Netherlands
Proarrhythmic Myocardial Remodeling

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 4 of 7
Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center, USA
Modulation of Gap Junctions in Heart Disease

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 5 of 7
George E. Billman, Ohio State University, USA
Autonomic Neural Remodeling after Myocardial Infarction

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 6 of 7
Michael P. O'Quinn, Medical University of South Carolina, USA
Short Talk: A Peptide Containing the Carboxy-Terminal Domain of Connexin43 Inhibits Cardiac Dilation and Reduces Arrhythmias after Myocardial Injury

Saturday, April 04 | 8:00AM - 11:15AM
Physiological Remodeling
Room: Shavano Peak

Speaker 7 of 7
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Studying the Genetics of Cardiac Dysfunction in Drosophila

Saturday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Torreys Peak 1-4


Saturday, April 04 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, April 04 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Saturday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Saturday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Torreys Peak 1-4


Saturday, April 04 | 5:00PM - 7:00PM
Novel Genetic Pathways
Room: Shavano Peak

Speaker 1 of 5
* Connie R. Bezzina, Academic Medical Center, Netherlands

Saturday, April 04 | 5:00PM - 7:00PM
Novel Genetic Pathways
Room: Shavano Peak

Speaker 2 of 5
Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Final Common Pathways in Cardiomyopathy and Arrhythmias

Saturday, April 04 | 5:00PM - 7:00PM
Novel Genetic Pathways
Room: Shavano Peak

Speaker 3 of 5
William J. McKenna, Heart Hospital, UK
Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy

Saturday, April 04 | 5:00PM - 7:00PM
Novel Genetic Pathways
Room: Shavano Peak

Speaker 4 of 5
Michael J. Ackerman, Mayo Clinic, USA
Novel Pathogenic Mechanisms for Heritable Arrhythmia Syndromes

Saturday, April 04 | 5:00PM - 7:00PM
Novel Genetic Pathways
Room: Shavano Peak

Speaker 5 of 5
Marie-Louise Bang, Institute of Biomedical Technologies (ITB), Italian Research Council (CNR), Italy
Short Talk: Ablation of Myopalladin Results in Pressure Overload-Induced Dilated Cardiomyopathy

Saturday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Saturday, April 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak 1-4


Sunday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak 1-4


Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 1 of 7
* Penelope A. Boyden, Columbia University, USA

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 2 of 7
Donald M. Bers, University of California, Davis, USA
Regulation of Intracellular Sodium and Calcium in Cardiac Myocytes

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 3 of 7
Xander H.T. Wehrens, Baylor College of Medicine, USA
Role of Ryanodine Receptor Leak in Heart Failure and Sudden Cardiac Death

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 4 of 7
Björn C. Knollmann, Vanderbilt University School of Medicine, USA
Calsequestrin in Cardiac Calcium Homeostasis and Arrhythmogenesis

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 5 of 7
James N. Weiss, University of California, Los Angeles, USA
Early Afterdepolarizations: How They Synchronize in Tissue to Cause Arrhythmias

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 6 of 7
Changwon Kho, Mount Sinai School of Medicine, USA
Short Talk: SUMO Modification Modulates SERCA2a Function

Sunday, April 05 | 8:00AM - 11:15AM
Regulation and Disorders of Ion Homeostasis I
Room: Shavano Peak

Speaker 7 of 7
Saumya Das, Massachusetts General Hospital, USA
Short Talk: The Serum and Glucocorticoid Responsive Kinase-1 (SGK1) Mediates Hypertrophy-Induced Changes in SCN5a by Phosphorylation and Altered Binding to Ubiquitin Ligase Nedd4-2

Sunday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Torreys Peak 1-4


Sunday, April 05 | 11:15AM - 11:15AM
On Own for Lunch


Sunday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Torreys Peak 1-4


Sunday, April 05 | 5:00PM - 7:00PM
Regulation and Disorders of Ion Homeostasis II
Room: Shavano Peak

Speaker 1 of 5
* Donald M. Bers, University of California, Davis, USA

Sunday, April 05 | 5:00PM - 7:00PM
Regulation and Disorders of Ion Homeostasis II
Room: Shavano Peak

Speaker 2 of 5
Mark E. Anderson, Johns Hopkins University School of Medicine, USA
Calmodulin Kinase II in Heart Failure and Arrhythmias

Sunday, April 05 | 5:00PM - 7:00PM
Regulation and Disorders of Ion Homeostasis II
Room: Shavano Peak

Speaker 3 of 5
Kenneth D. Philipson, University of California, Los Angeles, USA
Cardiac-Specific Knockout of Na-Ca Exchange

Sunday, April 05 | 5:00PM - 7:00PM
Regulation and Disorders of Ion Homeostasis II
Room: Shavano Peak

Speaker 4 of 5
Alfred L. George, Jr., Vanderbilt University, USA
Sodium Channel Dysfunction in Arrhythmias and Heart Failure

Sunday, April 05 | 5:00PM - 7:00PM
Regulation and Disorders of Ion Homeostasis II
Room: Shavano Peak

Speaker 5 of 5
Hiroshi Watanabe, Niigata University School of Medicine, Japan
Short Talk: D1275N SCN5A Mutation causes Dilated Cardiomyopathy and Arrhythmias: Mechanisms Revealed in Mice but Absent by Heterologous Expression

Sunday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Monday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak 1-4


Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 1 of 6
* Michael J. Ackerman, Mayo Clinic, USA

Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 2 of 6
R. John Solaro, University of Illinois at Chicago, USA
Arrhythmias, Heart Failure, and Signaling in Cardiac Sarcomeres

Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 3 of 6
Gisèle Bonne, INSERM UR582, France
Laminopathies

Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 4 of 6
Peter J. Mohler, University of Iowa, USA
Dysfunction in Ankyrin-Based Pathways and Human Arrhythmia

Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 5 of 6
Elizabeth M. McNally, Northwestern University, USA
Disorders of the Dystrophin-Sarcoglycan Complex

Monday, April 06 | 8:00AM - 11:00AM
Sarcomeric and Cystoskeletal Proteins I
Room: Shavano Peak

Speaker 6 of 6
Carolina Vasquez, New York University School of Medicine, USA
Short Talk: Arrhythmogenic Potential of Activated Fibroblasts

Monday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Torreys Peak 1-4


Monday, April 06 | 11:00AM - 11:00AM
On Own for Lunch


Monday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Torreys Peak 1-4


Monday, April 06 | 5:00PM - 7:00PM
Sarcomeric and Cystoskeletal Proteins II
Room: Shavano Peak

Speaker 1 of 4
* Elizabeth M. McNally, Northwestern University, USA

Monday, April 06 | 5:00PM - 7:00PM
Sarcomeric and Cystoskeletal Proteins II
Room: Shavano Peak

Speaker 2 of 4
Matteo Vatta, Baylor College of Medicine, USA
Z-Disk Disruption in Cardiac Failure and Arrhythmias

Monday, April 06 | 5:00PM - 7:00PM
Sarcomeric and Cystoskeletal Proteins II
Room: Shavano Peak

Speaker 3 of 4
Jil C. Tardiff, University of Arizona, USA
Thin Filament Protein Dynamics and Cardiomyopathies

Monday, April 06 | 5:00PM - 7:00PM
Sarcomeric and Cystoskeletal Proteins II
Room: Shavano Peak

Speaker 4 of 4
Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Myosin Binding Protein C and Regulation of Cardiac Hemodynamics

Monday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Monday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak 1-4


Monday, April 06 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak 1-4


Tuesday, April 07 | 10:25AM - 10:25AM
Departure


*Session Chair.