Past Meeting | Keystone Symposia

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Web Desc
Common Mechanisms in Arrhythmias and Heart Failure Organizer(s): Alfred L. George, Jeffrey A. Towbin and Elizabeth M. McNally Date: April 02 - 07, 2009 Location: Keystone Resort, Keystone, CO, USA Supported by the Directors' Fund Summary of Meeting: Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets. Scholarship Deadline: December 3 2008 Discounted Abstract Deadline: December 3 2008 Abstract Deadline: January 5 2009 Discounted Registration Deadline: February 2 2009 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Heart, Lung, and Blood Institute (NHLBI) Grant No. 1R13HL096236-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Common Mechanisms in Arrhythmias and Heart Failure

Organizer(s): Alfred L. George, Jeffrey A. Towbin and Elizabeth M. McNally

Date: April 02 - 07, 2009
Location: Keystone Resort, Keystone, CO, USA

Supported by the Directors' Fund

Summary of Meeting:

Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets.

Scholarship Deadline: December 3 2008

Discounted Abstract Deadline: December 3 2008

Abstract Deadline: January 5 2009

Discounted Registration Deadline: February 2 2009

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL096236-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Thursday, April 02 \| 3:00PM - 7:30PM Registration Room: Shavano Peak Foyer
Thursday, April 02 \| 6:30PM - 7:30PM Refreshments Room: Shavano Peak Foyer
Thursday, April 02 \| 7:30PM - 8:30PM Keynote Address Room: Shavano Peak Speaker 1 of 2 * Alfred L. George, Jr., Vanderbilt University, USA
Thursday, April 02 \| 7:30PM - 8:30PM Keynote Address Room: Shavano Peak Speaker 2 of 2 Christine E. Seidman, Harvard Medical School, USA Molecular Genetics of Familial Cardiomyopathies
Friday, April 03 \| 7:00AM - 8:00AM Breakfast Room: Torreys Peak 1-4
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 1 of 6 * Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 2 of 6 Connie R. Bezzina, Academic Medical Center, Netherlands Modifier Genes in Cardiac Sodium Channelopathy
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 3 of 6 Dan Arking, Johns Hopkins School of Medicine, USA QT Interval Genes as Modifiers of Sudden Cardiac Death
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 4 of 6 Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA Modifier Genes in the Cardiomyopathies
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 5 of 6 Howard A. Rockman, Duke University Medical Center, USA Mapping Modifiers in Drosophila
Friday, April 03 \| 8:00AM - 11:00AM Genetic Modifiers Room: Shavano Peak Speaker 6 of 6 Sharlene M. Day, University of Pennsylvania, USA Short Talk: Genetic and Phenotypic Complexity in a Unique Family with Arrhythmogenic Right Ventricular Cardiomyopathy
Friday, April 03 \| 9:20AM - 9:40AM Coffee Break Room: Torreys Peak 1-4
Friday, April 03 \| 11:00AM - 11:00AM On Own for Lunch
Friday, April 03 \| 11:00AM - 1:00PM Poster Setup Room: Torreys Peak 1-4
Friday, April 03 \| 1:00PM - 10:00PM Poster Viewing Room: Torreys Peak 1-4
Friday, April 03 \| 4:30PM - 5:00PM Coffee Available Room: Torreys Peak 1-4
Friday, April 03 \| 5:00PM - 7:00PM Transcriptional Remodeling Room: Shavano Peak Speaker 1 of 5 * Howard A. Rockman, Duke University Medical Center, USA
Friday, April 03 \| 5:00PM - 7:00PM Transcriptional Remodeling Room: Shavano Peak Speaker 2 of 5 Katherine T. Murray, Vanderbilt University Medical Center, USA Transcriptional Profiles in Healthy and Arrhythmic Heart
Friday, April 03 \| 5:00PM - 7:00PM Transcriptional Remodeling Room: Shavano Peak Speaker 3 of 5 Nikhil V. Munshi, University of Texas Southwestern Medical Center, USA A GATA4-Dependent Transcriptional Pathway Regulates Normal Atrioventricular Delay
Friday, April 03 \| 5:00PM - 7:00PM Transcriptional Remodeling Room: Shavano Peak Speaker 4 of 5 Fikru B. Bedada, University of Minnesota, USA Short Talk: MiR208 Prevents Phenylephrine Induced Hypertrophy in Adult Rat Cardiac Myocytes
Friday, April 03 \| 5:00PM - 7:00PM Transcriptional Remodeling Room: Shavano Peak Speaker 5 of 5 Farah Sheikh, University of California, San Diego, USA Short Talk: Early Defects in Connexin Signaling Underlie Arrhythmogenic Right Ventricular Cardiomyopathy in a Novel Mouse Model
Friday, April 03 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Torreys Peak 1-4
Friday, April 03 \| 7:30PM - 10:00PM Poster Session 1 Room: Torreys Peak 1-4
Saturday, April 04 \| 7:00AM - 8:00AM Breakfast Room: Torreys Peak 1-4
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 1 of 7 * Alfred L. George, Jr., Vanderbilt University, USA
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 2 of 7 Penelope A. Boyden, Columbia University, USA Ionic Mechanisms Influencing Regional Action Potentials and Conduction
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 3 of 7 Marc A. Vos, UMC Utrecht, Netherlands Proarrhythmic Myocardial Remodeling
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 4 of 7 Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center, USA Modulation of Gap Junctions in Heart Disease
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 5 of 7 George E. Billman, Ohio State University, USA Autonomic Neural Remodeling after Myocardial Infarction
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 6 of 7 Michael P. O'Quinn, Medical University of South Carolina, USA Short Talk: A Peptide Containing the Carboxy-Terminal Domain of Connexin43 Inhibits Cardiac Dilation and Reduces Arrhythmias after Myocardial Injury
Saturday, April 04 \| 8:00AM - 11:15AM Physiological Remodeling Room: Shavano Peak Speaker 7 of 7 Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA Short Talk: Studying the Genetics of Cardiac Dysfunction in Drosophila
Saturday, April 04 \| 9:20AM - 9:40AM Coffee Break Room: Torreys Peak 1-4
Saturday, April 04 \| 11:15AM - 11:15AM On Own for Lunch
Saturday, April 04 \| 11:15AM - 1:00PM Poster Setup Room: Torreys Peak 1-4
Saturday, April 04 \| 1:00PM - 10:00PM Poster Viewing Room: Torreys Peak 1-4
Saturday, April 04 \| 4:30PM - 5:00PM Coffee Available Room: Torreys Peak 1-4
Saturday, April 04 \| 5:00PM - 7:00PM Novel Genetic Pathways Room: Shavano Peak Speaker 1 of 5 * Connie R. Bezzina, Academic Medical Center, Netherlands
Saturday, April 04 \| 5:00PM - 7:00PM Novel Genetic Pathways Room: Shavano Peak Speaker 2 of 5 Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center, USA Final Common Pathways in Cardiomyopathy and Arrhythmias
Saturday, April 04 \| 5:00PM - 7:00PM Novel Genetic Pathways Room: Shavano Peak Speaker 3 of 5 William J. McKenna, Heart Hospital, UK Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy
Saturday, April 04 \| 5:00PM - 7:00PM Novel Genetic Pathways Room: Shavano Peak Speaker 4 of 5 Michael J. Ackerman, Mayo Clinic, USA Novel Pathogenic Mechanisms for Heritable Arrhythmia Syndromes
Saturday, April 04 \| 5:00PM - 7:00PM Novel Genetic Pathways Room: Shavano Peak Speaker 5 of 5 Marie-Louise Bang, Institute of Biomedical Technologies (ITB), Italian Research Council (CNR), Italy Short Talk: Ablation of Myopalladin Results in Pressure Overload-Induced Dilated Cardiomyopathy
Saturday, April 04 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Torreys Peak 1-4
Saturday, April 04 \| 7:30PM - 10:00PM Poster Session 2 Room: Torreys Peak 1-4
Sunday, April 05 \| 7:00AM - 8:00AM Breakfast Room: Torreys Peak 1-4
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 1 of 7 * Penelope A. Boyden, Columbia University, USA
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 2 of 7 Donald M. Bers, University of California, Davis, USA Regulation of Intracellular Sodium and Calcium in Cardiac Myocytes
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 3 of 7 Xander H.T. Wehrens, Baylor College of Medicine, USA Role of Ryanodine Receptor Leak in Heart Failure and Sudden Cardiac Death
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 4 of 7 Björn C. Knollmann, Vanderbilt University School of Medicine, USA Calsequestrin in Cardiac Calcium Homeostasis and Arrhythmogenesis
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 5 of 7 James N. Weiss, University of California, Los Angeles, USA Early Afterdepolarizations: How They Synchronize in Tissue to Cause Arrhythmias
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 6 of 7 Changwon Kho, Mount Sinai School of Medicine, USA Short Talk: SUMO Modification Modulates SERCA2a Function
Sunday, April 05 \| 8:00AM - 11:15AM Regulation and Disorders of Ion Homeostasis I Room: Shavano Peak Speaker 7 of 7 Saumya Das, Massachusetts General Hospital, USA Short Talk: The Serum and Glucocorticoid Responsive Kinase-1 (SGK1) Mediates Hypertrophy-Induced Changes in SCN5a by Phosphorylation and Altered Binding to Ubiquitin Ligase Nedd4-2
Sunday, April 05 \| 9:20AM - 9:40AM Coffee Break Room: Torreys Peak 1-4
Sunday, April 05 \| 11:15AM - 11:15AM On Own for Lunch
Sunday, April 05 \| 4:30PM - 5:00PM Coffee Available Room: Torreys Peak 1-4
Sunday, April 05 \| 5:00PM - 7:00PM Regulation and Disorders of Ion Homeostasis II Room: Shavano Peak Speaker 1 of 5 * Donald M. Bers, University of California, Davis, USA
Sunday, April 05 \| 5:00PM - 7:00PM Regulation and Disorders of Ion Homeostasis II Room: Shavano Peak Speaker 2 of 5 Mark E. Anderson, Johns Hopkins University School of Medicine, USA Calmodulin Kinase II in Heart Failure and Arrhythmias
Sunday, April 05 \| 5:00PM - 7:00PM Regulation and Disorders of Ion Homeostasis II Room: Shavano Peak Speaker 3 of 5 Kenneth D. Philipson, University of California, Los Angeles, USA Cardiac-Specific Knockout of Na-Ca Exchange
Sunday, April 05 \| 5:00PM - 7:00PM Regulation and Disorders of Ion Homeostasis II Room: Shavano Peak Speaker 4 of 5 Alfred L. George, Jr., Vanderbilt University, USA Sodium Channel Dysfunction in Arrhythmias and Heart Failure
Sunday, April 05 \| 5:00PM - 7:00PM Regulation and Disorders of Ion Homeostasis II Room: Shavano Peak Speaker 5 of 5 Hiroshi Watanabe, Niigata University School of Medicine, Japan Short Talk: D1275N SCN5A Mutation causes Dilated Cardiomyopathy and Arrhythmias: Mechanisms Revealed in Mice but Absent by Heterologous Expression
Sunday, April 05 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Torreys Peak 1-4
Monday, April 06 \| 7:00AM - 8:00AM Breakfast Room: Torreys Peak 1-4
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 1 of 6 * Michael J. Ackerman, Mayo Clinic, USA
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 2 of 6 R. John Solaro, University of Illinois at Chicago, USA Arrhythmias, Heart Failure, and Signaling in Cardiac Sarcomeres
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 3 of 6 Gisèle Bonne, INSERM UR582, France Laminopathies
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 4 of 6 Peter J. Mohler, University of Iowa, USA Dysfunction in Ankyrin-Based Pathways and Human Arrhythmia
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 5 of 6 Elizabeth M. McNally, Northwestern University, USA Disorders of the Dystrophin-Sarcoglycan Complex
Monday, April 06 \| 8:00AM - 11:00AM Sarcomeric and Cystoskeletal Proteins I Room: Shavano Peak Speaker 6 of 6 Carolina Vasquez, New York University School of Medicine, USA Short Talk: Arrhythmogenic Potential of Activated Fibroblasts
Monday, April 06 \| 9:20AM - 9:40AM Coffee Break Room: Torreys Peak 1-4
Monday, April 06 \| 11:00AM - 11:00AM On Own for Lunch
Monday, April 06 \| 4:30PM - 5:00PM Coffee Available Room: Torreys Peak 1-4
Monday, April 06 \| 5:00PM - 7:00PM Sarcomeric and Cystoskeletal Proteins II Room: Shavano Peak Speaker 1 of 4 * Elizabeth M. McNally, Northwestern University, USA
Monday, April 06 \| 5:00PM - 7:00PM Sarcomeric and Cystoskeletal Proteins II Room: Shavano Peak Speaker 2 of 4 Matteo Vatta, Baylor College of Medicine, USA Z-Disk Disruption in Cardiac Failure and Arrhythmias
Monday, April 06 \| 5:00PM - 7:00PM Sarcomeric and Cystoskeletal Proteins II Room: Shavano Peak Speaker 3 of 4 Jil C. Tardiff, University of Arizona, USA Thin Filament Protein Dynamics and Cardiomyopathies
Monday, April 06 \| 5:00PM - 7:00PM Sarcomeric and Cystoskeletal Proteins II Room: Shavano Peak Speaker 4 of 4 Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA Myosin Binding Protein C and Regulation of Cardiac Hemodynamics
Monday, April 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Torreys Peak 1-4
Monday, April 06 \| 8:00PM - 11:00PM Entertainment Room: Torreys Peak 1-4
Monday, April 06 \| 8:00PM - 11:00PM Cash Bar Room: Torreys Peak 1-4
Tuesday, April 07 \| 10:25AM - 10:25AM Departure *Session Chair.