Web Desc
Human Immunology and Immunodeficiencies
Organizer(s): Lennart Hammarström, Xiao-Jun Xu, Jean-Laurent Casanova and Xiao-Ming Gao
Date: May 12 - 17, 2009
Location: Capital Hotel, Beijing, China
Organized in Collaboration with the Chinese Society of Immunology. Sponsored by Pfizer Inc.
Summary of Meeting:
The study of human immunodeficiency, whether inherited or acquired, is an outstanding and illuminating approach for the understanding of human immunology. The clinical investigation of these experiments of nature provide novel insights into the physiology of immune responses. In the course of this Keystone Symposia meeting we aim to bring together experts in the three related fields of primary immunodeficiencies, complex genetics of infectious diseases, and virus-induced immunodeficiency. The immunological and clinical lessons learned from the care and investigation of patients with these conditions will be discussed.
Scholarship Deadline: January 12 2009
Discounted Abstract Deadline: January 12 2009
Abstract Deadline: February 11 2009
Discounted Registration Deadline: April 2 2009
We gratefully acknowledge additional support for this conference from:
Invitrogen CorporationPfizer Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, May 12 | 3:00PM - 7:30PM
Registration
Room: Jinyun Foyer


Tuesday, May 12 | 6:30PM - 7:30PM
Refreshments
Room: Jinyun Foyer


Tuesday, May 12 | 7:30PM - 8:30PM
Keynote Address
Room: Jinyun Ballroom

Speaker 1 of 5
* Lennart Hammarström, Karolinska Institute, Sweden

Tuesday, May 12 | 7:30PM - 8:30PM
Keynote Address
Room: Jinyun Ballroom

Speaker 2 of 5
* Xiao-Jun Xu, Peking University Health Science Center, China

Tuesday, May 12 | 7:30PM - 8:30PM
Keynote Address
Room: Jinyun Ballroom

Speaker 3 of 5
* Jean-Laurent Casanova, Rockefeller University, USA

Tuesday, May 12 | 7:30PM - 8:30PM
Keynote Address
Room: Jinyun Ballroom

Speaker 4 of 5
* Xiao-Ming Gao, Peking University Health Science Center, China

Tuesday, May 12 | 7:30PM - 8:30PM
Keynote Address
Room: Jinyun Ballroom

Speaker 5 of 5
Xuetao Cao, Nankai University and Chinese Academy of Medical Sciences, China
Immune Regulation by Antigen-Presenting Cells: From Basic to Clinic

Tuesday, May 12 | 8:30PM - 9:30PM
Orientation for New Attendees and New Investigators
Room: Jinyun Ballroom
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.

Wednesday, May 13 | 7:30AM - 8:30AM
Breakfast
Room: Four Seasons Restaurant


Wednesday, May 13 | 7:30AM - 8:30AM
Poster Setup
Room: Jinyun Ballroom


Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 1 of 6
* Lennart Hammarström, Karolinska Institute, Sweden

Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 2 of 6
* Jean-Laurent Casanova, Rockefeller University, USA

Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 3 of 6
Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
The Molecular Mechanism for Generation of Antibody Memory

Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 4 of 6
Michael S. Neuberger, Medical Research Council, UK
The Functions of AID and other DNA Deaminases in Immunity

Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 5 of 6
Max D. Cooper, Emory University, USA
Convergent Evolution of Adaptive Immunity

Wednesday, May 13 | 8:30AM - 11:30AM
Development of Immunity
Room: Jinyun Ballroom

Speaker 6 of 6
Yaofeng Zhao, China Agricultural University, China
Short Talk: Ornithorhynchus anatinus (platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Lower Tetrapods

Wednesday, May 13 | 10:10AM - 10:30AM
Coffee Break
Room: Jinyun Foyer


Wednesday, May 13 | 11:30AM - 12:30PM
Lunch
Room: Four Seasons Restaurant


Wednesday, May 13 | 12:15PM - 3:00PM
Poster Session 1
Room: Jinyun Ballroom


Wednesday, May 13 | 2:30PM - 3:00PM
Coffee Available
Room: Jinyun Foyer


Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 1 of 6
* Qiang Pan-Hammarström, Karolinska Institutet, Sweden

Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 2 of 6
* Xi-Qiang Yang, Chongqing University of Medical Sciences, China

Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 3 of 6
Mary Ellen Conley, Rockefeller University, USA
Defects in Early B Cell Development

Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 4 of 6
Lennart Hammarström, Karolinska Institute, Sweden
Genetics of IgAD and CVID

Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 5 of 6
Yu Lung Lau, University of Hong Kong, China
Primary Immunodeficiencies in Hong Kong

Wednesday, May 13 | 3:00PM - 5:00PM
Antibody Deficiencies
Room: Jinyun Ballroom

Speaker 6 of 6
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: B Cell Differentiation and Function in Patients with Defects in STAT3 Signaling

Wednesday, May 13 | 5:00PM - 5:00PM
On Own for Dinner


Thursday, May 14 | 7:30AM - 8:30AM
Breakfast
Room: Four Seasons Restaurant


Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 1 of 7
* Alain Fischer, CHU Necker, France

Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 2 of 7
* Xiao-Jun Xu, Peking University Health Science Center, China

Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 3 of 7
Luigi D. Notarangelo, Children's Hospital, Boston, USA
Human and Mice Models of Omenn Syndrome and Leaky SCID: Unraveling the Paradox of Autoreactivity, Immunopathology and Immune Deficiency

Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 4 of 7
Yoshiyuki Minegishi, University of Tokushima, Japan
Molecular Basis of Hyper IgE Syndrome (HIES)

Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 5 of 7
Jean-Pierre de Villartay, INSERM U768, France
DNA Repair in the Immune System: From V(D)J to IG Class Switch Recombination


Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 6 of 7
Amos Etzioni, Rambam Medical Center, Israel
Leukocyte Adhesion Defects

Thursday, May 14 | 8:30AM - 11:45AM
Non-B Cell PIDs
Room: Jinyun Ballroom

Speaker 7 of 7
Bodo Grimbacher, Royal Free Hospital & University College Medical School, UK
The Involvement of Th17 Cells in Primary Immunodeficiencies

Thursday, May 14 | 10:10AM - 10:30AM
Coffee Break
Room: Jinyun Foyer


Thursday, May 14 | 11:45AM - 1:00PM
Lunch
Room: Four Seasons Restaurant


Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 1 of 7
* Amos Etzioni, Rambam Medical Center, Israel

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 2 of 7
* Xiao-Dong Zhao, Chongqing Medical University, China

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 3 of 7
Saleh Zaid Al-Muhsen, King Saud University, and King Faisal Specialist Hospital, Saudi Arabia
Molecular and Clinical Profile of a Large Cohort with Chronic Granulomatous Disease from Saudi Arabia

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 4 of 7
Raffaele Badolato, Universita di Brescia, Italy
Abnormal Generation of NK-T Cell Subset in Hermansky-Pudlak Type 2 Syndrome Patients

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 5 of 7
Elissa K. Deenick, Garvan Institute of Medical Research, Australia
SAP Deficient Mice Reveal New Insights into the Mechanisms of T-B Collaboration

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 6 of 7
Liping Jiang, Children's Hospital of Chongqing Medical University, China
Deficiency of TH17 Cell Numbers in Two Hyper-IgE Syndrome Patients with STAT3 Gene Mutation

Thursday, May 14 | 1:00PM - 2:30PM
Workshop 1
Room: Jinyun Ballroom

Speaker 7 of 7
Pamela Lee, University of Hong Kong, Hong Kong
Genotype-Phenotype Correlation Study in 62 Patients with X-Linked Agammaglobulinemia

Thursday, May 14 | 2:30PM - 3:00PM
Coffee Available
Room: Jinyun Foyer


Thursday, May 14 | 3:00PM - 4:30PM
Therapy for Primary Immunodeficiency Diseases
Room: Jinyun Ballroom

Speaker 1 of 4
* Luigi D. Notarangelo, Children's Hospital, Boston, USA

Thursday, May 14 | 3:00PM - 4:30PM
Therapy for Primary Immunodeficiency Diseases
Room: Jinyun Ballroom

Speaker 2 of 4
* Xiao-Ming Gao, Peking University Health Science Center, China

Thursday, May 14 | 3:00PM - 4:30PM
Therapy for Primary Immunodeficiency Diseases
Room: Jinyun Ballroom

Speaker 3 of 4
Alain Fischer, CHU Necker, France
Severe Combined Immunodeficiences (SCID): Diversity, Pathophysiology and Gene Therapy

Thursday, May 14 | 3:00PM - 4:30PM
Therapy for Primary Immunodeficiency Diseases
Room: Jinyun Ballroom

Speaker 4 of 4
Matthew Porteus, Stanford University School of Medicine, USA
New Directions in Gene Therapy: Zinc Finger Nuclease Stimulated Homologous Recombination for the Treatement of Primary Immunodeficiencies

Thursday, May 14 | 4:30PM - 4:30PM
On Own for Dinner


Friday, May 15 | 7:30AM - 8:30AM
Breakfast
Room: Four Seasons Restaurant


Friday, May 15 | 7:30AM - 8:30AM
Poster Setup
Room: Jinyun Ballroom


Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 1 of 6
* Erwin Schurr, Research Institute of the McGill University Health Centre, Canada

Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 2 of 6
Alexandre Alcaïs, INSERM U550 Université of Paris René Descartes, France
Human Genetics of Mycobacterial Infections

Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 3 of 6
Etienne Pays, Universite Libre de Bruxelles, Belgium
Genetics of Trypanosome Infection

Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 4 of 6
Philip M. Murphy, NIAID, National Institutes of Health, USA
Complex Genetics of West Nile Virus Infection

Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 5 of 6
Luis Quintana-Murci, Institut Pasteur, CNRS URA3012, France
Evolutionary Genetics as a Tool for Exploring New Frontiers of Host Defence

Friday, May 15 | 8:30AM - 11:45AM
Genetics of Common Infectious Diseases
Room: Jinyun Ballroom

Speaker 6 of 6
Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Immunity to Infection in Natura

Friday, May 15 | 10:10AM - 10:30AM
Coffee Break
Room: Jinyun Foyer


Friday, May 15 | 11:45AM - 12:45PM
Lunch
Room: Four Seasons Restaurant


Friday, May 15 | 12:15PM - 3:00PM
Poster Session 2
Room: Jinyun Ballroom


Friday, May 15 | 2:30PM - 3:00PM
Coffee Available
Room: Jinyun Foyer


Friday, May 15 | 3:00PM - 5:00PM
Genetics of Common Infectious Diseases (continued)
Room: Jinyun Ballroom

Speaker 1 of 5
* Philip M. Murphy, NIAID, National Institutes of Health, USA

Friday, May 15 | 3:00PM - 5:00PM
Genetics of Common Infectious Diseases (continued)
Room: Jinyun Ballroom

Speaker 2 of 5
* Etienne Pays, Universite Libre de Bruxelles, Belgium

Friday, May 15 | 3:00PM - 5:00PM
Genetics of Common Infectious Diseases (continued)
Room: Jinyun Ballroom

Speaker 3 of 5
Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Complex Genetics of Leprosy

Friday, May 15 | 3:00PM - 5:00PM
Genetics of Common Infectious Diseases (continued)
Room: Jinyun Ballroom

Speaker 4 of 5
Thomas B. Boren, Umea University, Sweden
Dynamics of Adhesin-Receptor interactions: Lessons from H. pylori

Friday, May 15 | 3:00PM - 5:00PM
Genetics of Common Infectious Diseases (continued)
Room: Jinyun Ballroom

Speaker 5 of 5
Shen-Ying Zhang, Rockefeller University, USA
Mendelian Genetic Predisposition to Herpes Simplex Encephalitis in Childhood

Friday, May 15 | 5:00PM - 6:00PM
High Tea
Room: Jinyun Foyer


Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 1 of 7
* Yoshiyuki Minegishi, University of Tokushima, Japan

Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 2 of 7
* Yu Lung Lau, University of Hong Kong, China

Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 3 of 7
Kohsuke Imai, Tokyo Medical and Dental University, Japan
Primary Immunodeficiency Database Network in Japan

Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 4 of 7
Xiao-Fei Kong, Rockefeller University, Casanova Laboratory, USA
A Novel form of Recessive STAT1 Deficiency Associated with
Impaired but not Abolished Responses to IFN-alpha/beta, IFN-gamma, IFN-lambda1 and IL-27


Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 5 of 7
Elin Alexandra Kindberg, University of Linköping, Sweden
A Deletion in the Chemokine Receptor 5 (CCR5) Gene is Associated with Tick-Borne Encephalitis

Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 6 of 7
Marie Meeths, Karolinska Institutet, Sweden
Spectrum and Clinical Presentation of RAB27A Mutations

Friday, May 15 | 6:00PM - 7:30PM
Workshop 2
Room: Jinyun Ballroom

Speaker 7 of 7
Vanessa Sancho Shimizu, University Paris Descartes Faculty of Medicine Necker, France
Novel Genes Controlling Susceptibility to Herpes Simplex Encephalitis

Saturday, May 16 | 7:30AM - 8:30AM
Breakfast
Room: Four Seasons Restaurant


Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 1 of 6
* Daniel E. Kaufmann, University of Montreal, Canada

Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 2 of 6
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 3 of 6
Adriano Boasso, Imperial College London, UK
Type I IFN and IDO-Mediated Immune Dysregulation in HIV Infection

Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 4 of 6
Frank Kirchhoff, University of Ulm, Germany
Downregulation of Expression of MHC Class I Molecules by HIV

Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 5 of 6
Guido Silvestri, Emory University School of Medicine, USA
HIV-Associated Chronic Immune Activation

Saturday, May 16 | 8:30AM - 11:30AM
Mechanism of Immunodeficiency in HIV
Room: Jinyun Ballroom

Speaker 6 of 6
Mary Carrington, NCI, National Institutes of Health, USA
Immunogenetic Effects on HIV-1 Infection

Saturday, May 16 | 10:10AM - 10:30AM
Coffee Break
Room: Jinyun Foyer


Saturday, May 16 | 11:30AM - 11:30AM
On Own for Lunch


Saturday, May 16 | 4:30PM - 5:00PM
Coffee Available
Room: Jinyun Foyer


Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 1 of 6
* Frank Kirchhoff, University of Ulm, Germany

Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 2 of 6
* Mary Carrington, NCI, National Institutes of Health, USA

Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 3 of 6
* Michael S. Neuberger, Medical Research Council, UK

Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 4 of 6
Daniel E. Kaufmann, University of Montreal, Canada
Immunoregulatory Pathways and HIV-Specific T Cell Dysfunction

Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 5 of 6
Brent E. Palmer, University of Colorado Health Sciences Center, USA
Dysregulation of CD4+ T Cell Coregulatory Receptor Expression during Chronic HIV Infection

Saturday, May 16 | 5:00PM - 6:45PM
Mechanism of Immunodeficiency in HIV (continued)
Room: Jinyun Ballroom

Speaker 6 of 6
Zuopeng Wu, John Curtin School of Medical Research, Australia
Short Talk: Pre-mRNA Alternative Splicing is Essential in Regulating T Cell Immunity and Homeostasis

Saturday, May 16 | 6:45PM - 7:30PM
Concluding Remarks
Room: Jinyun Ballroom

Speaker 1 of 1
Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA
Common and Contrasting Mechanisms of Acquired and Inherited Immunodeficiencies

Saturday, May 16 | 7:30PM - 8:30PM
Social Hour
Room: Jinyun Foyer


Saturday, May 16 | 8:30PM - 9:30PM
Entertainment
Room: Jinyun Ballroom


Sunday, May 17 | 10:25AM - 10:25AM
Departure


*Session Chair.