Deregulation of Transcription in Cancer: Controlling Cell Fate Decisions

Organizer(s): Beverly M. Emerson and Edison T. Liu

Organized in Collaboration with Science Foundation Ireland. Sponsored by Amgen Inc.

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Summary of Meeting:

Transcription is an intricate process that is regulated with exquisite specificity at both the genetic and epigenetic levels through such aspects as chromatin and core RNA polymerase machinery. Sophisticated mechanisms have been recently deciphered concerning how specific genes and pathways are deregulated in human cancers. Master cancer regulators are commonly transcription factors. Yet a great disparity exists between the nonspecificity of most cancer therapies and this advanced understanding of aberrant gene expression. This conference will focus on exploiting novel mechanistic information to generate more efficacious targeted therapies . Current insights into the mechanisms by which specific genes are deregulated in cancer, the resulting transcriptome signature for particular cancers, and state-of-the-art therapeutic approaches using small molecules or RNA interference will be presented. The goals of this meeting are to explore how transcription as a regulator for cell fate outcomes can be parlayed into specific cancer therapies.

Scholarship Deadline: February 23 2009

Discounted Abstract Deadline: February 23 2009

Abstract Deadline: March 24 2009

Discounted Registration Deadline: May 8 2009

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck & Co., Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA139720-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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