Web Desc
Deregulation of Transcription in Cancer: Controlling Cell Fate Decisions
Organizer(s): Beverly M. Emerson and Edison T. Liu
Date: June 21 - 26, 2009
Location: INEC Killarney Convention Centre, Killarney, Co. Kerry, Ireland
Organized in Collaboration with Science Foundation Ireland. Sponsored by Amgen Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Transcription is an intricate process that is regulated with exquisite specificity at both the genetic and epigenetic levels through such aspects as chromatin and core RNA polymerase machinery. Sophisticated mechanisms have been recently deciphered concerning how specific genes and pathways are deregulated in human cancers. Master cancer regulators are commonly transcription factors. Yet a great disparity exists between the nonspecificity of most cancer therapies and this advanced understanding of aberrant gene expression. This conference will focus on exploiting novel mechanistic information to generate more efficacious targeted therapies . Current insights into the mechanisms by which specific genes are deregulated in cancer, the resulting transcriptome signature for particular cancers, and state-of-the-art therapeutic approaches using small molecules or RNA interference will be presented. The goals of this meeting are to explore how transcription as a regulator for cell fate outcomes can be parlayed into specific cancer therapies.
Scholarship Deadline: February 23 2009
Discounted Abstract Deadline: February 23 2009
Abstract Deadline: March 24 2009
Discounted Registration Deadline: May 8 2009
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenFáilte IrelandLilly Singapore Centre for Drug DiscoveryScience Foundation Ireland
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck & Co., Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell PressRoyal Society of Chemistry
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA139720-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 21 | 3:00PM - 7:30PM
Registration
Room: INEC Conference Centre Foyer


Sunday, June 21 | 6:30PM - 7:30PM
Refreshments
Room: INEC Conference Centre Foyer


Sunday, June 21 | 7:30PM - 9:45PM
Keynote Session
Room: INEC Main Auditorium

Speaker 1 of 3
Frank Gannon, QIMR Berghofer Medical Research Institute, Australia
Welcoming Remarks

Sunday, June 21 | 7:30PM - 9:45PM
Keynote Session
Room: INEC Main Auditorium

Speaker 2 of 3
Robert G. Roeder, Rockefeller University, USA
Function of Transcriptional Coactivators in Animal Cells

Sunday, June 21 | 7:30PM - 9:45PM
Keynote Session
Room: INEC Main Auditorium

Speaker 3 of 3
René Bernards, Netherlands Cancer Institute, Netherlands
Finding Mechanisms and Biomarkers of Drug Resistance in Cancer

Monday, June 22 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Monday, June 22 | 9:00AM - 12:00PM
Transcriptional Regulation through Epigenetic Control in Can
cer

Room: INEC Main Auditorium

Speaker 1 of 5
* Kristian Helin, University of Copenhagen and Memorial Sloan Kettering Cancer Center, Denmark
Histone Methyltransferases and Demethylases in Cell Proliferation and Cancer

Monday, June 22 | 9:00AM - 12:00PM
Transcriptional Regulation through Epigenetic Control in Can
cer

Room: INEC Main Auditorium

Speaker 2 of 5
Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Regulation of Stem Cell Commitment and Tumor Development by Polycomb Repressors

Monday, June 22 | 9:00AM - 12:00PM
Transcriptional Regulation through Epigenetic Control in Can
cer

Room: INEC Main Auditorium

Speaker 3 of 5
Manel Esteller, Josep Carreras Leukaemia Research Institute, Spain
Epigenetic Dysregulation in Human Cancer

Monday, June 22 | 9:00AM - 12:00PM
Transcriptional Regulation through Epigenetic Control in Can
cer

Room: INEC Main Auditorium

Speaker 4 of 5
Sung Hee Baek, Seoul National University, South Korea
Short Talk: Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Monday, June 22 | 9:00AM - 12:00PM
Transcriptional Regulation through Epigenetic Control in Can
cer

Room: INEC Main Auditorium

Speaker 5 of 5
Reuven Agami, Netherlands Cancer Institute, Netherlands
BRD 7 is Required for P53 Tumor Suppressor Activity

Monday, June 22 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Monday, June 22 | 12:00PM - 12:00PM
On Own for Lunch


Monday, June 22 | 12:00PM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Monday, June 22 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Monday, June 22 | 3:00PM - 4:30PM
Workshop 1: Presentations Selected from Submitted Abstracts
Room: INEC Main Auditorium

Speaker 1 of 5
* Deborah L. Johnson, Keystone Symposia on Molecular and Cellular Biology, USA
The c-Jun-N-Terminal Kinases Differentially Regulate RNA Polymerase III Transcription by Coordinately Modulating the Expression of all TFIIIB Subunits

Monday, June 22 | 3:00PM - 4:30PM
Workshop 1: Presentations Selected from Submitted Abstracts
Room: INEC Main Auditorium

Speaker 2 of 5
Rajnish A. Gupta, Stanford University School of Medicine, USA
Reprogramming of the Breast Cancer Epigenome and Promotion of Metastasis by a HOX Long Noncoding RNA

Monday, June 22 | 3:00PM - 4:30PM
Workshop 1: Presentations Selected from Submitted Abstracts
Room: INEC Main Auditorium

Speaker 3 of 5
Ralf Kittler, University of Texas Southwestern Medical Center, USA
A Nuclear Receptor Cis-regulatory Map for Breast Cancer

Monday, June 22 | 3:00PM - 4:30PM
Workshop 1: Presentations Selected from Submitted Abstracts
Room: INEC Main Auditorium

Speaker 4 of 5
Erich S. Huang, Duke University Medical Center, USA
An Experimentally-Annotated Strategy for Developing Factor Models of Oncogenic Activities & Sensitivity to Pathway-Specific Therapeutics

Monday, June 22 | 3:00PM - 4:30PM
Workshop 1: Presentations Selected from Submitted Abstracts
Room: INEC Main Auditorium

Speaker 5 of 5
Anchit Khanna, IMT, University of Tampere, Finland
C-Myc-Dependent Regulation and Prognostic Role of c-Myc Stabilizing Protein CIP2A, in Human Gastric Cancer

Monday, June 22 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Monday, June 22 | 5:00PM - 7:15PM
Mechanisms of Transcriptional Misregulation
Room: INEC Main Auditorium

Speaker 1 of 4
* Joan W. Conaway, Stowers Institute for Medical Research, USA
Alc1, a Putative Oncogene and Chromatin Remodeling Enzyme Regulated by Poly(ADP-ribosyl)ation

Monday, June 22 | 5:00PM - 7:15PM
Mechanisms of Transcriptional Misregulation
Room: INEC Main Auditorium

Speaker 2 of 4
Beverly M. Emerson, CEDAR, OHSU Knight Cancer Institute, USA
Aberrant Transcriptional Silencing in Human Cancers

Monday, June 22 | 5:00PM - 7:15PM
Mechanisms of Transcriptional Misregulation
Room: INEC Main Auditorium

Speaker 3 of 4
Peter N. Cockerill, Leeds Institute of Molecular Medicine, UK
Epigeneitc and Transcriptional Mechanisms Regulating Haematopoeitic Cells in Normal and Malignant Cancer Cells

Monday, June 22 | 5:00PM - 7:15PM
Mechanisms of Transcriptional Misregulation
Room: INEC Main Auditorium

Speaker 4 of 4
Howard Y. Chang, Stanford University, USA
A Histone Demethylase in Cell Cycle Control

Monday, June 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Monday, June 22 | 7:30PM - 10:00PM
Poster Session 1
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 8:00AM - 9:00AM
Poster Setup
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 9:00AM - 12:00PM
Tumor Promotion through Aberrant Transcription
Room: INEC Main Auditorium

Speaker 1 of 5
* Karen H. Vousden, Francis Crick Institute, UK
Functions of Mutant p53 in Promoting Invasion

Tuesday, June 23 | 9:00AM - 12:00PM
Tumor Promotion through Aberrant Transcription
Room: INEC Main Auditorium

Speaker 2 of 5
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Novel Mechanisms of Transcriptional Control in the p53 and Serum Response Gene Networks

Tuesday, June 23 | 9:00AM - 12:00PM
Tumor Promotion through Aberrant Transcription
Room: INEC Main Auditorium

Speaker 3 of 5
Constanze Bonifer, University of Birmingham, UK
Short Talk: Aberrant Transcriptional Activation of CSF-1R in Hodgkins Lymphoma

Tuesday, June 23 | 9:00AM - 12:00PM
Tumor Promotion through Aberrant Transcription
Room: INEC Main Auditorium

Speaker 4 of 5
Hugues de Thé, Hopital St. Louis, France
Recent Insights into PML/RARA Function in APL Pathogenesis


Tuesday, June 23 | 9:00AM - 12:00PM
Tumor Promotion through Aberrant Transcription
Room: INEC Main Auditorium

Speaker 5 of 5
Michael Karin, University of California, San Diego, USA
Inflammation induced Transcriptional Reprogramming in Metastatic Progression

Tuesday, June 23 | 9:00AM - 5:30PM
Poster Viewing
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 12:00PM - 1:00PM
Lunch
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 12:30PM - 3:00PM
Poster Session 2
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 3:00PM - 3:30PM
Coffee Available
Room: INEC Conference Centre Foyer


Tuesday, June 23 | 3:30PM - 5:30PM
Activation of Developmental Transcription Pathways in Cancer
Room: INEC Main Auditorium

Speaker 1 of 4
* Katherine A. Jones, The Salk Institute, USA
SKIP/SNW1 Regulates Transcription Elongation and Methylation

Tuesday, June 23 | 3:30PM - 5:30PM
Activation of Developmental Transcription Pathways in Cancer
Room: INEC Main Auditorium

Speaker 2 of 4
Stephen C. Blacklow, Harvard Medical School, USA
Transcriptional Dysregulation by Aberrant Notch Signaling in Leukemia

Tuesday, June 23 | 3:30PM - 5:30PM
Activation of Developmental Transcription Pathways in Cancer
Room: INEC Main Auditorium

Speaker 3 of 4
Jason S. Carroll, Cancer Research UK, University of Cambridge, UK
Short Talk: Defining the Role for Pioneer Factors in Estrogen Receptor Transcriptional Activity

Tuesday, June 23 | 3:30PM - 5:30PM
Activation of Developmental Transcription Pathways in Cancer
Room: INEC Main Auditorium

Speaker 4 of 4
Thea D. Tlsty, University of California, San Francisco, USA
Clues on the Activation and Regulation of Epigenetic Remodeling in Cancer

Tuesday, June 23 | 5:30PM - 5:30PM
On Own for Dinner


Wednesday, June 24 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 9:00AM - 12:00PM
Mapping the Transcriptome in Cancer States
Room: INEC Main Auditorium

Speaker 1 of 5
* Bing Ren, Ludwig Institute for Cancer Research, USA
Global Analysis of Gene Regulation in Human Cells

Wednesday, June 24 | 9:00AM - 12:00PM
Mapping the Transcriptome in Cancer States
Room: INEC Main Auditorium

Speaker 2 of 5
Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Epigenomics and Cellular States

Wednesday, June 24 | 9:00AM - 12:00PM
Mapping the Transcriptome in Cancer States
Room: INEC Main Auditorium

Speaker 3 of 5
Dearbhaile Collins, Royal College of Surgeons, Ireland, Ireland
Short Talk: Steroid and Growth Factor Pathway Crosstalk in Breast Cancer: The Impact of c-Myc and SMRT Interaction

Wednesday, June 24 | 9:00AM - 12:00PM
Mapping the Transcriptome in Cancer States
Room: INEC Main Auditorium

Speaker 4 of 5
Yijun Ruan, The Jackson Laboratory for Genomic Medicine, USA
Mapping Cancer Transcriptome and Long-Range Chromatin Interactions of Transcription Regulatory Elements through Genomic Sequencing Approaches

Wednesday, June 24 | 9:00AM - 12:00PM
Mapping the Transcriptome in Cancer States
Room: INEC Main Auditorium

Speaker 5 of 5
Edison T. Liu, The Jackson Laboratory, USA
Cellular Decisions in Transcription: The Topology of Transcription Factor Binding and Decision Nodes for Binding Site Selection

Wednesday, June 24 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 12:00PM - 12:00PM
On Own for Lunch


Wednesday, June 24 | 12:00PM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 3:00PM - 4:30PM
Workshop 2: Panel Discussion, Perspectives on Transcription
as a Therapeutic Target
Room: INEC Main Auditorium

Speaker 1 of 5
René Bernards, Netherlands Cancer Institute, Netherlands

Wednesday, June 24 | 3:00PM - 4:30PM
Workshop 2: Panel Discussion, Perspectives on Transcription
as a Therapeutic Target
Room: INEC Main Auditorium

Speaker 2 of 5
Robert G. Roeder, Rockefeller University, USA

Wednesday, June 24 | 3:00PM - 4:30PM
Workshop 2: Panel Discussion, Perspectives on Transcription
as a Therapeutic Target
Room: INEC Main Auditorium

Speaker 3 of 5
Gregory L. Verdine, Harvard University, USA

Wednesday, June 24 | 3:00PM - 4:30PM
Workshop 2: Panel Discussion, Perspectives on Transcription
as a Therapeutic Target
Room: INEC Main Auditorium

Speaker 4 of 5
Paul Workman, Institute of Cancer Research, UK

Wednesday, June 24 | 3:00PM - 4:30PM
Workshop 2: Panel Discussion, Perspectives on Transcription
as a Therapeutic Target
Room: INEC Main Auditorium

Speaker 5 of 5
John J. Rossi, Beckman Research Institute of the City of Hope, USA

Wednesday, June 24 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 5:00PM - 7:00PM
Gene Expression Cassettes and Transcriptional Networks in Ca
ncer

Room: INEC Main Auditorium

Speaker 1 of 4
* Joseph R. Nevins, Duke University Medical Center, USA
Genomic Analysis of Oncogenic Cell Signaling Networks

Wednesday, June 24 | 5:00PM - 7:00PM
Gene Expression Cassettes and Transcriptional Networks in Ca
ncer

Room: INEC Main Auditorium

Speaker 2 of 4
Erik S. Knudsen, UT Southwestern, USA
Short Talk: Disruption of the RB/E2F Regulatory Network in Cancer: Variant Impact on Tumorigenesis & Therapeutic Response

Wednesday, June 24 | 5:00PM - 7:00PM
Gene Expression Cassettes and Transcriptional Networks in Ca
ncer

Room: INEC Main Auditorium

Speaker 3 of 4
Fabrizio Bianchi, Istituto Europeo di Oncologia, Italy
Short Talk: Global Mapping of Oncogenic Expression Signatures in Lung Adenocarcinoma

Wednesday, June 24 | 5:00PM - 7:00PM
Gene Expression Cassettes and Transcriptional Networks in Ca
ncer

Room: INEC Main Auditorium

Speaker 4 of 4
Arul M. Chinnaiyan, University of Michigan, USA
The Next Generation of Gene Fusion Discovery in Cancer

Wednesday, June 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Wednesday, June 24 | 7:30PM - 10:00PM
Poster Session 3
Room: INEC Conference Centre Foyer


Thursday, June 25 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Thursday, June 25 | 9:00AM - 12:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics I

Room: INEC Main Auditorium

Speaker 1 of 5
* Gregory L. Verdine, Harvard University, USA
Drugging “Undruggable” Targets Using Stapled Peptides

Thursday, June 25 | 9:00AM - 12:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics I

Room: INEC Main Auditorium

Speaker 2 of 5
John J. Rossi, Beckman Research Institute of the City of Hope, USA
RNAi Post-transcriptional and Transcriptional Gene Silencing Mechanism

Thursday, June 25 | 9:00AM - 12:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics I

Room: INEC Main Auditorium

Speaker 3 of 5
Sandra E. Dunn, University of British Columbia, Canada
YB-1 induces CD44 and CD49f thereby promoting the capacity for tumor initiation

Thursday, June 25 | 9:00AM - 12:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics I

Room: INEC Main Auditorium

Speaker 4 of 5
Qiang Yu, Genome Institute of Singapore, Singapore
Combinatorial Treatment Targeting EZH2-Mediated Epigenetic Event for Cancer Therapy

Thursday, June 25 | 9:00AM - 12:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics I

Room: INEC Main Auditorium

Speaker 5 of 5
Lyubomir T. Vassilev, EMD Serono Research & Development Institute, Inc., USA
Small Molecule Inhibitors of p53-MDM2 Complexes for Cancer Therapy

Thursday, June 25 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Conference Centre Foyer


Thursday, June 25 | 12:00PM - 12:00PM
On Own for Lunch


Thursday, June 25 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Thursday, June 25 | 5:00PM - 7:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics II

Room: INEC Main Auditorium

Speaker 1 of 4
* Paul Workman, Institute of Cancer Research, UK
Drugging the Cancer Genome

Thursday, June 25 | 5:00PM - 7:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics II

Room: INEC Main Auditorium

Speaker 2 of 4
Sheng Ding, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Stem Cell Biology

Thursday, June 25 | 5:00PM - 7:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics II

Room: INEC Main Auditorium

Speaker 3 of 4
Elisabeth D. Martinez, University of Texas Southwestern Medical Center, USA
Short Talk: An Epigenetic Cell Based Screen Identifies a Novel Small Molecule with Specific Anti-Cancer Activity

Thursday, June 25 | 5:00PM - 7:00PM
Modifying Transcription and Transcription Targeted Therapeut
ics II

Room: INEC Main Auditorium

Speaker 4 of 4
Yosef Yarden, Weizmann Institute of Science, Israel
Oncogenic Signal Transduction Networks and their Feedback Regulation

Thursday, June 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Thursday, June 25 | 7:30PM - 10:00PM
Entertainment
Room: INEC Conference Centre Foyer


Thursday, June 25 | 8:00PM - 10:00PM
Cash Bar
Room: INEC Conference Centre Foyer


Friday, June 26 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.