Web Desc
Protein Dynamics, Allostery and Function
Organizer(s): Ivet Bahar and Lila M. Gierasch
Date: June 05 - 10, 2009
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
With recent progress in exploring biomolecular systems dynamics, an emerging view is that of the ‘intrinsic ability’ of biomolecular systems to populate an ensemble of fluctuating conformations, or alternative states, which include, in particular, the functional forms stabilized upon ligand/substrate binding or protein-protein interactions. Allosteric changes in conformations, or signal transduction mechanisms, thus emerge as properties encoded by the structure and energy landscape, which are evolutionarily selected due to their functional predisposition. Of particular interest is to elucidate the mechanisms of information flow, not only at the level of residue interactions, but also between the components of biomolecular machines or cell signaling networks. This Keystone Symposia meeting will provide a forum for researchers from diverse fields to explore the basic principles underlying allosteric responses at the molecular level, and their higher (cellular) level consequences, and to exchange expertise on methods to illuminate key dynamic properties of biomolecular systems.
Scholarship Deadline: February 5 2009
Discounted Abstract Deadline: February 5 2009
Abstract Deadline: March 5 2009
Discounted Registration Deadline: April 6 2009
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM087771-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, June 05 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Friday, June 05 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Friday, June 05 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud Peak

Speaker 1 of 1
Kenneth A. Dill, Stony Brook University, USA
Protein Folding: Physical Approaches to Predicting Structures and Stabilities

Saturday, June 06 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Saturday, June 06 | 8:00AM - 11:00AM
Dynamics, Energy Landscapes and Evolutionary Selection
Room: Red Cloud Peak

Speaker 1 of 5
Hans Frauenfelder, Los Alamos National Laboratory, USA
A Unified Model of Protein Dynamics

Saturday, June 06 | 8:00AM - 11:00AM
Dynamics, Energy Landscapes and Evolutionary Selection
Room: Red Cloud Peak

Speaker 2 of 5
Cecilia Clementi, Rice University, USA
Prediction of Protein Functional States by Multi-Resolution Protein Modeling

Saturday, June 06 | 8:00AM - 11:00AM
Dynamics, Energy Landscapes and Evolutionary Selection
Room: Red Cloud Peak

Speaker 3 of 5
Michele Vendruscolo, University of Cambridge, UK
Advances in the use of NMR Spectroscopy to Characterize Free Energy Landscapes of Proteins

Saturday, June 06 | 8:00AM - 11:00AM
Dynamics, Energy Landscapes and Evolutionary Selection
Room: Red Cloud Peak

Speaker 4 of 5
Walter Englander, University of Pennsylvania, USA
Short Talk: How Proteins Fold

Saturday, June 06 | 8:00AM - 11:00AM
Dynamics, Energy Landscapes and Evolutionary Selection
Room: Red Cloud Peak

Speaker 5 of 5
Matthias Buck, Case Western Reserve University, Medical School, USA
Short Talk: Conformational Coupling in an Effector-GTPase Interaction:
Differences in the Complex Formation of the Plexin GTPase Binding Domain with Rac1 and Rnd1


Saturday, June 06 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, June 06 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, June 06 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone Peak


Saturday, June 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 1 of 9
* Ada Yonath, Weizmann Institute of Science, Israel

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 2 of 9
Chad M. Petit, University of North Carolina, USA
Entropically Modulated Function in a PDZ domain

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 3 of 9
Miles A. Pufall, University of Iowa, USA
Modulating Protein Function: DNA as an Allosteric Effector of Glucocorticoid Receptor Activity

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 4 of 9
Paula Therese Lang, University of California, Berkeley, USA
Ghosts in the Machines: Using Novel X-Ray Crystallographic Methods to Identify Side Chain Polymorphism in Protein-Ligand Interactions

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 5 of 9
Jianpeng Ma, Baylor College of Medicine, USA
Minimalist Network Model (MNM): A Novel Coarse-grained Normal Mode Analysis

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 6 of 9
Eileen K. Jaffe, Fox Chase Cancer Center - TUHS, USA
Dynamic Dissociating Homo-Oligomers and Allosteric Regulation

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 7 of 9
Gail E. Fanucci, University of Florida, USA
Monitoring Motions and Flexibility of HIV-1 Protease with Pulsed EPR Spectroscopy

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 8 of 9
Ahmet Bakan, University of Pittsburgh, USA
Effect of Inhibitor Binding on Protein Structure and Dynamics: Intrinsic Dynamics or Induced Dynamics?

Saturday, June 06 | 2:30PM - 4:30PM
Workshop
Room: Red Cloud Peak

Speaker 9 of 9
Michelle A. Markus, Wyeth Pharmaceuticals, USA
Identifying Novel, Non-Chelating Inhibitors of MMP-9 using Virtual Screening, NMR Spectroscopy, and X-Ray Crystallography

Saturday, June 06 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Saturday, June 06 | 5:00PM - 7:00PM
Catalysis and Allostery
Room: Red Cloud Peak

Speaker 1 of 5
* Amnon Horovitz, Weizmann Institute of Science, Israel

Saturday, June 06 | 5:00PM - 7:00PM
Catalysis and Allostery
Room: Red Cloud Peak

Speaker 2 of 5
J. Patrick Loria, Yale University, USA
Short and Long-Range Interactions and Motions and their Impact on Enzyme Function

Saturday, June 06 | 5:00PM - 7:00PM
Catalysis and Allostery
Room: Red Cloud Peak

Speaker 3 of 5
Sebastian Doniach, Stanford University, USA
Allostery and riboswitch function

Saturday, June 06 | 5:00PM - 7:00PM
Catalysis and Allostery
Room: Red Cloud Peak

Speaker 4 of 5
Susan S. Taylor, University of California, San Diego, USA
Dynamics of Signaling by PKA

Saturday, June 06 | 5:00PM - 7:00PM
Catalysis and Allostery
Room: Red Cloud Peak

Speaker 5 of 5
Andrea Mozzarelli, University of Parma, Italy
Short Talk: Hemoglobin: Still the Paradigm for Allostery

Saturday, June 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone Peak


Saturday, June 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone Peak


Sunday, June 07 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Sunday, June 07 | 8:00AM - 8:50AM
Keynote Address
Room: Red Cloud Peak

Speaker 1 of 1
Jean-Pierre Changeux, Institut Pasteur, France
The Nicotinic Acetylcholine Receptor: A Membrane Allosteric Protein Engaged in Neuronal Communication

Sunday, June 07 | 8:50AM - 11:15AM
Allosteric Events in Membrane Proteins
Room: Red Cloud Peak

Speaker 1 of 5
Peter Peter Tieleman, University of Calgary, Canada
Coupling between Nucleotide Binding and Transmembrane Domains in ABC Transporters

Sunday, June 07 | 8:50AM - 11:15AM
Allosteric Events in Membrane Proteins
Room: Red Cloud Peak

Speaker 2 of 5
Ivet Bahar, University of Pittsburgh, USA
Allosteric Dynamics of Glutamate Transporters: Insights from Multiscale Computations

Sunday, June 07 | 8:50AM - 11:15AM
Allosteric Events in Membrane Proteins
Room: Red Cloud Peak

Speaker 3 of 5
Heidi E. Hamm, USA
Allosteric Connections from a G Protein-Coupled Receptor to the Nucleotide-Binding Pocket of a Heterotrimeric G Protein

Sunday, June 07 | 8:50AM - 11:15AM
Allosteric Events in Membrane Proteins
Room: Red Cloud Peak

Speaker 4 of 5
* Ofer Yifrach, Ben-Gurion University of the Negev, Israel
Short Talk: Principles Underlying Energetic Coupling Along an Allosteric Communication Trajectory of a Voltage-Activated K+ Channel

Sunday, June 07 | 8:50AM - 11:15AM
Allosteric Events in Membrane Proteins
Room: Red Cloud Peak

Speaker 5 of 5
Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
Short Talk: Simulation of a Protein Tertiary Complex: Study of the Interaction Interface and Conformational Dynamics of Dark State Rhodopsin in Complex with Transducin

Sunday, June 07 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, June 07 | 11:30AM - 11:30AM
On Own for Lunch


Sunday, June 07 | 11:30AM - 1:00PM
Poster Setup
Room: Crestone Peak


Sunday, June 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Sunday, June 07 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 1 of 6
* David A. Agard, University of California, San Francisco, USA

Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 2 of 6
Ada Yonath, Weizmann Institute of Science, Israel
Ribosomal Machinery: Peptide Bond Formation,
Chaperone Assistance, and Antibiotics Inactivation


Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 3 of 6
Devarajan Thirumalai, University of Maryland, USA
Structural Basis of Allosteric Transitions in Biological Machines: Common Themes

Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 4 of 6
Amnon Horovitz, Weizmann Institute of Science, Israel
Linking Allostery in Chaperonins to Protein Folding

Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 5 of 6
Lars Skjaerven, Universitetet i Bergen, Norway
Short Talk: Discovering the Intrinsic Dynamical Abilities of the GroEL Subunit by Molecular Dynamics Simulation

Sunday, June 07 | 5:00PM - 7:15PM
Dynamics and Biomolecular Machines
Room: Red Cloud Peak

Speaker 6 of 6
David P. Giedroc, Indiana University, USA
Short Talk: Structure and Energetics of Metal-induced Allosteric Regulation of DNA binding by ArsR Family Metal Sensor Proteins

Sunday, June 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Crestone Peak


Sunday, June 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone Peak


Monday, June 08 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 1 of 7
* Rama Ranganathan, University of Texas Southwestern Medical Center, USA

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 2 of 7
Vincent J. Hilser, University of Texas Medical Branch, USA
Allostery in an Ensemble

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 3 of 7
Kevin Donald Ridge, University of Texas, Houston, USA
Signaling via Structure Change: NMR Analysis of GPCR and G Protein Activation

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 4 of 7
Michael Grabe, University of Pittsburgh, USA
Insight into the Nature of Voltage Sensing in Voltage-gated Potassium Channels

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 5 of 7
Lila M. Gierasch, University of Massachusetts Amherst, USA
The Mechanism of Allostery in an Hsp70 Molecular Chaperone

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 6 of 7
Jeffrey W. Peng, University of Notre Dame, USA
Short Talk: Towards Establishing Flexibility-Activity-Relationships for Dynamic Protein-Ligand Interactions

Monday, June 08 | 8:00AM - 11:15AM
Signal Propagation in Molecular and Cellular Systems I
Room: Red Cloud Peak

Speaker 7 of 7
Akash Bhattacharya, University of Michigan, USA
Short Talk: A Comprehensive View of Allostery in the Hsp70 Chaperone Proteins

Monday, June 08 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, June 08 | 11:15AM - 11:15AM
On Own for Lunch


Monday, June 08 | 11:15AM - 1:00PM
Poster Setup
Room: Crestone Peak


Monday, June 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Monday, June 08 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 1 of 6
* Susan S. Taylor, University of California, San Diego, USA

Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 2 of 6
Rama Ranganathan, University of Texas Southwestern Medical Center, USA
The Evolutionary Design of Proteins

Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 3 of 6
David A. Agard, University of California, San Francisco, USA
Conformational Dynamics, Structure and Mechanism of Hsp90 Chaperones

Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 4 of 6
Andrew Hopkins, University of Dundee, UK
Pharmacological Approaches to Biological Network Perturbation and Allosteric Modulation

Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 5 of 6
Giorgio Colombo, University of Pavia, Italy
Short Talk: Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer

Monday, June 08 | 5:00PM - 7:15PM
Signal Propagation in Molecular and Cellular Systems II
Room: Red Cloud Peak

Speaker 6 of 6
Saskia Neher, University of California at San Francisco, USA
Short Talk: Signal Sequences Activate the Catalytic Switch of SRP RNA

Monday, June 08 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Crestone Peak


Monday, June 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone Peak


Tuesday, June 09 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 1 of 6
* J. Patrick Loria, Yale University, USA

Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 2 of 6
G. Marius Clore, NIDDK, National Institutes of Health, USA
Visualizing Transient Lowly-Populated Regions of the Free Energy Landscape of Macromolecules and their Complexes by Paramagnetic Relaxation Enhancement

Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 3 of 6
Ruben Abagyan, University of California, San Diego, USA
Induced Fit in Ligand Docking and Drug Discovery

Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 4 of 6
Ad Bax, NIDDK, National Institutes of Health, USA
Proteins, Lipids, and their Dynamic Interaction Viewed by NMR

Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 5 of 6
Justin L. P. Benesch, University of Oxford, UK
Short Talk: Thermo-Dynamically Controlled Chaperone Function of the Small Heat Shock Proteins

Tuesday, June 09 | 8:00AM - 11:00AM
Novel Methods for Dynamics and Allostery
Room: Red Cloud Peak

Speaker 6 of 6
Aron W. Fenton, University of Kansas Medical Center, USA
Short Talk: Mapping Individual Residues within the N-Terminus that are Energetically Coupled to Allosteric and Active Site Functions of Human Liver Pyruvate Kinase

Tuesday, June 09 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, June 09 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, June 09 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, June 09 | 5:00PM - 6:45PM
Novel Methods for Equilibrium Fluctuations
Room: Red Cloud Peak

Speaker 1 of 4
* Ad Bax, NIDDK, National Institutes of Health, USA

Tuesday, June 09 | 5:00PM - 6:45PM
Novel Methods for Equilibrium Fluctuations
Room: Red Cloud Peak

Speaker 2 of 4
Elliot L. Elson, Washington University School of Medicine, USA
Chemical Reaction Fluxes in Non-Equilibrium Steady State Systems

Tuesday, June 09 | 5:00PM - 6:45PM
Novel Methods for Equilibrium Fluctuations
Room: Red Cloud Peak

Speaker 3 of 4
Patrice Vachette, IBBMC, France
Synchrotron SAXS Study of Quaternary Structure Equilibrium for Wild-Type and Mutant Forms of Allosteric Aspartate Transcarbamoylase

Tuesday, June 09 | 5:00PM - 6:45PM
Novel Methods for Equilibrium Fluctuations
Room: Red Cloud Peak

Speaker 4 of 4
Brian M. Baker, University of Notre Dame, USA
Short Talk: T Cell Receptor Cross-Reactivity Triggered by Peptide-Specific Conformational Dynamics in an Unligated Peptide/MHC Complex

Tuesday, June 09 | 6:45PM - 7:15PM
Closing Remarks

Speaker 1 of 2
Ivet Bahar, University of Pittsburgh, USA

Tuesday, June 09 | 6:45PM - 7:15PM
Closing Remarks

Speaker 2 of 2
Lila M. Gierasch, University of Massachusetts Amherst, USA

Tuesday, June 09 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Crestone Peak


Tuesday, June 09 | 8:00PM - 11:00PM
Entertainment
Room: Crestone Peak


Tuesday, June 09 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone Peak


Wednesday, June 10 | 10:25AM - 10:25AM
Departure


*Session Chair.