Web Desc
TH17 Cells in Health and Disease
Organizer(s): Chen Dong, Vijay Kuchroo and Brigitta Stockinger
Date: February 05 - 10, 2009
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
T lymphocytes are important mediators of autoimmune diseases and their tolerance to self-antigens is tightly regulated. Regulatory T (Treg) cells maintain immune tolerance. Recently, a novel subset of CD4+ T cells that produce IL-17 (named Th17) has been identified and shown to be highly pathogenic in many autoimmune diseases. Surprisingly, there appears to be a reciprocal relationship between Th17 and Treg cells in their generation, and function. Therefore, T cell biology needs to be further re-examined in the context of molecular pathways that are required for their generation, mechanisms that are involved in their antagonism and function. The goal of this symposium is to bring the leaders in the field together to assess the increased complexity in the generation of pathogenic and regulatory T cells at the cellular, molecular and organismal levels and discuss the potential impact of these new findings on the development of treatments of human autoimmune diseases.
Scholarship Deadline: October 6 2008
Discounted Abstract Deadline: October 6 2008
Abstract Deadline: November 6 2008
Discounted Registration Deadline: December 5 2008
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research

ZymoGenetics, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI081325-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 05 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Thursday, February 05 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Thursday, February 05 | 7:30PM - 8:30PM
Keynote Address
Room: British Ballroom

Speaker 1 of 2
* Chen Dong, Tsinghua University, China

Thursday, February 05 | 7:30PM - 8:30PM
Keynote Address
Room: British Ballroom

Speaker 2 of 2
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Helper T Cell Differentiation and Autoimmunity

Friday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Columbia Ballroom


Friday, February 06 | 8:00AM - 11:00AM
Cytokines and TH17 Differentiation
Room: British Ballroom

Speaker 1 of 5
* Brigitta Stockinger, Francis Crick Institute, UK

Friday, February 06 | 8:00AM - 11:00AM
Cytokines and TH17 Differentiation
Room: British Ballroom

Speaker 2 of 5
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
IL-23 and TH17 Regulation

Friday, February 06 | 8:00AM - 11:00AM
Cytokines and TH17 Differentiation
Room: British Ballroom

Speaker 3 of 5
Marc Veldhoen, Faculdade de Medicina da Universidade de Lisboa Avenida, Portugal
Modulation of Th17 Differentiation and Function

Friday, February 06 | 8:00AM - 11:00AM
Cytokines and TH17 Differentiation
Room: British Ballroom

Speaker 4 of 5
Christopher A. Hunter, University of Pennsylvania, USA
IL-27 and Th17 Regulation

Friday, February 06 | 8:00AM - 11:00AM
Cytokines and TH17 Differentiation
Room: British Ballroom

Speaker 5 of 5
Ed C. Lavelle, Trinity College Dublin, Ireland
Promotion of IL-1 and TH17 Cells using Vaccine Adjuvants

Friday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, February 06 | 11:00AM - 11:00AM
On Own for Lunch


Friday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Columbia Ballroom


Friday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia Ballroom


Friday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, February 06 | 5:00PM - 7:00PM
IL-17 Signaling
Room: British Ballroom

Speaker 1 of 4
* Jay K. Kolls, Tulane School of Medicine, USA

Friday, February 06 | 5:00PM - 7:00PM
IL-17 Signaling
Room: British Ballroom

Speaker 2 of 4
Sarah L. Gaffen, University of Pittsburgh, USA
Mechanisms of IL-17 Receptor Signaling

Friday, February 06 | 5:00PM - 7:00PM
IL-17 Signaling
Room: British Ballroom

Speaker 3 of 4
Steve D. Levin, Alpine Immune Sciences, USA
Identification of the IL-17 Receptor Related Molecule, IL-17RC as the Receptor for IL-17F

Friday, February 06 | 5:00PM - 7:00PM
IL-17 Signaling
Room: British Ballroom

Speaker 4 of 4
Reen Wu, University of California, Davis, USA
IL-17 and Airway Mucosal Immunity

Friday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom


Friday, February 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Columbia Ballroom


Saturday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Columbia Ballroom


Saturday, February 07 | 7:00AM - 8:00AM
Poster Setup
Room: Columbia Ballroom


Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 1 of 6
* Casey T. Weaver, University of Alabama at Birmingham, USA

Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 2 of 6
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Reciprocal Relationship between CD4+, Fox-P3+ T-reg and Proinflammatory Th17 Cells

Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 3 of 6
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Controlling Tolerance and Protective Immunity from the Outside In

Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 4 of 6
Joan Goverman, University of Washington, USA
Th17/Th1 Ratios Shape Neuroinflammatory Responses

Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 5 of 6
Marie Wahren-Herlenius, Karolinska Institute, Sweden
Short Talk: Ro52 and TH17-Mediated Skin Inflammation

Saturday, February 07 | 8:00AM - 11:00AM
Treg, TH17 and Autoimmunity
Room: British Ballroom

Speaker 6 of 6
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Short Talk: Innate Immune Recognition of Infected Apoptotic Cells Directs TH17 Cell Differentiation

Saturday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, February 07 | 11:00AM - 12:00PM
Lunch
Room: Columbia Ballroom


Saturday, February 07 | 12:00PM - 2:30PM
Poster Session 2
Room: Columbia Ballroom


Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 1 of 8
* Rachel R. Caspi, NEI, National Institutes of Health, USA

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 2 of 8
Koji Atarashi, Research Center for Allergy & Immunology, RIKEN, Japan
Lamina Propria TH17 Cell Differentiation is Controlled by ATP Derived from Commensal Bacteria

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 3 of 8
Song Guo Zheng, University of Southern California, USA
Neither Smad2 or Smad3 is Essential for TGF-â to Induce Foxp3+ Tregs and Th17

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 4 of 8
Alessandra Pernis, Weill Cornell Medicine, USA
IBP (IRF-4 Binding Protein) Inhibits IL-17 and IL-21 Production by Controlling IRF-4 Function

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 5 of 8
Elisabetta Volpe, European Centre for Brain Research, Santa Lucia Foundation, Italy
A Multiparametric Analysis of Cytokine-Driven Human Th17 Differentiation

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 6 of 8
Kojiro Sato, Saitama Medical University, Japan
Proto-Oncogene MAF Plays an Important Role in Th17-Cell Differentiation

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 7 of 8
Andrew M. Jackson, University of Nottingham, UK
Interleukin-17 Expression in Human Tumours: Association with Survival and Cancer Invasiveness

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 1: Regulation of TH17 Cells
Room: British Ballroom

Speaker 8 of 8
Luis Alejandro Zúñiga, Merck, USA
IL17A Moderates Adipocyte Lipid Accumulation in vitro and Obesity in vivo, and is Expressed by gammadelta T-Cells in Fat

Saturday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, February 07 | 5:00PM - 7:00PM
Human TH17 Cells
Room: British Ballroom

Speaker 1 of 4
* Dan R. Littman, HHMI/New York University School of Medicine, USA

Saturday, February 07 | 5:00PM - 7:00PM
Human TH17 Cells
Room: British Ballroom

Speaker 2 of 4
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human TH17 Differentiation

Saturday, February 07 | 5:00PM - 7:00PM
Human TH17 Cells
Room: British Ballroom

Speaker 3 of 4
Rene de Waal Malefyt, Merck Research Labs, USA
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

Saturday, February 07 | 5:00PM - 7:00PM
Human TH17 Cells
Room: British Ballroom

Speaker 4 of 4
David A. Hafler, Yale University School of Medicine, USA
Natural Human CD4+CD25high Tregs and Th17 Effector Cells


Saturday, February 07 | 7:00PM - 7:00PM
On Own for Dinner


Sunday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Columbia Ballroom


Sunday, February 08 | 8:00AM - 11:00AM
Molecular Control of TH17 Cells
Room: British Ballroom

Speaker 1 of 5
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Sunday, February 08 | 8:00AM - 11:00AM
Molecular Control of TH17 Cells
Room: British Ballroom

Speaker 2 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
RORgammat and TH17 Differentiation

Sunday, February 08 | 8:00AM - 11:00AM
Molecular Control of TH17 Cells
Room: British Ballroom

Speaker 3 of 5
Michael Lohoff, University of Marburg, Germany
The Role of the Transcription Factor IRF4 for T Helper Cell Differentiation

Sunday, February 08 | 8:00AM - 11:00AM
Molecular Control of TH17 Cells
Room: British Ballroom

Speaker 4 of 5
John J. O'Shea, NIAMS, National Institutes of Health, USA
STATs and T Cell Differentiation

Sunday, February 08 | 8:00AM - 11:00AM
Molecular Control of TH17 Cells
Room: British Ballroom

Speaker 5 of 5
Gang Pei, TongJi University, China
A microRNA mediated Regulation of Th17 Cell Differentiation Contributes to Multiple Sclerosis

Sunday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, February 08 | 11:00AM - 11:00AM
On Own for Lunch


Sunday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Columbia Ballroom


Sunday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbia Ballroom


Sunday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, February 08 | 5:00PM - 7:00PM
TH17 in Mucosal Immunity
Room: British Ballroom

Speaker 1 of 4
* Wenjun Ouyang, Amgen, Inc., USA

Sunday, February 08 | 5:00PM - 7:00PM
TH17 in Mucosal Immunity
Room: British Ballroom

Speaker 2 of 4
Casey T. Weaver, University of Alabama at Birmingham, USA
TH17 Cell and Intestinal Inflammation

Sunday, February 08 | 5:00PM - 7:00PM
TH17 in Mucosal Immunity
Room: British Ballroom

Speaker 3 of 4
Andrea M. Cooper, University of Leicester, UK
Protection versus Pathogenesis in Tuberculosis, the Role of IL-17, IL-23 and IL-27

Sunday, February 08 | 5:00PM - 7:00PM
TH17 in Mucosal Immunity
Room: British Ballroom

Speaker 4 of 4
Jay K. Kolls, Tulane School of Medicine, USA
Th17 Cells and Cytokines: Roles in Mucosal Immunity and Chronic Inflammation

Sunday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom


Sunday, February 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Columbia Ballroom


Monday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Columbia Ballroom


Monday, February 09 | 8:00AM - 11:00AM
TH17 Cytokines
Room: British Ballroom

Speaker 1 of 5
* Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA

Monday, February 09 | 8:00AM - 11:00AM
TH17 Cytokines
Room: British Ballroom

Speaker 2 of 5
Yoichiro Iwakura, Institute of Medical Science, University of Tokyo, Japan
The Roles of IL-17A and IL-17F in the Immune System

Monday, February 09 | 8:00AM - 11:00AM
TH17 Cytokines
Room: British Ballroom

Speaker 3 of 5
Wenjun Ouyang, Amgen, Inc., USA
The Roles of Th17 Cytokine IL-22 and IL-17 in Autoimmune and Infectious Diseases

Monday, February 09 | 8:00AM - 11:00AM
TH17 Cytokines
Room: British Ballroom

Speaker 4 of 5
Chen Dong, Tsinghua University, China
Regulation and Function of TH17 Cells

Monday, February 09 | 8:00AM - 11:00AM
TH17 Cytokines
Room: British Ballroom

Speaker 5 of 5
Deborah Ann Young, Wyeth Research, USA
IL-22: A Th17 Cytokine Contributes to Chronic Skin Inflammation

Monday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, February 09 | 11:00AM - 11:00AM
On Own for Lunch


Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 1 of 8
* Sarah L. Gaffen, University of Pittsburgh, USA

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 2 of 8
Christopher Crowe, University of Pittsburgh, USA
Critical Role for IL-17RA Signaling in Immunopathology of Influenza Infection

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 3 of 8
Gaia Codolo, University of Padua, Italy
NapA of Borrelia Burgdorferi Drives Th17 Inflammation in Lyme Arthritis

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 4 of 8
Meena S. Kumar, Emory University, USA
Interleukin 17 Modulates Expression of Inflammatory Markers in Vascular Cells and Promotes the Late Phase of Angiotensin II Induced Hypertension In Vivo

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 5 of 8
Christine Delprat, CNRS5239, France
IL-17A Induces Cell Fusion and a New Anti Mycobacterium Program in GM-CSF-Stimulated Monocyte-Derived Dendritic Cells

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 6 of 8
Marika C. Kullberg, Centre for Immunology and Infection, University of York, UK
Th17 Cells in Helicobacter Hepaticus-Induced Intestinal Inflammation

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 7 of 8
Cintia S. De Paiva, Cullen Eye Institute, Baylor College of Medicine, USA
Neutralization of IL-17 Ameliorates Desiccating Stress-Induced Corneal Barrier Dysfunction

Monday, February 09 | 2:30PM - 4:30PM
Workshop 2: Novel Function of TH17 Cells/IL-17
Room: British Ballroom

Speaker 8 of 8
Manuela Raffatellu, University of California, San Diego, USA
Lipocalin-2, an IL-17 and IL-22-Induced Antimicrobial Peptide, is a Host Defense Exploited by Salmonella Typhimurium to Colonize the Inflamed Gut

Monday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, February 09 | 5:00PM - 7:00PM
Targeting TH17 in Clinics
Room: British Ballroom

Speaker 1 of 4
* Chen Dong, Tsinghua University, China

Monday, February 09 | 5:00PM - 7:00PM
Targeting TH17 in Clinics
Room: British Ballroom

Speaker 2 of 4
Michael Elliott, Centocor Inc., USA
Targeting IL-12/23 p40 in Autoimmune Disease

Monday, February 09 | 5:00PM - 7:00PM
Targeting TH17 in Clinics
Room: British Ballroom

Speaker 3 of 4
Tadamitsu Kishimoto, Osaka University, Japan
Anti-IL6 Receptor, TH17 and Arylhydrocarbon Receptor

Monday, February 09 | 5:00PM - 7:00PM
Targeting TH17 in Clinics
Room: British Ballroom

Speaker 4 of 4
Dhavalkumar D. Patel, UCB S.A., Belgium
Inhibition of IL-17A in Psoriasis

Monday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Columbia Ballroom


Monday, February 09 | 8:00PM - 11:00PM
Entertainment
Room: Columbia Ballroom


Monday, February 09 | 8:00PM - 11:00PM
Cash Bar
Room: Columbia Ballroom


Tuesday, February 10 | 10:25AM - 10:25AM
Departure


*Session Chair.