Web Desc
Complications of Diabetes and Obesity
joint with Dissecting the Vasculature: Function, Molecular Mechanisms and Malfunction
Organizer(s): Ann Marie Schmidt, George L. King and Thomas M. Coffman
Date: February 24 - March 01, 2009
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Pfizer Global Research & Development
Summary of Meeting:
The complications of diabetes and obesity are emerging as major health problems in the United States and world-wide. Obesity-linked complications may lead to the development of insulin resistance and, ultimately, hyperglycemia. Thus, the study of mechanisms underlying and linking these disorders holds promise for the identification of mechanism-targeted therapeutic agents. In addition to frank and often destructive recruitment of immune responses, diabetes and obesity are significantly modified by host and environment factors. Such factors as hypertension, innate aging, failure of effective pro- or anti- angiogenesis programs, genetic and epigenetic factors may influence the phenotype and outcome in diabetes and obesity. The goals of the meeting will be to integrate these concepts in close collaboration with the “Dissecting the Vasculature” concurrent meeting group. Beginning with the vessel, and addressing superimposed and modifying factors, this program will facilitate greater understanding of mechanisms linked to diabetes and its complications and obesity.
Scholarship Deadline: October 23 2008
Discounted Abstract Deadline: October 23 2008
Abstract Deadline: November 25 2008
Discounted Registration Deadline: December 29 2008
We gratefully acknowledge additional support for this conference from:
ALPCO DiagnosticsJDRFLilly Singapore Centre for Drug DiscoveryPfizer Global Research & Development
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-03
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 24 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Tuesday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: Pacific Ballroom


Tuesday, February 24 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 1 of 3
* William F. Jackson, Michigan State University, USA

Tuesday, February 24 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 2 of 3
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Tuesday, February 24 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 3 of 3
Joseph Loscalzo, Brigham and Women's Hospital, Harvard Medical School, USA
Redox Dysregulation in Vascular Disease

Wednesday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 1 of 6
* Michael A. Brownlee, Albert Einstein College of Medicine, USA
Unifying Mechanisms and the Complications of Diabetes

Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 2 of 6
Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Inflammation and the Complications of Diabetes

Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 3 of 6
George L. King, Joslin Diabetes Center, USA
Protein Kinase C and the Complications of Diabetes

Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 4 of 6
Adriana Machado-Lima, University of São Paulo, Brazil
Short Talk: Glycated Albumin Isolated from Uncontrolled Type 1 and Type 2 Diabetes Mellitus Patients Impairs Cell Cholesterol Removal and Induces Lipid Accumulation in Macrophages

Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 5 of 6
Paul Fernyhough, St Boniface Research Centre, Canada
Mitochondrial Stress and the Pathogenesis of Diabetic Neuropathy

Wednesday, February 25 | 8:00AM - 11:15AM
Glucose and Other Metabolites: Actions on Target Cells
Room: Columbia Ballroom

Speaker 6 of 6
Bruce A. Perkins, University of Toronto, Canada
Short Talk: Excess Urinary Excretion of Markers of Glycation Predict Subsequent Early Renal Function Decline in Type 1 Diabetes


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 1 of 8
* Jonathan H. Jaggar, University of Tennessee College of Medicine, USA


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 2 of 8
* Michel Feletou, Institut de Recherche Servier, France


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 3 of 8
Brant M. Weinstein, NICHD, National Institutes of Health, USA
Regulation of Developmental Angiogenesis and Lymphangiogenesis


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 4 of 8
Mark S. Taylor, University of South Alabama College of Medicine, USA
Localized Calcium Signaling in the Endothelium


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 5 of 8
Lothar A. Blatter, Rush University Chicago, USA
Calcium and NFAT Signaling in Vascular Endothelial Cells


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 6 of 8
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Intracrine VEGF Signaling in Endothelial Cells


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 7 of 8
Ralf Koehler, Phillips University Marburg, Germany
Short Talk: EDHF-Signaling and Arterial Blood Pressure in Mice Deficient of Endothelial KCa-Channels


Wednesday, February 25 | 8:00AM - 11:00AM
Endothelial Cell Signaling Components
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 8 of 8
Evgenia V. Gerasimovskaya, University of Colorado Denver, USA
Short Talk: PI3K and RhoA/ROCK Pathways Play a Critical Role in Hypoxia-Induced ATP Exocytosis and ATP-induced Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells


Wednesday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, February 25 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Techniques (Joint)
Room: British Columbia Ballroom

Speaker 1 of 4
* Karen Lounsbury, University of Vermont, USA

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Techniques (Joint)
Room: British Columbia Ballroom

Speaker 2 of 4
Paul L. Hermonat, University of Arkansas for Medical Sciences, USA
Viral Gene Therapy Targeting the Vasculature

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Techniques (Joint)
Room: British Columbia Ballroom

Speaker 3 of 4
W. Gil Wier, University of Maryland School of Medicine, USA
Techniques for Imaging Signal Transduction in the Vasculature

Wednesday, February 25 | 2:30PM - 4:30PM
Workshop 1: Techniques (Joint)
Room: British Columbia Ballroom

Speaker 4 of 4
Lloyd P. Aiello, Joslin Diabetes Center, USA
Designing Clinical Trials - The Fruits of Translational Research

Wednesday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Wednesday, February 25 | 5:00PM - 7:00PM
Insulin Resistance and Actions
Room: Columbia Ballroom

Speaker 1 of 4
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Actions and Cardiovascular Pathologies

Wednesday, February 25 | 5:00PM - 7:00PM
Insulin Resistance and Actions
Room: Columbia Ballroom

Speaker 2 of 4
Michael J. Quon, National Institutes of Health, USA
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: From Cells to Humans


Wednesday, February 25 | 5:00PM - 7:00PM
Insulin Resistance and Actions
Room: Columbia Ballroom

Speaker 3 of 4
Nir Barzilai, Albert Einstein College of Medicine, USA
Aging and Insulin Resistance

Wednesday, February 25 | 5:00PM - 7:00PM
Insulin Resistance and Actions
Room: Columbia Ballroom

Speaker 4 of 4
Manuel Roman Benito, Universidad de Complutense, Spain
Short Talk: Compensated and Non-Compensated Insulin Resistance Induces Differential Cardiovascular Damage in Obese BATIRKO Mice

Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 1 of 6
* Mark S. Taylor, University of South Alabama College of Medicine, USA


Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 2 of 6
* Richard A. Cohen, Boston University School of Medicine, USA


Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 3 of 6
Sarah Y. Yuan, University of California, Davis, USA
Endothelial Junction and Vascular Permeability


Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 4 of 6
Michel Feletou, Institut de Recherche Servier, France
The Endothelium as a Target for Drug Development


Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 5 of 6
Wolfgang F. Graier, Medical University of Graz, Austria
Endothelial Mitochondria as Key Players for Endothelial Cell Function and Dysfunction


Wednesday, February 25 | 5:00PM - 7:00PM
Endothelial Cell Interactions and Targeting
This session is from Vasculature
Room: British Ballroom
The Endothelial Cell: New Molecules and Markers
Speaker 6 of 6
Caroline Cheng, Erasmus Medical Center, Netherlands
Short Talk: Functional Analysis of a Newly Identified Regulator of New Vessel Formation “EGIP”


Wednesday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, February 26 | 7:00AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 1 of 6
Anthony W. Ferrante, Columbia University, USA
Inflammatory Mechanisms and Obesity

Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 2 of 6
Ajay Chawla, Merck Research Labs, USA
Macrophage Activation, Obesity and Insulin Resistance

Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 3 of 6
* Douglas Golenbock, University of Massachusetts Medical School, USA
Toll Like Receptors - Linking Innate and Adaptive Immunity

Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 4 of 6
Ishwarlal Jialal, University of California, Davis, USA
Diabetes (both Type 1 & 2) is a Pro-Inflammatory State?

Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 5 of 6
Patricia W. Bedard, Pfizer, USA
Short Talk: CX3CR1 Contributes to Adipose Tissue Macrophage Infiltration and Insulin Resistance on a High Fat, High Sucrose Diet

Thursday, February 26 | 8:00AM - 11:15AM
Inflammation and Immunity: Links to Diabetes and Obesity
Room: Columbia Ballroom

Speaker 6 of 6
Zhaoyun Zhang, Joslin Diabetes Center, USA
Short Talk: Overexpressing G6PD Reduces Oxidant Stress Induced by High Glucose via PKA Activation in Endothelial Cells

Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 1 of 8
* Julian H. Lombard, Medical College of Wisconsin, USA


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 2 of 8
* Keshari Thakali, Univ of Arkansas for Medical Sciences, USA


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 3 of 8
Mark W. Majesky, University of North Carolina at Chapel Hill, USA
Developmental Origins of Coronary Smooth Muscle


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 4 of 8
Jonathan H. Jaggar, University of Tennessee College of Medicine, USA
Mitochondrial Regulation of Arterial Calcium Signaling and Diameter


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 5 of 8
William F. Jackson, Michigan State University, USA
Vascular Ion Channels: Will the Key Players Please Stand Up?


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 6 of 8
Karen Lounsbury, University of Vermont, USA
Phenotype Switching in Vascular Smooth Muscle Cells: A Complex Interaction between Transcription Factors


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 7 of 8
Prasad V.G Katakam, Wake Forest University Health Sciences, USA
Short Talk: Impaired Mitochondria Dependent Vasodilation in Cerebral Arteries of Zucker Obese Rats with Insulin Resistance


Thursday, February 26 | 8:00AM - 11:15AM
Vascular Smooth Muscle Cell Components and Communicators
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 8 of 8
Magdalena M. Szewczyk, McMaster University, Canada
Short Talk: Inhibitors Bioengineered to Inhibit Different Isoforms of Plasma Membrane Ca2+ Pumps in Vascular Smooth Muscle and Endothelium


Thursday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Thursday, February 26 | 11:15AM - 12:00PM
Lunch
Room: Pacific Ballroom


Thursday, February 26 | 12:00PM - 2:30PM
Poster Session 2
Room: Pacific Ballroom


Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 1 of 7
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 2 of 7
* Nancy J. Rusch, University of Arkansas for Medical Sciences, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 3 of 7
Cristina Rabadan-Diehl, NHLBI, National Institutes of Health, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 4 of 7
Ronald A. Kohanski, NIA, National Institutes of Health, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 5 of 7
Teresa Jones, NIDDK, National Institutes of Health, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 6 of 7
R. Clinton Webb, Georgia Regents University, USA

Thursday, February 26 | 2:30PM - 4:30PM
Workshop 2: Funding for the Young Cardiovascular and Diabete
s Investigator (Joint)
Room: British Columbia Ballroom

Speaker 7 of 7
Barbara Araneo, Novo Nordisk, USA

Thursday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Thursday, February 26 | 5:00PM - 7:00PM
Regeneration and Diabetes
Room: Columbia Ballroom

Speaker 1 of 4
Douglas Zochodne, University of Calgary, Canada
Diabetes and Regenerative Failure of Peripheral Neurons

Thursday, February 26 | 5:00PM - 7:00PM
Regeneration and Diabetes
Room: Columbia Ballroom

Speaker 2 of 4
* Martin Friedlander, The Scripps Research Institute, USA
Cell-Based Therapies for Diabetic Retinopathy

Thursday, February 26 | 5:00PM - 7:00PM
Regeneration and Diabetes
Room: Columbia Ballroom

Speaker 3 of 4
Omaida C. Velazquez, University of Miami, Jackson Memorial Hospital, USA
The Potential Role of Hyperoxia and Endothelial Progenitor Cell Mobilization in Diabetic Wound Healing

Thursday, February 26 | 5:00PM - 7:00PM
Regeneration and Diabetes
Room: Columbia Ballroom

Speaker 4 of 4
Alex Chen, University of Pittsburgh, USA
Short Talk: Restoration of Endothelial Progenitor Cell Function with Manganese Superoxide Dismutase Gene Transfer in Type 2 Diabetic Wound Healing

Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 1 of 6
* Frank Chip Brosius III, University of Michigan, USA


Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 2 of 6
* Lothar A. Blatter, Rush University Chicago, USA


Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 3 of 6
Richard J. Paul, University of Cincinnati College of Medicine, USA
It’s Not Just [Ca2+]i Anymore or Rho, ROS and Hypoxic Vasorelaxation


Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 4 of 6
R. Clinton Webb, Georgia Regents University, USA
New Insights into Mechanisms of Vascular Contraction: STIM-1/Orai-1 Pathway and Vascular Dysfunction


Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 5 of 6
W. Gil Wier, University of Maryland School of Medicine, USA
Genetically Encoded FRET-Based Sensors Allow Visualization of Signal Transduction in Individual Cells of Intact Arteries


Thursday, February 26 | 5:00PM - 7:00PM
New Insights into Mechanisms of Vascular Contraction
This session is from Vasculature
Room: British Ballroom
Vascular Smooth Muscle Cell Dissection: From Birth to Function
Speaker 6 of 6
Zachary P. Neeb, Indiana University School of Medicine, USA
Short Talk: Store-Operated Ca2+ Influx in Coronary Smooth Muscle Cells Predicts Coronary Atherosclerosis in the Metabolic Syndrome


Thursday, February 26 | 7:00PM - 7:00PM
On Own for Dinner


Friday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 1 of 6
Lloyd P. Aiello, Joslin Diabetes Center, USA
Novel Targets and Treatments for Diabetic Retinopathy and Macular Edema

Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 2 of 6
Kumar Sharma, USA
A Systems Biology Understanding of Diabetic Nephropathy Based on Novel Anti-Fibrosis Treatments and Biomarkers

Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 3 of 6
* Ravichandran Ramasamy, New York University School of Medicine, USA
Aldose Reductase & Rage: Key Targets for Cardioprotective Interventions in Diabetes

Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 4 of 6
Nobuyo Maeda, University of North Carolina, USA
Antioxidant Defense against Diabetic Cardiovascular Disease

Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 5 of 6
Lokesh Kumar Bhatt, School of Pharmacy and Technology Management, India
Short Talk: Enhancement of MMP2 and MMP9 Inhibition in Presence of Aspirin, a COX Inhibitor: A New Therapeutic Approach in Treatment of Diabetic Neuropathy

Friday, February 27 | 8:00AM - 11:15AM
Novel Targets and Treatments for Diabetes and its Complicati
ons

Room: Columbia Ballroom

Speaker 6 of 6
Jia Liu, Joslin Diabetes Center, USA
Short Talk: Plasma Kallikrein Exacerbates Intracerebral Hemorrhage Expansion in Diabetic Rats

Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 1 of 8
* David Robertson, Vanderbilt University Medical Center, USA


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 2 of 8
* William F. Jackson, Michigan State University, USA


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 3 of 8
Jessica Andrea Filosa, Georgia Regents University, USA
Interpreting the Communication between Cerebral Microvessels and Astrocytes in the Brain


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 4 of 8
Ronald J. Korthuis, University of Missouri, USA
Postischemic Arteriolar Dysfunction is Dependent on Venular Leukocyte Adhesion and Mast Cells: Role of Cell-Cell Communication


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 5 of 8
Brant Isakson, University of Virginia, USA
Coordinated Function of Endothelial and Vascular Smooth Muscle Cells


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 6 of 8
Gregory Fink, Michigan State University, USA
Arteries and Veins: Substrates for Disparate But Integrated Sympathetic Control


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 7 of 8
Cécile Fligny, INSERM, France
Short Talk: Are Pericytes Responsible for Renal Interstitial Fibrosis through Transglutaminase-Mediated Collagen Assembly?


Friday, February 27 | 8:00AM - 11:15AM
Influences of Neighboring Cells on Vascular Smooth Muscle Fu
nction
This session is from Vasculature

Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 8 of 8
Lisa A. Lesniewski, University of Colorado, Boulder, USA
Short Talk: Age-Associated Endothelial Dysfunction is Associated with IKKbeta-Mediated Reductions in FoxO3a Activity and MnSOD Expression


Friday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, February 27 | 11:15AM - 11:15AM
On Own for Lunch


Friday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Vancouver Island Room


Friday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, February 27 | 5:00PM - 7:00PM
Cellular Mechanisms, Shaping the Nature and Severity of Comp
lications

Room: Columbia Ballroom

Speaker 1 of 4
Erwin P. Böttinger, Hasso-Plattner-Institut für Digital Engineering GmbH, Germany
Impact of Podocyte Injury in Diabetes

Friday, February 27 | 5:00PM - 7:00PM
Cellular Mechanisms, Shaping the Nature and Severity of Comp
lications

Room: Columbia Ballroom

Speaker 2 of 4
Thomas M. Coffman, NUS Duke Singapore, Singapore
Impact of Hypertension and the Renin-Angiotensin System

Friday, February 27 | 5:00PM - 7:00PM
Cellular Mechanisms, Shaping the Nature and Severity of Comp
lications

Room: Columbia Ballroom

Speaker 3 of 4
* Geoffrey C. Gurtner, Stanford University, USA
Impaired Neovascularization in Diabetes and Aging

Friday, February 27 | 5:00PM - 7:00PM
Cellular Mechanisms, Shaping the Nature and Severity of Comp
lications

Room: Columbia Ballroom

Speaker 4 of 4
Sandeep Raha, Hamilton Health Services, Canada
Short Talk: Maternal Obesity Results in Placental Mitochondrial Dysfunction and Compromised Neonatal Health

Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 1 of 6
* Gregory Fink, Michigan State University, USA


Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 2 of 6
* Nancy J. Rusch, University of Arkansas for Medical Sciences, USA


Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 3 of 6
David Robertson, Vanderbilt University Medical Center, USA
Human Phenotypes and Animal Knockout Models of Genetic Autonomic Disorders


Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 4 of 6
Paul L. Hermonat, University of Arkansas for Medical Sciences, USA
Viral Delivery of Therapeutic Genes for Vascular Pathologies


Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 5 of 6
David D. Gutterman, Medical College of Wisconsin, USA
Human Microvascular Function in Disease: Mechanistic Insights


Friday, February 27 | 5:00PM - 7:00PM
Synthesis of the Whole Vessel
This session is from Vasculature
Room: British Ballroom
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
Speaker 6 of 6
Hema Raina, University of Maryland, USA
Short Talk: Sympathetic Nerve Activity Enhances, and Endothelium Inhibits, the Vasoconstrictor Effect of Low-Dose Ouabain


Friday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Saturday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 1 of 8
* Ronald J. Korthuis, University of Missouri, USA

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 2 of 8
* Thomas M. Coffman, NUS Duke Singapore, Singapore

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 3 of 8
Susan Quaggin, Northwestern University, USA
Angiogenesis and Diabetic Nephropathy

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 4 of 8
Maria B. Grant, University of Florida, USA
Vascular Repair Strategies for Diabetic Retinopathy- Mobilization and Differentiation of Hematopoietic Stem Cell by IGFBP-3

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 5 of 8
Geert W. Schmid-Schönbein, University of California, San Diego, USA
A Molecular Mechanism for Blood Pressure Elevation, Type II Diabetes, Immune Suppression and Microvascular Rarefaction in the Spontaneously Hypertensive Rat

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 6 of 8
Frank Chip Brosius III, University of Michigan, USA
Flipped Signaling: Consequences of Altered Glucose Transporter Expression in Vascular Cells

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 7 of 8
Julia V. Busik, Michigan State University, USA
Short Talk: Inhibition of Sphingomyelinases Protects from Inflammation, Vascular Degeneration and Neovascularization in Retinopathy Animal Models

Saturday, February 28 | 8:00AM - 11:15AM
Hypertension and Angiogenesis - Responses to Vascular Injury
/Genomics - Disease Models and Human Genomics (Joint)

Room: British Columbia Ballroom

Speaker 8 of 8
David A. Antonetti, University of Michigan, USA
Short Talk: Atypical PKC Inhibitors Block both VEGF and TNF alpha Induced Endothelial Permeability

Saturday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, February 28 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, February 28 | 5:00PM - 7:00PM
Genetics and Epigenetics
Room: Columbia Ballroom

Speaker 1 of 4
* John Sedor, Case Western Reserve School of Medicine, USA
Genetics of Diabetic Nephropathy

Saturday, February 28 | 5:00PM - 7:00PM
Genetics and Epigenetics
Room: Columbia Ballroom

Speaker 2 of 4
Rama Natarajan, Beckman Research Institute of City of Hope, USA
Epigenetics, Metabolic Memory, Inflammation and Diabetic Complications

Saturday, February 28 | 5:00PM - 7:00PM
Genetics and Epigenetics
Room: Columbia Ballroom

Speaker 3 of 4
Juro Sakai, University of Tokyo, Japan
Short Talk: PPARgamma/RXRalpha Heterodimer Induces Histone Modification Enzyme PR-Set7/Setd8 and Promotes Adipogenesis through a Positive Feedback Loop

Saturday, February 28 | 5:00PM - 7:00PM
Genetics and Epigenetics
Room: Columbia Ballroom

Speaker 4 of 4
Monika A. Niewczas, Joslin Diabetes Center, USA
Short Talk: TNF alpha Related Markers Predict Glomerular Filtration Rate (GFR) Decline but not an Increase in Urinary Albumin Excretion in Patients with Early Diabetic Nephropathy: Results of a Prospective Study

Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 1 of 6
* David D. Gutterman, Medical College of Wisconsin, USA


Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 2 of 6
* R. Clinton Webb, Georgia Regents University, USA


Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 3 of 6
Andrea D. Eckhart, Thomas Jefferson University, USA
Novel Mouse Models for Studying Vascular Contributions to Hypertension


Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 4 of 6
Nancy J. Rusch, University of Arkansas for Medical Sciences, USA
Ion Channel Expression and Function in Hypertension


Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 5 of 6
Richard A. Cohen, Boston University School of Medicine, USA
Redox Regulation of SERCA in Diabetic Vascular Disease


Saturday, February 28 | 5:00PM - 7:00PM
Mechanisms and Targeted Treatment of Vascular Pathologies: F
ocus on Hypertension
This session is from Vasculature

Room: British Ballroom
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
Speaker 6 of 6
Julian H. Lombard, Medical College of Wisconsin, USA
Short Talk: Endothelial Dysfunction and Paradoxical Increase in Vascular Oxidative Stress with Angiotensin II Suppression


Saturday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Saturday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Sunday, March 01 | 10:25AM - 10:25AM
Departure


*Session Chair.