Web Desc
Structural Biology and Activation Mechanisms of Membrane Receptors
Organizer(s): Pierre De Meyts, Briony E. Forbes and Tom L. Blundell
Date: September 16 - 21, 2008
Location: St. John's College - Cambridge, University of Cambridge, Cambridge, United Kingdom
Supported by the Directors' Fund
Summary of Meeting:
Considerable progress has been made in understanding the structure and function of membrane receptors and receptor signaling complexes since the first radioligand binding studies nearly four decades ago. The structures of the extracellular domains of many receptors in diverse classes are now available. However, the structural data have not always provided unambiguous information as to what the relevant physiological structure is or the precise nature of the binding and activation mechanism. To get the full picture, it is necessary to integrate structural information, biochemical and molecular biology approaches such as site-directed mutagenesis, photoaffinity crosslinking and bioluminescence resonance energy transfer, kinetics, and mathematical modeling. This symposium brings together experts in these various disciplines, both seasoned and fresh, for an open-minded debate on how to realize this integrative approach. A strong theme of the meeting is that there are more similarities than previously estimated between the mechanisms of activation of various classes of receptors. The study of the biological evolution of the ligand and receptor families and signal transduction mechanisms also provides key information on highly conserved modules. Finally, the promises and challenges in translating our knowledge of the structural biology of membrane receptor signaling to drug discovery will be discussed.
Scholarship Deadline: May 15 2008
Discounted Abstract Deadline: June 17 2008
Abstract Deadline: July 17 2008
Discounted Registration Deadline: July 17 2008
We gratefully acknowledge additional support for this conference from:
BBSRC - Biotechnology & Biological Sciences Research Council, UK
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novo Nordisk A/S
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, September 16 | 3:00PM - 7:30PM
Registration
Room: Palmerston Foyer


Tuesday, September 16 | 6:30PM - 7:30PM
Refreshments
Room: Palmerston Foyer


Tuesday, September 16 | 7:30PM - 9:30PM
Keynote Session
Room: Palmerston

Speaker 1 of 3
* Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark

Tuesday, September 16 | 7:30PM - 9:30PM
Keynote Session
Room: Palmerston

Speaker 2 of 3
Michael C. Lawrence, Walter and Eliza Hall Institute of Medical Research, Australia
Structural Insights into Ligand Binding in the Insulin Receptor Family

Tuesday, September 16 | 7:30PM - 9:30PM
Keynote Session
Room: Palmerston

Speaker 3 of 3
Brian K. Kobilka, Stanford University School of Medicine, USA
Structure and Dynamics of the Human beta 2 Adrenergic Receptor

Wednesday, September 17 | 7:30AM - 8:30AM
Breakfast
Room: The Buttery


Wednesday, September 17 | 7:30AM - 11:30AM
Poster Setup
Room: Castlereigh/Foyer


Wednesday, September 17 | 8:30AM - 11:30AM
Structural Biology of Ligands and Receptors of the Insulin/I
GF Peptide Families

Room: Ballroom 3

Speaker 1 of 5
* Tom L. Blundell, University of Cambridge, UK

Wednesday, September 17 | 8:30AM - 11:30AM
Structural Biology of Ligands and Receptors of the Insulin/I
GF Peptide Families

Room: Ballroom 3

Speaker 2 of 5
Michael A. Weiss, Case Western Reserve University, USA
How Insulin Binds: Studies with Photoaffinity Crosslinking

Wednesday, September 17 | 8:30AM - 11:30AM
Structural Biology of Ligands and Receptors of the Insulin/I
GF Peptide Families

Room: Ballroom 3

Speaker 3 of 5
Jonathan Whittaker, Case Western Reserve University, USA
Insights into Insulin and IGF-I Ligand-Receptor Interactions from Mutational Analysis

Wednesday, September 17 | 8:30AM - 11:30AM
Structural Biology of Ligands and Receptors of the Insulin/I
GF Peptide Families

Room: Ballroom 3

Speaker 4 of 5
Briony E. Forbes, University of Adelaide, Australia
IGF Structural Determinants Involved in Receptor and Binding Protein Binding

Wednesday, September 17 | 8:30AM - 11:30AM
Structural Biology of Ligands and Receptors of the Insulin/I
GF Peptide Families

Room: Ballroom 3

Speaker 5 of 5
Yvonne Yvonne Jones, University of Oxford, UK
Crystal Structure of the IGF-II/Mannose-6-Phosphate Receptor Complex

Wednesday, September 17 | 9:40AM - 10:00AM
Coffee Break
Room: Palmerston Foyer


Wednesday, September 17 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Wednesday, September 17 | 12:30PM - 2:30PM
Poster Session 1
Room: Castlereigh/Foyer


Wednesday, September 17 | 2:30PM - 4:30PM
Workshop 1: New Structures or Structural Aspects
Room: Ballroom 3

Speaker 1 of 5
Brian M. Baker, University of Notre Dame, USA
T Cell Receptor Cross-Reactivity via Cooperative Conformational Plasticity

Wednesday, September 17 | 2:30PM - 4:30PM
Workshop 1: New Structures or Structural Aspects
Room: Ballroom 3

Speaker 2 of 5
* Tim R. Hercus, University of South Australia and SA Pathology, Australia
The Structure of the GM-CSF Receptor Complex Reveals a New Mode of Cytokine Receptor Activation

Wednesday, September 17 | 2:30PM - 4:30PM
Workshop 1: New Structures or Structural Aspects
Room: Ballroom 3

Speaker 3 of 5
† Jonathan K. Tyzack, Trends in Biochemical Sciences, UK
Dragging (and Zooming and Rotating) Publication of 3D Molecular Structures into the 21st Century

Wednesday, September 17 | 2:30PM - 4:30PM
Workshop 1: New Structures or Structural Aspects
Room: Ballroom 3

Speaker 4 of 5
Marie Parat, University of Montreal, Canada
Molecular Analysis of Natriuretic Peptide Receptor: A Transmembrane Signal Transduction

Wednesday, September 17 | 2:30PM - 4:30PM
Workshop 1: New Structures or Structural Aspects
Room: Ballroom 3

Speaker 5 of 5
Lennart Zabeau, Ghent University, Belgium
A Model for a Hexameric 2:4 Leptin:Leptin Receptor Complex

Wednesday, September 17 | 4:30PM - 5:00PM
Coffee Available
Room: Palmerston Foyer


Wednesday, September 17 | 5:00PM - 7:00PM
Evolution of the Insulin/IGF Receptor Systems
Room: Ballroom 3

Speaker 1 of 4
* Donald F. Steiner, University Of Chicago, USA

Wednesday, September 17 | 5:00PM - 7:00PM
Evolution of the Insulin/IGF Receptor Systems
Room: Ballroom 3

Speaker 2 of 4
Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark
Structure, Function and Evolution of Ligands and Receptors of the Insulin Peptide Family

Wednesday, September 17 | 5:00PM - 7:00PM
Evolution of the Insulin/IGF Receptor Systems
Room: Ballroom 3

Speaker 3 of 4
Shu-Jin Chan, University Of Chicago, USA
Where Insulin Binds: Mapping Contact Points in the Insulin:Insulin Receptor Complex

Wednesday, September 17 | 5:00PM - 7:00PM
Evolution of the Insulin/IGF Receptor Systems
Room: Ballroom 3

Speaker 4 of 4
Robert S. Garofalo, USA
Insulin Receptors and Signaling in Drosophila

Wednesday, September 17 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, September 18 | 7:30AM - 8:30AM
Breakfast
Room: The Buttery


Thursday, September 18 | 8:30AM - 11:30AM
From Receptor Structure to Activation Mechanism
Room: Ballroom 3

Speaker 1 of 4
* Joseph Schlessinger, Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Thursday, September 18 | 8:30AM - 11:30AM
From Receptor Structure to Activation Mechanism
Room: Ballroom 3

Speaker 2 of 4
Michael J. Waters, University of Queensland, Australia
The Mechanism of Growth Hormone Receptor Activation Revisited

Thursday, September 18 | 8:30AM - 11:30AM
From Receptor Structure to Activation Mechanism
Room: Ballroom 3

Speaker 3 of 4
Krzysztof Palczewski, Case Western Reserve University, USA
Oligomerization and Activation of GPCRs: Insights from Rhodopsin Structures

Thursday, September 18 | 8:30AM - 11:30AM
From Receptor Structure to Activation Mechanism
Room: Ballroom 3

Speaker 4 of 4
Wayne A. Hendrickson, Columbia University, USA
Dimeric Associations in G-Protein Coupled Receptors

Thursday, September 18 | 9:40AM - 10:00AM
Coffee Break
Room: Palmerston Foyer


Thursday, September 18 | 11:30AM - 11:30AM
On Own for Lunch


Thursday, September 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Palmerston Foyer


Thursday, September 18 | 5:00PM - 7:00PM
The Proximal Steps of Receptor Activation and Signaling
Room: Ballroom 3

Speaker 1 of 4
* Kenneth Siddle, University of Cambridge, UK

Thursday, September 18 | 5:00PM - 7:00PM
The Proximal Steps of Receptor Activation and Signaling
Room: Ballroom 3

Speaker 2 of 4
Linda J. Pike, Washington University School of Medicine, USA
Negative Cooperativity in EGF Receptor Signaling

Thursday, September 18 | 5:00PM - 7:00PM
The Proximal Steps of Receptor Activation and Signaling
Room: Ballroom 3

Speaker 3 of 4
Stevan R. Hubbard, New York University School of Medicine, USA
Mechanisms of Protein Recruitment to the Insulin Receptor

Thursday, September 18 | 5:00PM - 7:00PM
The Proximal Steps of Receptor Activation and Signaling
Room: Ballroom 3

Speaker 4 of 4
Tarik Issad, Institut Cochin-Institute de Recherches Biomédicales, France
Dynamics of Insulin and IGF-I Receptor Partnerships using BRET (Bioluminescence Resonance Energy Transfer)

Thursday, September 18 | 7:00PM - 7:00PM
On Own for Dinner


Friday, September 19 | 7:30AM - 8:30AM
Breakfast
Room: The Buttery


Friday, September 19 | 7:30AM - 11:30AM
Poster Setup
Room: Castlereigh/Foyer


Friday, September 19 | 8:30AM - 11:30AM
Structure, Function and Crosstalk of G-Protein-Coupled Recep
tors (GPCRs)

Room: Ballroom 3

Speaker 1 of 5
* Gilbert Vassart, Université Libre de Bruxelles, Belgium

Friday, September 19 | 8:30AM - 11:30AM
Structure, Function and Crosstalk of G-Protein-Coupled Recep
tors (GPCRs)

Room: Ballroom 3

Speaker 2 of 5
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
beta-Arrestin Biased Agonism at Seven Transmembrane Receptors

Friday, September 19 | 8:30AM - 11:30AM
Structure, Function and Crosstalk of G-Protein-Coupled Recep
tors (GPCRs)

Room: Ballroom 3

Speaker 3 of 5
Ross A.D. Bathgate, University of Melbourne, Australia
Structural Relationships of the INSL/Relaxin Ligands and their G-Protein Coupled Receptors

Friday, September 19 | 8:30AM - 11:30AM
Structure, Function and Crosstalk of G-Protein-Coupled Recep
tors (GPCRs)

Room: Ballroom 3

Speaker 4 of 5
Sabine Costagliola, IRIBHM-Université libre de Bruxelles, Belgium
Functional Significance of Oligomerization and Negative Cooperativity in Glycoprotein Hormone Receptors

Friday, September 19 | 8:30AM - 11:30AM
Structure, Function and Crosstalk of G-Protein-Coupled Recep
tors (GPCRs)

Room: Ballroom 3

Speaker 5 of 5
Ilpo Huhtaniemi, Imperial College London, UK
In vivo Validation of LH Receptor Dimerization by Complementation in Knockout Mice

Friday, September 19 | 9:40AM - 10:00AM
Coffee Break
Room: Palmerston Foyer


Friday, September 19 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Friday, September 19 | 12:30PM - 2:30PM
Poster Session 2
Room: Castlereigh/Foyer


Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 1 of 6
* Fariba M. Assadi-Porter, University of Wisconsin-Madison, USA
Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR

Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 2 of 6
Helen L. Attrill, University of Oxford, UK
Characterising The Multimerization Of The Neurotensin Receptor Type I In Model Lipid Membrane Bilayers

Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 3 of 6
Nancy E. Caceres, Ludgwig Institute for Cancer Research, Belgium
Investigating the Stoichiometry of the Active G-CSF Receptor (G-CSFR) Complex by Testing the Activity of coiled coil-G-CSFR Fusion Proteins

Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 4 of 6
Anja Krippner-Heidenreich, University of Newcastle, UK
Efficient Activation of the Tumour Necrosis Factor (TNF) Receptor is Highly Determined by the Stalk Region

Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 5 of 6
Philippe Rondard, Institut de Génomique Fonctionnelle, France
Molecular Functioning of the GABAB Receptor Revealed by Glycan Wedge Scanning

Friday, September 19 | 2:30PM - 4:30PM
Workshop 2: New Methodological Approaches
Room: Ballroom 3

Speaker 6 of 6
Johannes van Agthoven, Biological NMR and Crystallography, France
The Stoichiometry and Stability of the Prolactin/Prolactin Receptor Complex is Influenced by its N-Terminus


Friday, September 19 | 4:30PM - 5:00PM
Coffee Available
Room: Palmerston Foyer


Friday, September 19 | 5:00PM - 7:00PM
From Receptor Activation to Signal Transduction: Quantitativ
e Approaches

Room: Ballroom 3

Speaker 1 of 4
* Ralph A. Bradshaw, University of California-Irvine, USA

Friday, September 19 | 5:00PM - 7:00PM
From Receptor Activation to Signal Transduction: Quantitativ
e Approaches

Room: Ballroom 3

Speaker 2 of 4
Blagoy Blagoev, University of Southern Denmark, Denmark
Quantitative Proteomics: Analysis of Signal Transduction Networks

Friday, September 19 | 5:00PM - 7:00PM
From Receptor Activation to Signal Transduction: Quantitativ
e Approaches

Room: Ballroom 3

Speaker 3 of 4
James Faeder, University of Pittsburgh School of Medicine, USA
Structure-Based Modeling of EGF Receptor Signal Transduction

Friday, September 19 | 5:00PM - 7:00PM
From Receptor Activation to Signal Transduction: Quantitativ
e Approaches

Room: Ballroom 3

Speaker 4 of 4
Yuko Saeki, RIKEN, Genomic Sciences Center, Japan
Crosstalk between Signaling and Transcription Produces Switch-like Response in ErbB Receptor Network

Friday, September 19 | 7:00PM - 7:00PM
On Own for Dinner


Saturday, September 20 | 7:30AM - 8:30AM
Breakfast
Room: The Buttery


Saturday, September 20 | 8:30AM - 11:30AM
Challenges in Structural Biology of Membrane Receptors
Room: Ballroom 3

Speaker 1 of 5
* Wayne A. Hendrickson, Columbia University, USA

Saturday, September 20 | 8:30AM - 11:30AM
Challenges in Structural Biology of Membrane Receptors
Room: Ballroom 3

Speaker 2 of 5
Gebhard F. X. Schertler, Paul Scherrer Institut, Switzerland
Structure of a Conformationally Stabilized beta1 Adrenergic G Protein-Coupled Receptor

Saturday, September 20 | 8:30AM - 11:30AM
Challenges in Structural Biology of Membrane Receptors
Room: Ballroom 3

Speaker 3 of 5
Ulf Skoglund, Karolinska Institutet, Sweden
Studies on Proteins, Membrane Proteins and Receptors using Molecular Electron Tomography

Saturday, September 20 | 8:30AM - 11:30AM
Challenges in Structural Biology of Membrane Receptors
Room: Ballroom 3

Speaker 4 of 5
Milka Vrecl, Univerza v Ljubljani, Slovenia
The Use of Bioluminescence Resonance Energy Transfer 2 (BRET2) to Study G-Protein-Coupled Receptor (GPCR) Partner Interactions

Saturday, September 20 | 8:30AM - 11:30AM
Challenges in Structural Biology of Membrane Receptors
Room: Ballroom 3

Speaker 5 of 5
Marisa Martin-Fernandez, Daresbury Laboratory, UK
ErbB1 Inside-Out Signalling Regulates Global Ectodomain Orientation and Oligomer Topology

Saturday, September 20 | 9:40AM - 10:00AM
Coffee Break
Room: Palmerston Foyer


Saturday, September 20 | 11:30AM - 11:30AM
On Own for Lunch


Saturday, September 20 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Palmerston Foyer


Saturday, September 20 | 5:00PM - 7:00PM
Receptor Structural Biology and Drug Discovery
Room: Ballroom 3

Speaker 1 of 3
Maja Jensen, Plougmann and Vingtoft, Denmark
Allosteric and Biological Properties of Insulin Mimetic and Antagonist Peptides Targeting the Insulin Receptor Binding Sites

Saturday, September 20 | 5:00PM - 7:00PM
Receptor Structural Biology and Drug Discovery
Room: Ballroom 3

Speaker 2 of 3
* Alexander Levitzky, Alexander Silberman Institute of Life Sciences, Israel
Developments in Signal Transduction Therapy of Cancer

Saturday, September 20 | 5:00PM - 7:00PM
Receptor Structural Biology and Drug Discovery
Room: Ballroom 3

Speaker 3 of 3
Tom L. Blundell, University of Cambridge, UK
Targeting Membrane Receptors and Signalling Systems for Drug Discovery

Saturday, September 20 | 7:00PM - 7:30PM
Social Hour
Room: The Hall


Saturday, September 20 | 7:30PM - 8:30PM
Dinner
Room: The Hall


Saturday, September 20 | 8:00PM - 11:00PM
Entertainment
Room: The Hall


Saturday, September 20 | 8:00PM - 11:00PM
Cash Bar
Room: The Hall


Sunday, September 21 | 10:25AM - 10:25AM
Departure


*Session Chair.