Web Desc
Metabolism and Cardiovascular Risk
Organizer(s): E. Dale Abel, Ira J. Goldberg and Karin E. Bornfeldt
Date: September 23 - 28, 2008
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Cardiovascular disease is the major cause of mortality in developed countries and emerging economies worldwide. Important risk factors include diabetes, obesity, and dyslipidemia. Given the growing worldwide epidemic of obesity and the metabolic syndrome, there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.
Scholarship Deadline: May 22 2008
Discounted Abstract Deadline: June 24 2008
Abstract Deadline: July 24 2008
Discounted Registration Deadline: July 24 2008
We gratefully acknowledge additional support for this conference from:
Seahorse Bioscience, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-03
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, September 23 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, September 23 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, September 23 | 7:30PM - 8:30PM
Keynote Address
Room: Peak 5

Speaker 1 of 2
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Tuesday, September 23 | 7:30PM - 8:30PM
Keynote Address
Room: Peak 5

Speaker 2 of 2
Ruth McPherson, University of Ottawa Heart Institute, Canada
Genetic Insights into Coronary Artery Disease

Tuesday, September 23 | 8:30PM - 9:00PM
Orientation for New Attendees and New Investigators
Room: Peak 5
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.

Wednesday, September 24 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Wednesday, September 24 | 8:00AM - 11:15AM
New Genetic Insights Linking Metabolism and Cardiovascular R
isk

Room: Peak 5

Speaker 1 of 5
Markku Laakso, Kuopio University Central Hospital, Finland
Genetics of Type 2 Diabetes

Wednesday, September 24 | 8:00AM - 11:15AM
New Genetic Insights Linking Metabolism and Cardiovascular R
isk

Room: Peak 5

Speaker 2 of 5
* Alan D. Attie, University of Wisconsin-Madison, USA
Genes, Gene Networks, and Type 2 Diabetes

Wednesday, September 24 | 8:00AM - 11:15AM
New Genetic Insights Linking Metabolism and Cardiovascular R
isk

Room: Peak 5

Speaker 3 of 5
Aldons J. Lusis, University of California, Los Angeles, USA
Systems Biology of Cardiovascular Disease

Wednesday, September 24 | 8:00AM - 11:15AM
New Genetic Insights Linking Metabolism and Cardiovascular R
isk

Room: Peak 5

Speaker 4 of 5
Zhiguang Su, The Jackson Laboratory, USA
Short Talk: Obesity, Adiponectin, and HDL are Controlled by Common Genetic Factors in the Mouse

Wednesday, September 24 | 8:00AM - 11:15AM
New Genetic Insights Linking Metabolism and Cardiovascular R
isk

Room: Peak 5

Speaker 5 of 5
Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Hepatic Insulin Resistance Suppresses Cholesterologenic Gene Expression by Inhibiting SREBP-2

Wednesday, September 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, September 24 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Wednesday, September 24 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, September 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Wednesday, September 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, September 24 | 5:00PM - 7:00PM
Adipocytokines and Cardiovascular Risk
Room: Peak 5

Speaker 1 of 5
* Scott A. Summers, University of Utah, USA

Wednesday, September 24 | 5:00PM - 7:00PM
Adipocytokines and Cardiovascular Risk
Room: Peak 5

Speaker 2 of 5
Kenneth Walsh, University of Virginia School of Medicine, USA
Adiponectin and Cardiac Injury

Wednesday, September 24 | 5:00PM - 7:00PM
Adipocytokines and Cardiovascular Risk
Room: Peak 5

Speaker 3 of 5
Daniel T. Eitzman, University of Michigan, USA
Visceral Adipose Tissue and Atherosclerosis

Wednesday, September 24 | 5:00PM - 7:00PM
Adipocytokines and Cardiovascular Risk
Room: Peak 5

Speaker 4 of 5
Cuihua Zhang, University of Missouri-Columbia, USA
TNF-Alpha and Vascular Dysfunction

Wednesday, September 24 | 5:00PM - 7:00PM
Adipocytokines and Cardiovascular Risk
Room: Peak 5

Speaker 5 of 5
Anne Marie Minihane, Hugh Sinclair Nutrition Group, UK
Short Talk: Influence of a Leptin Receptor Gene Variant on Postprandial Triglyceride Metabolism: Impact of Gender

Wednesday, September 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Wednesday, September 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-4


Thursday, September 25 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 1 of 7
* Kenneth Walsh, University of Virginia School of Medicine, USA

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 2 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Insulin and Growth Factor Regulation of Cardiac Mitochondria

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 3 of 7
Anthony Rosenzweig, Massachusetts General Hospital, USA
Akt and SGK Signaling in the Heart

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 4 of 7
William C. Sessa, Yale University School of Medicine, USA
Role of Akt in the vasculature

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 5 of 7
Paul Huang, Massachusetts General Hospital, USA
eNOS, Metabolic Diseases, and Cardiovascular Risk

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 6 of 7
Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: Accelerated Atherosclerosis in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous ApoE Knockout Mice

Thursday, September 25 | 8:00AM - 11:15AM
Insulin and Akt Signaling in the Heart and Vasculature
Room: Peak 5

Speaker 7 of 7
Carlos Fern√°ndez-Hernando, New York University School of Medicine, USA
Short Talk: Endothelial Caveolin-1 Regulates the Progression of Atherosclerosis by Controlling LDL Infiltration, Expression of Vascular Adhesion Molecules and Production of Nitric Oxide

Thursday, September 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, September 25 | 11:15AM - 12:00PM
Lunch
Room: Peaks 1-4


Thursday, September 25 | 12:00PM - 2:30PM
Poster Session 2
Room: Peaks 1-4


Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 1 of 10
* Ira J. Goldberg, New York University, USA

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 2 of 10
* Karin E. Bornfeldt, University of Washington School of Medicine, USA

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 3 of 10
Peter C. Lucas, University of Pittsburgh School of Medicine, USA
The CARMA3-Bcl10-MALT1 Signalosome as a mediator of Angiotensin II-dependent NF-kappaB activation and atherogenesis

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 4 of 10
Jenny E. Kanter, University of Washington, USA
Macrophage Long-Chain acyl-CoA Synthetase 1 Plays an Important Role in Lipid Loading by Inhibiting Cholesterol Efflux via ATP-Binding Cassette Transporter 1

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 5 of 10
Heiko Bugger, Heart Center Freiburg University, Germany
Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthetase 1 Impairs Mitochondrial Function and Dynamics

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 6 of 10
Xiaoyue Pan, SUNY Downstate Medical Center, USA
Clock is Required for Diurnal and Food-Entrained Regulation of Plasma Lipids and Lipoproteins

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 7 of 10
Zoltan P. Arany, University of Pennsylvania, USA
Regulation of VEGF and Angiogenesis by the Transcriptional Coactivator PGC-1alpha

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 8 of 10
Denis J. Glenn, University of California, San Francisco, USA
Transgenic Expression of DGAT1 in Cardiac Myocytes Results in Cardiac Steatosis

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 9 of 10
Adam R. Wende, University of Alabama at Birmingham, USA
Short-term, Cardiac Specific Overexpression of GLUT4 does not Rescue Metabolic and Contractile Dysfunction in the Diabetic Heart

Thursday, September 25 | 2:30PM - 4:30PM
Workshop: Hot Topics in Cardiac and Vascular Metabolism
Room: Peak 5

Speaker 10 of 10
Leo Timmers, University Medical Center Utrecht, Netherlands
Cardioprotective Effects of Exenatide, a Glucagon-Like Peptide 1 Receptor Agonist

Thursday, September 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, September 25 | 5:00PM - 7:00PM
Signaling Mechanisms Regulating Mitochondrial Function and M
etabolism

Room: Peak 5

Speaker 1 of 5
* Margaret P. Chandler, National Institutes of Health, USA

Thursday, September 25 | 5:00PM - 7:00PM
Signaling Mechanisms Regulating Mitochondrial Function and M
etabolism

Room: Peak 5

Speaker 2 of 5
Daniel P. Kelly, University of Pennsylvania, USA
PGC1, Mitochondria and Cardiac Dysfunction in Insulin Resistance and Diabetes

Thursday, September 25 | 5:00PM - 7:00PM
Signaling Mechanisms Regulating Mitochondrial Function and M
etabolism

Room: Peak 5

Speaker 3 of 5
Jiandie Lin, University of Michigan Medical School, USA
Transcriptional Networks in the Control of Energy Metabolism

Thursday, September 25 | 5:00PM - 7:00PM
Signaling Mechanisms Regulating Mitochondrial Function and M
etabolism

Room: Peak 5

Speaker 4 of 5
Martin E. Young, University of Alabama at Birmingham, USA
Circadian Clocks and Cardiac Metabolism

Thursday, September 25 | 5:00PM - 7:00PM
Signaling Mechanisms Regulating Mitochondrial Function and M
etabolism

Room: Peak 5

Speaker 5 of 5
Michael N. Sack, NHLBI, National Institutes of Health, USA
Short Talk: PGC-1alpha Integrates Insulin Signaling, Mitochondrial Regulation and Bioenergetic Function in Skeletal Muscle

Thursday, September 25 | 7:00PM - 7:00PM
On Own for Dinner


Friday, September 26 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 1 of 6
Christopher K. Glass, University of California, San Diego, USA
Transcriptional Regulation of Macrophage Function

Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 2 of 6
* Ajay Chawla, Merck Research Labs, USA
Macrophage Activation in Obesity and Insulin Resistance

Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 3 of 6
Kitt F. Petersen, Yale University School of Medicine, USA
Lipid-Mediated Insulin Resistance

Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 4 of 6
Li Wang, University of Connecticut, USA
Nuclear Receptor SHP in Metabolic Regulation

Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 5 of 6
Michael G. Usher, University of Michigan, USA
Short Talk: The Mineralocorticoid Receptor Controls Macrophage Polarization in Cardiovascular Inflammation

Friday, September 26 | 8:00AM - 11:15AM
Inflammation, Lipids and Other Risk Factors
Room: Peak 5

Speaker 6 of 6
Ming-Dong Wang, University of Ottawa Heart Institute, Canada
Short Talk: SR-BI Deficiency in Macrophage Labeled with LDL-Derived Cholesterol Leads to Reduced in vivo Reverse Cholesterol Transport

Friday, September 26 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, September 26 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Friday, September 26 | 11:15AM - 11:15AM
On Own for Lunch


Friday, September 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Friday, September 26 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, September 26 | 5:00PM - 7:15PM
Vascular Metabolism
Room: Peak 5

Speaker 1 of 5
* Alan R. Tall, Columbia University, USA

Friday, September 26 | 5:00PM - 7:15PM
Vascular Metabolism
Room: Peak 5

Speaker 2 of 5
Ira J. Goldberg, New York University, USA
Glucose and Lipids in Cardiovascular Diseases

Friday, September 26 | 5:00PM - 7:15PM
Vascular Metabolism
Room: Peak 5

Speaker 3 of 5
Clay F. Semenkovich, Washington University School of Medicine, USA
Vascular Metabolism and Atherosclerosis

Friday, September 26 | 5:00PM - 7:15PM
Vascular Metabolism
Room: Peak 5

Speaker 4 of 5
Jerry L. Nadler, Eastern Virginia Medical School, USA
Inflammatory Mechanisms Linking Metabolic Changes and Atherosclerosis

Friday, September 26 | 5:00PM - 7:15PM
Vascular Metabolism
Room: Peak 5

Speaker 5 of 5
Cecilia M. Giachelli, University of Washington, USA
Regulation of Vascular Calcification

Friday, September 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Peaks 1-4


Friday, September 26 | 7:30PM - 10:00PM
Open Viewing Poster Sessions 1 & 2
Room: Peaks 1-4


Saturday, September 27 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 1 of 7
* † Mahmood Hussain, SUNY Downstate Medical Center, USA

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 2 of 7
Rudolf Zechner, University of Graz, Austria
Adipose Triglyceride Lipase

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 3 of 7
* Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA
Lipotoxicity: Mapping the Response to Metabolic Stress

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 4 of 7
Jay W. Heinecke, University of Washington School of Medicine, USA
Proteomics Implicates a Macrophage Sterol-Regulated Network in Atherogenesis

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 5 of 7
Scott A. Summers, University of Utah, USA
Ceramides, Insulin Resistance, and Metabolic Disease

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 6 of 7
Luuk Jon Rijzewijk, Vrije Universiteit University Medical Center, Netherlands
Short Talk: The Phenotype of Human Diabetic-Lipotoxic Cardiomyopathy and the Effects of Anti-Steatotic PPARgamma-Agonist Therapy: Studies with PET and MRI/MRS

Saturday, September 27 | 8:00AM - 11:15AM
Lipid Signaling and Lipotoxicity
Room: Peak 5

Speaker 7 of 7
Babak Razani, Washington University School Of Medicine, USA
Short Talk: Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress

Saturday, September 27 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, September 27 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, September 27 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, September 27 | 5:00PM - 7:00PM
Molecular Mechanisms of Atherosclerosis
Room: Peak 5

Speaker 1 of 4
Alan R. Tall, Columbia University, USA
Anti-Atherogenic Mechanisms of HDL

Saturday, September 27 | 5:00PM - 7:00PM
Molecular Mechanisms of Atherosclerosis
Room: Peak 5

Speaker 2 of 4
* Karin E. Bornfeldt, University of Washington School of Medicine, USA
Diabetes-Accelerated Atherosclerosis: Evidence from a Mouse Model

Saturday, September 27 | 5:00PM - 7:00PM
Molecular Mechanisms of Atherosclerosis
Room: Peak 5

Speaker 3 of 4
Edward A. Fisher, New York University School of Medicine, USA
Regulation of Atherosclerosis Regression in Novel Mouse Models and the Effects of Hyperglycemia

Saturday, September 27 | 5:00PM - 7:00PM
Molecular Mechanisms of Atherosclerosis
Room: Peak 5

Speaker 4 of 4
Jason Voogt, Amyris Inc, USA
Short Talk: In vivo Effects of Two ApoA-1 Mimetics on Plasma Cholesterol Flux, de novo Cholesterol Synthesis and Reverse Cholesterol Transport

Saturday, September 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Saturday, September 27 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-4


Saturday, September 27 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-4


Sunday, September 28 | 10:25AM - 10:25AM
Departure


*Session Chair.