Web Desc
Stem Cells, Cancer and Aging
Organizer(s): Sir David P. Lane, Hans C. Clevers, Arnold J. Levine and Xin Lu
Date: September 29 - October 04, 2008
Location: Swissotel The Stamford, Singapore, Singapore
In collaboration with Agency for Science, Technology and Research (A*STAR) and held in conjunction with the International Society of Differentiation. Sponsored by Lilly Singapore Centre for Drug Discovery.
Summary of Meeting:
Recent studies on the effect of polymorphisms in human tumor suppressor pathways on cancer incidence and longevity have confirmed long held views of the link between the key processes that control human aging and cancer incidence. One interpretation of these findings is that the stem cell is the key target for carcinogenesis. Further, the thresholds that regulate stem cell death in response to damage make the bargain between too-resilient stem cells, which result in long life but increased cancer risk, and too-sensitive stem cells, which ablate the occurrence of cancer but can shorten life span through stem cell exhaustion. Dramatic progress in the understanding of signaling pathways and points of intervention which will be debated in this meeting offers the enticing prospect of regulating these pathways to extend healthy lifespan and reduce cancer incidence in the human population.
Scholarship Deadline: June 12 2008
Discounted Abstract Deadline: May 29 2008
Abstract Deadline: June 30 2008
Discounted Registration Deadline: July 29 2008
We gratefully acknowledge additional support for this conference from:
Agency for Science, Technology and Research (A*STAR)Cell Signaling Technology, Inc.International Society of DifferentiationIsis Pharmaceuticals, Inc.Lilly Singapore Centre for Drug DiscoverySingapore Tourism Board
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, September 29 | 3:00PM - 7:00PM
Registration and Sign-Up for Biopolis Tours
Room: Stamford Foyer


Tuesday, September 30 | 7:00AM - 8:00AM
Breakfast
Room: Canning


Tuesday, September 30 | 7:00AM - 12:00PM
Poster Setup
Room: Stamford Foyer


Tuesday, September 30 | 8:00AM - 8:15AM
Welcoming Remarks
Room: Stamford Ballroom

Speaker 1 of 1
Lim Chuan Poh, Agency for Science, Technology and Research (A*STAR), Singapore

Tuesday, September 30 | 8:15AM - 8:30AM
Opening Remarks
Room: Stamford Ballroom

Speaker 1 of 2
David P. Lane, Agency for Science, Technology and Research, Singapore

Tuesday, September 30 | 8:15AM - 8:30AM
Opening Remarks
Room: Stamford Ballroom

Speaker 2 of 2
Hans C. Clevers, Hubrecht Institute, Netherlands

Tuesday, September 30 | 8:30AM - 12:00PM
Models of Aging
Room: Stamford Ballroom

Speaker 1 of 5
* David P. Lane, Agency for Science, Technology and Research, Singapore

Tuesday, September 30 | 8:30AM - 12:00PM
Models of Aging
Room: Stamford Ballroom

Speaker 2 of 5
Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair and the Connection between Cancer and Aging

Tuesday, September 30 | 8:30AM - 12:00PM
Models of Aging
Room: Stamford Ballroom

Speaker 3 of 5
Lawrence A. Donehower, Baylor College of Medicine, USA
Insights into Stem Cells and Aging Provided by A P53 Mutant Mouse

Tuesday, September 30 | 8:30AM - 12:00PM
Models of Aging
Room: Stamford Ballroom

Speaker 4 of 5
Heidi Scrable, Mayo Clinic, USA
p53 and IGF: An Ancient Connection

Tuesday, September 30 | 8:30AM - 12:00PM
Models of Aging
Room: Stamford Ballroom

Speaker 5 of 5
Mary Ellen Perry, DPCPSI, OD, National Institutes of Health, USA
p53 and Aging in Experimental Animals

Tuesday, September 30 | 9:40AM - 10:00AM
Coffee Break
Room: Stamford Foyer


Tuesday, September 30 | 12:00PM - 1:00PM
Lunch
Room: Canning


Tuesday, September 30 | 1:00PM - 2:00PM
ISD Award Lecture: Anne McLaren Memorial Lecturer
Room: Stamford Ballroom

Speaker 1 of 2
* Hans C. Clevers, Hubrecht Institute, Netherlands

Tuesday, September 30 | 1:00PM - 2:00PM
ISD Award Lecture: Anne McLaren Memorial Lecturer
Room: Stamford Ballroom

Speaker 2 of 2
Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK
Cell Fate, Plasticity and Pluripotency in the Early Mouse embryo

Tuesday, September 30 | 2:00PM - 2:30PM
Coffee Available
Room: Stamford Foyer


Tuesday, September 30 | 2:30PM - 4:00PM
Regulating Tumor Suppression
Room: Stamford Ballroom

Speaker 1 of 3
* Hans C. Clevers, Hubrecht Institute, Netherlands

Tuesday, September 30 | 2:30PM - 4:00PM
Regulating Tumor Suppression
Room: Stamford Ballroom

Speaker 2 of 3
Gerard I. Evan, University of Cambridge, UK
Switchable Tumor Suppression Models to Control Cancer and Aging

Tuesday, September 30 | 2:30PM - 4:00PM
Regulating Tumor Suppression
Room: Stamford Ballroom

Speaker 3 of 3
Alea A. Mills, Cold Spring Harbor Laboratory, USA
p63 Deficiency and Aging

Tuesday, September 30 | 4:00PM - 6:00PM
Poster Session 1
Room: Stamford Foyer


Tuesday, September 30 | 5:00PM - 6:00PM
Social Hour
Room: Stamford Foyer


Wednesday, October 01 | 7:00AM - 8:00AM
Breakfast
Room: Canning


Wednesday, October 01 | 7:00AM - 12:00PM
Poster Setup
Room: Stamford Foyer


Wednesday, October 01 | 8:00AM - 11:30AM
Signaling Pathways in Cancer and Development
Room: Stamford Ballroom

Speaker 1 of 5
* Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore

Wednesday, October 01 | 8:00AM - 11:30AM
Signaling Pathways in Cancer and Development
Room: Stamford Ballroom

Speaker 2 of 5
Hans C. Clevers, Hubrecht Institute, Netherlands
Identification of Stem Cells in Small Intestine and Colon by a Single Marker Gene LGR5

Wednesday, October 01 | 8:00AM - 11:30AM
Signaling Pathways in Cancer and Development
Room: Stamford Ballroom

Speaker 3 of 5
Yoshiaki Ito, National University of Singapore, Singapore
RUNX3, a Novel Gate Keeper of Colon Carcinogenesis

Wednesday, October 01 | 8:00AM - 11:30AM
Signaling Pathways in Cancer and Development
Room: Stamford Ballroom

Speaker 4 of 5
Vinay B. Tergaonkar, Institute of Molecular and Cell Biology, Singapore
New Controls of the NF-kappa B Pathway

Wednesday, October 01 | 8:00AM - 11:30AM
Signaling Pathways in Cancer and Development
Room: Stamford Ballroom

Speaker 5 of 5
Michael Karin, University of California, San Diego, USA
Inflammatory Processes in Metastatic Progression

Wednesday, October 01 | 9:40AM - 10:00AM
Coffee Break
Room: Stamford Foyer


Wednesday, October 01 | 11:30AM - 12:30PM
Lunch
Room: Canning


Wednesday, October 01 | 12:30PM - 2:30PM
Poster Session 2
Room: Stamford Foyer


Wednesday, October 01 | 2:00PM - 2:30PM
Coffee Available
Room: Stamford Foyer


Wednesday, October 01 | 2:30PM - 4:30PM
Counting Stem Cells
Room: Stamford Ballroom

Speaker 1 of 4
* Gerard I. Evan, University of Cambridge, UK

Wednesday, October 01 | 2:30PM - 4:30PM
Counting Stem Cells
Room: Stamford Ballroom

Speaker 2 of 4
Connie J. Eaves, British Columbia Cancer Agency, Canada
Title to be Determined

Wednesday, October 01 | 2:30PM - 4:30PM
Counting Stem Cells
Room: Stamford Ballroom

Speaker 3 of 4
Andrei V. Gudkov, Roswell Park Cancer Institute, USA
Saving Stem Cells to Survive Radiation

Wednesday, October 01 | 2:30PM - 4:30PM
Counting Stem Cells
Room: Stamford Ballroom

Speaker 4 of 4
Hongyan Wang, Duke NUS-Graduate Medical School Singapore, Singapore
Short Talk: Brain Tumor Suppressors and Neural Stem Cell Self-Renewal in Drosophila

Thursday, October 02 | 7:00AM - 8:00AM
Breakfast
Room: Canning


Thursday, October 02 | 7:00AM - 12:00PM
Poster Setup
Room: Stamford Foyer


Thursday, October 02 | 8:00AM - 9:00AM
Keynote Address
Room: Stamford Ballroom

Speaker 1 of 2
* Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore

Thursday, October 02 | 8:00AM - 9:00AM
Keynote Address
Room: Stamford Ballroom

Speaker 2 of 2
Arnold J. Levine, Institute for Advanced Study, USA
Single Nucleotide Polymorphisms in the p53 Pathway

Thursday, October 02 | 9:00AM - 11:30AM
New Models to Find Novel Cancer and Aging Pathways
Room: Stamford Ballroom

Speaker 1 of 4
* Arnold J. Levine, Institute for Advanced Study, USA

Thursday, October 02 | 9:00AM - 11:30AM
New Models to Find Novel Cancer and Aging Pathways
Room: Stamford Ballroom

Speaker 2 of 4
Xin Lu, Ludwig Institute for Cancer Research, UK
ASPP2 Mediates Senescence and Inhibits Autophagy and Tumourgenicity Induced by H-RasV12

Thursday, October 02 | 9:00AM - 11:30AM
New Models to Find Novel Cancer and Aging Pathways
Room: Stamford Ballroom

Speaker 3 of 4
Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore
Harnessing Transposons for Cancer Gene Discovery

Thursday, October 02 | 9:00AM - 11:30AM
New Models to Find Novel Cancer and Aging Pathways
Room: Stamford Ballroom

Speaker 4 of 4
Edison T. Liu, The Jackson Laboratory, USA
Comprehensive Identification of Genomic Rearrangements in Human Cancer

Thursday, October 02 | 9:00AM - 9:20AM
Coffee Break
Room: Stamford Foyer


Thursday, October 02 | 11:30AM - 12:30PM
Lunch
Room: Canning


Thursday, October 02 | 12:30PM - 2:30PM
Poster Session 3
Room: Stamford Foyer


Thursday, October 02 | 2:00PM - 2:30PM
Coffee Available
Room: Stamford Foyer


Thursday, October 02 | 2:30PM - 4:30PM
New Targets and Therapeutic Approaches to Cancer and Aging
Room: Stamford Ballroom

Speaker 1 of 4
* Xin Lu, Ludwig Institute for Cancer Research, UK

Thursday, October 02 | 2:30PM - 4:30PM
New Targets and Therapeutic Approaches to Cancer and Aging
Room: Stamford Ballroom

Speaker 2 of 4
Gregory L. Verdine, Harvard University, USA
Drugging “Undruggable” Targets in Cancer

Thursday, October 02 | 2:30PM - 4:30PM
New Targets and Therapeutic Approaches to Cancer and Aging
Room: Stamford Ballroom

Speaker 3 of 4
David P. Lane, Agency for Science, Technology and Research, Singapore
Small Molecule Switches to Control p53 Activity

Thursday, October 02 | 2:30PM - 4:30PM
New Targets and Therapeutic Approaches to Cancer and Aging
Room: Stamford Ballroom

Speaker 4 of 4
Axel Ullrich, Max Planck Institute of Biochemistry, Germany
The Singapore OncoGenome Project as Part of an Effort to Develop a Portfolio of Targeted Cancer Therapeutics

Friday, October 03 | 7:00AM - 8:00AM
Breakfast
Room: Canning


Friday, October 03 | 7:30AM - 8:30AM
Transfer to Biopolis


Friday, October 03 | 8:30AM - 10:30AM
Cancer Stem Cells
Room: Biopolis

Speaker 1 of 4
* Xin Lu, Ludwig Institute for Cancer Research, UK

Friday, October 03 | 8:30AM - 10:30AM
Cancer Stem Cells
Room: Biopolis

Speaker 2 of 4
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Cancer Stem Cells in the Hematopoietic System

Friday, October 03 | 8:30AM - 10:30AM
Cancer Stem Cells
Room: Biopolis

Speaker 3 of 4
Colin L. Stewart, Institute of Medical Biology, Singapore
The Lamins and the Functional Architecture of the Nucleus in Disease and Aging

Friday, October 03 | 8:30AM - 10:30AM
Cancer Stem Cells
Room: Biopolis

Speaker 4 of 4
Daniel G. Tenen, Cancer Science Institute, Singapore
Transcription Factor C/EBP alpha Regulates Hematopoietic Stem Cell Proliferation and Maintenance during Aging

Friday, October 03 | 10:30AM - 11:00AM
Coffee Break
Room: Biopolis Foyer


Friday, October 03 | 11:00AM - 12:00PM
ISD Award Lecture: Jean Brachet Memorial Lecturer
Room: Biopolis

Speaker 1 of 2
* Hans C. Clevers, Hubrecht Institute, Netherlands

Friday, October 03 | 11:00AM - 12:00PM
ISD Award Lecture: Jean Brachet Memorial Lecturer
Room: Biopolis

Speaker 2 of 2
Giulio Cossu, Stem Cell Research Institute, Italy
Towards Cell Therapy for Muscular Dystrophies

Friday, October 03 | 12:00PM - 1:00PM
Lunch Catered by Biopolis
Room: Biopolis


Friday, October 03 | 12:30PM - 2:00PM
Optional Tour of Biopolis


Friday, October 03 | 12:30PM - 2:00PM
Transfer to Hotel


Friday, October 03 | 2:30PM - 3:00PM
Coffee Available
Room: Stamford Foyer


Friday, October 03 | 3:00PM - 4:45PM
More Adult Stem Cells in the Self-Renewing Tissues
Room: Stamford Ballroom

Speaker 1 of 2
Davor Solter, Institute of Medical Biology, Singapore
Preformation Versus Epigenesis in Driving Mammalian Development

Friday, October 03 | 3:00PM - 4:45PM
More Adult Stem Cells in the Self-Renewing Tissues
Room: Stamford Ballroom

Speaker 2 of 2
Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore
Potentiality of Mammary Epithelial Cells with a Basal Phenotype

Friday, October 03 | 4:45PM - 5:00PM
Meeting Sum Up
Room: Stamford Ballroom

Speaker 1 of 2
Xin Lu, Ludwig Institute for Cancer Research, UK

Friday, October 03 | 4:45PM - 5:00PM
Meeting Sum Up
Room: Stamford Ballroom

Speaker 2 of 2
Arnold J. Levine, Institute for Advanced Study, USA

Friday, October 03 | 5:00PM - 6:00PM
Social Hour
Room: Stamford Foyer


Saturday, October 04 | 10:25AM - 10:25AM
Departure


*Session Chair.