Web Desc
The Molecular Basis of Schizophrenia and Bipolar Disorder
joint with Epigenetic Basis of Neurodevelopmental Disorders
Organizer(s): Pamela Sklar, David J. Porteous and Christopher A. Ross
Date: March 06 - 10, 2009
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Johnson & Johnson Pharmaceutical Research and Development, L.L.C.
Summary of Meeting:
This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches.
Scholarship Deadline: November 6 2008
Discounted Abstract Deadline: November 6 2008
Abstract Deadline: December 4 2008
Discounted Registration Deadline: January 6 2009
We gratefully acknowledge additional support for this conference from:
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH085429-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 06 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Friday, March 06 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Friday, March 06 | 7:30PM - 8:30PM
Keynote Address
Room: Grays 1 & 2

Speaker 1 of 2
* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA

Friday, March 06 | 7:30PM - 8:30PM
Keynote Address
Room: Grays 1 & 2

Speaker 2 of 2
Thomas R. Insel, Mindstrong Health, USA
The Molecular Basis of Schizophrenia and Bipolar Disorder: What Do We Know? What Do We Need?

Saturday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
Room: Grays 1 & 2

Speaker 1 of 4
Shaun Purcell, Massachusetts General Hospital, USA
Varieties of Genetic Variation of Neuropsychiatric Disease

Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
Room: Grays 1 & 2

Speaker 2 of 4
* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA
Genetics and Genomics of Schizophrenia and Bipolar Disorder

Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
Room: Grays 1 & 2

Speaker 3 of 4
Patrick Sullivan, University of North Carolina, USA
SCZ GWAS - Update 3/09

Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
Room: Grays 1 & 2

Speaker 4 of 4
Jonathan Sebat, University of California, San Diego, USA
Microduplication of 16p11.2 is Associated with Schizophrenia

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 6
Peter A. Jones, Van Andel Research Institute, USA
Epigenetic Regulation in Cancer


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 6
* Joseph F. Costello, University of California, San Francisco, USA
Role of Intragenic DNA Methylation in Gene Expression


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 6
Guoping Fan, University of California, Los Angeles, USA
Epigenetic Regulation in Neuronal Survival and Brain Development


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 4 of 6
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Profiling Chromatin Structure Across Cell Lineages


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 5 of 6
Dengke Ma, Johns Hopkins University, USA
Short Talk: Neuronal Induction of Gadd45b Links Epigenetic DNA Demethylation to Activity-Dependent Adult Neurogenesis


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 6 of 6
Jing Wang, Hospital for Sick Children, Canada
Short Talk: The Histone Acetyltransferase Activity of the CBP Transcriptional Coactivator, which is Haploinsufficient in Rubinstein-Taybi Syndrome, is Essential for Differentiation of Developing Neural Stem Cells


Saturday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, March 07 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, March 07 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Saturday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Saturday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
Room: Grays 1 & 2

Speaker 1 of 3
Peter B. Jones, Cambridge University, UK
Epidemiology and Risk Factors, Shared or Not?

Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
Room: Grays 1 & 2

Speaker 2 of 3
Nick J. Craddock, Cardiff University School of Medicine, UK
Boundaries of the phenotypes: Reconstructing and Rethinking Psychosis

Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
Room: Grays 1 & 2

Speaker 3 of 3
* Christopher A. Ross, Johns Hopkins University School of Medicine, USA
Neurogenetics: Insights from Neurodegeneration, Approaches to Psychiatric Disease

Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 5
* Art Petronis, University of Toronto, Canada
Epigenomics of Major Psychosis


Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 5
Schahram Akbarian, Icahn School of Medicine at Mount Sinai, USA
Epigenetic Regulation in Human and Mouse Brain - Focus on Histone Lysine Methylation


Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 5
Yue Feng, Emory University, USA
Talk Title to be Determined


Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 4 of 5
Anne O'Donnell-Luria, Broad Institute, USA
Short Talk: Whole Genome DNA Methylation Profiling of Major Depression


Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 5 of 5
Fatemeh G. Haghighi, Columbia University, USA
Short Talk: DNA Methylation Profiling of Schizophrenia


Saturday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Saturday, March 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Sunday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
Room: Grays 1 & 2

Speaker 1 of 5
* David J. Porteous, University of Edinburgh, UK
DISC1: Approaching Causality

Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
Room: Grays 1 & 2

Speaker 2 of 5
Hongjun Song, University of Pennsylvania, USA
Regulation of Development of Dentate Granule Neurons by Disrupted-In-Schizophrenia 1 (DISC1)

Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
Room: Grays 1 & 2

Speaker 3 of 5
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Disrupted In Schizophrenia 1 (DISC1) Regulates Neural Progenitor Proliferation via beta-Catenin/GSKbeta Signaling

Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
Room: Grays 1 & 2

Speaker 4 of 5
Jonathan D. Wood, University of Sheffield Medical School, UK
Short Talk: Schizophrenia Susceptibility Genes in Zebrafish

Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
Room: Grays 1 & 2

Speaker 5 of 5
Gianluca De Rienzo, Whitehead Institute, USA
Short Talk: DISC-1 is an Essential Modulator of the Wnt Signaling Pathway

Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 6
Daniel H. Geschwind, University of California, Los Angeles, USA
Autism: From Genes to Brain


Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 6
David H. Ledbetter, Geisinger Health, USA
Early Identification of Genetic Sub-Types of Autism Spectrum Disorders (ASDs) by Clinical aCGH Testing and Establishment of an International Public Database


Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 6
* Janine M. LaSalle, University of California, Davis, USA
Epigenetic Etiologies of Autism Spectrum Disorders


Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 4 of 6
Addie May Ingrid Nesbitt, University of Connecticut, USA
Short Talk: Genomic Imprinting of the X-Linked Gene Transketolase-like 1 in Mouse and Human


Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 5 of 6
Rodney C. Samaco, Baylor College of Medicine, USA
Short Talk: Haploinsufficiency of Crh Ameliorates the Autistic-Like Features in a Mouse Model of MECP2 Duplication Syndrome


Sunday, March 08 | 8:00AM - 11:00AM
Autism
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 6 of 6
Steven W. Long, University of Illinois, USA
Short Talk: Purification of a Novel MeCP2 Complex from Rat Brain


Sunday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, March 08 | 11:00AM - 11:00AM
On Own for Lunch


Sunday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Sunday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
Room: Grays 1 & 2

Speaker 1 of 3
Marc G. Caron, Duke University Medical Center, USA
D2 Dopamine Receptor-Mediated Akt/GSK3 Signaling: Behavioral and Therapeutic Implications

Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
Room: Grays 1 & 2

Speaker 2 of 3
Ricardo E. Dolmetsch, uniQure, USA
From Calcium Channels to Autism

Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
Room: Grays 1 & 2

Speaker 3 of 3
* Daniel R. Weinberger, NIMH/National Institutes of Health, USA
Genetic and Molecular Studies of NRG1/ErbB4

Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 4
* Arthur L. Beaudet, Baylor College of Medicine, USA
Molecular Basis of Angelman Syndrome


Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 4
Laura Herzing, Children's Memorial Research Center, USA
Epigenetic Consequences of Fetal Alcohol Exposure


Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 4
Edwin J. Weeber, University of South Florida, USA
Synaptic Plasticity Defects in Angelman Syndrome


Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 4 of 4
Jon F. Wilkins, Ronin Institute, USA
Short Talk: Imprinted Genes, Risk Preferences, and Delay Discounting


Sunday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
Room: Grays 1 & 2

Speaker 1 of 5
* David J. Porteous, University of Edinburgh, UK

Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
Room: Grays 1 & 2

Speaker 2 of 5
Fred H. Gage, The Salk Institute for Biological Studies, USA
L1 Retrotransposons During Neurogenesis

Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
Room: Grays 1 & 2

Speaker 3 of 5
Bruce T. Lahn, University of Chicago, USA
Fast-Evolving Genes of the Human Brain

Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
Room: Grays 1 & 2

Speaker 4 of 5
Vann Bennett, Duke University Medical Center, USA
Facile Evolution of Ankyrin-Binding Activity as a Mechanism for Co-Localization of Functionally Related Proteins at Axon Initial Segments

Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
Room: Grays 1 & 2

Speaker 5 of 5
Judith L. Rapoport, NIMH, National Institutes of Health, USA
Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009

Monday, March 09 | 8:00AM - 9:20AM
Monogenic Neurodevelopmental Disorders: Rett Syndrome
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 2
David Katz, Case Western Reserve University School of Medicine, USA
Dysregulation of Neuronal Excitability in Mecp2 Null Mice


Monday, March 09 | 8:00AM - 9:20AM
Monogenic Neurodevelopmental Disorders: Rett Syndrome
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 2
Xinyu Zhao, University of Wisconsin-Madison, USA
Methyl-CpG Binding Proteins in Neurogenesis and Autism Spectrum Disorders


Monday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 3
Stephen T. Warren, Emory University School of Medicine, USA
Newborn and Conventional Mutation Screening in Fragile X


Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 3
* David L. Nelson, Baylor College of Medicine, USA
Development of Animal Models for Fragile X Syndrome


Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 3
Peng Jin, Emory University School of Medicine, USA
Fragile X Mental Retardation Protein and Stem Cells


Monday, March 09 | 11:00AM - 11:00AM
On Own for Lunch


Monday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
Room: Grays 1 & 2

Speaker 1 of 3
* Christopher A. Ross, Johns Hopkins University School of Medicine, USA

Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
Room: Grays 1 & 2

Speaker 2 of 3
John R. Kelsoe, University of California, San Diego, USA
Perspectives on Pharmacogenomics: Medication Response in Bipolar Disorder as an Endophenotype

Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
Room: Grays 1 & 2

Speaker 3 of 3
Edward M. Scolnick, MIT Broad Institute, USA
Clinical Applications of Emerging Psychiatric Genetics

Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 1 of 4
* Xinyu Zhao, University of Wisconsin-Madison, USA


Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 2 of 4
* Peng Jin, Emory University School of Medicine, USA


Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 3 of 4
Jeffrey M. Besterman, MethylGene Inc., Canada
Epigenetic Therapy of Neurodegenerative Diseases


Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
This session is from Epigenetics & Neurodevel
Room: Quandary 1 & 2

Speaker 4 of 4
Bing Ren, Ludwig Institute for Cancer Research, USA
Global Chromatin Modifications at Transcriptional Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome


Monday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Monday, March 09 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Tuesday, March 10 | 10:25AM - 10:25AM
Departure


*Session Chair.