Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Pathways of Neurodevelopmental Disorders (2015C8)

Web Desc
The Molecular Basis of Schizophrenia and Bipolar Disorder joint with Epigenetic Basis of Neurodevelopmental Disorders Organizer(s): Pamela Sklar, David J. Porteous and Christopher A. Ross Date: March 06 - 10, 2009 Location: Keystone Resort, Keystone, CO, USA Sponsored by Johnson & Johnson Pharmaceutical Research and Development, L.L.C. Summary of Meeting: This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches. Scholarship Deadline: November 6 2008 Discounted Abstract Deadline: November 6 2008 Abstract Deadline: December 4 2008 Discounted Registration Deadline: January 6 2009 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Mental Health (NIMH) Grant No. 1R13MH085429-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

The Molecular Basis of Schizophrenia and Bipolar Disorder

joint with Epigenetic Basis of Neurodevelopmental Disorders

Organizer(s): Pamela Sklar, David J. Porteous and Christopher A. Ross

Date: March 06 - 10, 2009
Location: Keystone Resort, Keystone, CO, USA

Sponsored by Johnson & Johnson Pharmaceutical Research and Development, L.L.C.

Summary of Meeting:

This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches.

Scholarship Deadline: November 6 2008

Discounted Abstract Deadline: November 6 2008

Abstract Deadline: December 4 2008

Discounted Registration Deadline: January 6 2009

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH085429-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Friday, March 06 \| 3:00PM - 7:30PM Registration Room: Longs Peak Foyer
Friday, March 06 \| 6:30PM - 7:30PM Refreshments Room: Longs Peak Foyer
Friday, March 06 \| 7:30PM - 8:30PM Keynote Address Room: Grays 1 & 2 Speaker 1 of 2 * Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA
Friday, March 06 \| 7:30PM - 8:30PM Keynote Address Room: Grays 1 & 2 Speaker 2 of 2 Thomas R. Insel, Mindstrong Health, USA The Molecular Basis of Schizophrenia and Bipolar Disorder: What Do We Know? What Do We Need?
Saturday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Saturday, March 07 \| 8:00AM - 11:00AM Genome-Wide Studies of Disease-Related Variation Room: Grays 1 & 2 Speaker 1 of 4 Shaun Purcell, Massachusetts General Hospital, USA Varieties of Genetic Variation of Neuropsychiatric Disease
Saturday, March 07 \| 8:00AM - 11:00AM Genome-Wide Studies of Disease-Related Variation Room: Grays 1 & 2 Speaker 2 of 4 * Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA Genetics and Genomics of Schizophrenia and Bipolar Disorder
Saturday, March 07 \| 8:00AM - 11:00AM Genome-Wide Studies of Disease-Related Variation Room: Grays 1 & 2 Speaker 3 of 4 Patrick Sullivan, University of North Carolina, USA SCZ GWAS - Update 3/09
Saturday, March 07 \| 8:00AM - 11:00AM Genome-Wide Studies of Disease-Related Variation Room: Grays 1 & 2 Speaker 4 of 4 Jonathan Sebat, University of California, San Diego, USA Microduplication of 16p11.2 is Associated with Schizophrenia
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 6 Peter A. Jones, Van Andel Research Institute, USA Epigenetic Regulation in Cancer
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 6 * Joseph F. Costello, University of California, San Francisco, USA Role of Intragenic DNA Methylation in Gene Expression
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 6 Guoping Fan, University of California, Los Angeles, USA Epigenetic Regulation in Neuronal Survival and Brain Development
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 4 of 6 John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA Profiling Chromatin Structure Across Cell Lineages
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 5 of 6 Dengke Ma, Johns Hopkins University, USA Short Talk: Neuronal Induction of Gadd45b Links Epigenetic DNA Demethylation to Activity-Dependent Adult Neurogenesis
Saturday, March 07 \| 8:00AM - 11:15AM Epigenetic Mechanisms in Human Biology This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 6 of 6 Jing Wang, Hospital for Sick Children, Canada Short Talk: The Histone Acetyltransferase Activity of the CBP Transcriptional Coactivator, which is Haploinsufficient in Rubinstein-Taybi Syndrome, is Essential for Differentiation of Developing Neural Stem Cells
Saturday, March 07 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Saturday, March 07 \| 11:00AM - 11:00AM On Own for Lunch
Saturday, March 07 \| 11:00AM - 1:00PM Poster Setup Room: Longs Peak
Saturday, March 07 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak
Saturday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Saturday, March 07 \| 5:00PM - 7:00PM Clinical Epidemiology and Etiology Room: Grays 1 & 2 Speaker 1 of 3 Peter B. Jones, Cambridge University, UK Epidemiology and Risk Factors, Shared or Not?
Saturday, March 07 \| 5:00PM - 7:00PM Clinical Epidemiology and Etiology Room: Grays 1 & 2 Speaker 2 of 3 Nick J. Craddock, Cardiff University School of Medicine, UK Boundaries of the phenotypes: Reconstructing and Rethinking Psychosis
Saturday, March 07 \| 5:00PM - 7:00PM Clinical Epidemiology and Etiology Room: Grays 1 & 2 Speaker 3 of 3 * Christopher A. Ross, Johns Hopkins University School of Medicine, USA Neurogenetics: Insights from Neurodegeneration, Approaches to Psychiatric Disease
Saturday, March 07 \| 5:00PM - 7:00PM Psychiatric Epigenetics This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 5 * Art Petronis, University of Toronto, Canada Epigenomics of Major Psychosis
Saturday, March 07 \| 5:00PM - 7:00PM Psychiatric Epigenetics This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 5 Schahram Akbarian, Icahn School of Medicine at Mount Sinai, USA Epigenetic Regulation in Human and Mouse Brain - Focus on Histone Lysine Methylation
Saturday, March 07 \| 5:00PM - 7:00PM Psychiatric Epigenetics This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 5 Yue Feng, Emory University, USA Talk Title to be Determined
Saturday, March 07 \| 5:00PM - 7:00PM Psychiatric Epigenetics This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 4 of 5 Anne O'Donnell-Luria, Broad Institute, USA Short Talk: Whole Genome DNA Methylation Profiling of Major Depression
Saturday, March 07 \| 5:00PM - 7:00PM Psychiatric Epigenetics This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 5 of 5 Fatemeh G. Haghighi, Columbia University, USA Short Talk: DNA Methylation Profiling of Schizophrenia
Saturday, March 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Longs Peak
Saturday, March 07 \| 7:30PM - 10:00PM Poster Session 1 Room: Longs Peak
Sunday, March 08 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Sunday, March 08 \| 8:00AM - 11:00AM Genes and Pathways Room: Grays 1 & 2 Speaker 1 of 5 * David J. Porteous, University of Edinburgh, UK DISC1: Approaching Causality
Sunday, March 08 \| 8:00AM - 11:00AM Genes and Pathways Room: Grays 1 & 2 Speaker 2 of 5 Hongjun Song, University of Pennsylvania, USA Regulation of Development of Dentate Granule Neurons by Disrupted-In-Schizophrenia 1 (DISC1)
Sunday, March 08 \| 8:00AM - 11:00AM Genes and Pathways Room: Grays 1 & 2 Speaker 3 of 5 Li-Huei Tsai, Massachusetts Institute of Technology, USA Disrupted In Schizophrenia 1 (DISC1) Regulates Neural Progenitor Proliferation via beta-Catenin/GSKbeta Signaling
Sunday, March 08 \| 8:00AM - 11:00AM Genes and Pathways Room: Grays 1 & 2 Speaker 4 of 5 Jonathan D. Wood, University of Sheffield Medical School, UK Short Talk: Schizophrenia Susceptibility Genes in Zebrafish
Sunday, March 08 \| 8:00AM - 11:00AM Genes and Pathways Room: Grays 1 & 2 Speaker 5 of 5 Gianluca De Rienzo, Whitehead Institute, USA Short Talk: DISC-1 is an Essential Modulator of the Wnt Signaling Pathway
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 6 Daniel H. Geschwind, University of California, Los Angeles, USA Autism: From Genes to Brain
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 6 David H. Ledbetter, Geisinger Health, USA Early Identification of Genetic Sub-Types of Autism Spectrum Disorders (ASDs) by Clinical aCGH Testing and Establishment of an International Public Database
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 6 * Janine M. LaSalle, University of California, Davis, USA Epigenetic Etiologies of Autism Spectrum Disorders
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 4 of 6 Addie May Ingrid Nesbitt, University of Connecticut, USA Short Talk: Genomic Imprinting of the X-Linked Gene Transketolase-like 1 in Mouse and Human
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 5 of 6 Rodney C. Samaco, Baylor College of Medicine, USA Short Talk: Haploinsufficiency of Crh Ameliorates the Autistic-Like Features in a Mouse Model of MECP2 Duplication Syndrome
Sunday, March 08 \| 8:00AM - 11:00AM Autism This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 6 of 6 Steven W. Long, University of Illinois, USA Short Talk: Purification of a Novel MeCP2 Complex from Rat Brain
Sunday, March 08 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Sunday, March 08 \| 11:00AM - 11:00AM On Own for Lunch
Sunday, March 08 \| 1:00PM - 10:00PM Poster Viewing Room: Longs Peak
Sunday, March 08 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Sunday, March 08 \| 5:00PM - 7:00PM Genes and Pathways II Room: Grays 1 & 2 Speaker 1 of 3 Marc G. Caron, Duke University Medical Center, USA D2 Dopamine Receptor-Mediated Akt/GSK3 Signaling: Behavioral and Therapeutic Implications
Sunday, March 08 \| 5:00PM - 7:00PM Genes and Pathways II Room: Grays 1 & 2 Speaker 2 of 3 Ricardo E. Dolmetsch, uniQure, USA From Calcium Channels to Autism
Sunday, March 08 \| 5:00PM - 7:00PM Genes and Pathways II Room: Grays 1 & 2 Speaker 3 of 3 * Daniel R. Weinberger, NIMH/National Institutes of Health, USA Genetic and Molecular Studies of NRG1/ErbB4
Sunday, March 08 \| 5:00PM - 7:00PM Imprinting Disorders This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 4 * Arthur L. Beaudet, Baylor College of Medicine, USA Molecular Basis of Angelman Syndrome
Sunday, March 08 \| 5:00PM - 7:00PM Imprinting Disorders This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 4 Laura Herzing, Children's Memorial Research Center, USA Epigenetic Consequences of Fetal Alcohol Exposure
Sunday, March 08 \| 5:00PM - 7:00PM Imprinting Disorders This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 4 Edwin J. Weeber, University of South Florida, USA Synaptic Plasticity Defects in Angelman Syndrome
Sunday, March 08 \| 5:00PM - 7:00PM Imprinting Disorders This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 4 of 4 Jon F. Wilkins, Ronin Institute, USA Short Talk: Imprinted Genes, Risk Preferences, and Delay Discounting
Sunday, March 08 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Longs Peak
Monday, March 09 \| 7:00AM - 8:00AM Breakfast Room: Longs Peak
Monday, March 09 \| 8:00AM - 11:00AM Evolution and Development of the Brain Room: Grays 1 & 2 Speaker 1 of 5 * David J. Porteous, University of Edinburgh, UK
Monday, March 09 \| 8:00AM - 11:00AM Evolution and Development of the Brain Room: Grays 1 & 2 Speaker 2 of 5 Fred H. Gage, The Salk Institute for Biological Studies, USA L1 Retrotransposons During Neurogenesis
Monday, March 09 \| 8:00AM - 11:00AM Evolution and Development of the Brain Room: Grays 1 & 2 Speaker 3 of 5 Bruce T. Lahn, University of Chicago, USA Fast-Evolving Genes of the Human Brain
Monday, March 09 \| 8:00AM - 11:00AM Evolution and Development of the Brain Room: Grays 1 & 2 Speaker 4 of 5 Vann Bennett, Duke University Medical Center, USA Facile Evolution of Ankyrin-Binding Activity as a Mechanism for Co-Localization of Functionally Related Proteins at Axon Initial Segments
Monday, March 09 \| 8:00AM - 11:00AM Evolution and Development of the Brain Room: Grays 1 & 2 Speaker 5 of 5 Judith L. Rapoport, NIMH, National Institutes of Health, USA Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009
Monday, March 09 \| 8:00AM - 9:20AM Monogenic Neurodevelopmental Disorders: Rett Syndrome This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 2 David Katz, Case Western Reserve University School of Medicine, USA Dysregulation of Neuronal Excitability in Mecp2 Null Mice
Monday, March 09 \| 8:00AM - 9:20AM Monogenic Neurodevelopmental Disorders: Rett Syndrome This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 2 Xinyu Zhao, University of Wisconsin-Madison, USA Methyl-CpG Binding Proteins in Neurogenesis and Autism Spectrum Disorders
Monday, March 09 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Monday, March 09 \| 9:40AM - 11:15AM Monogenic Neurodevelopmental Disorders: Fragile X Syndrome This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 3 Stephen T. Warren, Emory University School of Medicine, USA Newborn and Conventional Mutation Screening in Fragile X
Monday, March 09 \| 9:40AM - 11:15AM Monogenic Neurodevelopmental Disorders: Fragile X Syndrome This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 3 * David L. Nelson, Baylor College of Medicine, USA Development of Animal Models for Fragile X Syndrome
Monday, March 09 \| 9:40AM - 11:15AM Monogenic Neurodevelopmental Disorders: Fragile X Syndrome This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 3 Peng Jin, Emory University School of Medicine, USA Fragile X Mental Retardation Protein and Stem Cells
Monday, March 09 \| 11:00AM - 11:00AM On Own for Lunch
Monday, March 09 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, March 09 \| 5:00PM - 7:00PM Chemical Biology and Therapeutic Strategies Room: Grays 1 & 2 Speaker 1 of 3 * Christopher A. Ross, Johns Hopkins University School of Medicine, USA
Monday, March 09 \| 5:00PM - 7:00PM Chemical Biology and Therapeutic Strategies Room: Grays 1 & 2 Speaker 2 of 3 John R. Kelsoe, University of California, San Diego, USA Perspectives on Pharmacogenomics: Medication Response in Bipolar Disorder as an Endophenotype
Monday, March 09 \| 5:00PM - 7:00PM Chemical Biology and Therapeutic Strategies Room: Grays 1 & 2 Speaker 3 of 3 Edward M. Scolnick, MIT Broad Institute, USA Clinical Applications of Emerging Psychiatric Genetics
Monday, March 09 \| 5:00PM - 7:00PM Lessons, Conclusions, and Perspectives This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 1 of 4 * Xinyu Zhao, University of Wisconsin-Madison, USA
Monday, March 09 \| 5:00PM - 7:00PM Lessons, Conclusions, and Perspectives This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 2 of 4 * Peng Jin, Emory University School of Medicine, USA
Monday, March 09 \| 5:00PM - 7:00PM Lessons, Conclusions, and Perspectives This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 3 of 4 Jeffrey M. Besterman, MethylGene Inc., Canada Epigenetic Therapy of Neurodegenerative Diseases
Monday, March 09 \| 5:00PM - 7:00PM Lessons, Conclusions, and Perspectives This session is from Epigenetics & Neurodevel Room: Quandary 1 & 2 Speaker 4 of 4 Bing Ren, Ludwig Institute for Cancer Research, USA Global Chromatin Modifications at Transcriptional Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome
Monday, March 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Longs Peak
Monday, March 09 \| 8:00PM - 11:00PM Entertainment Room: Longs Peak
Monday, March 09 \| 8:00PM - 11:00PM Cash Bar Room: Longs Peak
Tuesday, March 10 \| 10:25AM - 10:25AM Departure *Session Chair.