Web Desc
Epigenetic Basis of Neurodevelopmental Disorders
joint with The Molecular Basis of Schizophrenia and Bipolar Disorder
Organizer(s): Xinyu Zhao and Peng Jin
Date: March 06 - 10, 2009
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Neurodevelopmental disorders are highly heterogeneous constellations of disorders, both in terms of etiology and clinical manifestations. Past effort has focused on identifying the genetic basis of these disorders with minimal success. Epigenetic modulations, mediated by DNA methylation, RNA-associated silencing, and histone modification, can imprint dynamic environmental experiences on the “fixed” genome, resulting in stable alterations in phenotypes. This conference will focus on an emerging area of biomedical research: how epigenetic modulation shapes brain development and disorders. The meeting will examine the common molecular pathways affected in several related neurodevelopmental disorders and discuss how pre- and postnatal exposures to pollutants, alcohol, drug, nutrition, and parental care, etc., may affect neurodevelopment via epigenetic pathways. The overall goal of the meeting is to gain insight into the common molecular pathways affected among these disorders and to discover potential therapeutic targets that have been missed by looking at one disorder at a time.
Scholarship Deadline: November 6 2008
Discounted Abstract Deadline: November 6 2008
Abstract Deadline: December 4 2008
Discounted Registration Deadline: January 6 2009
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
BioMed CentralCell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH085352-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 06 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Friday, March 06 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Friday, March 06 | 8:30PM - 9:30PM
Keynote Address
Room: Grays 1 & 2

Speaker 1 of 3
* Xinyu Zhao, University of Wisconsin-Madison, USA
and

Friday, March 06 | 8:30PM - 9:30PM
Keynote Address
Room: Grays 1 & 2

Speaker 2 of 3
* Peng Jin, Emory University School of Medicine, USA
Opening Remarks

Friday, March 06 | 8:30PM - 9:30PM
Keynote Address
Room: Grays 1 & 2

Speaker 3 of 3
Fred H. Gage, The Salk Institute for Biological Studies, USA
L1 Retrotransposition and Neuronal Diversity

Saturday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 1 of 6
Peter A. Jones, Van Andel Research Institute, USA
Epigenetic Regulation in Cancer

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 2 of 6
* Joseph F. Costello, University of California, San Francisco, USA
Role of Intragenic DNA Methylation in Gene Expression

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 3 of 6
Guoping Fan, University of California, Los Angeles, USA
Epigenetic Regulation in Neuronal Survival and Brain Development

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 4 of 6
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Profiling Chromatin Structure Across Cell Lineages

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 5 of 6
Dengke Ma, Johns Hopkins University, USA
Short Talk: Neuronal Induction of Gadd45b Links Epigenetic DNA Demethylation to Activity-Dependent Adult Neurogenesis

Saturday, March 07 | 8:00AM - 11:15AM
Epigenetic Mechanisms in Human Biology
Room: Quandary 1 & 2

Speaker 6 of 6
Jing Wang, Hospital for Sick Children, Canada
Short Talk: The Histone Acetyltransferase Activity of the CBP Transcriptional Coactivator, which is Haploinsufficient in Rubinstein-Taybi Syndrome, is Essential for Differentiation of Developing Neural Stem Cells

Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 4
Shaun Purcell, Massachusetts General Hospital, USA
Varieties of Genetic Variation of Neuropsychiatric Disease


Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 4
* Pamela Sklar, Harvard Medical School, Massachusetts General Hospital, USA
Genetics and Genomics of Schizophrenia and Bipolar Disorder


Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 4
Patrick Sullivan, University of North Carolina, USA
SCZ GWAS - Update 3/09


Saturday, March 07 | 8:00AM - 11:00AM
Genome-Wide Studies of Disease-Related Variation
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 4 of 4
Jonathan Sebat, University of California, San Diego, USA
Microduplication of 16p11.2 is Associated with Schizophrenia


Saturday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, March 07 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, March 07 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Saturday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Saturday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
Room: Quandary 1 & 2

Speaker 1 of 5
* Art Petronis, University of Toronto, Canada
Epigenomics of Major Psychosis

Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
Room: Quandary 1 & 2

Speaker 2 of 5
Schahram Akbarian, Icahn School of Medicine at Mount Sinai, USA
Epigenetic Regulation in Human and Mouse Brain - Focus on Histone Lysine Methylation

Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
Room: Quandary 1 & 2

Speaker 3 of 5
Yue Feng, Emory University, USA
Talk Title to be Determined

Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
Room: Quandary 1 & 2

Speaker 4 of 5
Anne O'Donnell-Luria, Broad Institute, USA
Short Talk: Whole Genome DNA Methylation Profiling of Major Depression

Saturday, March 07 | 5:00PM - 7:00PM
Psychiatric Epigenetics
Room: Quandary 1 & 2

Speaker 5 of 5
Fatemeh G. Haghighi, Columbia University, USA
Short Talk: DNA Methylation Profiling of Schizophrenia

Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 3
Peter B. Jones, Cambridge University, UK
Epidemiology and Risk Factors, Shared or Not?


Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 3
Nick J. Craddock, Cardiff University School of Medicine, UK
Boundaries of the phenotypes: Reconstructing and Rethinking Psychosis


Saturday, March 07 | 5:00PM - 7:00PM
Clinical Epidemiology and Etiology
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 3
* Christopher A. Ross, Johns Hopkins University School of Medicine, USA
Neurogenetics: Insights from Neurodegeneration, Approaches to Psychiatric Disease


Saturday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Saturday, March 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Sunday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 1 of 6
Daniel H. Geschwind, University of California, Los Angeles, USA
Autism: From Genes to Brain

Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 2 of 6
David H. Ledbetter, Geisinger Health, USA
Early Identification of Genetic Sub-Types of Autism Spectrum Disorders (ASDs) by Clinical aCGH Testing and Establishment of an International Public Database

Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 3 of 6
* Janine M. LaSalle, University of California, Davis, USA
Epigenetic Etiologies of Autism Spectrum Disorders

Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 4 of 6
Addie May Ingrid Nesbitt, University of Connecticut, USA
Short Talk: Genomic Imprinting of the X-Linked Gene Transketolase-like 1 in Mouse and Human

Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 5 of 6
Rodney C. Samaco, Baylor College of Medicine, USA
Short Talk: Haploinsufficiency of Crh Ameliorates the Autistic-Like Features in a Mouse Model of MECP2 Duplication Syndrome

Sunday, March 08 | 8:00AM - 11:00AM
Autism
Room: Quandary 1 & 2

Speaker 6 of 6
Steven W. Long, University of Illinois, USA
Short Talk: Purification of a Novel MeCP2 Complex from Rat Brain

Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 5
* David J. Porteous, University of Edinburgh, UK
DISC1: Approaching Causality


Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 5
Hongjun Song, University of Pennsylvania, USA
Regulation of Development of Dentate Granule Neurons by Disrupted-In-Schizophrenia 1 (DISC1)


Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 5
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Disrupted In Schizophrenia 1 (DISC1) Regulates Neural Progenitor Proliferation via beta-Catenin/GSKbeta Signaling


Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 4 of 5
Jonathan D. Wood, University of Sheffield Medical School, UK
Short Talk: Schizophrenia Susceptibility Genes in Zebrafish


Sunday, March 08 | 8:00AM - 11:00AM
Genes and Pathways
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 5 of 5
Gianluca De Rienzo, Whitehead Institute, USA
Short Talk: DISC-1 is an Essential Modulator of the Wnt Signaling Pathway


Sunday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, March 08 | 11:15AM - 11:15AM
On Own for Lunch


Sunday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Sunday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
Room: Quandary 1 & 2

Speaker 1 of 4
* Arthur L. Beaudet, Baylor College of Medicine, USA
Molecular Basis of Angelman Syndrome

Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
Room: Quandary 1 & 2

Speaker 2 of 4
Laura Herzing, Children's Memorial Research Center, USA
Epigenetic Consequences of Fetal Alcohol Exposure

Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
Room: Quandary 1 & 2

Speaker 3 of 4
Edwin J. Weeber, University of South Florida, USA
Synaptic Plasticity Defects in Angelman Syndrome

Sunday, March 08 | 5:00PM - 7:00PM
Imprinting Disorders
Room: Quandary 1 & 2

Speaker 4 of 4
Jon F. Wilkins, Ronin Institute, USA
Short Talk: Imprinted Genes, Risk Preferences, and Delay Discounting

Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 3
Marc G. Caron, Duke University Medical Center, USA
D2 Dopamine Receptor-Mediated Akt/GSK3 Signaling: Behavioral and Therapeutic Implications


Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 3
Ricardo E. Dolmetsch, uniQure, USA
From Calcium Channels to Autism


Sunday, March 08 | 5:00PM - 7:00PM
Genes and Pathways II
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 3
* Daniel R. Weinberger, NIMH/National Institutes of Health, USA
Genetic and Molecular Studies of NRG1/ErbB4


Sunday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, March 09 | 8:00AM - 9:20AM
Monogenic Neurodevelopmental Disorders: Rett Syndrome
Room: Quandary 1 & 2

Speaker 1 of 2
David Katz, Case Western Reserve University School of Medicine, USA
Dysregulation of Neuronal Excitability in Mecp2 Null Mice

Monday, March 09 | 8:00AM - 9:20AM
Monogenic Neurodevelopmental Disorders: Rett Syndrome
Room: Quandary 1 & 2

Speaker 2 of 2
Xinyu Zhao, University of Wisconsin-Madison, USA
Methyl-CpG Binding Proteins in Neurogenesis and Autism Spectrum Disorders

Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 5
* David J. Porteous, University of Edinburgh, UK


Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 5
Fred H. Gage, The Salk Institute for Biological Studies, USA
L1 Retrotransposons During Neurogenesis


Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 5
Bruce T. Lahn, University of Chicago, USA
Fast-Evolving Genes of the Human Brain


Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 4 of 5
Vann Bennett, Duke University Medical Center, USA
Facile Evolution of Ankyrin-Binding Activity as a Mechanism for Co-Localization of Functionally Related Proteins at Axon Initial Segments


Monday, March 09 | 8:00AM - 11:00AM
Evolution and Development of the Brain
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 5 of 5
Judith L. Rapoport, NIMH, National Institutes of Health, USA
Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009


Monday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
Room: Quandary 1 & 2

Speaker 1 of 3
Stephen T. Warren, Emory University School of Medicine, USA
Newborn and Conventional Mutation Screening in Fragile X

Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
Room: Quandary 1 & 2

Speaker 2 of 3
* David L. Nelson, Baylor College of Medicine, USA
Development of Animal Models for Fragile X Syndrome

Monday, March 09 | 9:40AM - 11:15AM
Monogenic Neurodevelopmental Disorders: Fragile X Syndrome
Room: Quandary 1 & 2

Speaker 3 of 3
Peng Jin, Emory University School of Medicine, USA
Fragile X Mental Retardation Protein and Stem Cells

Monday, March 09 | 11:00AM - 11:00AM
On Own for Lunch


Monday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
Room: Quandary 1 & 2

Speaker 1 of 4
* Xinyu Zhao, University of Wisconsin-Madison, USA

Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
Room: Quandary 1 & 2

Speaker 2 of 4
* Peng Jin, Emory University School of Medicine, USA

Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
Room: Quandary 1 & 2

Speaker 3 of 4
Jeffrey M. Besterman, MethylGene Inc., Canada
Epigenetic Therapy of Neurodegenerative Diseases

Monday, March 09 | 5:00PM - 7:00PM
Lessons, Conclusions, and Perspectives
Room: Quandary 1 & 2

Speaker 4 of 4
Bing Ren, Ludwig Institute for Cancer Research, USA
Global Chromatin Modifications at Transcriptional Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome

Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 1 of 3
* Christopher A. Ross, Johns Hopkins University School of Medicine, USA


Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 2 of 3
John R. Kelsoe, University of California, San Diego, USA
Perspectives on Pharmacogenomics: Medication Response in Bipolar Disorder as an Endophenotype


Monday, March 09 | 5:00PM - 7:00PM
Chemical Biology and Therapeutic Strategies
This session is from Schizophrenia & Bipolar
Room: Grays 1 & 2

Speaker 3 of 3
Edward M. Scolnick, MIT Broad Institute, USA
Clinical Applications of Emerging Psychiatric Genetics


Monday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Monday, March 09 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Tuesday, March 10 | 10:25AM - 10:25AM
Departure


*Session Chair.