Web Desc
HIV Immunobiology: From Infection to Immune Control
joint with Prevention of HIV/AIDS
Organizer(s): Didier Trono, Dana H. Gabuzda and Robert F. Siliciano
Date: March 22 - 27, 2009
Location: Keystone Resort, Keystone, CO, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
This meeting will highlight the latest breakthroughs in basic HIV research, ranging from the molecular bases of HIV replication to the host genetic determinants influencing viral spread and disease susceptibility; and from the intricacy of the interaction between HIV and the immune system to the most promising progress in therapeutic development. The meeting will identify new levels of possible intervention to control the progression of HIV-induced disease and, more generally, deepen our understanding of the intimate interaction between retroelements and human hosts. Dynamism will be ensured by having concise, up-to-date talks rather than lengthy lectures, by giving ample room to speakers chosen from the abstracts, and by a close coordination with the concurrent meeting on 'Prevention of HIV/AIDS'. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting, which will share a keynote address and three plenary sessions with this meeting.
Global Health Travel Award Deadline: October 14 2008
Scholarship Deadline: November 24 2008
Discounted Abstract Deadline: November 24 2008
Abstract Deadline: December 22 2008
Discounted Registration Deadline: January 22 2009
We gratefully acknowledge additional support for this conference from:
Amnis CorporationBill & Melinda Gates Foundation
GenVec, Inc.
Gilead Sciences, Inc.International AIDS Vaccine Initiative (IAVI)Office of AIDS Research, NIHTibotec, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI081594-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 22 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, March 22 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 22 | 7:30PM - 9:30PM
Keynote Address (Joint)
Room: Grays Peak / Longs Peak

Speaker 1 of 4
* Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Address (Joint)
Room: Grays Peak / Longs Peak

Speaker 2 of 4
* Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Address (Joint)
Room: Grays Peak / Longs Peak

Speaker 3 of 4
Françoise Barré-Sinoussi, Institut Pasteur, France
HIV Diversity and Pathogenesis

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Address (Joint)
Room: Grays Peak / Longs Peak

Speaker 4 of 4
Rafi Ahmed, Emory University School of Medicine, USA
Vaccination and Immune Memory

Monday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud / Shavano / Torreys


Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland

Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
Amalio Telenti, Centre Hospitalier Universitaire Vaudois, Switzerland
Evolutionary and Integrative Genomics of Susceptibility to HIV

Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
Mary Carrington, NCI, National Institutes of Health, USA
Immunogenetic Variation Characterizing Exceptional Control of HIV

Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
HIV Controllers: A Model for T Cell Vaccination?

Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Ioannis Theodorou, INSERM U543, France
Short Talk: Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study

Monday, March 23 | 8:00AM - 11:00AM
Host Genomics and HIV Disease (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
David I. Watkins, University of Miami, USA
Vaccine-Induced Cellular Responses Control Acute SIV Replication after Heterologous Challenge

Monday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 23 | 11:00AM - 11:00AM
On Own for Lunch


Monday, March 23 | 11:00AM - 12:30PM
Hands On Computer Workshop on Los Alamos Sequence Database
Room: Castle Peaks
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.

Monday, March 23 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud / Shavano / Torreys


Monday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud / Shavano / Torreys


Monday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 23 | 5:00PM - 7:00PM
Hiding from Immunity: Reservoirs and Latency
Room: Grays/Longs Peaks

Speaker 1 of 5
* Douglas D. Richman, University of California, San Diego, USA

Monday, March 23 | 5:00PM - 7:00PM
Hiding from Immunity: Reservoirs and Latency
Room: Grays/Longs Peaks

Speaker 2 of 5
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Quantitative Analysis of the Control of HIV Replication by Drugs and Vaccines

Monday, March 23 | 5:00PM - 7:00PM
Hiding from Immunity: Reservoirs and Latency
Room: Grays/Longs Peaks

Speaker 3 of 5
Joel N. Blankson, Johns Hopkins School of Medicine, USA
HIV-1 Latency and Low Level Viremia in Elite Suppressors

Monday, March 23 | 5:00PM - 7:00PM
Hiding from Immunity: Reservoirs and Latency
Room: Grays/Longs Peaks

Speaker 4 of 5
Dana H. Gabuzda, Dana Farber Cancer Institute, USA
Macrophage Reservoirs

Monday, March 23 | 5:00PM - 7:00PM
Hiding from Immunity: Reservoirs and Latency
Room: Grays/Longs Peaks

Speaker 5 of 5
Matthias Geyer, Max Planck Institute for Molecular Physiology, Germany
Short Talk: Structural Insights into the Cyclin T1–Tat–TAR RNA Transcription Activation Complex

Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 1 of 7
* Glenda E. Gray, South African Medical Research Council, South Africa


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 2 of 7
Bertran Auvert, CHU Ambroise Paré, France
Circumcision: Uptake and Impact


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 3 of 7
Minh H. Dinh, Northwestern University Feinberg School of Medicine, USA
Short Talk: HIV-1 Interactions with Adult Human Penile Epithelium


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 4 of 7
Barbara L. Shacklett, University of California, Davis, USA
Short Talk: Do Mucosal T Cell Responses to HIV-1 Matter?


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 5 of 7
Carolina Herrera, Imperial College, UK
Short Talk: Early Colorectal Responses to HIV-1 and Modulation by Microbicides


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 6 of 7
Gilda Tachedjian, Burnet Institute, Australia
Short Talk: Enhancement of HIV-1 Infection is Not Intrinsic to Polyanion-Based Microbicides


Monday, March 23 | 5:00PM - 7:15PM
The Bigger Picture: Microbicides, Circumcision and Drugs for
Prevention
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 7 of 7
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
Antiretroviral Therapy to Prevent Sexual Transmission of HIV-1


Monday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud / Shavano / Torreys


Monday, March 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud / Shavano / Torreys


Tuesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud / Shavano / Torreys


Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA

Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
Immune Correlates of Protection to HIV

Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
Joseph (Mike) McCune, Bill & Melinda Gates Foundation, USA
Short Talk: Immune Control in Pathogenic and Nonpathogenic SIV Infection

Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
Mark Connors, NIAID, National Institutes of Health, USA
Short Talk: Effective Control of HIV by CD8+ T-Cells is Associated with Infected CD4+ T Cell Elimination: Ramifications for T Cell Based Vaccines

Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Philip J. Goulder, University of Oxford, UK
HIV Escape and T-Cell Control of HIV

Tuesday, March 24 | 8:00AM - 11:00AM
Immune Control of HIV and Virus Escape (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
George M. Shaw, University of Pennsylvania, USA
HIV-1 Sequences in Acute and Early Infection Reveal the Genetic Identity, Biological Phenotype, and Precise Evolutionary Pathways of Transmitted/Founder Viruses and their Progeny

Tuesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 24 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, March 24 | 11:00AM - 12:30PM
Hands On Computer Workshop on Los Alamos Sequence Database
Room: Castle Peaks
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.

Tuesday, March 24 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud / Shavano / Torreys


Tuesday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud / Shavano / Torreys


Tuesday, March 24 | 2:30PM - 3:30PM
Workshop 1A: New Therapeutics
Room: Grays/Longs Peaks

Speaker 1 of 4
* Dana H. Gabuzda, Dana Farber Cancer Institute, USA

Tuesday, March 24 | 2:30PM - 3:30PM
Workshop 1A: New Therapeutics
Room: Grays/Longs Peaks

Speaker 2 of 4
Daria J. Hazuda, Merck Research Laboratories, USA
Integrase Inhibitors

Tuesday, March 24 | 2:30PM - 3:30PM
Workshop 1A: New Therapeutics
Room: Grays/Longs Peaks

Speaker 3 of 4
Mike Westby, Pfizer Global Research and Development, UK
CCR5 Antagonists as HIV Entry Inhibitors

Tuesday, March 24 | 2:30PM - 3:30PM
Workshop 1A: New Therapeutics
Room: Grays/Longs Peaks

Speaker 4 of 4
Navid Madani, Dana Farber Cancer Institute, USA
New Entry Inhibitors: Interaction of Small-Molecule CD4 Mimics with a Highly Conserved Pocket on the HIV gp120 Envelope Glycoprotein

Tuesday, March 24 | 3:30PM - 4:30PM
Workshop 1B: Th17 Cells
Room: Grays/Longs Peaks

Speaker 1 of 5
* Robert F. Siliciano, Johns Hopkins University School of Medicine, USA

Tuesday, March 24 | 3:30PM - 4:30PM
Workshop 1B: Th17 Cells
Room: Grays/Longs Peaks

Speaker 2 of 5
Aimee El Hed, New York University School of Medicine, USA
Human Th17 Cells are Highly Susceptible to CCR5-Tropic HIV Infection and are Preferentially Depleted in Infected Individuals

Tuesday, March 24 | 3:30PM - 4:30PM
Workshop 1B: Th17 Cells
Room: Grays/Longs Peaks

Speaker 3 of 5
Nicolas Manel, Institut Curie, France
The Differentiation of Human Th17 Cells Requires TGF-beta and Induction of the Nuclear Receptor RORgammat and this Renders T Cells more Susceptible to HIV-1 Infection

Tuesday, March 24 | 3:30PM - 4:30PM
Workshop 1B: Th17 Cells
Room: Grays/Longs Peaks

Speaker 4 of 5
Petronela Ancuta, Centre de Recherche de l'Universite de Montreal, Canada
HIV Replicates in CCR6+IFN-gamma+IL-17+ but Not CCR6negIFN-gamma+IL-10+ Primary CD4+ T-Cell Subsets

Tuesday, March 24 | 3:30PM - 4:30PM
Workshop 1B: Th17 Cells
Room: Grays/Longs Peaks

Speaker 5 of 5
Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
Tat-Induced FOXO3a is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T-Lymphocytes

Tuesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 24 | 5:00PM - 7:00PM
Models of HIV Immunobiology
Room: Grays/Longs Peaks

Speaker 1 of 4
* Frank Kirchhoff, University of Ulm, Germany

Tuesday, March 24 | 5:00PM - 7:00PM
Models of HIV Immunobiology
Room: Grays/Longs Peaks

Speaker 2 of 4
Guido Silvestri, Emory University School of Medicine, USA
SIV Infection of African Monkeys: A New Paradigm for AIDS Pathogenesis and Vaccines

Tuesday, March 24 | 5:00PM - 7:00PM
Models of HIV Immunobiology
Room: Grays/Longs Peaks

Speaker 3 of 4
Cecilia Cheng-Mayer, Aaron Diamond AIDS Research Center (ADARC), USA
Coreceptor switching in the SHIV/macaque model

Tuesday, March 24 | 5:00PM - 7:00PM
Models of HIV Immunobiology
Room: Grays/Longs Peaks

Speaker 4 of 4
Sarah L. Rowland-Jones, Oxford University, UK
Long-term non-progression with HIV infection: lessons from HIV-2

Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 1 of 6
* David I. Watkins, University of Miami, USA


Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 2 of 6
Bali Pulendran, Stanford University School of Medicine, USA
Modulating Vaccine Responses with Innate Immunity



Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 3 of 6
Susan W. Barnett, Bill & Melinda Gates Foundation, USA
HIV Antigen Discovery and Novel Vaccine Deliveries Using Recombinant Alphavirus Replicon Particles and Adjuvanted Proteins


Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 4 of 6
Christopher J. Miller, University of California, Davis, USA
A T Cell Vaccine that Elicits Mucosal CD8+ Effector Cells in a Setting of Minimal Immune Activation Can Protect Rhesus Monkeys from Vaginal SIV Challenge


Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 5 of 6
Barbara K. Felber, NCI, National Institutes of Health, USA
Short Talk: Electroporation of Optimized DNA Vaccines Leads to Greatly Enhanced Systemic and Mucosal Immune Responses and Control of Pathogenic SIVmac251 Challenge: Antibodies Contribute to Virus Containment


Tuesday, March 24 | 5:00PM - 7:15PM
How to Improve Vaccine Efficacy? Adjuvants, Route of Adminis
tration...
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 6 of 6
Johannes Fabian Scheid, Massachusetts General Hospital - Harvard, USA
Short Talk: Search for Broadly Neutralizing Antibodies against HIV using a Single Cell Approach


Tuesday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud / Shavano / Torreys


Tuesday, March 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud / Shavano / Torreys


Wednesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud / Shavano / Torreys


Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 1 of 6
* Michael H. Malim, King's College London, UK

Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 2 of 6
Frank Kirchhoff, University of Ulm, Germany
Role of Nef in vivo and in vitro

Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 3 of 6
Christopher Aiken, Vanderbilt University School of Medicine, USA
Cyclophilin A and HIV-1 Uncoating

Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 4 of 6
Nathaniel R. Landau, New York University School of Medicine, USA
Vpr and DNA Damage

Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 5 of 6
John C. Guatelli, University of California, San Diego, USA
Short Talk: Vpu Antagonizes BST-2-Mediated Restriction of HIV-1 Release via b-TrCP and Endo-Lysosomal Trafficking

Wednesday, March 25 | 8:00AM - 11:00AM
New Insights in HIV Replication
Room: Grays/Longs Peaks

Speaker 6 of 6
Andres Finzi, CRCHUM, Université de Montréal, Canada
Short Talk: A Layered Structure in the HIV-1 gp120 Inner Domain Regulates gp41 Interaction and Facilitates Transitions into the CD4-Bound Conformation

Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 1 of 6
* Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland


Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 2 of 6
Barton F. Haynes, Duke University Medical Center, USA
What Does a Successful HIV-1 Vaccine Need To Do? Clues From Acute HIV-1 Infection


Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 3 of 6
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Novel Adenovirus Vector-Based Vaccines for HIV-1


Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 4 of 6
Dennis R. Burton, The Scripps Research Institute, USA
Mechanisms of Antibody Protection Against HIV


Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 5 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
Structure-Based Envelope Immunogens


Wednesday, March 25 | 8:00AM - 11:00AM
How to Generate Vaccine Efficacy against HIV? T Cell-Based
and B-Cell Based Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 6 of 6
Amitinder Kaur, New England Regional Primate Research Center, USA
Short Talk: Protective Efficacy of a Replication-Defective Herpes Simplex Virus-based AIDS Vaccine Against High Dose Intra-Rectal SIVmac239 Challenge


Wednesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 25 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud / Shavano / Torreys


Wednesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud / Shavano / Torreys


Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 1 of 8
Carl W. Dieffenbach, NIAID, National Institutes of Health, USA
Workshop Objectives

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 2 of 8
* Roger Ptak, Southern Research Institute, USA
Cataloging the HIV-Human Protein Interaction Network

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 3 of 8
John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Genome-Wide Screeing of HIV-Host Interactions

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 4 of 8
Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Regulation of HIV-1 Nuclear Entry

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 5 of 8
* Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 6 of 8
Dana H. Gabuzda, Dana Farber Cancer Institute, USA
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 7 of 8
Tariq M. Rana, University of California, San Diego, USA
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening

Wednesday, March 25 | 1:30PM - 4:30PM
NIAID Workshop on Identification and Validation of New Cellu
lar Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
Room: Grays/Longs Peaks
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
Speaker 8 of 8
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
Wrap-Up and Future Directions

Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 1 of 9
* Richard A. Koup, NIAID, National Institutes of Health, USA


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 2 of 9
Asier Sáez-Cirión, Institut Pasteur, France
The Strong HIV Suppressive Capacity of CD8+ T Cells from HIV Controllers is Associated with Gag-Specific CD8+ T Cell Responses


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 3 of 9
Adam R. Hersperger, Thomas Jefferson University, USA
HIV-Specific CD8 T Cells from Elite Controllers Rapidly Upregulate Perforin


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 4 of 9
Meritxell Genescà, Health Sciences Research Institute Germans Trias i Pujol Foundation, Spain
For the CD8+ T Cells to be Effective in the Context of a Live-Attenuated Vaccine Differential Immune Activation is Critical


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 5 of 9
Jorge Ramos de Almeida, NIAID, National Institutes of Health, USA
Antigen Sensitivity is a Major Determinant of CD8+ T Cell Efficacy in HIV-1 Infection


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 6 of 9
Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA
Broad Neutralizing Antibody Responses during HIV-1 Infection: Prevalence and Epitope Specificities


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 7 of 9
Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA
Breadth of Neutralizing Antibodies in HIV+ Serum: Clustering Analysis and Association with Clinical Variables


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 8 of 9
Ann J. Hessell, Oregon Health & Science University, USA
Complete Protection Provided by Antibodies 2F5 and 4E10 Against Mucosal SHIV BaL Challenge


Wednesday, March 25 | 2:30PM - 4:30PM
Workshop 1: Which Immune Correlates of Protection against HI
V? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 9 of 9
Vincent Holl, Institute of Virology, France
Identification of HIV-Specific IgG that Inhibit Infection of Mucosal HIV Target Cells


Wednesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 25 | 5:00PM - 7:00PM
HIV at the Mucosa: Portal of Entry and Front-Line Defense (J
oint)

Room: Columbine Ballroom

Speaker 1 of 5
* Daniel C. Douek, NIAID, National Institutes of Health, USA

Wednesday, March 25 | 5:00PM - 7:00PM
HIV at the Mucosa: Portal of Entry and Front-Line Defense (J
oint)

Room: Columbine Ballroom

Speaker 2 of 5
Ashley T. Haase, University of Minnesota, USA
Keynote Address: Quest for Design Principles for an Effective HIV Vaccine/Microbicide in Studies of SIV Pathogenesis

Wednesday, March 25 | 5:00PM - 7:00PM
HIV at the Mucosa: Portal of Entry and Front-Line Defense (J
oint)

Room: Columbine Ballroom

Speaker 3 of 5
Alison Simmons, Weatherall Institute of Molecular Medicine, UK
Dendritic Cell Factors Required for HIV-1 Infection

Wednesday, March 25 | 5:00PM - 7:00PM
HIV at the Mucosa: Portal of Entry and Front-Line Defense (J
oint)

Room: Columbine Ballroom

Speaker 4 of 5
Ronald S. Veazey, Tulane National Primate Research Center, USA
_7 Integrin Expression on CD4+ T Cells as a Surrogate Marker for Tracking Intestinal CD4+ T Cell Loss in SIV Infection

Wednesday, March 25 | 5:00PM - 7:00PM
HIV at the Mucosa: Portal of Entry and Front-Line Defense (J
oint)

Room: Columbine Ballroom

Speaker 5 of 5
Satya Dandekar, University of California, Davis, USA
Short Talk: Mechanisms of Impaired Gut Mucosal Defenses during HIV and SIV Infections

Wednesday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud / Shavano / Torreys


Wednesday, March 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 7:00AM - 8:00AM
Poster Setup
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 8:00AM - 11:00AM
Innate Antiviral Immunity
Room: Grays/Longs Peaks

Speaker 1 of 5
* Christopher Aiken, Vanderbilt University School of Medicine, USA

Thursday, March 26 | 8:00AM - 11:00AM
Innate Antiviral Immunity
Room: Grays/Longs Peaks

Speaker 2 of 5
Michael H. Malim, King's College London, UK
APOBEC3 Proteins and Intrinsic Resistance to HIV-1 Infection

Thursday, March 26 | 8:00AM - 11:00AM
Innate Antiviral Immunity
Room: Grays/Longs Peaks

Speaker 3 of 5
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
The Role of APOBEC3 Enzymes in Counteracting “Retro-Threats”, Both Foreign and Domestic

Thursday, March 26 | 8:00AM - 11:00AM
Innate Antiviral Immunity
Room: Grays/Longs Peaks

Speaker 4 of 5
Greg J. Towers, University College London, UK
Inhibition of Retroviral Infection by TRIMCyp and Tetherin Reveals a Delicate Balance between Viral Countermeasures and Host Restriction

Thursday, March 26 | 8:00AM - 11:00AM
Innate Antiviral Immunity
Room: Grays/Longs Peaks

Speaker 5 of 5
Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Epigenetic Control of Retroelements

Thursday, March 26 | 8:00AM - 11:15AM
HIV-HSV-2 Interactions and Lessons from Clinical Trials of P
reventative Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 1 of 5
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA
Mechanism behind the HSV-2-HIV Interaction: Subclinical Persistence of HIV Receptor Positive Cells


Thursday, March 26 | 8:00AM - 11:15AM
HIV-HSV-2 Interactions and Lessons from Clinical Trials of P
reventative Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 2 of 5
* Scott M. Hammer, Columbia University, USA
Challenges in Preventative Vaccine Development


Thursday, March 26 | 8:00AM - 11:15AM
HIV-HSV-2 Interactions and Lessons from Clinical Trials of P
reventative Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 3 of 5
Susan P. Buchbinder, San Francisco Department of Public Health, USA
Clinical Endpoints in the Step Study


Thursday, March 26 | 8:00AM - 11:15AM
HIV-HSV-2 Interactions and Lessons from Clinical Trials of P
reventative Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 4 of 5
M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Lessons from the HIV-Ad5 Vaccine Phase II Clinical Trial


Thursday, March 26 | 8:00AM - 11:15AM
HIV-HSV-2 Interactions and Lessons from Clinical Trials of P
reventative Vaccines
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 5 of 5
Merlin L. Robb, Walter Reed Army Institute of Research, USA
Lessons from the Thai ALVAC-gp120 HIV Vaccine Efficacy Trial: A Community Based Study


Thursday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 26 | 11:00AM - 12:00PM
Lunch
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 12:00PM - 2:30PM
Poster Session 4
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Clinical Trials Design. Supported in part by th
e French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 1 of 5
* Scott M. Hammer, Columbia University, USA


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Clinical Trials Design. Supported in part by th
e French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 2 of 5
Dean Follmann, NIH: National Institute of Allergy and Infectious Diseases (NIAID), USA
Crossover Designs for HIV Prevention Trials


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Clinical Trials Design. Supported in part by th
e French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 3 of 5
Peter Gilbert, Fred Hutchinson Cancer Research Center, USA
Leveraging Baseline Characteristics to Improve Prevention Trials


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Clinical Trials Design. Supported in part by th
e French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 4 of 5
Frances Priddy, International AIDS Vaccine Initiative, USA
HIV Vaccines and PrEP


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Clinical Trials Design. Supported in part by th
e French Agency for AIDS Research (ANRS)
This session is from Prevention of HIV/AIDS (Vac)
Room: Quandary

Speaker 5 of 5
Heather B. Jaspan, University of Cape Town, South Africa
HIV Vaccine Trials in Adolescents


Thursday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 1 of 6
* Alison Simmons, Weatherall Institute of Molecular Medicine, UK

Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 2 of 6
Olivier Schwartz, Institut Pasteur, France
Mechanisms of Direct HIV Lymphocyte-to-Lymphocyte Transfer: Role of “Polysynapses”

Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 3 of 6
Thomas J. Hope, Northwestern University, USA
Interaction of HIV with Cells within Intact Mucosal Tissue

Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 4 of 6
Vincent Piguet, Cardiff University, UK
Mechanisms of DC-T Cell HIV-1 Transmission via an Infectious Synapse

Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 5 of 6
Walther Mothes, Yale University School of Medicine, USA
Short Talk: Retroviral Assembly is Directed Towards Sites of Cell-Cell Contact

Thursday, March 26 | 5:00PM - 7:15PM
Virus Spread
Room: Grays/Longs Peaks

Speaker 6 of 6
Sriram Subramaniam, University of British Columbia, Canada
Short Talk: 3D Architecture of the Virological Synapse and Structural Mechanisms of HIV Entry

Thursday, March 26 | 5:00PM - 7:00PM
Prevention of AIDS: What can we Learn from Therapeutic Vacci
nes
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 1 of 4
Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Lessons for Therapeutic Vaccines against HIV for Immune Correlates of Protection against HIV


Thursday, March 26 | 5:00PM - 7:00PM
Prevention of AIDS: What can we Learn from Therapeutic Vacci
nes
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 2 of 4
* Rafick Sekaly, Emory University, USA
Improving and Modeling of Therapeutic Autologous Dendritic Cell Vaccine for HIV-1 Infection


Thursday, March 26 | 5:00PM - 7:00PM
Prevention of AIDS: What can we Learn from Therapeutic Vacci
nes
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 3 of 4
Stephen J. Kent, University of Melbourne, Australia
Short Talk: Reduced Viremia and Delayed Disease Progression Following Immunotherapy of SIV with Antigen Pulsed Blood


Thursday, March 26 | 5:00PM - 7:00PM
Prevention of AIDS: What can we Learn from Therapeutic Vacci
nes
This session is from Prevention of HIV/AIDS (Vac)

Room: Quandary

Speaker 4 of 4
Glenda E. Gray, South African Medical Research Council, South Africa
HIV Vaccine Trials in South Africa: Looking Forward from Phambili


Thursday, March 26 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud / Shavano / Torreys


Thursday, March 26 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud / Shavano / Torreys


Friday, March 27 | 10:25AM - 10:25AM
Departure


*Session Chair.