Web Desc
Mitochondrial Dynamics and Physiology
joint with Cell Death Pathways
Organizer(s): Janet M. Shaw and David C. Chan
Date: March 22 - 27, 2009
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
The view of mitochondria as dynamic organelles that are continuously remodeled by fission, fusion and transport has finally become mainstream. Research reveals that these processes impact mitochondrial function in healthy and apoptotic cells and cause inherited neuropathies in humans when disturbed. Progress has been made in identifying the molecular machineries that carry out these events and the signaling pathways that integrate mitochondrial behavior with cell physiology. The current challenge for researchers and clinicians is to incorporate these findings into testable models for the etiology of mitochondrial diseases. The goal of this meeting is to bring together international leaders in basic and clinical research to discuss new and exciting findings and the best strategies for applying this information in the laboratory and the clinic. By including workshops and short talks chosen from abstracts, the program will showcase late-breaking “hot” topics, provide a forum to critically evaluate current controversies, and will be of interest to scientists interested in basic mechanisms of organelle biology as well as clinicians interested in mitochondrial pathology. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Cell Death Pathways”, which will share a Keynote and two plenary sessions with this meeting.
Scholarship Deadline: November 25 2008
Discounted Abstract Deadline: November 25 2008
Abstract Deadline: December 23 2008
Discounted Registration Deadline: January 22 2009
We gratefully acknowledge additional support for this conference from:
MitoSciences, an Abcam CompanyThe Ellison Medical FoundationUnited Mitochondrial Disease Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 22 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, March 22 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, March 22 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 4
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 4
* Janet M. Shaw, University of Utah, USA

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 4
Douglas R. Green, St. Jude Children's Research Hospital, USA
The Mitochondrial Pathway of Apoptosis

Sunday, March 22 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 4
Richard J. Youle, NINDS, National Institutes of Health, USA
Mitochondrial Morphogenesis and Apoptosis

Monday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 7
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 7
Jean-Claude Martinou, University of Geneva, Switzerland
Mechanisms of Bax Activation

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 7
Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Mitochondrial Fusion and Fission, as Regulated by the Bcl-2 homolog CED-9

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Short Talk: Mitochondrial Fission-Fusion Dynamics and Apoptosis

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 7
Luca Scorrano, University of Padova, Italy
EMBO Young Investigator Lecture: Multiple Fuctional Roles of Mitochondrial-Shaping Proteins

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 6 of 7
Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Multiple Mitochondrial Events Critical for Cell Death

Monday, March 23 | 8:00AM - 11:15AM
Mitochondrial Dynamics and Cell Death (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 7 of 7
David C. Chan, California Institute of Technology, USA
Mitochondrial Dynamiscs, mtDNA Stability and Tolerance of mtDNA Mutations

Monday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 23 | 11:15AM - 11:15AM
On Own for Lunch


Monday, March 23 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 23 | 5:00PM - 7:00PM
Molecular Mechanisms of Mitochondrial Fusion
Room: Sea to Sky Ballroom C

Speaker 1 of 4
* Jodi Nunnari, University of California, Davis, USA
The Molecular Mechanism of Mitochondrial Fusion

Monday, March 23 | 5:00PM - 7:00PM
Molecular Mechanisms of Mitochondrial Fusion
Room: Sea to Sky Ballroom C

Speaker 2 of 4
Zhongyan Zhang, John Hopkins University School of Medicine, USA
Role of Opa1 in Pancreatic Beta Cells

Monday, March 23 | 5:00PM - 7:00PM
Molecular Mechanisms of Mitochondrial Fusion
Room: Sea to Sky Ballroom C

Speaker 3 of 4
György Hajnóczky, Thomas Jefferson University, USA
Short Talk: Interdependence of Mitochondrial Fusion- Fission and Motility Dynamics

Monday, March 23 | 5:00PM - 7:00PM
Molecular Mechanisms of Mitochondrial Fusion
Room: Sea to Sky Ballroom C

Speaker 4 of 4
Astrid C. Schauss, University of Ottawa Heart Institute, Canada
Short Talk: Characterization of a Bimolecular Complementation Assay to Quantify Mammalian Mitochondrial Fusion in vitro

Monday, March 23 | 5:00PM - 7:00PM
Caspases and IAPs
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Seamus J. Martin, Trinity College Dublin, Ireland


Monday, March 23 | 5:00PM - 7:00PM
Caspases and IAPs
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 5
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Caspases and Their Substrates


Monday, March 23 | 5:00PM - 7:00PM
Caspases and IAPs
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Domagoj Vucic, Genentech, Inc., USA
Targeting IAPs: TNFalpha and Ubiquitin Connections


Monday, March 23 | 5:00PM - 7:00PM
Caspases and IAPs
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Francesco Cecconi, University of Rome Tor Vergata, Italy
Short Talk: Molecular Analysis of Synaptic Degeneration at the Onset of Alzheimer’s Disease


Monday, March 23 | 5:00PM - 7:00PM
Caspases and IAPs
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Pascal Meier, Institute of Cancer Research, UK
Regulation of Caspases by Ubiquitin and Ubiquitin-like Proteins


Monday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Monday, March 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Tuesday, March 24 | 7:00AM - 8:00AM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 1 of 6
Janet M. Shaw, University of Utah, USA
Recruitment and Assembly of the Mitochondrial Membrane Fission Machinery

Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 2 of 6
* Alexander M. van der Bliek, University of California, Los Angeles, USA
Mitochondrial Fission and Fusion in C. elegans

Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 3 of 6
Heidi M. McBride, McGill University, Canada
Mitochondrial Derived Vesicles as a New Vehicle for Intracellular Transport

Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 4 of 6
Tsuneyoshi Kuroiwa, Rikkyo (St. Paul’s) University, Japan
Isolation of Mitochondrial Division Machineries

Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 5 of 6
Naotada Ishihara, Kurume University, Japan
Short Talk: Fis1 Acts as Mitochondrial Receptor for Novel Protein that Regulates Mitochondrial Morphology

Tuesday, March 24 | 8:00AM - 11:15AM
Mitochondrial Fission and Evolution of the Division Apparatu
s

Room: Sea to Sky Ballroom C

Speaker 6 of 6
Sarah R. Horn, Duke University Medical Center, USA
Short Talk: Degradation of the Mitochondrial Fission Protein Drp1 by the APCcdh1 Ubiquitin Ligase

Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Pascal Meier, Institute of Cancer Research, UK


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Joan S. Brugge, Harvard Medical School, USA
Regulation of Cell Metabolism by Extracellular Matrix


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Andreas Bergmann, University of Massachusetts Medical School, USA
Genetic Regulation of Programmed Cell Death during Drosophila Development


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Kim McCall, Boston University, USA
Short Talk: Cell-Autonomous Requirement for DNaseII and Lysosomal Genes during Non-Apoptotic Cell Death in the Drosophila Ovary


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 7
W. Brent Derry, Hospital for Sick Children, Canada
Genetic Regulation of Cell Death during Germline Development in C. elegans


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Anatoly Nikolaev, Genentech, USA
Short Talk: Axonal Self-Destruction and Neurodegenerative Disease


Tuesday, March 24 | 8:00AM - 11:15AM
Cell Survival and Death Signaling during Development
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Laura A. Johnston, Columbia University, USA
Competitive Interactions during Growth in Drosophila: A Mechanism for Tissue Homeostasis


Tuesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 24 | 11:15AM - 12:00PM
Lunch
Room: Foyer/Sea to Sky Ballroom A


Tuesday, March 24 | 12:00PM - 2:30PM
Poster Session 2
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 1 of 8
* Edward A. Fon, McGill University, Canada

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 2 of 8
* Ming Guo, University of California, Los Angeles, USA

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 3 of 8
Konstanze F. Winklhofer, Ruhr University Bochum, Germany
A Role of Parkin and PINK1 in the Regulation of Mitochondrial Dynamics

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 4 of 8
Alex J. Whitworth, University of Sheffield, UK
Rhomboid-7 Cleaves the Parkinson Disease Factors PINK1 and Omi/HtrA2 and Promotes Mitochondrial Fission

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 5 of 8
Vanessa A. Morais, Katholieke Universiteit Leuven & VIB, Belgium
PINK1 Primarily Regulates Complex I Activity and Synaptic Function

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 6 of 8
Lian Li, Emory University School of Medicine, USA
The PINK1 Mitochondrial Signaling Pathways and Pakinson Disease

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 7 of 8
Isabella Irrcher, Ottawa Health Research Institute/University of Ottawa, Canada
Loss of the Parkinson’s Disease-Linked Gene DJ-1 Results in Abnormal Mitochondrial Dynamics

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Dynamics and Parkinson's Disease
Room: Sea to Sky Ballroom C

Speaker 8 of 8
Olga Corti, INSERM, France
A Differential Proteomic Screen to Identify Proteins Altered in Abundance in Parkin-deficient Mice

Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Identifying the Factors that Determine Specificity in the Autophagy Response


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Ying-Chen Claire Hou, British Columbia Cancer Agency, Canada
Molecular Mechanism of Effector Caspase Dcp-1 in Starvation-Induced Autophagy


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Marc Germain, University of Ottawa, Canada
MCL-1 is a Key Regulator of Autophagy


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Natasha Chang, McGill University, Canada
Antagonism of Beclin 1 by Bcl-2 is Mediated by the Endoplasmic Reticulum Protein, Naf-1


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Anna Katharina Simon, University of Oxford, UK
Hematopoietic Cells Require Mitophagy Mediated by the Core Autophagy Gene Atg7 for Survival in vivo


Tuesday, March 24 | 2:30PM - 4:30PM
Workshop 1: Relationship between Autophagy and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Mondira Kundu, St. Jude Children's Hospital, USA
Hsp90 Regulates Ulk1-Mediated Autophagic Clearance of Mitochondria


Tuesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 24 | 5:00PM - 7:00PM
Regulation of Mitochondrial Dynamics
Room: Sea to Sky Ballroom C

Speaker 1 of 5
* Richard J. Youle, NINDS, National Institutes of Health, USA

Tuesday, March 24 | 5:00PM - 7:00PM
Regulation of Mitochondrial Dynamics
Room: Sea to Sky Ballroom C

Speaker 2 of 5
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics

Tuesday, March 24 | 5:00PM - 7:00PM
Regulation of Mitochondrial Dynamics
Room: Sea to Sky Ballroom C

Speaker 3 of 5
Andreas S. Reichert, Goethe University Frankfurt am Main, Germany
Molecular Insights into Mitochondrial Membrane Dynamics and Structure

Tuesday, March 24 | 5:00PM - 7:00PM
Regulation of Mitochondrial Dynamics
Room: Sea to Sky Ballroom C

Speaker 4 of 5
Katsuyoshi Mihara, Kyushu University, Japan
The Physiologic Importance of Mammalian Mitochondrial Fission Factor Drp1

Tuesday, March 24 | 5:00PM - 7:00PM
Regulation of Mitochondrial Dynamics
Room: Sea to Sky Ballroom C

Speaker 5 of 5
Daniel Tondera, Dana-Faber Cancer Institute, USA
Short Talk: Key Players and Physiological Role of Stress-Induced Mitochondrial Hyperfusion

Tuesday, March 24 | 5:00PM - 7:00PM
Bcl-2 Family
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Sally A. Kornbluth, Duke University Medical Center, USA


Tuesday, March 24 | 5:00PM - 7:00PM
Bcl-2 Family
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 5
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Bcl-2 Proteins Regulate Mitochondria in Neurons and Yeast…Where the Trail Leads


Tuesday, March 24 | 5:00PM - 7:00PM
Bcl-2 Family
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Evripidis Gavathiotis, Albert Einstein College of Medicine, USA
Short Talk: Structural and Functional Characterization of the Trigger Mechanism for BH3-Induced Direct BAX Activation


Tuesday, March 24 | 5:00PM - 7:00PM
Bcl-2 Family
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Andreas Villunger, Medical University Innsbruck, Austria
Role and Function of the BH3-Only Protein Bmf in Development and Disease


Tuesday, March 24 | 5:00PM - 7:00PM
Bcl-2 Family
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Emily H. Cheng, Washington University Medical School, USA
The VDAC2-BAK Axis Controls Survival of Thymocytes


Tuesday, March 24 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 6
* Eileen P. White, Rutgers Cancer Institute of New Jersey, USA

Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 6
Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Metabolism and Bcl-2 Family Proteins

Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 6
Ming Guo, University of California, Los Angeles, USA
Mitochondrial Pathways to Pakinson’s Disease

Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 6
Nils-Goran Larsson, Karolinska Institutet, Sweden
Regulation of Mammalian mtDNA Gene Expression

Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 6
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of Endogenous Pro-Survival Bcl-2 Family Members in Tumor Development and Sustained Tumor Growth


Wednesday, March 25 | 8:00AM - 11:15AM
Mitochondrial Factors, Cell Death and Disease (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 6 of 6
David W. Andrews, Sunnybrook Research Institute, Canada
Bcl-2 Family Proteins as Therapeutic Targets

Wednesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 25 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 1 of 6
* Nils-Goran Larsson, Karolinska Institutet, Sweden

Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 2 of 6
Jeffery M. Vance, University of Miami, USA
Mitochondria and Hereditary Neurologic Disease

Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 3 of 6
Marcela Votruba, Cardiff University, UK
OPA1 and OPA3 Mutations in Mouse Models of Inherited Optic Atrophy

Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 4 of 6
Hugo J. Bellen, Baylor College of Medicine, USA
The Mitochondrial Methionyl-tRNA Synthetase's Role in Neurodegeneration

Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 5 of 6
Francesca Maltecca, San Raffaele Scientific Institute, Italy
Short Talk: The Mitochondrial Protease AFG3L2 is a Key Player in the Development and Maintenance of Cerebellum and Spinal Cord

Wednesday, March 25 | 5:00PM - 7:15PM
Mitochondrial Disease in Humans and Animal Models
Room: Sea to Sky Ballroom C

Speaker 6 of 6
Dominik Mousa Haddad, University of California, USA
Short Talk: Systematic Analysis of Genes Implicated in Human Neuronal Disease

Wednesday, March 25 | 5:00PM - 7:00PM
Alternative Forms of Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Douglas R. Green, St. Jude Children's Research Hospital, USA


Wednesday, March 25 | 5:00PM - 7:00PM
Alternative Forms of Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 5
Shai Shaham, Rockefeller University, USA
A New C. elegans Cell Death Program


Wednesday, March 25 | 5:00PM - 7:00PM
Alternative Forms of Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Francis Ka-Ming Chan, Duke University, USA
Short Talk: A RNA Interference Screen Identifies Novel Regulators of TNF-Induced Programmed Necrosis


Wednesday, March 25 | 5:00PM - 7:00PM
Alternative Forms of Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal control of transformation and cell death


Wednesday, March 25 | 5:00PM - 7:00PM
Alternative Forms of Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Role of a Phagocytosis Receptor, Draper, in Developmental Autophagic Cell Death in Drosophila


Wednesday, March 25 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, March 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 1 of 6
* Liza A. Pon, Columbia University Medical Center, USA
Mitochondrial Inheritance Contributes to Lifespan Control in Budding Yeast

Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 2 of 6
William M. Saxton, University of California, Santa Cruz, USA
Organizing Cytoplasm via Filament-Based Transport Mechanisms

Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 3 of 6
Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
The Regulation of Mitochondrial Motility by Ca++ and Other Signaling Pathways

Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 4 of 6
Albert L. Misko, Washington University in St. Louis, USA
Short Talk: Mitofusin 2 is Essential for the Axonal Transport of Mitochondria

Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 5 of 6
Konrad E. Zinsmaier, University of Arizona, USA
Short Talk: Drosophila Miro is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

Thursday, March 26 | 8:00AM - 11:00AM
Mitochondrial Transport in Polarized Cells
Room: Sea to Sky Ballroom C

Speaker 6 of 6
Myrrhe van Spronsen, Erasmus Medical Center, Netherlands
Short Talk: Milton Proteins Regulate Trafficking of Mitochondria in Neurons

Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* † Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in vivo


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Henning Walczak, University College London, Cancer Institute, UK
Short Talk: Identification of Axin 1 as a Factor Required for TRAIL-Induced Apoptosis


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Characterizing HMG-CoA Reductase as a Novel Metabolic Oncogene


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Anti-Cancer Activities of HDAC Inhibitors Used Alone and in Combination with other Pro-Apoptotic Agents


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Jan Paul Medema, Academic Medical Center, Netherlands
Betulinic Acid-induced Death


Thursday, March 26 | 8:00AM - 11:15AM
Cell Death and Cancer
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Role of Autophagy in Cancer and Therapy


Thursday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 26 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 1 of 7
Atsushi Tanaka, Yamagata University, Japan
Parkin Scavenges Damaged Mitochondria

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 2 of 7
* Koji Okamoto, Osaka University, Japan
Molecular Basis of Mitophagy, Degradation of Mitochondria via Autophagy-Related Membrane Dynamics in Yeast

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 3 of 7
* Orian S. Shirihai, University of California, Los Angeles, USA
Simulation of Mitochondrial Dynamics: Frequency and Selectivity of Mitochondrial Fusion are Key to its Quality Maintenance Function

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Hagai Abeliovich, Hebrew University of Jerusalem, Israel
Regulation of Mitochondrial Autophagy in S. cerevisiae

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Hector Sandoval, Baylor College of Medicine, USA
Essential Roles for Bnip3L/Nix in Autophagic Maturation of Erythroid Cells

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Eun Hee Kim, Ajou University, South Korea
Superoxide Anion Induces Mitophagy in Glioma Cells

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Mitochondrial Dynamics and Mitophagy
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Lígia Carinha Gomes, Venetian Institute of Molecular Medicine, Italy
Mitochondrial Fusion is an Early and Protective Step of Autophagy

Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Henning Walczak, University College London, Cancer Institute, UK


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 6
Huseyin Mehmet, Atlas Venture, USA
Omics Approach to Apoptosis Biomarker Discovery


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Chris Peter Reutelingsperger, Maastricht University, Netherlands
Cell Surface Expressed Phosphatidylserine: A Biomarker of Cell Death


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Caroline Dive, Cancer Research UK Manchester Institute, UK
Blood Borne Biomarkers of Cell Death Applied to Early Clinical Trials of Novel Mechanism Based Anticancer Drugs


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Claudia Maier, Oregon State University, USA
Mitochondrial Protein Markers of Oxidative Stress


Thursday, March 26 | 2:30PM - 4:30PM
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis a
nd Therapy Response
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 6 of 6
James A. Wells, University of California, San Francisco, USA
New Tools for Dissecting and Triggering Apoptosis


Thursday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 26 | 5:00PM - 7:00PM
The Shape of Things to Come: Strategies for Remodeling Biolo
gical Membranes

Room: Sea to Sky Ballroom C

Speaker 1 of 4
* Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK
Membrane Curvature and Mechanisms of Dynamic Cell Membrane Remodeling

Thursday, March 26 | 5:00PM - 7:00PM
The Shape of Things to Come: Strategies for Remodeling Biolo
gical Membranes

Room: Sea to Sky Ballroom C

Speaker 2 of 4
Benoit Kornmann, ETH Zurich, Switzerland
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

Thursday, March 26 | 5:00PM - 7:00PM
The Shape of Things to Come: Strategies for Remodeling Biolo
gical Membranes

Room: Sea to Sky Ballroom C

Speaker 3 of 4
Gia K. Voeltz, University of Colorado Boulder, USA
Proteins that Shape the Endoplasmic Reticulum

Thursday, March 26 | 5:00PM - 7:00PM
The Shape of Things to Come: Strategies for Remodeling Biolo
gical Membranes

Room: Sea to Sky Ballroom C

Speaker 4 of 4
Christian A. Wurm, MPI for biophys. Chemistry, Germany
Short Talk: Protein Distributions within Mitochondria - STED Microscopy as a Tool in Mitochondria Research

Thursday, March 26 | 5:00PM - 7:00PM
Metabolism and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA


Thursday, March 26 | 5:00PM - 7:00PM
Metabolism and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 2 of 5
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Apoptosis, Mitochondria and Cancer


Thursday, March 26 | 5:00PM - 7:00PM
Metabolism and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Karen H. Vousden, Francis Crick Institute, UK
p53, Metabolism and Death


Thursday, March 26 | 5:00PM - 7:00PM
Metabolism and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Mariia Yuneva, Francis Crick Institute, UK
Short Talk: Glutamine Metabolism as a Target for Selective Elimination of Myc Over-Expressing Cells


Thursday, March 26 | 5:00PM - 7:00PM
Metabolism and Cell Death
This session is from Cell Death Pathways
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Sally A. Kornbluth, Duke University Medical Center, USA
Regulation of Caspase 2


Thursday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, March 26 | 8:00PM - 11:00PM
Entertainment
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, March 26 | 8:00PM - 11:00PM
Cash Bar
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Friday, March 27 | 10:25AM - 10:25AM
Departure


*Session Chair.