Web Desc
PI 3-Kinase Signaling in Disease
joint with Complex Lipids in Biology: Signaling, Compartmentalization and Disease
Organizer(s): Peter M. Finan, Jean Zhao and Lewis C. Cantley
Date: April 22 - 27, 2009
Location: Resort at Squaw Creek, Olympic Valley, CA, USA
Sponsored by Amgen Inc. and Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
The PI 3-kinase signaling pathway controls multiple physiological processes including cell growth, cell proliferation and cell movement. Dysregulation of this pathway in cancer, inflammation and heart disease has led to the emergence of PI 3-kinase as a promising therapeutic target. One of the most exciting developments in this field is the discovery of new PI 3-kinase inhibitors. The balance between modulating PI 3-kinase activity in pathophysiological setting, whilst avoiding unwanted side-effects, is the subject of intense debate. In addition, as PI 3-kinase is a member of a multigene family, the rationale for inhibiting individual isoforms or multiple isoforms of PI 3-kinase is constantly changing. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI 3-kinase pathway in disease, drawing on human pathophysiology and genetics, mouse models and preclinical data with new PI 3-kinase inhibitors.
Scholarship Deadline: December 23 2008
Discounted Abstract Deadline: December 23 2008
Abstract Deadline: January 26 2009
Discounted Registration Deadline: February 23 2009
Late Abstracts


We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Cell Signaling Technology, Inc.Educational donation provided by AmgenInvitrogen CorporationNovartis Institutes for BioMedical ResearchVertex Pharmaceuticals Incorporated
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Intellikine, Inc.

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA139718-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 22 | 3:00PM - 7:30PM
Registration
Room: Lobby Alcove


Wednesday, April 22 | 6:30PM - 7:30PM
Refreshments
Room: Sierra Prefunction A,B,C,D


Wednesday, April 22 | 7:30PM - 8:30PM
Keynote Address
Room: Grand Sierra B,C,D

Speaker 1 of 3
* Peter M. Finan, Epidarex Capital, UK

Wednesday, April 22 | 7:30PM - 8:30PM
Keynote Address
Room: Grand Sierra B,C,D

Speaker 2 of 3
* Lewis C. Cantley, Weill Cornell Medicine, USA

Wednesday, April 22 | 7:30PM - 8:30PM
Keynote Address
Room: Grand Sierra B,C,D

Speaker 3 of 3
William R. Sellers, Broad Institute of MIT and Harvard, USA
The Development of PI3K Pathway Modulators for Cancer

Thursday, April 23 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 1 of 6
* Phillip T. Hawkins, Babraham Institute, UK

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 2 of 6
* Michael J.O. Wakelam, Babraham Institute, UK

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 3 of 6
Lewis C. Cantley, Weill Cornell Medicine, USA
Growth Control by the PI3K/mTOR Pathway

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 4 of 6
Len R. Stephens, Babraham Institute, UK
Signaling via PI3Ks in Neutrophils

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 5 of 6
Kevan M. Shokat, University of California, San Francisco, USA
Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 6 of 6
Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA
Functions of PH Domains and other Phosphoinositide/Phospholipid Binding Domains

Thursday, April 23 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Thursday, April 23 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, April 23 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Thursday, April 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Thursday, April 23 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy

Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
Room: Grand Sierra B,C,D

Speaker 2 of 5
Phillip T. Hawkins, Babraham Institute, UK
PI3K Regulation of the Neutrophil NADPH Oxidase

Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
Room: Grand Sierra B,C,D

Speaker 3 of 5
Matthias P. Wymann, University of Basel, Switzerland
PI3K Signaling in Immune Cells

Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
Room: Grand Sierra B,C,D

Speaker 4 of 5
Alex Berndt, MRC-Laboratory of Molecular Biology, UK
Short Talk: The Crystal Structure of the Murine Class IA PI3K p110delta in Complex with Isoform Selective Inhibitors

Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
Room: Grand Sierra B,C,D

Speaker 5 of 5
Tamas Oravecz, Celgene, USA
Short Talk: Phosphoinositide 3-kinase-C2alpha is Essential for Normal Renal Function in Mice

Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 4
* H. Alex Brown, Vanderbilt University, USA


Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 4
Christina C. Leslie, National Jewish Health, USA
Regulation of Cytosolic Phospholipase A2alpha by Phosphorylation and Basic Residues in the Catalytic Domain


Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 4
Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation


Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 4
Michael J.O. Wakelam, Babraham Institute, UK
Regulation of Phospholipase D in Normal and Diseased Cells


Thursday, April 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Thursday, April 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Alpine Ballroom


Friday, April 24 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Lewis C. Cantley, Weill Cornell Medicine, USA

Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
Room: Grand Sierra B,C,D

Speaker 2 of 5
Levi A. Garraway, Genentech, Inc, USA
AKT-Independent Signaling in PI3 Kinase-Driven Cancers

Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
Room: Grand Sierra B,C,D

Speaker 3 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Crosstalk between PI3K and mTOR

Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
Room: Grand Sierra B,C,D

Speaker 4 of 5
Anne Brunet, Stanford University, USA
Role of FOXO Transcription Factors in Aging

Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
Room: Grand Sierra B,C,D

Speaker 5 of 5
Leon O. Murphy, Casma Therapeutics, USA
Amino Acid Signaling to mTOR

Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 5
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA


Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 5
Jilly F. Evans, PharmAkea Therapeutics, USA
5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target


Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 5
Marc Peters-Golden, University of Michigan, USA
Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation


Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 5
Robert C. Murphy, University of Colorado Denver, USA
Transcellular Biosynthesis of Leukotrienes


Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 5 of 5
Colin D. Funk, Queen's University, Canada
Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns


Friday, April 24 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Friday, April 24 | 11:00AM - 11:00AM
On Own for Lunch


Friday, April 24 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Friday, April 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Friday, April 24 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Jean J. Zhao, Dana-Farber Cancer Institute, USA

Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
Room: Grand Sierra B,C,D

Speaker 2 of 4
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Roles of PI3 Kinase Isoforms

Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
Room: Grand Sierra B,C,D

Speaker 3 of 4
Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain
Distinct Activation Requirements and Function for Phosphoinositide 3-Kinase p110alpha and beta in Cell Division

Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
Room: Grand Sierra B,C,D

Speaker 4 of 4
Brendan D. Manning, Harvard School of Public Health, USA
Molecular Mechanisms and Consequences of mTOR Activation Downstream of PI3K

Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 4
* Sarah Spiegel, Virginia Commonwealth University, USA


Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 4
Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA
S1P Signaling in the Vasculature


Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 4
Shaun R. Coughlin, University of California, San Francisco, USA
Compartmentalization of S1P Signaling


Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 4
Richard L. Proia, National Institutes of Health, USA
Sphingosine-1-Phosphate and its Role in Physiology


Friday, April 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Friday, April 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Alpine Ballroom


Saturday, April 25 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK

Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
Room: Grand Sierra B,C,D

Speaker 2 of 5
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
PTEN and the Control of Tumorigenesis

Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
Room: Grand Sierra B,C,D

Speaker 3 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
PI 3-Kinase Signaling and Tumorigenesis

Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
Room: Grand Sierra B,C,D

Speaker 4 of 5
Jean J. Zhao, Dana-Farber Cancer Institute, USA
Class IA PI3K Isoforms in Signaling and Cancer

Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
Room: Grand Sierra B,C,D

Speaker 5 of 5
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Inhibition of PI3K in Cancers

Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 5
* Julie D. Saba, University of California, San Francisco, USA


Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 5
Jerold J. Chun, The Scripps Research Institute, USA
Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms


Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 5
Sarah Spiegel, Virginia Commonwealth University, USA
Signaling and Compartmentalization of Sphingosine-1-Phosphate


Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 5
Teresa M. Dunn, Uniformed Services University of the Health Sciences, USA
Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?


Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 5 of 5
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Mapping Lipid Signaling Networks by Integrated Proteomics and Metabolomics


Saturday, April 25 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Saturday, April 25 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, April 25 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Saturday, April 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 1 of 6
* Peter M. Finan, Epidarex Capital, UK

Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 2 of 6
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 3 of 6
Giovanna Bergamini, Cellzome a GSK Company, Germany
Identification and Characterization of Selective PI3Kgamma Inhibitors

Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 4 of 6
Xu Tao, Curis, Inc, USA
A Single Small Molecule that Inhibits Histone Deacetylase and Phosphatidylinositol-3-kinase

Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 5 of 6
Sabita Sankar, Celgene Corporation, USA
Distinguishing mTOR Inhibitors from Rapamycin

Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
Room: Grand Sierra B,C,D

Speaker 6 of 6
Jo-Anne Pinson, Monash University, Australia
PI3-Kinase and Inhibitors: 2-Iminothiazolidinones for Targeting Isoform Selectivity

Saturday, April 25 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Matthias P. Wymann, University of Basel, Switzerland

Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
Room: Grand Sierra B,C,D

Speaker 2 of 4
Alexandra C. Newton, University of California, San Diego, USA
Signal Termination: PHLiPPing the Switch in Cell Signaling

Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
Room: Grand Sierra B,C,D

Speaker 3 of 4
Nick Reid Leslie, Heriot Watt University, UK
The Regulation and Mechanisms of Action of PTEN

Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
Room: Grand Sierra B,C,D

Speaker 4 of 4
Takehiko Sasaki, Tokyo Medical and Dental University, Japan
In vivo Role of Inositol Polyphosphate Phosphatase 4A

Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 5
* Takao Shimizu, University of Tokyo, Japan


Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 5
William L. Smith, University of Michigan, USA
Allosteric Regulation of Cyclooxygenases by Fatty Acids and Inhibitors


Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 5
Garret A. FitzGerald, University of Pennsylvania, USA
Translational Therapeutics of the Arachidonic Acid Cascade


Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 5
Frank A. Fitzpatrick, University of Utah, USA
Akt Activation by Arachidonic Acid Metabolism


Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 5 of 5
Tzipora Goldkorn, University of California, Davis, USA
Short Talk: nSMase2: Role and Molecular Mechanism in Lung Injury


Saturday, April 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Saturday, April 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Alpine Ballroom


Sunday, April 26 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 1 of 6
* Paul Workman, Institute of Cancer Research, UK

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 2 of 6
Klaus P. Hoeflich, Blueprint Medicines, USA
Targeted Therapy Combinations with Class I PI3K Inhibitor GDC-0941

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 3 of 6
Richard F. Wooster, GlaxoSmithKline, USA
GSK2126458: A Novel and Potent Small Molecule Inhibitor of Phosphoinositol 3-Kinase

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 4 of 6
Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
Dual Targeting PI3Kdelta/gamma Prevents and Reverts Immune-Mediated Inflammation

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 5 of 6
Amy Kiger, University of California, San Diego, USA
Short Talk: Roles for a Class II PI3K/Mtm Pathway for PI3P-Mediated Cellular Remodeling in Development

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Room: Grand Sierra B,C,D

Speaker 6 of 6
Charlotte Edling, Barts and the London School of Medicine, UK
Short Talk: p110gamma Upregulation Promotes Cell Growth and Drug Resistance in Pancreatic Cancer


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 5
* Christina C. Leslie, National Jewish Health, USA


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 5
Michael A. Frohman, Stony Brook University, USA
Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 5
H. Alex Brown, Vanderbilt University, USA
Phospholipase D Signaling Pathways and Inhibitors


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 5
Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 5 of 5
Julie D. Saba, University of California, San Francisco, USA
Sphingadienes Inhibit AKT-Dependent Signaling and Prevent Intestinal Tumorigenesis


Sunday, April 26 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Sunday, April 26 | 11:00AM - 11:00AM
On Own for Lunch


Sunday, April 26 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Peter M. Finan, Epidarex Capital, UK

Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Room: Grand Sierra B,C,D

Speaker 2 of 4
Paul Workman, Institute of Cancer Research, UK
Drugging the PI3 Kinome for Cancer Treatment

Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Room: Grand Sierra B,C,D

Speaker 3 of 4
Neill A. Giese, USA
The Development of PI3K p110delta Inhibitors for Hematological Malignancies and Inflammation

Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Room: Grand Sierra B,C,D

Speaker 4 of 4
David A. Fruman, University of California, Irvine, USA
Anti-Leukemic Effects of Novel, Orally Active mTOR Inhibitor

Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 1 of 4
* Robert C. Murphy, University of Colorado Denver, USA


Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 2 of 4
Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Identification of Lipid-Protein Covalent Adducts and the Cellular Consequences of their Formation


Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 3 of 4
Suzanne E. Barbour, Virginia Commonwealth University, USA
Regulation of Lipoprotein-Associated PLA2/ PAF-AH by Oxidized Phospholipids


Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
This session is from Complex Lipids in Biol
Room: Grand Sierra A

Speaker 4 of 4
Atsuo Kawahara, Kyoto University, Japan
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors


Sunday, April 26 | 6:45PM - 7:00PM
Closing Remarks
Room: Grand Sierra B,C,D

Speaker 1 of 1
Lewis C. Cantley, Weill Cornell Medicine, USA
Closing Remarks

Sunday, April 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Sunday, April 26 | 8:00PM - 11:00PM
Entertainment
Room: Alpine Ballroom


Sunday, April 26 | 8:00PM - 11:00PM
Cash Bar
Room: Alpine Ballroom


Monday, April 27 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.