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Web Desc
Complex Lipids in Biology: Signaling, Compartmentalization and Disease joint with PI 3-Kinase Signaling in Disease Organizer(s): Robert C. Murphy, Julie D. Saba and Michael J.O. Wakelam Date: April 22 - 27, 2009 Location: Resort at Squaw Creek, Olympic Valley, CA, USA Supported by the Directors' Fund For important information on the coronavirus, please click here Summary of Meeting: Complex lipids constitute a diverse family of biomolecules of seven general classes that serve essential roles in Biology. For example, lipids include structural phospholipids that form cellular membranes but are also the reservoirs and source of polyunsaturated fatty acids that are signaling mediators. Intense research effort over the past years has substantially changed our understanding of lipid biochemistry and lipid function in cells with the application of new tools and techniques to study these molecules. This meeting will bring together a group of individuals who have the common goal of understanding the role that lipids play in cell biology, physiology and disease processes. Scholarship Deadline: December 23 2008 Discounted Abstract Deadline: December 23 2008 Abstract Deadline: January 26 2009 Discounted Registration Deadline: February 23 2009 Late Abstracts We gratefully acknowledge additional support for this conference from: Journal of Lipid Research We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Complex Lipids in Biology: Signaling, Compartmentalization and Disease

joint with PI 3-Kinase Signaling in Disease

Organizer(s): Robert C. Murphy, Julie D. Saba and Michael J.O. Wakelam

Date: April 22 - 27, 2009
Location: Resort at Squaw Creek, Olympic Valley, CA, USA

Supported by the Directors' Fund

For important information on the coronavirus, please click here

Summary of Meeting:

Complex lipids constitute a diverse family of biomolecules of seven general classes that serve essential roles in Biology. For example, lipids include structural phospholipids that form cellular membranes but are also the reservoirs and source of polyunsaturated fatty acids that are signaling mediators. Intense research effort over the past years has substantially changed our understanding of lipid biochemistry and lipid function in cells with the application of new tools and techniques to study these molecules. This meeting will bring together a group of individuals who have the common goal of understanding the role that lipids play in cell biology, physiology and disease processes.

Scholarship Deadline: December 23 2008

Discounted Abstract Deadline: December 23 2008

Abstract Deadline: January 26 2009

Discounted Registration Deadline: February 23 2009

Late Abstracts

We gratefully acknowledge additional support for this conference from:

Journal of Lipid Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Wednesday, April 22 \| 3:00PM - 7:30PM Registration Room: Lobby Alcove
Wednesday, April 22 \| 6:30PM - 7:30PM Refreshments Room: Sierra Prefunction A,B,C,D
Wednesday, April 22 \| 7:30PM - 7:45PM Welcoming and Introduction Room: Grand Sierra Ballroom Speaker 1 of 1 Julie D. Saba, University of California, San Francisco, USA
Wednesday, April 22 \| 7:45PM - 8:45PM Keynote Address: 50th Anniversary JLR Lecturer Room: Grand Sierra A Speaker 1 of 2 * Robert C. Murphy, University of Colorado Denver, USA Keynote Introduction and JLR Award
Wednesday, April 22 \| 7:45PM - 8:45PM Keynote Address: 50th Anniversary JLR Lecturer Room: Grand Sierra A Speaker 2 of 2 Takao Shimizu, University of Tokyo, Japan Phospholipid Metabolism: Phospholipases and Acyltransferases
Thursday, April 23 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 1 of 6 * Phillip T. Hawkins, Babraham Institute, UK
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 2 of 6 * Michael J.O. Wakelam, Babraham Institute, UK
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 3 of 6 Lewis C. Cantley, Weill Cornell Medicine, USA Growth Control by the PI3K/mTOR Pathway
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 4 of 6 Len R. Stephens, Babraham Institute, UK Signaling via PI3Ks in Neutrophils
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 5 of 6 Kevan M. Shokat, University of California, San Francisco, USA Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2
Thursday, April 23 \| 8:00AM - 11:00AM Phosphoinositides and Signaling (Joint) Room: Grand Sierra Ballroom Speaker 6 of 6 Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA Functions of PH Domains and other Phosphoinositide/Phospholipid Binding Domains
Thursday, April 23 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction A,B,C,D
Thursday, April 23 \| 11:00AM - 11:00AM On Own for Lunch
Thursday, April 23 \| 11:00AM - 1:00PM Poster Setup Room: Alpine Ballroom
Thursday, April 23 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Thursday, April 23 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction A,B,C,D
Thursday, April 23 \| 5:00PM - 7:00PM Phospholipases and Acyl Transferases Room: Grand Sierra A Speaker 1 of 4 * H. Alex Brown, Vanderbilt University, USA
Thursday, April 23 \| 5:00PM - 7:00PM Phospholipases and Acyl Transferases Room: Grand Sierra A Speaker 2 of 4 Christina C. Leslie, National Jewish Health, USA Regulation of Cytosolic Phospholipase A2alpha by Phosphorylation and Basic Residues in the Catalytic Domain
Thursday, April 23 \| 5:00PM - 7:00PM Phospholipases and Acyl Transferases Room: Grand Sierra A Speaker 3 of 4 Michael H. Gelb, University of Washington, USA Role of Phospholipases A2 in Eicosanoid Generation
Thursday, April 23 \| 5:00PM - 7:00PM Phospholipases and Acyl Transferases Room: Grand Sierra A Speaker 4 of 4 Michael J.O. Wakelam, Babraham Institute, UK Regulation of Phospholipase D in Normal and Diseased Cells
Thursday, April 23 \| 5:00PM - 7:00PM PI 3-Kinase Pathway and Inflammation This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 5 * Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
Thursday, April 23 \| 5:00PM - 7:00PM PI 3-Kinase Pathway and Inflammation This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 5 Phillip T. Hawkins, Babraham Institute, UK PI3K Regulation of the Neutrophil NADPH Oxidase
Thursday, April 23 \| 5:00PM - 7:00PM PI 3-Kinase Pathway and Inflammation This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 5 Matthias P. Wymann, University of Basel, Switzerland PI3K Signaling in Immune Cells
Thursday, April 23 \| 5:00PM - 7:00PM PI 3-Kinase Pathway and Inflammation This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 5 Alex Berndt, MRC-Laboratory of Molecular Biology, UK Short Talk: The Crystal Structure of the Murine Class IA PI3K p110delta in Complex with Isoform Selective Inhibitors
Thursday, April 23 \| 5:00PM - 7:00PM PI 3-Kinase Pathway and Inflammation This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 5 of 5 Tamas Oravecz, Celgene, USA Short Talk: Phosphoinositide 3-kinase-C2alpha is Essential for Normal Renal Function in Mice
Thursday, April 23 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Thursday, April 23 \| 7:30PM - 10:00PM Poster Session 1 Room: Alpine Ballroom
Friday, April 24 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Friday, April 24 \| 8:00AM - 11:00AM Leukotrienes: New Frontiers Room: Grand Sierra A Speaker 1 of 5 * Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Friday, April 24 \| 8:00AM - 11:00AM Leukotrienes: New Frontiers Room: Grand Sierra A Speaker 2 of 5 Jilly F. Evans, PharmAkea Therapeutics, USA 5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target
Friday, April 24 \| 8:00AM - 11:00AM Leukotrienes: New Frontiers Room: Grand Sierra A Speaker 3 of 5 Marc Peters-Golden, University of Michigan, USA Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation
Friday, April 24 \| 8:00AM - 11:00AM Leukotrienes: New Frontiers Room: Grand Sierra A Speaker 4 of 5 Robert C. Murphy, University of Colorado Denver, USA Transcellular Biosynthesis of Leukotrienes
Friday, April 24 \| 8:00AM - 11:00AM Leukotrienes: New Frontiers Room: Grand Sierra A Speaker 5 of 5 Colin D. Funk, Queen's University, Canada Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns
Friday, April 24 \| 8:00AM - 11:00AM Cell Growth, Metabolism and Aging This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 5 * Lewis C. Cantley, Weill Cornell Medicine, USA
Friday, April 24 \| 8:00AM - 11:00AM Cell Growth, Metabolism and Aging This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 5 Levi A. Garraway, Genentech, Inc, USA AKT-Independent Signaling in PI3 Kinase-Driven Cancers
Friday, April 24 \| 8:00AM - 11:00AM Cell Growth, Metabolism and Aging This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 5 David M. Sabatini, Whitehead Institute for Biomedical Research, USA Crosstalk between PI3K and mTOR
Friday, April 24 \| 8:00AM - 11:00AM Cell Growth, Metabolism and Aging This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 5 Anne Brunet, Stanford University, USA Role of FOXO Transcription Factors in Aging
Friday, April 24 \| 8:00AM - 11:00AM Cell Growth, Metabolism and Aging This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 5 of 5 Leon O. Murphy, Casma Therapeutics, USA Amino Acid Signaling to mTOR
Friday, April 24 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction A,B,C,D
Friday, April 24 \| 11:00AM - 11:00AM On Own for Lunch
Friday, April 24 \| 11:00AM - 1:00PM Poster Setup Room: Alpine Ballroom
Friday, April 24 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Friday, April 24 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction A,B,C,D
Friday, April 24 \| 5:00PM - 7:00PM Sphingolipid Signaling Room: Grand Sierra A Speaker 1 of 4 * Sarah Spiegel, Virginia Commonwealth University, USA
Friday, April 24 \| 5:00PM - 7:00PM Sphingolipid Signaling Room: Grand Sierra A Speaker 2 of 4 Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA S1P Signaling in the Vasculature
Friday, April 24 \| 5:00PM - 7:00PM Sphingolipid Signaling Room: Grand Sierra A Speaker 3 of 4 Shaun R. Coughlin, University of California, San Francisco, USA Compartmentalization of S1P Signaling
Friday, April 24 \| 5:00PM - 7:00PM Sphingolipid Signaling Room: Grand Sierra A Speaker 4 of 4 Richard L. Proia, National Institutes of Health, USA Sphingosine-1-Phosphate and its Role in Physiology
Friday, April 24 \| 5:00PM - 7:00PM Dissecting the Complexity of PI 3-Kinase Signaling This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 4 * Jean J. Zhao, Dana-Farber Cancer Institute, USA
Friday, April 24 \| 5:00PM - 7:00PM Dissecting the Complexity of PI 3-Kinase Signaling This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 4 Bart Vanhaesebroeck, University College London, Cancer Institute, UK Roles of PI3 Kinase Isoforms
Friday, April 24 \| 5:00PM - 7:00PM Dissecting the Complexity of PI 3-Kinase Signaling This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 4 Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain Distinct Activation Requirements and Function for Phosphoinositide 3-Kinase p110alpha and beta in Cell Division
Friday, April 24 \| 5:00PM - 7:00PM Dissecting the Complexity of PI 3-Kinase Signaling This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 4 Brendan D. Manning, Harvard School of Public Health, USA Molecular Mechanisms and Consequences of mTOR Activation Downstream of PI3K
Friday, April 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Friday, April 24 \| 7:30PM - 10:00PM Poster Session 2 Room: Alpine Ballroom
Saturday, April 25 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Saturday, April 25 \| 8:00AM - 11:00AM Ceramides, LysoPA and other Lipid Mediators Room: Grand Sierra A Speaker 1 of 5 * Julie D. Saba, University of California, San Francisco, USA
Saturday, April 25 \| 8:00AM - 11:00AM Ceramides, LysoPA and other Lipid Mediators Room: Grand Sierra A Speaker 2 of 5 Jerold J. Chun, The Scripps Research Institute, USA Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms
Saturday, April 25 \| 8:00AM - 11:00AM Ceramides, LysoPA and other Lipid Mediators Room: Grand Sierra A Speaker 3 of 5 Sarah Spiegel, Virginia Commonwealth University, USA Signaling and Compartmentalization of Sphingosine-1-Phosphate
Saturday, April 25 \| 8:00AM - 11:00AM Ceramides, LysoPA and other Lipid Mediators Room: Grand Sierra A Speaker 4 of 5 Teresa M. Dunn, Uniformed Services University of the Health Sciences, USA Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?
Saturday, April 25 \| 8:00AM - 11:00AM Ceramides, LysoPA and other Lipid Mediators Room: Grand Sierra A Speaker 5 of 5 Benjamin F. Cravatt III, The Scripps Research Institute, USA Mapping Lipid Signaling Networks by Integrated Proteomics and Metabolomics
Saturday, April 25 \| 8:00AM - 11:00AM PI 3-Kinase Signaling and Cancer This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 5 * Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Saturday, April 25 \| 8:00AM - 11:00AM PI 3-Kinase Signaling and Cancer This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 5 Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA PTEN and the Control of Tumorigenesis
Saturday, April 25 \| 8:00AM - 11:00AM PI 3-Kinase Signaling and Cancer This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 5 Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada PI 3-Kinase Signaling and Tumorigenesis
Saturday, April 25 \| 8:00AM - 11:00AM PI 3-Kinase Signaling and Cancer This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 5 Jean J. Zhao, Dana-Farber Cancer Institute, USA Class IA PI3K Isoforms in Signaling and Cancer
Saturday, April 25 \| 8:00AM - 11:00AM PI 3-Kinase Signaling and Cancer This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 5 of 5 Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA Inhibition of PI3K in Cancers
Saturday, April 25 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction A,B,C,D
Saturday, April 25 \| 11:00AM - 11:00AM On Own for Lunch
Saturday, April 25 \| 11:00AM - 1:00PM Poster Setup Room: Alpine Ballroom
Saturday, April 25 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 6 * Peter M. Finan, Epidarex Capital, UK
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 6 * Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 6 Giovanna Bergamini, Cellzome a GSK Company, Germany Identification and Characterization of Selective PI3Kgamma Inhibitors
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 6 Xu Tao, Curis, Inc, USA A Single Small Molecule that Inhibits Histone Deacetylase and Phosphatidylinositol-3-kinase
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 5 of 6 Sabita Sankar, Celgene Corporation, USA Distinguishing mTOR Inhibitors from Rapamycin
Saturday, April 25 \| 2:30PM - 4:30PM Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr ug Discovery Projects This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 6 of 6 Jo-Anne Pinson, Monash University, Australia PI3-Kinase and Inhibitors: 2-Iminothiazolidinones for Targeting Isoform Selectivity
Saturday, April 25 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction A,B,C,D
Saturday, April 25 \| 5:00PM - 7:00PM Recent Advances in PGH Synthase and 5-Lipoxygenase Room: Grand Sierra A Speaker 1 of 5 * Takao Shimizu, University of Tokyo, Japan
Saturday, April 25 \| 5:00PM - 7:00PM Recent Advances in PGH Synthase and 5-Lipoxygenase Room: Grand Sierra A Speaker 2 of 5 William L. Smith, University of Michigan, USA Allosteric Regulation of Cyclooxygenases by Fatty Acids and Inhibitors
Saturday, April 25 \| 5:00PM - 7:00PM Recent Advances in PGH Synthase and 5-Lipoxygenase Room: Grand Sierra A Speaker 3 of 5 Garret A. FitzGerald, University of Pennsylvania, USA Translational Therapeutics of the Arachidonic Acid Cascade
Saturday, April 25 \| 5:00PM - 7:00PM Recent Advances in PGH Synthase and 5-Lipoxygenase Room: Grand Sierra A Speaker 4 of 5 Frank A. Fitzpatrick, University of Utah, USA Akt Activation by Arachidonic Acid Metabolism
Saturday, April 25 \| 5:00PM - 7:00PM Recent Advances in PGH Synthase and 5-Lipoxygenase Room: Grand Sierra A Speaker 5 of 5 Tzipora Goldkorn, University of California, Davis, USA Short Talk: nSMase2: Role and Molecular Mechanism in Lung Injury
Saturday, April 25 \| 5:00PM - 7:00PM Phosphatases and Control of the PI 3-Kinase Pathway This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 4 * Matthias P. Wymann, University of Basel, Switzerland
Saturday, April 25 \| 5:00PM - 7:00PM Phosphatases and Control of the PI 3-Kinase Pathway This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 4 Alexandra C. Newton, University of California, San Diego, USA Signal Termination: PHLiPPing the Switch in Cell Signaling
Saturday, April 25 \| 5:00PM - 7:00PM Phosphatases and Control of the PI 3-Kinase Pathway This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 4 Nick Reid Leslie, Heriot Watt University, UK The Regulation and Mechanisms of Action of PTEN
Saturday, April 25 \| 5:00PM - 7:00PM Phosphatases and Control of the PI 3-Kinase Pathway This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 4 Takehiko Sasaki, Tokyo Medical and Dental University, Japan In vivo Role of Inositol Polyphosphate Phosphatase 4A
Saturday, April 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Saturday, April 25 \| 7:30PM - 10:00PM Poster Session 3 Room: Alpine Ballroom
Sunday, April 26 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Sunday, April 26 \| 8:00AM - 11:00AM Phospholipases, Kinases and Signaling Systems Room: Grand Sierra A Speaker 1 of 5 * Christina C. Leslie, National Jewish Health, USA
Sunday, April 26 \| 8:00AM - 11:00AM Phospholipases, Kinases and Signaling Systems Room: Grand Sierra A Speaker 2 of 5 Michael A. Frohman, Stony Brook University, USA Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways
Sunday, April 26 \| 8:00AM - 11:00AM Phospholipases, Kinases and Signaling Systems Room: Grand Sierra A Speaker 3 of 5 H. Alex Brown, Vanderbilt University, USA Phospholipase D Signaling Pathways and Inhibitors
Sunday, April 26 \| 8:00AM - 11:00AM Phospholipases, Kinases and Signaling Systems Room: Grand Sierra A Speaker 4 of 5 Ana Olivera, NIAMS, National Institutes of Health, USA Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness
Sunday, April 26 \| 8:00AM - 11:00AM Phospholipases, Kinases and Signaling Systems Room: Grand Sierra A Speaker 5 of 5 Julie D. Saba, University of California, San Francisco, USA Sphingadienes Inhibit AKT-Dependent Signaling and Prevent Intestinal Tumorigenesis
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 6 * Paul Workman, Institute of Cancer Research, UK
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 6 Klaus P. Hoeflich, Blueprint Medicines, USA Targeted Therapy Combinations with Class I PI3K Inhibitor GDC-0941
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 6 Richard F. Wooster, GlaxoSmithKline, USA GSK2126458: A Novel and Potent Small Molecule Inhibitor of Phosphoinositol 3-Kinase
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 6 Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland Dual Targeting PI3Kdelta/gamma Prevents and Reverts Immune-Mediated Inflammation
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 5 of 6 Amy Kiger, University of California, San Diego, USA Short Talk: Roles for a Class II PI3K/Mtm Pathway for PI3P-Mediated Cellular Remodeling in Development
Sunday, April 26 \| 8:00AM - 11:00AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 6 of 6 Charlotte Edling, Barts and the London School of Medicine, UK Short Talk: p110gamma Upregulation Promotes Cell Growth and Drug Resistance in Pancreatic Cancer
Sunday, April 26 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction A,B,C,D
Sunday, April 26 \| 11:00AM - 11:00AM On Own for Lunch
Sunday, April 26 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction A,B,C,D
Sunday, April 26 \| 5:00PM - 7:00PM Emerging Nexi Room: Grand Sierra A Speaker 1 of 4 * Robert C. Murphy, University of Colorado Denver, USA
Sunday, April 26 \| 5:00PM - 7:00PM Emerging Nexi Room: Grand Sierra A Speaker 2 of 4 Lawrence J. Marnett, Vanderbilt University School of Medicine, USA Identification of Lipid-Protein Covalent Adducts and the Cellular Consequences of their Formation
Sunday, April 26 \| 5:00PM - 7:00PM Emerging Nexi Room: Grand Sierra A Speaker 3 of 4 Suzanne E. Barbour, Virginia Commonwealth University, USA Regulation of Lipoprotein-Associated PLA2/ PAF-AH by Oxidized Phospholipids
Sunday, April 26 \| 5:00PM - 7:00PM Emerging Nexi Room: Grand Sierra A Speaker 4 of 4 Atsuo Kawahara, Kyoto University, Japan The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
Sunday, April 26 \| 5:00PM - 6:45PM PI 3-Kinase Pathway Modulation: Transition to the Clinic II This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 4 * Peter M. Finan, Epidarex Capital, UK
Sunday, April 26 \| 5:00PM - 6:45PM PI 3-Kinase Pathway Modulation: Transition to the Clinic II This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 2 of 4 Paul Workman, Institute of Cancer Research, UK Drugging the PI3 Kinome for Cancer Treatment
Sunday, April 26 \| 5:00PM - 6:45PM PI 3-Kinase Pathway Modulation: Transition to the Clinic II This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 3 of 4 Neill A. Giese, USA The Development of PI3K p110delta Inhibitors for Hematological Malignancies and Inflammation
Sunday, April 26 \| 5:00PM - 6:45PM PI 3-Kinase Pathway Modulation: Transition to the Clinic II This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 4 of 4 David A. Fruman, University of California, Irvine, USA Anti-Leukemic Effects of Novel, Orally Active mTOR Inhibitor
Sunday, April 26 \| 6:45PM - 7:00PM Closing Remarks This session is from PI 3-Kinases Room: Grand Sierra B,C,D Speaker 1 of 1 Lewis C. Cantley, Weill Cornell Medicine, USA Closing Remarks
Sunday, April 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Sunday, April 26 \| 8:00PM - 11:00PM Entertainment Room: Alpine Ballroom
Sunday, April 26 \| 8:00PM - 11:00PM Cash Bar Room: Alpine Ballroom
Monday, April 27 \| 10:22AM - 10:22AM Departure *Session Chair †Invited, not yet responded.