Web Desc
Complex Lipids in Biology: Signaling, Compartmentalization and Disease
joint with PI 3-Kinase Signaling in Disease
Organizer(s): Robert C. Murphy, Julie D. Saba and Michael J.O. Wakelam
Date: April 22 - 27, 2009
Location: Resort at Squaw Creek, Olympic Valley, CA, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Complex lipids constitute a diverse family of biomolecules of seven general classes that serve essential roles in Biology. For example, lipids include structural phospholipids that form cellular membranes but are also the reservoirs and source of polyunsaturated fatty acids that are signaling mediators. Intense research effort over the past years has substantially changed our understanding of lipid biochemistry and lipid function in cells with the application of new tools and techniques to study these molecules. This meeting will bring together a group of individuals who have the common goal of understanding the role that lipids play in cell biology, physiology and disease processes.
Scholarship Deadline: December 23 2008
Discounted Abstract Deadline: December 23 2008
Abstract Deadline: January 26 2009
Discounted Registration Deadline: February 23 2009
Late Abstracts


We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.
Journal of Lipid Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 22 | 3:00PM - 7:30PM
Registration
Room: Lobby Alcove


Wednesday, April 22 | 6:30PM - 7:30PM
Refreshments
Room: Sierra Prefunction A,B,C,D


Wednesday, April 22 | 7:30PM - 7:45PM
Welcoming and Introduction
Room: Grand Sierra Ballroom

Speaker 1 of 1
Julie D. Saba, University of California, San Francisco, USA

Wednesday, April 22 | 7:45PM - 8:45PM
Keynote Address: 50th Anniversary JLR Lecturer
Room: Grand Sierra A

Speaker 1 of 2
* Robert C. Murphy, University of Colorado Denver, USA
Keynote Introduction and JLR Award

Wednesday, April 22 | 7:45PM - 8:45PM
Keynote Address: 50th Anniversary JLR Lecturer
Room: Grand Sierra A

Speaker 2 of 2
Takao Shimizu, University of Tokyo, Japan
Phospholipid Metabolism: Phospholipases and Acyltransferases

Thursday, April 23 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 1 of 6
* Phillip T. Hawkins, Babraham Institute, UK

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 2 of 6
* Michael J.O. Wakelam, Babraham Institute, UK

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 3 of 6
Lewis C. Cantley, Weill Cornell Medicine, USA
Growth Control by the PI3K/mTOR Pathway

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 4 of 6
Len R. Stephens, Babraham Institute, UK
Signaling via PI3Ks in Neutrophils

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 5 of 6
Kevan M. Shokat, University of California, San Francisco, USA
Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2

Thursday, April 23 | 8:00AM - 11:00AM
Phosphoinositides and Signaling (Joint)
Room: Grand Sierra Ballroom

Speaker 6 of 6
Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA
Functions of PH Domains and other Phosphoinositide/Phospholipid Binding Domains

Thursday, April 23 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Thursday, April 23 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, April 23 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Thursday, April 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Thursday, April 23 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
Room: Grand Sierra A

Speaker 1 of 4
* H. Alex Brown, Vanderbilt University, USA

Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
Room: Grand Sierra A

Speaker 2 of 4
Christina C. Leslie, National Jewish Health, USA
Regulation of Cytosolic Phospholipase A2alpha by Phosphorylation and Basic Residues in the Catalytic Domain

Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
Room: Grand Sierra A

Speaker 3 of 4
Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation

Thursday, April 23 | 5:00PM - 7:00PM
Phospholipases and Acyl Transferases
Room: Grand Sierra A

Speaker 4 of 4
Michael J.O. Wakelam, Babraham Institute, UK
Regulation of Phospholipase D in Normal and Diseased Cells

Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy


Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 5
Phillip T. Hawkins, Babraham Institute, UK
PI3K Regulation of the Neutrophil NADPH Oxidase


Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 5
Matthias P. Wymann, University of Basel, Switzerland
PI3K Signaling in Immune Cells


Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 5
Alex Berndt, MRC-Laboratory of Molecular Biology, UK
Short Talk: The Crystal Structure of the Murine Class IA PI3K p110delta in Complex with Isoform Selective Inhibitors


Thursday, April 23 | 5:00PM - 7:00PM
PI 3-Kinase Pathway and Inflammation
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 5 of 5
Tamas Oravecz, Celgene, USA
Short Talk: Phosphoinositide 3-kinase-C2alpha is Essential for Normal Renal Function in Mice


Thursday, April 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Thursday, April 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Alpine Ballroom


Friday, April 24 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
Room: Grand Sierra A

Speaker 1 of 5
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA

Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
Room: Grand Sierra A

Speaker 2 of 5
Jilly F. Evans, PharmAkea Therapeutics, USA
5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target

Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
Room: Grand Sierra A

Speaker 3 of 5
Marc Peters-Golden, University of Michigan, USA
Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation

Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
Room: Grand Sierra A

Speaker 4 of 5
Robert C. Murphy, University of Colorado Denver, USA
Transcellular Biosynthesis of Leukotrienes

Friday, April 24 | 8:00AM - 11:00AM
Leukotrienes: New Frontiers
Room: Grand Sierra A

Speaker 5 of 5
Colin D. Funk, Queen's University, Canada
Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns

Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Lewis C. Cantley, Weill Cornell Medicine, USA


Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 5
Levi A. Garraway, Genentech, Inc, USA
AKT-Independent Signaling in PI3 Kinase-Driven Cancers


Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Crosstalk between PI3K and mTOR


Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 5
Anne Brunet, Stanford University, USA
Role of FOXO Transcription Factors in Aging


Friday, April 24 | 8:00AM - 11:00AM
Cell Growth, Metabolism and Aging
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 5 of 5
Leon O. Murphy, Casma Therapeutics, USA
Amino Acid Signaling to mTOR


Friday, April 24 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Friday, April 24 | 11:00AM - 11:00AM
On Own for Lunch


Friday, April 24 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Friday, April 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Friday, April 24 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
Room: Grand Sierra A

Speaker 1 of 4
* Sarah Spiegel, Virginia Commonwealth University, USA

Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
Room: Grand Sierra A

Speaker 2 of 4
Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA
S1P Signaling in the Vasculature

Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
Room: Grand Sierra A

Speaker 3 of 4
Shaun R. Coughlin, University of California, San Francisco, USA
Compartmentalization of S1P Signaling

Friday, April 24 | 5:00PM - 7:00PM
Sphingolipid Signaling
Room: Grand Sierra A

Speaker 4 of 4
Richard L. Proia, National Institutes of Health, USA
Sphingosine-1-Phosphate and its Role in Physiology

Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Jean J. Zhao, Dana-Farber Cancer Institute, USA


Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 4
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Roles of PI3 Kinase Isoforms


Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 4
Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain
Distinct Activation Requirements and Function for Phosphoinositide 3-Kinase p110alpha and beta in Cell Division


Friday, April 24 | 5:00PM - 7:00PM
Dissecting the Complexity of PI 3-Kinase Signaling
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 4
Brendan D. Manning, Harvard School of Public Health, USA
Molecular Mechanisms and Consequences of mTOR Activation Downstream of PI3K


Friday, April 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Friday, April 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Alpine Ballroom


Saturday, April 25 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
Room: Grand Sierra A

Speaker 1 of 5
* Julie D. Saba, University of California, San Francisco, USA

Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
Room: Grand Sierra A

Speaker 2 of 5
Jerold J. Chun, The Scripps Research Institute, USA
Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms

Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
Room: Grand Sierra A

Speaker 3 of 5
Sarah Spiegel, Virginia Commonwealth University, USA
Signaling and Compartmentalization of Sphingosine-1-Phosphate

Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
Room: Grand Sierra A

Speaker 4 of 5
Teresa M. Dunn, Uniformed Services University of the Health Sciences, USA
Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?

Saturday, April 25 | 8:00AM - 11:00AM
Ceramides, LysoPA and other Lipid Mediators
Room: Grand Sierra A

Speaker 5 of 5
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Mapping Lipid Signaling Networks by Integrated Proteomics and Metabolomics

Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 5
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK


Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 5
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
PTEN and the Control of Tumorigenesis


Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
PI 3-Kinase Signaling and Tumorigenesis


Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 5
Jean J. Zhao, Dana-Farber Cancer Institute, USA
Class IA PI3K Isoforms in Signaling and Cancer


Saturday, April 25 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 5 of 5
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Inhibition of PI3K in Cancers


Saturday, April 25 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Saturday, April 25 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, April 25 | 11:00AM - 1:00PM
Poster Setup
Room: Alpine Ballroom


Saturday, April 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Alpine Ballroom


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 6
* Peter M. Finan, Epidarex Capital, UK


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 6
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 6
Giovanna Bergamini, Cellzome a GSK Company, Germany
Identification and Characterization of Selective PI3Kgamma Inhibitors


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 6
Xu Tao, Curis, Inc, USA
A Single Small Molecule that Inhibits Histone Deacetylase and Phosphatidylinositol-3-kinase


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 5 of 6
Sabita Sankar, Celgene Corporation, USA
Distinguishing mTOR Inhibitors from Rapamycin


Saturday, April 25 | 2:30PM - 4:30PM
Workshop: Targeting the PI3 Kinase Pathway: Insights from Dr
ug Discovery Projects
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 6 of 6
Jo-Anne Pinson, Monash University, Australia
PI3-Kinase and Inhibitors: 2-Iminothiazolidinones for Targeting Isoform Selectivity


Saturday, April 25 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
Room: Grand Sierra A

Speaker 1 of 5
* Takao Shimizu, University of Tokyo, Japan

Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
Room: Grand Sierra A

Speaker 2 of 5
William L. Smith, University of Michigan, USA
Allosteric Regulation of Cyclooxygenases by Fatty Acids and Inhibitors

Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
Room: Grand Sierra A

Speaker 3 of 5
Garret A. FitzGerald, University of Pennsylvania, USA
Translational Therapeutics of the Arachidonic Acid Cascade

Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
Room: Grand Sierra A

Speaker 4 of 5
Frank A. Fitzpatrick, University of Utah, USA
Akt Activation by Arachidonic Acid Metabolism

Saturday, April 25 | 5:00PM - 7:00PM
Recent Advances in PGH Synthase and 5-Lipoxygenase
Room: Grand Sierra A

Speaker 5 of 5
Tzipora Goldkorn, University of California, Davis, USA
Short Talk: nSMase2: Role and Molecular Mechanism in Lung Injury

Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Matthias P. Wymann, University of Basel, Switzerland


Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 4
Alexandra C. Newton, University of California, San Diego, USA
Signal Termination: PHLiPPing the Switch in Cell Signaling


Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 4
Nick Reid Leslie, Heriot Watt University, UK
The Regulation and Mechanisms of Action of PTEN


Saturday, April 25 | 5:00PM - 7:00PM
Phosphatases and Control of the PI 3-Kinase Pathway
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 4
Takehiko Sasaki, Tokyo Medical and Dental University, Japan
In vivo Role of Inositol Polyphosphate Phosphatase 4A


Saturday, April 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Saturday, April 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Alpine Ballroom


Sunday, April 26 | 7:00AM - 8:00AM
Breakfast
Room: Alpine Ballroom


Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
Room: Grand Sierra A

Speaker 1 of 5
* Christina C. Leslie, National Jewish Health, USA

Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
Room: Grand Sierra A

Speaker 2 of 5
Michael A. Frohman, Stony Brook University, USA
Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways

Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
Room: Grand Sierra A

Speaker 3 of 5
H. Alex Brown, Vanderbilt University, USA
Phospholipase D Signaling Pathways and Inhibitors

Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
Room: Grand Sierra A

Speaker 4 of 5
Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness

Sunday, April 26 | 8:00AM - 11:00AM
Phospholipases, Kinases and Signaling Systems
Room: Grand Sierra A

Speaker 5 of 5
Julie D. Saba, University of California, San Francisco, USA
Sphingadienes Inhibit AKT-Dependent Signaling and Prevent Intestinal Tumorigenesis

Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 6
* Paul Workman, Institute of Cancer Research, UK


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 6
Klaus P. Hoeflich, Blueprint Medicines, USA
Targeted Therapy Combinations with Class I PI3K Inhibitor GDC-0941


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 6
Richard F. Wooster, GlaxoSmithKline, USA
GSK2126458: A Novel and Potent Small Molecule Inhibitor of Phosphoinositol 3-Kinase


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 6
Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
Dual Targeting PI3Kdelta/gamma Prevents and Reverts Immune-Mediated Inflammation


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 5 of 6
Amy Kiger, University of California, San Diego, USA
Short Talk: Roles for a Class II PI3K/Mtm Pathway for PI3P-Mediated Cellular Remodeling in Development


Sunday, April 26 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Modulation: Transition to the Clinic I
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 6 of 6
Charlotte Edling, Barts and the London School of Medicine, UK
Short Talk: p110gamma Upregulation Promotes Cell Growth and Drug Resistance in Pancreatic Cancer


Sunday, April 26 | 9:20AM - 9:40AM
Coffee Break
Room: Sierra Prefunction A,B,C,D


Sunday, April 26 | 11:00AM - 11:00AM
On Own for Lunch


Sunday, April 26 | 4:30PM - 5:00PM
Coffee Available
Room: Sierra Prefunction A,B,C,D


Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
Room: Grand Sierra A

Speaker 1 of 4
* Robert C. Murphy, University of Colorado Denver, USA

Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
Room: Grand Sierra A

Speaker 2 of 4
Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Identification of Lipid-Protein Covalent Adducts and the Cellular Consequences of their Formation

Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
Room: Grand Sierra A

Speaker 3 of 4
Suzanne E. Barbour, Virginia Commonwealth University, USA
Regulation of Lipoprotein-Associated PLA2/ PAF-AH by Oxidized Phospholipids

Sunday, April 26 | 5:00PM - 7:00PM
Emerging Nexi
Room: Grand Sierra A

Speaker 4 of 4
Atsuo Kawahara, Kyoto University, Japan
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 4
* Peter M. Finan, Epidarex Capital, UK


Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 2 of 4
Paul Workman, Institute of Cancer Research, UK
Drugging the PI3 Kinome for Cancer Treatment


Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 3 of 4
Neill A. Giese, USA
The Development of PI3K p110delta Inhibitors for Hematological Malignancies and Inflammation


Sunday, April 26 | 5:00PM - 6:45PM
PI 3-Kinase Pathway Modulation: Transition to the Clinic II
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 4 of 4
David A. Fruman, University of California, Irvine, USA
Anti-Leukemic Effects of Novel, Orally Active mTOR Inhibitor


Sunday, April 26 | 6:45PM - 7:00PM
Closing Remarks
This session is from PI 3-Kinases
Room: Grand Sierra B,C,D

Speaker 1 of 1
Lewis C. Cantley, Weill Cornell Medicine, USA
Closing Remarks


Sunday, April 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alpine Ballroom


Sunday, April 26 | 8:00PM - 11:00PM
Entertainment
Room: Alpine Ballroom


Sunday, April 26 | 8:00PM - 11:00PM
Cash Bar
Room: Alpine Ballroom


Monday, April 27 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.