Web Desc
Advances in Biopharmaceuticals
Organizer(s): John M. McPherson and Thomas F. Bumol
Date: January 08 - 13, 2010
Location: Zermatt Resort & Spa - Utah, Midway, Utah, USA
Sponsored by Alnylam Pharmaceuticals, Inc. and Pfizer Global Research & Development
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Summary of Meeting:
This meeting will contain eight sessions covering both biotechnology discovery platforms supporting biopharmaceutical product research and development (4 sessions) and specific disease areas where biopharmaceuticals either have or are likely to have a major positive impact on clinical outcomes for patients (4 sessions).
Scholarship Deadline: September 14 2009
Discounted Abstract Deadline: September 14 2009
Abstract Deadline: October 5 2009
Discounted Registration Deadline: November 5 2009
We gratefully acknowledge additional support for this conference from:
Alnylam Pharmaceuticals, Inc.BioMarin Pharmaceutical Inc.Dendreon CorporationMyriad-RBMOtsuka America Pharmaceutical, Inc.Pfizer Global Research & Development
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Amunix Inc.

Educational donation provided by Amgen

Educational grant from Lilly USA, LLC

Genzyme Corporation

Isis Pharmaceuticals, Inc.

MedImmune

Merck Vaccine Division

Pfizer Inc.

Regeneron Pharmaceuticals, Inc.

Seattle Genetics, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
ACS Publications
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 08 | 3:00PM - 7:30PM
Registration
Room: Matterhorn Foyer


Friday, January 08 | 6:30PM - 7:30PM
Refreshments
Room: Matterhorn Foyer


Friday, January 08 | 7:30PM - 8:30PM
Keynote Address
Room: Matterhorn Ballroom

Speaker 1 of 1
Napoleone Ferrara, University of California, San Diego, USA
The Avastin Story: Challenges and Lessons

Saturday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's


Saturday, January 09 | 8:00AM - 11:00AM
Antibody Discovery and Engineering
Room: Matterhorn Ballroom

Speaker 1 of 4
Matthew Sleeman, MedImmune, USA
Antibody Structure Function Relationships

Saturday, January 09 | 8:00AM - 11:00AM
Antibody Discovery and Engineering
Room: Matterhorn Ballroom

Speaker 2 of 4
Tillman U. Gerngross, Adimab, Inc., USA
Adimab’s Novel Human Antibody Discovery Platform: A New Benchmark for Antibody Discovery Technologies

Saturday, January 09 | 8:00AM - 11:00AM
Antibody Discovery and Engineering
Room: Matterhorn Ballroom

Speaker 3 of 4
John R. Desjarlais, Xencor, Inc., USA
Creating Novel and Enhanced Antibody Therapeutics through Fc Engineering

Saturday, January 09 | 8:00AM - 11:00AM
Antibody Discovery and Engineering
Room: Matterhorn Ballroom

Speaker 4 of 4
James A. Van Deventer, California Institute of Technology, USA
Short Talk: Antibody Fragment Engineering With Non-Canonical Amino Acids

Saturday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Matterhorn Foyer


Saturday, January 09 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Saturday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Matterhorn Foyer


Saturday, January 09 | 5:00PM - 7:00PM
Protein and Peptide Engineering
Room: Matterhorn Ballroom

Speaker 1 of 3
W. David Shen, Merck & Co., Inc., USA
From Mammalian Cell Display to Cross-Species Display of Antibodies

Saturday, January 09 | 5:00PM - 7:00PM
Protein and Peptide Engineering
Room: Matterhorn Ballroom

Speaker 2 of 3
Clark Pan, Genzyme Corporation, USA
Carbohydrate Engineering of Acid alpha-Glucosidase for Treatment of Pompe Disease

Saturday, January 09 | 5:00PM - 7:00PM
Protein and Peptide Engineering
Room: Matterhorn Ballroom

Speaker 3 of 3
David V. Liu, Massachusetts Institute of Technology, USA
Short Talk: Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells

Saturday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grindelwald/Davos


Sunday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's


Sunday, January 10 | 8:00AM - 11:00AM
Next Generation Protein-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 1 of 5
Volker Schellenberger, Amunix Inc., USA
Protein Pharmaceuticals Comprising an XTEN Half-Life Extension Module

Sunday, January 10 | 8:00AM - 11:00AM
Next Generation Protein-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 2 of 5
Richard J.M. Ross, University of Sheffield, UK
Hormone/Hormone Receptor Fusion Proteins for Improving the Pharmacokinetic/Pharmacodynamic Properties of Hormone Replacement Therapies

Sunday, January 10 | 8:00AM - 11:00AM
Next Generation Protein-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 3 of 5
Peter D. Senter, Seattle Genetics Inc., USA
Antibody-Drug Conjugates for Cancer Therapy

Sunday, January 10 | 8:00AM - 11:00AM
Next Generation Protein-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 4 of 5
Chengbin Wu, Abbott Bioresearch Center, USA
Protein Engineering of DVD-Ig: Focusing on Pharmacokinetics, Manufacturing, and Preformulation Studies

Sunday, January 10 | 8:00AM - 11:00AM
Next Generation Protein-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 5 of 5
Bernd J. Wranik, Genentech, USA
Short Talk: LUZ-Y: An Engineered Antibody Format for the Production of One-Armed and Bispecific Antibodies in Mammalian (CHO) Cells

Sunday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Matterhorn Foyer


Sunday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Grindelwald/Davos


Sunday, January 10 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Sunday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Grindelwald/Davos


Sunday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Matterhorn Foyer


Sunday, January 10 | 5:00PM - 7:00PM
Nucleic Acid-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 1 of 4
James M. Wilson, University of Pennsylvania, USA
Gene Therapy: Lessons Learned and Opportunities for the Future

Sunday, January 10 | 5:00PM - 7:00PM
Nucleic Acid-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 2 of 4
C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Progress in Antisense Therapeutics

Sunday, January 10 | 5:00PM - 7:00PM
Nucleic Acid-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 3 of 4
Dinah Sah, Voyager Therapeutics, USA
Development of RNAi Therapeutics

Sunday, January 10 | 5:00PM - 7:00PM
Nucleic Acid-Based Biopharmaceuticals
Room: Matterhorn Ballroom

Speaker 4 of 4
Pengbo Zhou, Weill Cornell Medical College, USA
Short Talk: Integration of RNAi and Protein Knockout Technology for Efficient Eradication of Cellular Proteins

Sunday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grindelwald/Davos


Sunday, January 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Grindelwald/Davos


Monday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's


Monday, January 11 | 8:00AM - 11:00AM
Cancer and Cancer Supportive Care
Room: Matterhorn Ballroom

Speaker 1 of 5
Michael Reiss, Robert Wood Johnson Medical School, USA
TGF-beta as a New Cancer Therapy Target

Monday, January 11 | 8:00AM - 11:00AM
Cancer and Cancer Supportive Care
Room: Matterhorn Ballroom

Speaker 2 of 5
Elisabeth G.E. de Vries, Universitair Medisch Centrum Groningen, Netherlands
Use of Zirconium-89 Labeled Antibodies for Tumor Imaging: Possible Applications for Guiding Targeted Tumor Therapy

Monday, January 11 | 8:00AM - 11:00AM
Cancer and Cancer Supportive Care
Room: Matterhorn Ballroom

Speaker 3 of 5
Patrick A. Baeuerle, Amgen Research (Munich) GmbH, Germany
Cancer Therapy by T Cell-Engaging BiTE Antibodies

Monday, January 11 | 8:00AM - 11:00AM
Cancer and Cancer Supportive Care
Room: Matterhorn Ballroom

Speaker 4 of 5
Antonio Gualberto, Pfizer Oncology, USA
Development of Figitumumab (CP-751,871), a Fully Human Monoclonal Antibody against the IGF-1R

Monday, January 11 | 8:00AM - 11:00AM
Cancer and Cancer Supportive Care
Room: Matterhorn Ballroom

Speaker 5 of 5
John C. Zwaagstra, Biotechnology Research Institute NRCC, Canada
Short Talk: Design and Efficacy of Single-Chain Traps Targeting Ligands of the Transforming Growth Factor-beta (TGF-beta) Family: The New Generation of Cancer Therapeutics/Diagnostics

Monday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Matterhorn Foyer


Monday, January 11 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Grindelwald/Davos


Monday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Matterhorn Foyer


Monday, January 11 | 5:00PM - 7:00PM
Immune-Mediated Diseases/Transplant
Room: Matterhorn Ballroom

Speaker 1 of 3
C. Randal Mills, California Institute for Regenerative Medicine, USA
Mesenchymal Stem Cells for Treatment of GVHD

Monday, January 11 | 5:00PM - 7:00PM
Immune-Mediated Diseases/Transplant
Room: Matterhorn Ballroom

Speaker 2 of 3
Alasdair Coles, University of Cambridge, UK
Anti-CD52 Antibodies for the Treatment of Multiple Sclerosis

Monday, January 11 | 5:00PM - 7:00PM
Immune-Mediated Diseases/Transplant
Room: Matterhorn Ballroom

Speaker 3 of 3
Kristine Kikly, Eli Lilly and Company, USA
Anti-BAFF for the Treatment of Rheumatoid Arthritis

Monday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grindelwald/Davos


Monday, January 11 | 7:30PM - 10:00PM
Poster Session Viewing
Room: Grindelwald/Davos


Tuesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's


Tuesday, January 12 | 8:00AM - 11:00AM
Diabetes
Room: Matterhorn Ballroom

Speaker 1 of 5
Bart Keymeulen, Vrije Universiteit Brussel, Belgium
Preservation of Beta Cell Function in Human Type 1 Diabetes

Tuesday, January 12 | 8:00AM - 11:00AM
Diabetes
Room: Matterhorn Ballroom

Speaker 2 of 5
Sushil G. Rane, NIDDK, National Institutes of Health, USA
Protection from Obesity and Diabetes by Blockade of TGF-beta/Smad3 Signaling

Tuesday, January 12 | 8:00AM - 11:00AM
Diabetes
Room: Matterhorn Ballroom

Speaker 3 of 5
Alexei Kharitonenkov, Novo Nordisk, USA
FGF-21 and its Novel Variants to Treat Metabolic Disorders

Tuesday, January 12 | 8:00AM - 11:00AM
Diabetes
Room: Matterhorn Ballroom

Speaker 4 of 5
Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Restoration of Self Tolerance in Autoimmune Diabetes


Tuesday, January 12 | 8:00AM - 11:00AM
Diabetes
Room: Matterhorn Ballroom

Speaker 5 of 5
Biju Parekkadan, Rutgers University, USA
Short Talk: Natural Therapeutics Derived from the Bone Marrow Stroma

Tuesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Matterhorn Foyer


Tuesday, January 12 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Matterhorn Foyer


Tuesday, January 12 | 5:00PM - 7:00PM
Metabolic and Neurological Disorders
Room: Matterhorn Ballroom

Speaker 1 of 4
Ronald B. DeMattos, Lilly Research Laboratories, USA
Abeta Immunotherapy: The Development of Compound Specific Biomarkers to Aid the Translation of Preclinical to Clinical Studies

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolic and Neurological Disorders
Room: Matterhorn Ballroom

Speaker 2 of 4
Mike Ominsky, Amgen Inc., USA
OPG/RANKL and Sclerostin; Physiological Regulators of Bone Density; Targets for the Treatment of Bone Loss Indications

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolic and Neurological Disorders
Room: Matterhorn Ballroom

Speaker 3 of 4
Marco A. Passini, Genzyme Corporation, USA
Gene and Antisense Oligonucleotide Therapies for Spinal Muscular Atrophy

Tuesday, January 12 | 5:00PM - 7:00PM
Metabolic and Neurological Disorders
Room: Matterhorn Ballroom

Speaker 4 of 4
John Chaddock, Syntaxin Ltd, UK
Short Talk: Clostridial Endopeptidases - A Novel Platform for Therapeutic Proteins

Tuesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grindelwald/Davos


Tuesday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Grindelwald/Davos


Tuesday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Grindelwald/Davos


Wednesday, January 13 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.