Web Desc
Triglycerides and Triglyceride-Rich Particles in Health and Disease
Organizer(s): Robert H. Eckel, Ira J. Goldberg and Ruth McPherson
Date: January 09 - 14, 2010
Location: Big Sky Resort, Big Sky, MT, USA
Supported by The Directors' Fund
Summary of Meeting:
Triglycerides are important storage molecules that play important roles in lipid and lipoprotein metabolism, insulin action, energy balance, and atherosclerosis. The purpose of this meeting will be to critically examine the broad spectrum of triglyceride biology from the molecular biology of triglyceride biosynthesis in the liver and intestine to lipoprotein assembly and secretion to lipid fuel partitioning to adipose tissue, muscle and the liver. A discussion of the regulation of free fatty acid flux from adipose tissue to the liver by insulin and pro- and anti-inflammatory cytokines will precede a detailed coverage of chylomicron and VLDL transport, intravascular lipolysis and tissue-specific lipid partitioning. A transition to the science and medicine of triglycerides will then occur with expected updates on the understanding of the genetic basis of disorders of triglyceride-rich lipoprotein metabolism and the pathogenesis of atherosclerosis that relate specifically to circulating triglyceride-rich particles. The clinical relevance of hypertriglyceridemia, new insights into the mechanisms of pharmacological treatment of hypertriglyceridemia, and clinical trial evidence pro and con that triglyceride lowering reduces cardiovascular disease risk will follow. The meeting should attract basic, clinical, and population scientists from academia and industry, and will deal with the many issues that remain unclear or controversial surrounding triglycerides and triglyceride rich particles in health and disease.
Scholarship Deadline: September 15 2009
Discounted Abstract Deadline: September 15 2009
Abstract Deadline: October 12 2009
Discounted Registration Deadline: November 9 2009
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Bristol-Myers Squibb Company

Isis Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL099162-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 09 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Saturday, January 09 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Saturday, January 09 | 7:30PM - 8:30PM
Keynote Address
Room: Gallatin

Speaker 1 of 1
Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Increased Assembly and Secretion of Triglyceride-Rich Lipoproteins in
Insulin Resistance: Greasing the Path to Atherosclerosis


Sunday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Sunday, January 10 | 8:00AM - 8:15AM
Welcome and Scientific Introduction
Room: Gallatin

Speaker 1 of 1
Robert H. Eckel, University of Colorado Denver, Anschutz Medical Campus, USA
Triglycerides in Health and Disease

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 1 of 8
* Mats Rudling, Karolinska Institutet, Sweden

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 2 of 8
* Douglas G. Mashek, University of Minnesota, USA

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 3 of 8
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Metabolic Channeling and Control of Fatty Acid Metabolism

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 4 of 8
Bart Staels, Institut Pasteur de Lille, Université Lille, France
Nuclear Receptor Control of Triglyceride Metabolism

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 5 of 8
Edward A. Fisher, New York University School of Medicine, USA
Omega-3 Fatty Acids and Lipoprotein Metabolism: Mechanistic Basis for their Clinical Effects

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 6 of 8
Mark D. Erion, Janssen Pharmaceuticals, USA
Reduction in Plasma and Liver Triglycerides with a Liver-Targeted Thyroid Hormone Receptor-beta Agonist

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 7 of 8
John M. Stafford, Vanderbilt University, USA
Short Talk: Impaired Inactivation of FoxO1 Contributes to Glucose-Mediated Increases in Serum VLDL

Sunday, January 10 | 8:15AM - 11:30AM
Molecular/Cell Biology and Physiology of Triglyceride Synthe
sis and TG-Rich Lipoprotein Assembly and Secretion

Room: Gallatin

Speaker 8 of 8
J. Brandon Dixon, Georgia Institute of Technology, USA
Short Talk: Quantifying the Functional Transport of Lipoproteins by Lymphatic Endothelial Cells

Sunday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 10 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Sunday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 1 of 6
* Miklos Péterfy, Western University of Health Sciences, USA

Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 2 of 6
* Richard Lehner, University of Alberta, Canada

Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 3 of 6
Rudolf Zechner, University of Graz, Austria
Intracellular Lipolysis and the Regulation of Lipid and Lipoprotein Metabolism

Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 4 of 6
Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Adipokines and Lipolysis in Human Obesity

Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 5 of 6
Samuel Klein, Washington University School of Medicine, USA
Therapeutic Implications of Adipose Tissue and Hepatic Lipid Metabolism in Obesity

Sunday, January 10 | 5:00PM - 7:00PM
Regulation of Lipolysis in Man and Rodents
Room: Gallatin

Speaker 6 of 6
Janna A. van Diepen, University Medical Center St. Radboud, Netherlands
Short Talk: Hepatocyte-Specific Inflammation Enhances VLDL Production in Mice

Sunday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Monday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 1 of 8
* Andre Bensadoun, Cornell University, USA

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 2 of 8
* Rudolf Zechner, University of Graz, Austria

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 3 of 8
Ira J. Goldberg, New York University, USA
LPL Mediated Lipid Uptake

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 4 of 8
Nada A. Abumrad, Washington University, USA
Free Fatty Acid Uptake and Intracellular Trafficking: Evolving Concepts

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 5 of 8
Keith N. Frayn, University of Oxford, UK
Triglyceride Uptake into Human Adipose Tissue

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 6 of 8
Stephen G. Young, University of California, Los Angeles, USA
An Endothelial Cell Protein Required for the Lipolytic Processing of Triglyceride-Rich Lipoproteins

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 7 of 8
Jason A. Magida, The Salk Institute, USA
Short Talk: Genetic Heart Disease Results in a Diabetic Phenotype via Reduced Clearance of VLDL-Triglycerides

Monday, January 11 | 8:00AM - 11:15AM
Chylomicron and VLDL Transport, Lipolysis and Tissue-Specifi
c Lipid Partitioning

Room: Gallatin

Speaker 8 of 8
Douglas G. Mashek, University of Minnesota, USA
Short Talk: Hepatic Adipose Triglyceride Lipase (ATGL) Alters Hepatic Triglyceride Turnover, Fatty Acid Channeling and PPAR-alpha Activity

Monday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 11 | 11:15AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Monday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Monday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 1 of 6
* John D. Brunzell, University of Washington, USA

Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 2 of 6
* Leanne Hodson, University of Oxford, UK

Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 3 of 6
Ruth McPherson, University of Ottawa Heart Institute, Canada
Triglycerides and CAD Risk: Insights from Genome-Wide Association Studies

Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 4 of 6
Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Genome-Wide Studies of Serum Lipids: Lessons from the Old Order Amish

Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 5 of 6
Gary F. Lewis, Toronto General Hospital, Canada
ApoB Production - Human Gut and Liver

Monday, January 11 | 5:00PM - 7:00PM
Genetics and Pathophysiology of Disorders of TG-Rich Lipopro
tein Metabolism

Room: Gallatin

Speaker 6 of 6
Michael Olivier, Medical College of Wisconsin, USA
Short Talk: Genomic and Proteomic Analysis of Human Dyslipidemia Characteristic of the Metabolic Syndrome

Monday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Monday, January 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson/Madison


Tuesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 1 of 8
* Bo Anders Angelin, Karolinska Institutet, Sweden

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 2 of 8
* Lars B. Nielsen, Rigshospitalet, University of Copenhagen, Denmark

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 3 of 8
Frank M. Sacks, Harvard School of Public Health, USA
Apolipoprotein C-III: Diverse Actions Contributing to Dyslipidemia and Atherosclerosis

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 4 of 8
Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Deconvoluting the Metabolic Syndrome: The Role of Hepatic Insulin Resistance

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 5 of 8
John C. Rutledge, University of California, Davis, USA
Triglyceride-Rich Lipoproteins and Mechanisms of Inflammation and Atherosclerosis

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 6 of 8
Clay F. Semenkovich, Washington University School of Medicine, USA
Lipids and Stress Responses in the Evolution of Atherosclerosis

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 7 of 8
Dagmar Kratky, Medical University of Graz, Austria
Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR(-/-) Mice

Tuesday, January 12 | 8:00AM - 11:15AM
TG-Rich Lipoproteins and Mechanisms of Atherosclerosis
Room: Gallatin

Speaker 8 of 8
Nora Gray, University of California, Berkeley, USA
Short Talk: The Role of Angiopoietin-like 4 in Glucocorticoid-Regulated Lipid Metabolism

Tuesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 12 | 11:15AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Tuesday, January 12 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Tuesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 1 of 6
* Geesje M. Dallinga-Thie, Academic Medical Center, Netherlands

Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 2 of 6
* Ruth McPherson, University of Ottawa Heart Institute, Canada

Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 3 of 6
Michael H. Criqui, University of California, San Diego, USA
Population Studies of TG and ASCVD

Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 4 of 6
Børge Nordestgaard, University of Copenhagen, Denmark
Non-Fasting TGs and CVD Risk


Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 5 of 6
Elizabeth J. Parks, University of Missouri, USA
Dietary Influences on Triglyceride-Rich Lipoprotein Production

Tuesday, January 12 | 5:00PM - 7:00PM
Population Science on the Relationship between TG-Rich Lipop
roteins and ASCVD

Room: Gallatin

Speaker 6 of 6
Carlos O. Mendivil, Harvard School of Public Health, USA
Short Talk: Tryglicerides in VLDL and LDL with apoC-III are a Strong Coronary Heart Disease Risk Factor when LDL Cholesterol is Low

Tuesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Tuesday, January 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson/Madison


Wednesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 1 of 8
* Mark W. Sleeman, Regeneron Pharmaceuticals, USA

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 2 of 8
* Walter Singleton, Ionis Pharmaceuticals, Inc., USA

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 3 of 8
Rosanne M. Crooke, Ionis Pharmaceuticals, Inc., USA
Development of Novel Antisense Inhibitors for the Treatment of Hypertriglyceridemia

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 4 of 8
Dong Cheng, Bristol-Myers Squibb Company, USA
Are DGAT Inhibitors a Target for Triglyceride Lowering?

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 5 of 8
Matthew T. Flowers, University of Wisconsin, Madison, USA
Tissue-Specific Roles for SCD1 in Regulating Obesity

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 6 of 8
David Robert Neff, Merck, USA
The Potential Role of CETP Inhibition to Manage Dyslipidemia and CVD Risk

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 7 of 8
Mark Graham, Ionis Pharmaceuticals, Inc., USA
Short Talk: Antisense Inhibition of Angiopoietin-Like 3 in Rodent Models

Wednesday, January 13 | 8:00AM - 11:15AM
Therapeutics of Hypertriglyceridemia
Room: Gallatin

Speaker 8 of 8
Jennifer L. Lachey, Ember Therapeutics, USA
Short Talk: Treatment with a Soluble Activin Receptor Type IIB Attenuates Diet-Induced Obesity in High-Fat Diet-Fed Mice

Wednesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 13 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 13 | 5:00PM - 7:00PM
Clinical Trials of Triglyceride Lowering and Outcomes
Room: Gallatin

Speaker 1 of 5
* Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA

Wednesday, January 13 | 5:00PM - 7:00PM
Clinical Trials of Triglyceride Lowering and Outcomes
Room: Gallatin

Speaker 2 of 5
* Robert H. Eckel, University of Colorado Denver, Anschutz Medical Campus, USA

Wednesday, January 13 | 5:00PM - 7:00PM
Clinical Trials of Triglyceride Lowering and Outcomes
Room: Gallatin

Speaker 3 of 5
Marshall B. Elam, University of Tennessee Health Science Center, USA
Fibrates and Cardiovascular Risk Reduction

Wednesday, January 13 | 5:00PM - 7:00PM
Clinical Trials of Triglyceride Lowering and Outcomes
Room: Gallatin

Speaker 4 of 5
Alan Chait, University of Washington School of Medicine, USA
Modalities of Triglyceride Lowering in the Prevention and Treatment of Cardiovascular Disease – Role of Niacin

Wednesday, January 13 | 5:00PM - 7:00PM
Clinical Trials of Triglyceride Lowering and Outcomes
Room: Gallatin

Speaker 5 of 5
Mahmood Hussain, SUNY Downstate Medical Center, USA
Regulation and Targeting of Microsomal Triglyceride Transfer Protein (MTP)

Wednesday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Wednesday, January 13 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson/Madison


Wednesday, January 13 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson/Madison


Thursday, January 14 | 10:25AM - 10:25AM
Departure


*Session Chair.