Web Desc
Molecular Basis for Chromatin Structure and Regulation
Organizer(s): Jonathan Widom, Geeta Narlikar and Dinshaw J. Patel
Date: January 17 - 22, 2010
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by The Directors' Fund
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Summary of Meeting:
Chromatin structure and dynamics underlie every aspect of genome function. The past several years have seen an exponential growth in our knowledge of facts, ranging from catalogs of histone protein posttranslational modifications to complete genome sequences of many organisms to atomic resolution structures of many key molecular players. But our mechanistic understanding lags far behind. New reagents, methodologies and concepts are needed. This meeting will bring together leading experts in diverse areas of chromatin biology who are developing and applying new approaches to develop a concrete mechanistic link between chromatin structure and chromatin function. The topics covered include: fundamental in vivo physical chemical studies of transcription factor binding; real-time single molecule in vivo imaging; state-of-the-art methods for discovery, characterization, and manipulation of histone- and nucleosome-modifying enzymes and for the synthesis and characterization of their specifically-modified histone and nucleosome substrates; single molecule biophysics studies of molecular mechanisms; atomic resolution structural studies; and locus- and chromosome-wide phenomena such as heterochromatin formation and dosage compensation.
Scholarship Deadline: September 18 2009
Discounted Abstract Deadline: September 18 2009
Abstract Deadline: October 21 2009
Discounted Registration Deadline: November 17 2009
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Integrated DNA Technologies
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 17 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Sunday, January 17 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Sunday, January 17 | 7:30PM - 9:30PM
Keynote Session
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Jonathan Widom, Northwestern University, USA

Sunday, January 17 | 7:30PM - 9:30PM
Keynote Session
Room: Chamisa Ballroom 1

Speaker 2 of 3
Roger D. Kornberg, Stanford University, USA
Chromatin Structure and Transcription

Sunday, January 17 | 7:30PM - 9:30PM
Keynote Session
Room: Chamisa Ballroom 1

Speaker 3 of 3
C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Writing and Reading the Histone Code



Monday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 1 of 7
Timothy J. Stasevich, National Institutes of Health, USA
Dissecting the Binding Mechanism of the Linker Histone in Live Cells: An Integrated FRAP Analysis

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 2 of 7
John T. Lis, Cornell University, USA
Very Rapid and Locus-Wide Changes in Chromatin Caused by Activation of a Potentiated Gene

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 3 of 7
X. Sunney Xie, Peking University, China
Transcription Factor and Chromatin Dynamics in vivo

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 4 of 7
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Role of Nucleosome Remodelers in the Positioning and Dynamics of DNA during Expression and Repair

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 5 of 7
Hinrich Boeger, University of California, Santa Cruz, USA
Short Talk: The Kinetics of Stochastic Fluctuations in Chromatin Structure and Gene Expression

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 6 of 7
Maya M. Kasowski, Howard Hughes Medical Institute, USA
Short Talk: Analyzing Variation in Gene Regulation in Humans: Global Analysis of NF-kappaB and Polii Binding using CHIP-SEQ

Monday, January 18 | 8:00AM - 11:15AM
Transcription Factor and Chromatin Dynamics in vivo
Room: Chamisa Ballroom 1

Speaker 7 of 7
Alexander Tarakhovsky, Rockefeller University, USA
Short Talk: Histone Mimicry by Pathogens

Monday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Monday, January 18 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 18 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, January 18 | 3:30PM - 4:30PM
Workshop Panel
Room: Chamisa Ballroom 1
To be geared toward helping women (and men, if interested) graduate students, postdocs, and junior faculty address the challenges of balancing an academic career and family.
Speaker 1 of 1
* Geeta J. Narlikar, University of California, San Francisco, USA

Monday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, January 18 | 5:00PM - 7:00PM
Functional Elements
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Insulators and Enhancer Blockers

Monday, January 18 | 5:00PM - 7:00PM
Functional Elements
Room: Chamisa Ballroom 1

Speaker 2 of 4
Stavros Lomvardas, Columbia University, USA
Molecular Mechanisms of Olfactory Receptor Choice

Monday, January 18 | 5:00PM - 7:00PM
Functional Elements
Room: Chamisa Ballroom 1

Speaker 3 of 4
Robert E. Kingston, Massachusetts General Hospital, USA
Nucleosome Occupancy and Transcriptional Regulation

Monday, January 18 | 5:00PM - 7:00PM
Functional Elements
Room: Chamisa Ballroom 1

Speaker 4 of 4
J.J. Miranda, Gladstone Institutes and University of California, San Francisco, USA
Short Talk: Molecular Architecture of CTCF and the Insulatosome

Monday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Monday, January 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Tuesday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Karolin Luger, University of Colorado Boulder, USA
Histone Chaperone Mechanisms in Chromatin Assembly and Disassembly

Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 2 of 6
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Histone Chaperones, Chromatin Assembly and the Challenges of Cell Cycle

Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 3 of 6
James T. Kadonaga, University of California, San Diego, USA
Chromatin Assembly and DNA Dynamics

Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 4 of 6
Shelley L. Berger, University of Pennsylvania, USA
Histone Covalent Modifications in Genome Regulation

Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 5 of 6
Song Tan, Pennsylvania State University, USA
Short Talk: Structural Basis for Nucleosome Recognition by the RCC1 Chromatin Factor

Tuesday, January 19 | 8:00AM - 11:15AM
Chromatin Assembly and Modification
Room: Chamisa Ballroom 1

Speaker 6 of 6
Michael A. Shogren-Knaak, Iowa State University, USA
Short Talk: Acetylation-Dependent Multimerization of the Yeast SAGA Coactivator Complex in Inducible Gene Transcription

Tuesday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, January 19 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 19 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, January 19 | 5:00PM - 7:00PM
Histone Code Modules and Enzyme Mechanism
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA

Tuesday, January 19 | 5:00PM - 7:00PM
Histone Code Modules and Enzyme Mechanism
Room: Chamisa Ballroom 1

Speaker 2 of 5
Or P. Gozani, Stanford University, USA
Role of Protein Lysine Methylation Signaling in Health and Disease

Tuesday, January 19 | 5:00PM - 7:00PM
Histone Code Modules and Enzyme Mechanism
Room: Chamisa Ballroom 1

Speaker 3 of 5
Cheryl Arrowsmith, University of Toronto, Canada
Structural and Chemical Biology of Histone Code Modules

Tuesday, January 19 | 5:00PM - 7:00PM
Histone Code Modules and Enzyme Mechanism
Room: Chamisa Ballroom 1

Speaker 4 of 5
Philip A. Cole, Johns Hopkins University School of Medicine, USA
Chemical Approaches to Mechanisms of Histone Modifying Enzymes

Tuesday, January 19 | 5:00PM - 7:00PM
Histone Code Modules and Enzyme Mechanism
Room: Chamisa Ballroom 1

Speaker 5 of 5
Alexander J. Ruthenburg, University of Chicago, USA
Short Talk: Multivalent Interactions Interpret the Histone Code at the Nucleosome Level

Tuesday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Tuesday, January 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Wednesday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Bradley R. Cairns, HHMI/University of Utah, USA
DNA Translocation by the RSC Chromatin Remodeler in ‘Tethered’ Formats

Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 2 of 6
Geeta J. Narlikar, University of California, San Francisco, USA
Structure and Mechanisms of ATP-Dependent Chromatin Remodeling Motors

Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 3 of 6
Michelle D. Wang, Cornell University, USA
The Dynamics of Accessing DNA

Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 4 of 6
Xiaowei Zhuang, Harvard University, USA
Single Molecule Studies of Chromatin Remodeling Enzymes

Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 5 of 6
Gregory D. Bowman, Johns Hopkins University, USA
Short Talk: Crystal Structure of the Chd1 Remodeler Reveals that Chromodomains can Directly Regulate the ATPase Motor

Wednesday, January 20 | 8:00AM - 11:15AM
Dynamic Transitions and ATP-Dependent Remodeling
Room: Chamisa Ballroom 1

Speaker 6 of 6
Hua-Ying Fan, Fox Chase Cancer Center, USA
Short Talk: UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression

Wednesday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, January 20 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 20 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 20 | 5:00PM - 7:00PM
Chromatin Structure
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Geeta J. Narlikar, University of California, San Francisco, USA

Wednesday, January 20 | 5:00PM - 7:00PM
Chromatin Structure
Room: Chamisa Ballroom 1

Speaker 2 of 5
Timothy J. Richmond, ETH Zürich, Switzerland
Structure and Interactions of the Chromatin Remodeling Factor ISW1a

Wednesday, January 20 | 5:00PM - 7:00PM
Chromatin Structure
Room: Chamisa Ballroom 1

Speaker 3 of 5
Eran Segal, Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Toward Understanding the Code of Chromatin Regulation

Wednesday, January 20 | 5:00PM - 7:00PM
Chromatin Structure
Room: Chamisa Ballroom 1

Speaker 4 of 5
John van Noort, BF/ LION, Leiden University, Netherlands
Unraveling Chromatin Higher Order Structure with Magnetic Tweezers

Wednesday, January 20 | 5:00PM - 7:00PM
Chromatin Structure
Room: Chamisa Ballroom 1

Speaker 5 of 5
Yvonne N. Fondufe-Mittendorf, University of Kentucky, USA
Short Talk: Nucleosome Positioning and Dynamic Nucleosome Repositioning in Transcription Regulation

Wednesday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, January 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Thursday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Danesh Moazed, Harvard Medical School, USA
In Vitro Reconstitution of Heterochromatin-Dependent Transcriptional Gene Silencing

Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 2 of 6
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Mediated Epigenetic Control of the Genome

Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 3 of 6
Barbara J. Meyer, University of California, Berkeley, USA
X-Chromosome-Wide Gene Regulation

Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 4 of 6
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
Separating Repressive and Activating Chromatin Domains at the X-Inactivation Center

Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 5 of 6
Joanna Wysocka, Stanford University, USA
Short Talk: Coordinated Control of PRC2 Enzymatic Activity and
Target Gene Occupancy in Pluripotent Cells


Thursday, January 21 | 8:00AM - 11:15AM
Silencing and Dosage Compensation
Room: Chamisa Ballroom 1

Speaker 6 of 6
Yali Dou, University of Michigan, USA
Short Talk: The Heterodimer of Non-SET Domain Proteins Ash2L and RbBP5 has Intrinsic Histone Methyltransferase Activity that Synergizes with the MLL1 SET Domain in H3 K4 Methylation

Thursday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, January 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, January 21 | 5:00PM - 7:00PM
Protein Chemistry
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Tom W. Muir, Princeton University, USA
A Synthetic ‘Kiss of Death’

Thursday, January 21 | 5:00PM - 7:00PM
Protein Chemistry
Room: Chamisa Ballroom 1

Speaker 2 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
A Structural Perspective of How Chromatin-Binding Modules Interpret Histone Modifications

Thursday, January 21 | 5:00PM - 7:00PM
Protein Chemistry
Room: Chamisa Ballroom 1

Speaker 3 of 5
Jennifer J. Ottesen, Ohio State University, USA
Short Talk: Ligation Strategies to Probe Histone Modifications in the Nucleosome Core

Thursday, January 21 | 5:00PM - 7:00PM
Protein Chemistry
Room: Chamisa Ballroom 1

Speaker 4 of 5
Benjamin A. Garcia, University of Pennsylvania, USA
Short Talk: Next Generation Quantitative Proteomic Tools for Analyzing Histone Modifications

Thursday, January 21 | 5:00PM - 7:00PM
Protein Chemistry
Room: Chamisa Ballroom 1

Speaker 5 of 5
Daniele Canzio, University of California, San Francisco, USA
Short Talk: Polymerizable Chromodomain 'Sticky Ends' in HP1 Couple H3K9me3 Recognition to Nucleosome Arrangement in Heterochromatin Assembly

Thursday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, January 21 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Thursday, January 21 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Friday, January 22 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.