Web Desc
Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response Pathways
Organizer(s): Navdeep S. Chandel, Peter J. Ratcliffe, Volker H. Haase and Agnes Görlach
Date: January 19 - 24, 2010
Location: Keystone Resort, Keystone, CO, USA
Supported by The Directors' Fund
Summary of Meeting:
Molecular oxygen is absolutely essential for cellular respiration and higher organisms have developed sophisticated physiological responses that allow adaptation to a low oxygen environment. These include neurotransmitter release from the carotid body to increase respiration; pulmonary vascular constriction to redirect blood flow from poorly to well oxygenated regions; and in the kidney, enhanced erythropoietin secretion to boost red blood cell production to augment oxygen carrying capacity. Tissue hypoxia is not only associated with a variety of pathological conditions such as pulmonary, cardiovascular and neoplastic diseases, but also occurs during normal embryonic development and plays an important role in stem cell maintenance. This meeting will highlight the latest, cutting-edge advances in hypoxia research and discuss (1) the cellular and molecular mechanisms that underlie physiological responses to hypoxia, (2) the role of hypoxic signaling in the pathogenesis and progression of pulmonary hypertension, ischemia and cancer, (3) the importance of hypoxia in stem cell maintenance and embryonic development, and (4) the overall state of the art in hypoxic signaling in inflammation and metabolism.
Scholarship Deadline: September 21 2009
Discounted Abstract Deadline: September 21 2009
Abstract Deadline: October 22 2009
Discounted Registration Deadline: November 19 2009
We gratefully acknowledge additional support for this conference from:
HypOxygenRuskinn Technology Ltd, a division of the Baker Company, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL097559-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 19 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Tuesday, January 19 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Tuesday, January 19 | 7:30PM - 8:30PM
Keynote Address
Room: Grays/Longs Peaks

Speaker 1 of 1
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms Underlying Responses to Hypoxia

Wednesday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, January 20 | 8:00AM - 11:15AM
Biology of Hypoxia Signaling
Room: Grays/Longs Peaks

Speaker 1 of 5
Volker H. Haase, Vanderbilt University, USA
Pathophysiological Consequences of Chronic HIF Activation

Wednesday, January 20 | 8:00AM - 11:15AM
Biology of Hypoxia Signaling
Room: Grays/Longs Peaks

Speaker 2 of 5
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Genetic Analyses of Prolyl Hydroxylases in Mice

Wednesday, January 20 | 8:00AM - 11:15AM
Biology of Hypoxia Signaling
Room: Grays/Longs Peaks

Speaker 3 of 5
* Peter J. Ratcliffe, University of Oxford, UK
Protein Hydroxylation and the Signaling of Hypoxia

Wednesday, January 20 | 8:00AM - 11:15AM
Biology of Hypoxia Signaling
Room: Grays/Longs Peaks

Speaker 4 of 5
Joel I. Perez-Perri, Instituto Leloir, Argentina
Short Talk: Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF Dependent Transcription in Hypoxia

Wednesday, January 20 | 8:00AM - 11:15AM
Biology of Hypoxia Signaling
Room: Grays/Longs Peaks

Speaker 5 of 5
Peter J. Espenshade, Johns Hopkins University School of Medicine, USA
Short Talk: Oxygen-Regulated Degradation of Yeast SREBP by a Candidate Prolyl Hydroxylase

Wednesday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 20 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 20 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 1 of 9
* Volker H. Haase, Vanderbilt University, USA

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 2 of 9
David Hoogewijs, University of Fribourg, Switzerland
A Zinc Finger and BTB Domain-Containing Protein as a Novel PHD Interactor

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 3 of 9
Sarah Linke, Karolinska Institutet, Sweden
The LL-Motif in HIF-alpha Contributes to FIH-1 Binding

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 4 of 9
Heidi Menrad, Goethe-University Frankfurt, Germany
Divergent Roles of HIF-1alpha vs. HIF-2alpha in the Survival of Multicellular Tumor Spheroids

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 5 of 9
Zhizhong Li, Genomics Institute of the Novartis Research Foundation, USA
Hypoxic Microenvironment and Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 6 of 9
Kevin Rouault, INSERM, France
HIF-1a and -2a Knockdown Induced Deficiency in the Long-Term Reconstitution Ability of Human Haematopoietic Cells

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 7 of 9
Kate M. Harms, University of New Mexico School of Medicine, USA
Neural Stem/Progenitor Cells Display a Glycolytic Metabolic Phenotype Under Non-Hypoxic Conditions: Role of Constitutive Stabilization of Hypoxia Inducible Factor-1alpha (HIF-1alpha)

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 8 of 9
Carissa L. Perez, Fred Hutchinson Cancer Research Center, USA
Exposure to Hypoxic Environments Results in Elevated de novo Fatty Acid Synthesis as Revealed by a 13C Isotope Labeling Strategy

Wednesday, January 20 | 2:30PM - 4:30PM
Workshop 1: Graduate Students/PostDoc Symposium
Room: Grays/Longs Peaks

Speaker 9 of 9
Federico Formenti, University of Oxford, UK
Chuvash Polycythaemia Demonstrates the Importance of Hypoxia-Inducible Factor in Human Skeletal Muscle Metabolism

Wednesday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 1 of 6
* Paul T. Schumacker, Northwestern University, USA

Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 2 of 6
Karen M. Ridge, Northwestern University, USA
Cytoskeletal Rearrangements in Lung Cells during Hypoxia

Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 3 of 6
Larrisa A. Shimoda, Johns Hopkins School of Medicine, USA
HIF-1 and Pulmonary Responses to Hypoxia

Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 4 of 6
Marlene Rabinovitch, Stanford University, USA
Dysregulated Wnt-PPARgamma Interactions in Pulmonary Vascular Pathology

Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 5 of 6
Gregory B. Waypa, Northwestern University, USA
Short Talk: Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

Wednesday, January 20 | 5:00PM - 7:15PM
Pulmonary Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 6 of 6
Friederike C. Weisel, University of Giessen Lung Center (UGLC), Germany
Short Talk: Reverse Remodeling in Pulmonary Arterial Hypertension

Wednesday, January 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak


Wednesday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Thursday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 1 of 6
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Dioxygenases as Therapeutic Targets in Cancer

Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 2 of 6
Patrick H. Maxwell, Rayne Institute, UK
The HIF/PHD/VHLAxis in Kidney Cancer

Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 3 of 6
Tricia M. Wright, University of North Carolina, Chapel Hill, USA
Short Talk: Ror2 is a Non-Hypoxia HIF Target of VHL Inactivation in Renal Cell Carcinoma

Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 4 of 6
Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA
Targeting Hypoxic Cell Signaling for Cancer Therapy

Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 5 of 6
Leisa K. Johnson, Genentech, Inc., USA
Interrogating alpha-VEGF responses in genetically engineered mouse models of oncology

Thursday, January 21 | 8:00AM - 11:15AM
Cancer
Room: Grays/Longs Peaks

Speaker 6 of 6
Luciana P. Schwab, University of Tennessee Health Science Center, USA
Short Talk: HIF-1alpha Promotes Primary Tumor Growth, Lung Macrometastasis and Stem Cell Activity in the MMTV-PyMT Model of Luminal Breast Cancer


Thursday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, January 21 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Thursday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Thursday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 21 | 5:00PM - 7:15PM
Acute Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 1 of 5
* Nanduri R. Prabhakar, University of Chicago, USA
Acute Hypoxic Sensing and Reactive Oxygen Species

Thursday, January 21 | 5:00PM - 7:15PM
Acute Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 2 of 5
Joseph A. Garcia, Columbia University Medical Center, USA
Intersections of Stress-Responsive Signal Transduction Pathways

Thursday, January 21 | 5:00PM - 7:15PM
Acute Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 3 of 5
Gabriel G. Haddad, University of California, San Diego, USA
Adaptive responses to hypoxia: Insights from a genetic model

Thursday, January 21 | 5:00PM - 7:15PM
Acute Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 4 of 5
Vikram Sudarsan, Stanford University, USA
Short Talk: Acute Oxygen and Carbon Dioxide Sensing in a Drosophila Respiratory Neural Circuit

Thursday, January 21 | 5:00PM - 7:15PM
Acute Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 5 of 5
Mark R. Band, University of Illinois, USA
Short Talk: Evolution of the p53 Pathway in the Hypoxia Tolerant Mole-Rat Mimics a Cancer Survival Mechanism

Thursday, January 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak


Thursday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Friday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 1 of 6
* M. Celeste Simon, University of Pennsylvania, USA
Hypoxia and Stem Cells

Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 2 of 6
Toshio Suda, Keio University, Japan
Hematopoietic Stem Cell in Hypoxic Niche

Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 3 of 6
Emin Maltepe, University of California, San Francisco, USA
Oxygen, Mitochondria and Stem Cell Fate in the Placenta

Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 4 of 6
Lorenz Poellinger, Karolinska Institutet, Sweden
Hypoxia Signaling of Notch

Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 5 of 6
Till Acker, University of Giessen, Germany
Short Talk: A Hypoxic Niche Regulates Glioma Stem Cells

Friday, January 22 | 8:00AM - 11:15AM
Stem Cells and Hypoxia
Room: Grays/Longs Peaks

Speaker 6 of 6
Ernestina Schipani, University of Michigan, USA
Short Talk: Dual Action of Von Hippel Lindau Protein (pVHL) in Limb Bud Mesenchyme

Friday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, January 22 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, January 22 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Friday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 1 of 9
* Amato J. Giaccia, Stanford University, USA

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 2 of 9
Matthew R. Pawlus, University of Colorado Denver, USA
USF2 is a HIF2 Specific Co-transcriptional Activator

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 3 of 9
Sven Pahlman, Lund University, Sweden
HIF-2alpha is a Negative Prognostic Marker in Human Neuroblastoma and Maintains Stemness in Neural Crest-like Neuroblastoma Tumor-Initiating Cells

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 4 of 9
William Y. Kim, University of North Carolina, USA
HIF2alpha Cooperates with RAS Activation to Promote Lung Cancer Progression

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 5 of 9
Hilda Mujcic, Ontario Cancer Institute, Canada
Hypoxic Activation of the Unfolded Protein Response (UPR) Induces Expression of the Metastasis-Associated Gene LAMP3

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 6 of 9
Stilla Frede, University of Duisburg-Essen, Germany
Acute Hypoxia Induces HIF-1 Independent Monocyte Adhesion to Endothelial Cells through Increased ICAM-1 Expression

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 7 of 9
Isabelle Ader, Institut de Pharmacologie et de Biologie Structurale, France
Neutralization of Exogenous Sphingosine 1-Phosphate by Therapeutic Antibody Strategy Inhibits Hypoxia in vitro and Animal Models

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 8 of 9
Peppi Koivunen, University of Oulu, Finland
Hearts of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection Against Ischemia-Reperfusion Injury

Friday, January 22 | 2:30PM - 4:30PM
Workshop 2: Therapeutics
Room: Grays/Longs Peaks

Speaker 9 of 9
Dana L. Miller, University of Washington, USA
Hydrogen Sulfide Protects against Hypoxia in C. elegans

Friday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, January 22 | 5:00PM - 7:15PM
Inflammation
Room: Grays/Longs Peaks

Speaker 1 of 5
* Agnes Görlach, German Heart Center Munich, TU Munich, Germany
ROS and HIF Crosstalk

Friday, January 22 | 5:00PM - 7:15PM
Inflammation
Room: Grays/Longs Peaks

Speaker 2 of 5
Sean P. Colgan, University of Colorado Denver, USA
The Interplay of Hypoxia and Mucosal Inflammation

Friday, January 22 | 5:00PM - 7:15PM
Inflammation
Room: Grays/Longs Peaks

Speaker 3 of 5
Cormac Taylor, University College Dublin, Ireland
Short Talk: Loss of Prolyl Hydroxylase-1 (PHD-1) is Protective in a Murine Model of Inflammatory Bowel Disease

Friday, January 22 | 5:00PM - 7:15PM
Inflammation
Room: Grays/Longs Peaks

Speaker 4 of 5
Gabriele A.I. Bergers, University of Leuven, Belgium
HIF Induces Influx of Intratumoral Bone Marrow Derived Cells to Drive Neovascularization

Friday, January 22 | 5:00PM - 7:15PM
Inflammation
Room: Grays/Longs Peaks

Speaker 5 of 5
Thorsten Cramer, RWTH Aachen University, Germany
Short Talk: Dual Role of HIF-1alpha in the Pathogenesis of Inflammation-Associated Cancer

Friday, January 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak


Friday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Saturday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 1 of 6
* Christopher J. Schofield, University of Oxford, UK
Iron- and 2-Oxoglutarate-Dependent Dioxygenases

Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 2 of 6
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Fatty Acid Oxidation and Survival of Cancer Cells

Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 3 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Complex III Regulates Signaling

Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 4 of 6
Siegfried Hekimi, McGill University, Canada
Short Talk: Mitochondrial ROS Increases HIF-1alpha Expression and Enhance the Immune Response in Long-Lived Mclk1+/- Mutant Mice

Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 5 of 6
Lewis C. Cantley, Weill Cornell Medicine, USA
PI-3Kinase and cancer metabolism

Saturday, January 23 | 8:00AM - 11:15AM
Metabolism
Room: Grays/Longs Peaks

Speaker 6 of 6
Luis del Peso, Universidad Autonoma, Spain
Short Talk: Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

Saturday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, January 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, January 23 | 5:00PM - 7:15PM
Stress Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 1 of 5
Thomas Kietzmann, University of Oulu, Finland
Signalling Cross-Talk between Hypoxia and Insulin

Saturday, January 23 | 5:00PM - 7:15PM
Stress Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 2 of 5
* L. Eric Huang, University of Utah, USA
HIF-1alpha, Genetic Alteration, and Tumor Progression

Saturday, January 23 | 5:00PM - 7:15PM
Stress Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 3 of 5
Amato J. Giaccia, Stanford University, USA
Stress Responses Induced by Hypoxia that Modulate Tumor Progression

Saturday, January 23 | 5:00PM - 7:15PM
Stress Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 4 of 5
Tobias Eckle, University of Colorado Denver, USA
Short Talk: Adenosine-Dependant Stabilization of Period 2 Promotes Metabolic Adaptation of the Myocardium to Limited Oxygen Availability

Saturday, January 23 | 5:00PM - 7:15PM
Stress Responses to Hypoxia
Room: Grays/Longs Peaks

Speaker 5 of 5
Lisa Heiserich, Beatson Institute for Cancer Research, UK
Short Talk: PHD3 Activity Regulates Hypoxia-Induced Actin Cytoskeleton Rearrangement and Cell Migration

Saturday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak


Saturday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Saturday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Sunday, January 24 | 10:25AM - 10:25AM
Departure


*Session Chair.